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International Journal of Astronomy and Astrophysics 2014年第1期4卷 39-53页

作者： Dimitrie olenici Alexander F. Pugach Ilie Cosovanu Cezar Lesanu Jean-Bernard Deloly Danil Vorobyov Alexander Delets stefan-bogdan olenici-craciunescu Association AIRAMA Paris France Astronomical Observatory Stefan cel Mare University of Suceava Suceava Romania Leibniz-Institut fur Analytische Wisenschaften-ISAS-e.V Dortmund Germany Main Astronomical Observatory of National Academy of Sciences Kiev Ukraine Tomsa Voda Technological Highschool Solca Romania

Several simultaneous observations are presented of Syzygy effects during two solar eclipses, performed with torsinds and Foucault pendulums. The experiments/measurements were of a simple nature, conducted in several of places in Romania and Ukraine. It is shown that during Syzygy effects both the torsind and the Foucault pendulum exhibit specific reactions: the torsind’s disk is rotated, whereas the direction of the swing plane, the period, the eccentricity and the chirality of the ellipse of oscillation of the Foucault pendulum are all altered. We term all these perturbations “Syzygy effects” and found that they take place even when the devices are in locations where the eclipse is not visible and even when they are underground. An unusual time shifts?between the responses of the devices and the maximum phase of the eclipse is detected. The importance of simultaneous simple observations of astronomical phenomena using these two devices of fundamentally different types is emphasized.

关键词： Paraconical Pendulum Antieclipse Effect Torsind

Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance

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Neural Regeneration Research 2025年第11期20卷 3113-3123页

作者： Theodora Ntetsika Sergiu-bogdan Catrina Ioanna Markaki Department of Clinical Neuroscience Karolinska InstituteStockholmSweden Department of Neurology Karolinska University HospitalStockholmSweden Department of Molecular Medicine and Surgery Karolinska InstituteStockholmSweden Center for Diabetes Academic Specialist CenterStockholmSweden Center for Neurology Academic Specialist CenterStockholmSweden

Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic *** data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular *** insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological *** contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.

关键词： brain insulin resistance brain insulin signaling diabetes type 2 GLP-1 receptor agonists GLP-1 signaling insulin resistance insulin signaling neurodegeneration Parkinson's disease targeted therapy

Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites

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Neural Regeneration Research 2025年第9期20卷 2645-2654页

作者： Kirsty Goncalves stefan Przyborski Department of Biosciences Durham UniversityDurhamUK Reprocell Europe Ltd. GlasgowUK

Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's *** accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is believed to induce neuritic abnormalities,including reduced growth,extension,and abnormal growth cone morphology,all of which contribute to decreased ***,the precise cellular and molecular mechanisms governing this response remain *** this study,we used an innovative approach to demonstrate the effect of amyloid-βon neurite dynamics in both two-dimensional and three-dimensional cultu re systems,in order to provide more physiologically relevant culture *** utilized various methodologies,including the addition of exogenous amyloid-βpeptides to the culture medium,growth substrate coating,and the utilization of human-induced pluripotent stem cell technology,to investigate the effect of endogenous amyloid-βsecretion on neurite outgrowth,thus paving the way for potential future applications in personalized ***,we also explore the involvement of the Nogo signaling cascade in amyloid-β-induced neurite *** demonstrate that inhibition of downstream ROCK and RhoA components of the Nogo signaling pathway,achieved through modulation with Y-27632(a ROCK inhibitor)and Ibuprofen(a Rho A inhibitor),respectively,can restore and even enhance neuronal connectivity in the presence of amyloid-β.In summary,this study not only presents a novel culture approach that offers insights into the biological process of neurite growth and inhibition,but also proposes a specific mechanism for reduced neural connectivity in the presence of amyloid-βpeptides,along with potential intervention points to restore neurite ***,we aim to establish a culture system that has the potential to serve as an assay for measuring preclinical,predictive outcomes of drugs and their ability to promote neurite outgrowth,both generally and in a patie

关键词： Alzheimer's disease induced pluripotent stem cell neurite outgrowth neuron Nogo Rho A ROCK stem cell three-dimensional culture

Autologous cord blood vs individualized supplements in autistic spectrum disorder:CORDUS study results

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World Journal of Clinical Pediatrics 2025年第1期14卷 101-112页

作者： Felician A Stancioiu Raluca bogdan bogdan Ivanescu Radu Dumitrescu Department of Clinical Research Bio-Forum FoundationBucharest 040245BucurestiRomania Department of Pediatrics Medicover Hospital BucharestBucharest 013982BucurestiRomania Doctor MiT Clinic Bucharest 013929BucurestiRomania Department of Anesthesiology and Intensive Therapy Medicover HospitalBucharest 013982BucurestiRomania

BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell *** cells have yielded so far mixed results in clinical trials,and at patient level the results varied from impressive to no *** this context we have administered autologous cord blood(ACB)and a non-placebo,material intervention repre-sented by an individualized combination of supplements(ICS)to ASD *** CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children;ACB was infused as an inpatient *** efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist,Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score,after interviewing the children’s parents and *** and after each intervention participants had a set of blood tests including inflammatory,metabolic and oxidative markers,and the neuronal specific *** No serious adverse reactions were noted during and after cord blood or supplement *** improved evaluation scores in 78%of children with age 3–7-years(n=28),but was much less effective in kids older than 8 years or with body weight of more than 35 kg(n=28;only 11%of children improved scores).ICS yielded better results than ACB in 5 cases out of 28,while in 23 kids ACB brought more improvement than ICS(P<0.05);high initial levels of inflammation and ferritin were associated with no *** individual differences were noted in children's progress,and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction,but not on irritability or

关键词： Autistic spectrum disorder Cord blood Stem cells Neuroinflammation Autologous stem cell treatment Neuronal specific enolase

Bridging element-free Galerkin and pluri-Gaussian simulation for geological uncertainty estimation in an ensemble smoother data assimilation framework

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Petroleum Science 2024年第3期21卷 1683-1698页

作者： bogdan Sebacher Remus Hanea Department of Applied Informatics Military Technical Academy“Ferdinand I”Bucharest 050141Romania Equinor Sandslivegen 905254 SandsliBergenNorway

The facies distribution of a reservoir is one of the biggest concerns for geologists,geophysicists,reservoir modelers,and reservoir engineers due to its high importance in the setting of any reliable decisionmaking/optimization of field development *** approach for parameterizing the facies distribution as a random variable comes naturally through using the probability *** the prior probability fields of facies come either from a seismic inversion or from other sources of geologic information,they are not conditioned to the data observed from the cores extracted from the *** paper presents a regularized element-free Galerkin(R-EFG)method for conditioning facies probability fields to facies *** conditioned probability fields respect all the conditions of the probability theory(*** the values are between 0 and 1,and the sum of all fields is a uniform field of 1).This property achieves by an optimization procedure under equality and inequality constraints with the gradient projection *** conditioned probability fields are further used as the input in the adaptive pluri-Gaussian simulation(APS)methodology and coupled with the ensemble smoother with multiple data assimilation(ES-MDA)for estimation and uncertainty quantification of the facies *** history-matching of the facies models shows a good estimation and uncertainty quantification of facies distribution,a good data match and prediction capabilities.

关键词： Element free Galerkin(EFG) Adaptive pluri-Gaussian simulation(APS) Facies distribution estimation Ensemble smoother with multipledata assimilation(ESMDA)

Miniature Detonating Cord (MDC) for Breaking Organic Glass Plates

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含能材料 2008年第5期16卷 618-620页

作者： bogdan ZYGMUNT Military University of Technology Mechatronics Faculty2 Kaliski Str.00-908 WarsawPoland

In order to develop a method to break the aircrafts canopy,a miniature detonating cords (MDC) of 1 mm in diameter were manufactured and its detonation properties were *** in a heavy lead confinement were also manufactured and were examined for breaking of organic glass *** showthat MDC in lead confinement with 1g plastic explosive per metre,cuts organic glass plate 10 mm thick.

关键词：有机玻璃爆炸性能物理性能功能材料塑胶炸弹

Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage,histopathological grade of malignancy and clinical features

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World Journal of Gastroenterology 2004年第4期10卷 583-585页

作者： bogdan Zalewski 2nd Department of General and Gastroenterological Surgery Medical University of BialystokPoland

AIM:This study was designed to compare the levels of v5 and v6 splice variants of CD44 evaluated using EITSA test in the serum of patients with colorectal cancer in different stages of progression of the disease estimated in pT stage according to WHO score,histopathological grade of malignancy and some clinicopathological features. METHODS:The serum obtained from 114 persons with colorectal adenocarcinomas was examined using ELISA method,pT stage and grade of malignancy of the tumour were examined in formalin fixed and paraffin embedded materials obtained during operation. RESULTS:Only the level of CD44 v5 in the serum of patients before operation with G2 pT4 tumour was lower than that in other probes and the difference was statistically significant. We did not find any other correlations between the level of v5 and v6 CD44 variants and other evaluated parameters. CONCLUSION:The level of CD44 v5 and v6 estimated by ELISA test in the serum can not be used as a prognostic factor in colorectal cancer.

关键词： Alternative Splicing Adenocarcinoma Adult Aged Aged, 80 and over Antigens, CD44 Colorectal Neoplasms Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Predictive Value of Tests Prognosis Tumor Markers, Biological

Response of photosynthesis,growth,and acorn mass of pedunculate oak to diff erent levels of nitrogen in wet and dry growing seasons

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Journal of Forestry Research 2023年第1期34卷 167-176页

作者： Krunoslav Sever Saša bogdan ŽeljkoŠkvorc Faculty of Forestry and Wood Technology University of ZagrebSvetošimunska 2510000 ZagrebCroatia

The objective was to examine the effects of optimal leaf nitrogen levels>2.0%and suboptimal levels<2.0%,nitrogen nutrition on net photo synthetic rate,stem diameter increment,height growth increment and acorn mass of pedunculate oak during 2010 in the absence of drought stress and during 2011 under the impact of moderate drought *** to the results,moderate drought stress significantly reduced net photo synthetic rate,stem diameter increment and height growth increment,while acorn mass was not *** nitrogen nutrition significantly reduced the net photo synthetic rate and stem diameter increment only in the wet year,acorn mass in both wet and dry years,while height growth increment was not significantly reduced by suboptimal nitrogen nutrition in either *** results indicate that optimal nitrogen levels can stimulate photo synthetic rate and stem diameter increment of pedunculate oak only in the absence of moderate drought ***,the results show that moderate drought stress is a more dominant stressor for photosynthesis and growth of pedunculate oak than suboptimal nitrogen nutrition,while for acorn development,it is the more dominant stressor.

关键词： Quercus robur L. Drought stress Net photosynthic rate Stem diameter increment Height growth increment Acorn mass

Stressed axons craving for glial sugar: links to regeneration?

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Neural Regeneration Research 2022年第2期17卷 304-306页

作者： Elisabetta Babetto bogdan Beirowski Hunter James Kelly Research Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA

Extract The contrary but interrelated processes of axon degeneration and regeneration are the yin and yang of many neurodegenerative conditions. Here we discuss recent evidence for metabolic cross-talk between glia and injured axons regulating these processes. We especially focus on potential bioenergetic mechanisms as to how axon-flanking glia may promote regeneration.

关键词： degeneration conditions. processes.

Light tuning CO/H_(2)composition on Ag:Unraveling CO_(2)mass transfer and electron-phonon coupling in plasmon-enhanced electrocatalysis

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Nano Research 2025年第1期18卷 173-185页

作者： Rui Lin Dong Fan Luca MBerger Thomas Possmayer Yu Zhou Jiexin Zhu Xingbao Chen Wen Luo Lars Allmendinger Andreas Tittl Leonardo de Souza Menezes Guillaume Maurin Shihe Yang and stefan AMaier Nanoinstitute Munich Faculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Institut Charles Gerhardt Montpellier UMR 5253 CNRS ENSCM UniversitéMontpellierPlace E.Bataillon34090 MontpellierFrance Guangdong Provincial Key Lab of Nano-Micro Material Research School of Advanced MaterialsPeking University Shenzhen Graduate SchoolShenzhen 518055China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München81377 MunichGermany Departamento de Física Universidade Federal de Pernambuco50670-901 Recife-PEBrazil School of Physics and Astronomy Monash University Clayton CampusMelbourneVictoria 3800Australia Department of Physics Imperial College LondonSW72AZ LondonUK

Plasmon-enhanced electrocatalysis(PEEC)is an emerging approach to mitigate CO_(2)*** mechanisms behind CO_(2)adsorption and reduction at the catalyst-electrolyte interface in PEEC still need to be further ***,we employ a well-defined Ag nanostructure to elucidate these pivotal *** shining light with wavelengths of 625,525,405 nm on Ag,an adjustable CO/H_(2)ratio from 35 to 1 can be *** reaction pathway changing under plasmonic excitation does not originate from the lowered CO_(2)mass transfer in the vicinity of Ag,as the electrochemical quartz crystal microbalance results unravel that a slightly elevated temperature in bulk electrolyte caused by light irradiation cannot weaken the CO_(2)adsorption at the Ag catalyst-electrolyte *** calculations reveal that optical excitation towards shorter wavelengths leads to a progressive lowered energy barrier for H_(2)formation together with an enhanced energy barrier for^(*)COOH *** thermodynamically suppressed,CO_(2)reduction can still be improved kinetically by optimizing the excitation wavelength and intensity,being accompanied with the enhanced *** absorption spectroscopy results further correlate the higher photocurrent with a prolonged electron-phonon coupling time,verifying that the improvement of CO_(2)reduction kinetics in PEEC can be realized by hot electron harnessing.

关键词： plasmonic catalysis photoelectrochemical CO_(2)reduction CO/H_(2)ratio hot electron generation electronphonon coupling thermal effect