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The JAK2<sup>V617F</sup>Mutation Seen in Myeloproliferative Neoplasms (MPNs) Occurs in Patients with Inflammatory Bowel Disease: Implications of a Pilot Study

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International Journal of Clinical Medicine 2013年第12期4卷 10-15页

作者： Emil Kuriakose Elena Lascu Y. Lynn Wang stefani gjoni Nicholas C. P. Cross Ruth Baumann Kerilee Tam Ellen Scherl Randy S. Longman Richard T. Silver Department of Pathology University of Chicago Chicago USA Division of Hematology and Medical Oncology Weill Cornell Medical College New York USA Jill Roberts Center for Inflammatory Bowel Disease Division of Gastroenterology Weill Cornell Medical College New York USA Wessex Regional Genetics Laboratory Salisbury District Hospital University of Southampton Salisbury UK

Patients with IBD frequently have hematologic abnormalities suggestive of JAK2 mutated MPNs, but are traditionally classified as reactive processes. Haplotype 46/1 is a well-characterized genetic predisposition, common to both inflammatory bowel disease (IBD) and myeloproliferative neoplasms (MPN). In view of this shared genetic predisposition, we measured the frequency of the JAK2V617F mutation in IBD patients with thrombocytosis or erythrocytosis, in order to ascertain whether a higher than expected proportion of these patients may in fact have underlying MPNs. 1121 patients were identified with an active diagnosis of Crohn’s disease or ulcerative colitis, of which 474 had either thrombocytosis or erythrocytosis. Patients with abnormal counts were tested for the JAK2V617F mutation during routine follow-up visits. Interim analysis of first 23 patients tested was performed to assess whether the JAK2V617F positivity rate was statistically significant compared with known expected frequencies in a comparable control population. Of 23 patients, 13 patients had thrombocytosis and 10 had erythrocytosis. Three patients with thrombocytosis (23%), and 1 patient with erythrocytosis (10%), tested positive for JAK2V617F, exceeding the expected thresholds for statistical significance. In patients with IBD and thrombocytosis or erythrocytosis, a meaningful proportion may harbor an undiagnosed MPN, as indicated by clonal abnormalities such as JAK2V617F. These findings imply the need for increased testing of these patients for clonal hematologic abnormalities, and importantly, if found, suggest the need for therapeutic strategies with drugs, such as JAK2 inhibitors, in patients with both MPN and IBD.

关键词： JAK2V617F Myeloproliferative Neoplasms Inflammatory Bowel Disease Thrombocythemia Polycythemia

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Conversion surgery for gastric cancer patients:A review

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 398-409页

作者： Tommaso Zurleni Elson gjoni Michele Altomare Stefano Rausei Department of Surgery ASST Valle OlonaBusto Arsizio 21052Italy Department of Surgery ASST Valle OlonaGallarate.21013Italy

Gastric cancer(GC) is the third most common cancer-related cause of death worldwide. In locally advanced tumors, neoadjuvant chemotherapy has recently been introduced in most international Western guidelines. For metastatic and unresectable disease, there is still debate regarding correct management and the role of surgery. The standard approach for stage IV GC is palliative chemotherapy. Over the last decade, an increasing number of M1 patients who responded to palliative regimens of induction chemotherapy have been subsequently undergone surgery with curative intent. The objective of the present review is to analyze the literature regarding this approach, known as "conversion surgery", which has become one of the most commonly adopted therapeutic options. It is defined as a treat-ment aiming at an R0 resection after chemotherapy in initially unresectable tumors. The 13 retrospective studies analyzed, with a total of 411 patients treated with conversion therapy, clearly show that even if standardization of unresectable and metastatic criteria, post-chemotherapy resectability evaluation and timing of surgery has not yet been established, an R0 surgery after induction chemotherapy with partial or complete response seems to offer superior survival results than chemotherapy alone. Additional larger sample-size randomized control trials are needed to identify subgroups of well-stratified patients who could benefit from this multimodal approach.

关键词： Metastatic gastric cancer Gastric cancer Conversion surgery R0 resection Stage IV gastric cancer Palliative chemotherapy Unresectable gastric cancer

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From Passive Viewers to Content Generators： Audience Role on TV Programs and Online Media

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Journalism and Mass Communication 2017年第2期7卷 63-77页

作者： Edlira gjoni Tirana University Tirana Albania

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国际医学放射学杂志 2023年第3期 367-367页

作者： M.O.Awiwi A.Abudayyeh N.Abdel-Wahab A.Diab M.gjoni G.Xu 赵一婷

摘要目的免疫检查点抑制剂相关性肾炎的影像学表现目前尚无文献报道。本研究的主要目的是描述免疫治疗相关肾炎在CT和PET上的影像表现。次要目的是探讨影像学

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Sixth and seventh tumor-node-metastasis staging system compared in gastric cancer patients

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World Journal of Gastrointestinal Surgery 2013年第11期5卷 287-293页

作者： Tommaso Zurleni Elson gjoni Andrea Ballabio Roberto Casieri Paola Ceriani Luca Marzoli Francesco Zurleni Department of General Surgery Hospital of Busto Arsizio21052 Busto ArsizioItaly Department of Medical Physics Hospital of BustoArsizio21052 Busto ArsizioItaly

AIM: To investigate the clinical relevance and prognosis regarding survival according to the changes of the tumor-node-metastasis(TNM) in gastric cancer patients. METHODS: We retrospectively studied 347 consecutive subjects who underwent surgery for gastric adenocarcinoma at the Division of General Surgery, Hospital of Busto Arsizio, Busto Arsizio, Italy between June 1998 and December 2009. Patients who underwent surgery without curative intent, patients with tumors of the gastric stump and patients with tumors involving the esophagus were excluded for survival analysis. Patients were staged according to the 6thand 7thedition TNM criteria; 5-year overall survival rates were investigated, and the event was defined as death from any cause. RESULTS: After exclusion, our study population included 241 resected patients with curative intent for gastric adenocarcinoma. The 5-year overall survival(5-year OS) rate of all the patients was 52.8%. Thediagnosed stage differed in 32% of 241 patients based on the TNM edition used for the diagnosis. The patients in stage Ⅱ according to the 6thedition who were reclassified as stage Ⅲ had significantly worse prognosis than patients classified as stage Ⅱ(5-year OS, 39% vs 71%). According to the 6thedition, 135 patients were classifed as T2, and 75% of these patients migrated to T3 and exhibited a significantly worse prognosis than those who remained T2, regardless of lymph node involvement(37% vs 71%). The new N1 patients exhibited a better prognosis than the previous N1 patients(67% vs 43%). CONCLUSION: 7thTNM allows new T2 and N1 patients to be selected with better prognosis, which leads to different staging. New stratification is important in multimodal therapy.

关键词： Gastric cancer Tumor-node-metastasis staging system Survival analysis Prognostic factor Lymphadenectomy

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