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Computed tomography-based radiomic to predict resectability in locally advanced pancreatic cancer treated with chemotherapy and radiotherapy

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 703-715页

作者： Gabriella Rossi Luisa Altabella Nicola Simoni Giulio Benetti Roberto Rossi Martina Venezia Salvatore Paiella Giuseppe Malleo Roberto Salvia stefania Guariglia Claudio Bassi Carlo Cavedon Renzo Mazzarotto Department of Radiation Oncology University of Verona Hospital TrustVerona 37126Italy Department of Medical Physics University of Verona Hospital TrustVerona 37126Italy Department of General and Pancreatic Surgery Pancreas InstituteUniversity of Verona Hospital TrustVerona 37126Italy

BACKGROUND Surgical resection after neoadjuvant treatment is the main driver for improved survival in locally advanced pancreatic cancer(LAPC).However,the diagnostic performance of computed tomography(CT)imaging to evaluate the residual tumour burden at restaging after neoadjuvant therapy is low due to the difficulty in distinguishing neoplastic tissue from fibrous scar or *** this context,radiomics has gained popularity over conventional imaging as a complementary clinical tool capable of providing additional,unprecedented information regarding the intratumor heterogeneity and the residual neoplastic tissue,potentially serving in the therapeutic decision-making *** To assess the capability of radiomic features to predict surgical resection in LAPC treated with neoadjuvant chemotherapy and *** Patients with LAPC treated with intensive chemotherapy followed by ablative radiation therapy were retrospectively *** thousand six hundred and fifty-five radiomic features were extracted from planning CT inside the gross tumour *** extracted features and clinical data contribute to create and validate the predictive model of resectability *** were repeatedly divided into training and validation *** discriminating performance of each model,obtained applying a LASSO regression analysis,was assessed with the area under the receiver operating characteristic curve(AUC).The validated model was applied to the entire dataset to obtain the most significant *** Seventy-one patients were included in the *** age was 65 years and 57.8%of patients were *** patients underwent induction chemotherapy followed by ablative radiotherapy,and 19(26.8%)ultimately received surgical *** the first step of variable selections,a predictive model of resectability was developed with a median AUC for training and validation sets of 0.862(95%CI:0.792-0.921)and 0.853(95%CI:0.706-0.960),respectivel

关键词： Computed tomography Radiomics Predictive model Resectability Locally advanced pancreatic cancer Radiation oncology

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Quality of life in patients with minimal hepatic encephalopathy

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World Journal of Gastroenterology 2018年第48期24卷 5446-5453页

作者： Lorenzo Ridola Silvia Nardelli stefania Gioia Oliviero Riggio Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome Department of Clinical Medicine Sapienza University of Rome

Minimal hepatic encephalopathy(MHE) represents the mildest type of hepatic encephalopathy(HE). This condition alters the performance of psychometric tests by impairing attention, working memory, psychomotor speed, and visuospatial ability, as well as electrophysiological and other functional brain measures. MHE is a frequent complication of liver disease, affecting up to 80% of tested patients, depending of the diagnostic tools used for the diagnosis. MHE is related to falls, to an impairment in fitness to drive and the development of overt HE, MHE severely affects the lives of patients and caregivers by altering their quality of life(QoL) and their socioeconomic status. MHE is detected in clinically asymptomatic patients through appropriate psychometric tests and neurophysiological methods which highlight neuropsychological alterations such as video-spatial orientation deficits, attention disorders, memory, reaction times, electroencephalogram slowing, prolongation of latency evoked cognitive potentials and reduction in the critical flicker frequency. Several treatments have been proposed for MHE treatment such as non-absorbable disaccharides, poorly absorbable antibiotics such rifaximin, probiotics and branched chain amino acids. However, because of the multiple diagnosis methods, the various endpoints of treatment trials and the variety of agents used in trials, to date the treatment of MHE is not routinely recommended apart from on a case-by-case basis. Aim of this review is analyze the burden of MHE on QoL of patients and provide a brief summary of therapeutic approaches.

关键词： Cirrhosis Minimal hepatic encephalopathy Covert hepatic encephalopathy Health related quality of life

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Protein kinase CK2: a potential therapeutic target for diverse human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1698-1717页

作者： Christian Borgo Claudio D'Amore stefania Sarno Mauro Salvi Maria Ruzzene Department of Biomedical Sciences University of PaduaPaduaItaly CNR Institute of Neuroscience University of PaduaPaduaItaly

CK2 is a constitutively active Ser/Thr protein kinase,which phosphorylates hundreds of substrates,controls several signaling pathways,and is implicated in a plethora of human *** best documented role is in cancer,where it regulates practically all malignant *** well-known functions of CK2 are in human infections;in particular,several viruses exploit host cell CK2 for their life *** recently,also SARS-CoV-2,the virus responsible for the COVID-19 pandemic,has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates(either viral and host proteins).CK2 is also considered an emerging target for neurological diseases,inflammation and autoimmune disorders,diverse ophthalmic pathologies,diabetes,and *** addition,CK2 activity has been associated with cardiovascular diseases,as cardiac ischemia-reperfusion injury,atherosclerosis,and cardiac *** hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many ***,psychiatric disorders and syndromes due to CK2 mutations have been recently *** these bases,CK2 is emerging as an increasingly attractive target in various fields of human medicine,with the advantage that several very specific and effective inhibitors are already ***,we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.

关键词： diseases inflammation potential

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Endoscopic ultrasound-guided fine-needle aspiration pancreatic adenocarcinoma samples yield adequate DNA for next-generation sequencing:A cohort analysis

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World Journal of Gastroenterology 2023年第18期29卷 2864-2874页

作者： stefania Bunduc Bianca Varzaru Razvan Andrei Iacob Andrei Sorop Ioana Manea Andreea Spiridon Raluca Chelaru Adina Emilia Croitoru Gabriel Becheanu Mona Dumbrava Simona Dima Irinel Popescu Cristian Gheorghe Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 020021Romania Digestive Diseases and Liver Transplantation Center Fundeni Clinical InstituteBucharest 022328Romania Center of Excellence in Translational Medicine Fundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Genetic tests are increasingly performed for the management of unresectable pancreatic *** genotyping aimed samples current guidelines recommend using core specimens,although based on moderate quality ***,in clinical practice among the endoscopic ultrasound(EUS) guided tissue acquisition methods,fine needle aspiration(FNA) is the most widely *** To assess the adequacy for next generation sequencing(NGS) of the DNA yielded from EUS-FNA pancreatic adenocarcinoma(PDAC) *** Between November 2018 and December 2021,105 patients with PDAC confirmed by EUS-FNA were included in the study at our tertiary gastroenterology *** 22 gauge(G) or 19G FNA needles were *** pass was dedicated to DNA *** concentration and purity(A260/280,A260/230) were assessed by *** assessed the differences in DNA parameters according to needle size and tumor characteristics(size,location) and the adequacy of the extracted DNA for NGS(defined as A260/280 ≥ 1.7,and DNA yield:≥ 10 ng for amplicon based NGS,≥ 50 ng for whole exome sequencing [WES],≥ 100 ng for whole genome sequencing [WGS]) by analysis of variance and ttest ***,we compared DNA purity parameters across the different DNA yield *** Our cohort included 49% male patients,aged 67.02 ± 8.38 *** 22G needle was used in 71%of the *** DNA parameters across our samples varied as follows:DNA yield:1289 ng(inter quartile range:534.75-3101),A260/280 = 1.85(1.79-1.86),A260/230 = 2.2(1.72-2.36).DNA yield was > 10 ng in all samples and > 100 ng in 93% of them(one sample < 50 ng).There were no significant differences in the concentration and A260/280 between samples by needle *** size was the only independent predictor of A260/230 which was higher in the 22G samples(P =0.038).NGS adequacy rate was 90% for 19G samples regardless of NGS type,and for 22G samples it reached 89% for WGS adequacy and 91% for WES and

关键词： Pancreatic adenocarcinoma Endoscopic ultrasound guided fine needle aspiration Next generation sequencing DNA yield Needle size Genetic testing

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Soil bacterial communities under slash and burn in Mozambique as revealed by a metataxonomic approach

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Pedosphere 2023年第3期33卷 508-520页

作者： Dominique SERRANI Ilario FERROCINO Cristiana GAROFALO Andrea OSIMANI Maria Rita CORVAGLIA Vesna MILANOVIĆ Lucia AQUILANTI stefania COCCO Valeria CARDELLI Rogério Borguete Alves RAFAEL Elena FRANCIOSI Kieran TUOHY Francesca CLEMENTI Giuseppe CORTI Department of Agriculture Food and Environmental SciencesPolytechnic University of MarcheAncona 60131(Italy) Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco 10095(Italy) Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257(Mozambique) Research and Innovation Center Fondazione Edmund Mach(FEM)San Michele all'Adige 38010(Italy)

The slash-and-burn system is a subsistence agronomical practice widespread in tropical areas *** system has been extensively studied,especially for its impacts on agronomical aspects and soil physicochemical properties;however,knowledge of soil microbial diversity under slash and bum is *** this study,for the first time,soil bacterial diversity of three locations from Central Mozambique,where slash and burn has been practiced for different durations of the forest fallow period(ca.25,35,and 50 years),was elucidated through a metataxonomic *** communities were evaluated in the genetic horizons of soils under charcoal kilns,crop fields,and *** aim of this study was to examine the influence of spatial(location and land use),temporal(forest fallow period),and vertical(horizon)variations on bacterial community structure in relation to soil physicochemical *** analysis detected 25 different phyla whose distribution varied horizontally and vertically in relation to soil properties(i.e.,p H,easily oxidizable organic carbon,total nitrogen,and available phosphorus),as well as particle size distribution and mineralogical *** properties were strongly affected and altered by land-use management;in particular,charcoal kilns exhibited better soil properties and greater differences in bacterial community than crop fields and forests,which were quite *** might suggest the inability of a forest fallow period shorter than 50 years to improve soil fertility and induce changes in bacterial *** uncommon application of the pedological approach for microbial evaluation facilitated the detection of a clear separation in bacterial composition along the soil profile,with eutrophic bacteria mainly located in the A horizon whereas oligotrophic bacteria were found in the Bo *** horizontal and vertical heterogeneities in the same study represent a novelty for bacterial metataxonomic analysis.

关键词： 16S rRNA gene agroforestry land use soil microbiota soil physicochemical property

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Simulation of dam-break waves on movable beds using a multi-stage centered scheme

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International Journal of Sediment Research 2013年第3期28卷 269-284页

作者： stefania EVANGELISTA Mustafa S.ALTINAKAR Cristiana DI CRISTO Angelo LEOPARDI Dipartimento di Ingegneria Civile e Meccanica Universita degli Studi di Cassino e del Lazio Meridionale NCCHE National Center for Computational Hydroscience and EngineeringUniversity of Mississippi

This paper presents the application of the multi-stage first-order centered scheme GMUSTA to solve a two-phase flow model with four equations for simulating dam-break floods without and with sediment *** of generalized Riemann invariants can be particularly complex and costly in simulating dam-break floods with sediment *** numerical scheme,which does not require complete knowledge of the eigenstructure of the hyperbolic mathematical model,offers a suitable and attractive *** quality of the dam-break flood simulations with GMUSTA scheme is verified by comparing the results against laboratory tests and some experimental data available in the literature,on fixed and mobile bed conditions,with different bed materials and flush or stepped *** numerical results reproduce quite well the experimental evidence,proving that the model is capable of predicting the temporal evolution of the free-surface and the *** GMUSTA scheme,which is not only simple to implement but also both accurate and computationally efficient,is proposed as an appropriate tool for integrating non-equilibrium sediment-transport models.

关键词： Dam break Sediment transport Shallow water Multi-stage scheme GMUSTA

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Unique immunological profile in patients with COVID-19

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Cellular & Molecular Immunology 2021年第3期18卷 604-612页

作者： stefania Varchetta Dalila Mele Barbara Olivier stefania Mantovani Serena Ludovisi Antonella Cerino Raffaele Bruno Alberto Castelli Mario Mosconi Marco Vecchia Silvia Roda Michele Sachs Catherine Klersy Mario U.Mondelli Division of Infectious Diseases Ⅱ and Immunology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Internal Medicine and Therapeutics University of PaviaPaviaItaly Division of Infectious Diseases I Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical SurgicalDiagnosticand Pediatric SciencesUniversity of PaviaPaviaItaly Division of Orthopaedics and Traumatology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPaviaItaly Clinical Epidemiology&Biometry Unit IRCCS Fondazione Polidinico San MatteoPaviaItaly

The relationship between severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and host immunity is poorly *** performed an extensive analysis of immune responses in 32 patients with severe COVID-19,some of whom succumbed A control population of healthy subjects was *** with COVID-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell *** cells and CD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and *** cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature CD56^(bright) and an expansion of mature CD57^(+)F_(CEI)Rlγ^(eng) adaptive NK cells compared to *** serum levels of IL-6 were also more frequently identified in deceased patients compared to *** note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69,PD-1 and TIM-3 expression and restoration of CD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by *** findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.

关键词： C0VID-19 NK cells TIM-3 IL6 Monocytes

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Perimesencephalic Subarachnoid Hemorrhage in Pregnancy: A Case Report

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Maternal-Fetal Medicine 2022年第4期4卷 290-292页

作者： stefania Ruggieri Maurizia Gatto Maria Annunziata Gentile Salvatore D'Oria Filippo Tamma Domenico Caringella Alessandra Giocolano Chiara Taccalti Maurizio Guido Department of Obstetrics and Gynecology Catholic University of theSacred HeartPoliclinico Agostino Gemell iRCCSRome 00168Italy Department of Obstetrics and Gynecology General Regional Hospital"F.Miull"Acquaviva delle Fonti 70021Italy Department of Neurology General Regional Hospital"F.Miuli"AcquavivadelleFonti70021litaly Department of Neuroradiology General Regional Hospital“F.Miulli"Acquaviva delle Fonti 70021Italy Department of Neurosurgery General Regional Hospital"F.Miulli"Acquavivadelle Fonti 70021Italy MeSVA Department University of L'AquilaL'Aquila 67100Italy

Perimesencephalic subarachnoid hemorrhage (P-SAH) is a benign subset of subarachnoid hemorrhage. Only two cases of P-SAH during pregnancy have been reported in the literature. We describe a case of P-SAH detected at 29 weeks’ gestation, arose with severe bilateral frontal headache, neck rigidity, and vomiting. A diagnosis of P-SAH was confirmed on magnetic resonance angiography with no evidence of vascular malformation or bleeding sources and conservatively treated. Hemorrhage, vasospasm, and cerebellar edema observed on initial magnetic resonance angiography resolved after two months. The clinical course of P-SAH during pregnancy appears to be favorable. Our case shows for the first time in literature that magnetic resonance angiography is a valid diagnostic test for P-SAH during pregnancy that circumvents radiological risk associated with conventional imaging.

关键词： Subarachnoid hemorrhage Cerebrovascular diseases Headache Magnetic resonance angiography Pregnancy

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Genotoxicity of gold nanoparticles functionalized with indolicidin towards Saccharomyces cerevisiae

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Journal of Environmental Sciences 2018年第4期30卷 138-145页

作者： Elisabetta de Alteriis Annarita Falanga stefania Galdiero Marco Ouida Valeria Maselli Emilia Galdiero Department of Biology University of Naples "Federico II" 80100 Naples Italy Department of Pharmacy University of Naples "Federico II" 80134 Naples Italy

The toxic effects of gold nanoparticles surface-functionalized with the antimicrobial peptide indolicidin（Au NPs-indolicidin） towards the yeast Saccharomyces cerevisiae, one of the major eukaryotic model organisms, have been evaluated. Growth and survival,genotoxicity, as measured by comet assay, and expression of the YCA1, an apoptosis indicating gene, following 72 hr exposure of yeast to Au NPs-indolicidin, and to Au NPs and indolicidin alone have been examined. The gold nanoparticles exerted toxicity with DNA damage, accompanied by reactive oxygen species production（ROS）, but they do not inhibit yeast growth and viability. Genotoxicity was less pronounced for surface-functionalized nanoparticles, showing that S. cerevisiae is quite resistant to the complex Au NPs-indolicidin.A progressive reduction of the genotoxic effect was observed along 72 hr exposure,presumably due to the activation of DNA repair mechanisms. These findings suggest the occurrence of a physiological protective response of S. cerevisiae towards nanoparticles,thereby providing useful information to the assessment of the environmental impact of metal nanoparticles.

关键词： Ecotoxicity Antimicrobial peptide Comet assay Yeast Nanoparticles Oxidative stress

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Calibration and validation of a simulation model for predicting pedestrian fatalities at unsignalized crosswalks by means of statistical traffic data

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 1-18页

作者： Claudio Feliciani Andrea Gorrini Luca Crociani Giuseppe Vizzari Katsuhiro Nishinari stefania Bandini Research Center for Advanced Science and Technology The University of TokyoTokyo 1538904Japan Department of Aeronautics and Astronautics Graduate School of EngineeringThe University of TokyoTokyo 113-8656Japan

This work presents a simulation model for unsignalized crosswalks which takes into account collisions between vehicles and pedestrians,thus allowing to assess the estimated yearly pedestrian *** particular,we focus on a method to calibrate such a model combining measurable crosswalk characteristics,such as maximum speed limit or drivers’compliance,with statistical data for past accidents obtained from local *** order to perform simulations under realistic conditions,we constructed a one-week scenario where pedestrian and vehicle traffic vary using specific patterns each hour of the *** constructed traffic profile is based on openly available data and the suitability for the scenario considered(a crosswalk in Milan,Italy)is investigated showing that cultural/lifestyle elements determine the variation of weekly *** using the constructed one-week scenario were used to obtain the only non-measurable parameter which account for pedestrians’and drivers’*** addition,we also focused on the presence of elderly pedestrians which have different physiological characteristics compared to adults or children and are becoming an important part of the population in several countries around the *** simulation model presented here and the method suggested for calibration may be employed in different contexts,thus allowing to build an important tool to be used not only for transportation efficiency/optimization but also for safety analysis.

关键词： Traffic simulation Accident prevention Unsignalized crosswalk Vehicle-pedestrian interaction Weekly traffic variation

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