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Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites

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Neural Regeneration Research 2025年第9期20卷 2645-2654页

作者： Kirsty Goncalves stefan Przyborski Department of Biosciences Durham UniversityDurhamUK Reprocell Europe Ltd. GlasgowUK

Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's *** accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is believed to induce neuritic abnormalities,including reduced growth,extension,and abnormal growth cone morphology,all of which contribute to decreased ***,the precise cellular and molecular mechanisms governing this response remain *** this study,we used an innovative approach to demonstrate the effect of amyloid-βon neurite dynamics in both two-dimensional and three-dimensional cultu re systems,in order to provide more physiologically relevant culture *** utilized various methodologies,including the addition of exogenous amyloid-βpeptides to the culture medium,growth substrate coating,and the utilization of human-induced pluripotent stem cell technology,to investigate the effect of endogenous amyloid-βsecretion on neurite outgrowth,thus paving the way for potential future applications in personalized ***,we also explore the involvement of the Nogo signaling cascade in amyloid-β-induced neurite *** demonstrate that inhibition of downstream ROCK and RhoA components of the Nogo signaling pathway,achieved through modulation with Y-27632(a ROCK inhibitor)and Ibuprofen(a Rho A inhibitor),respectively,can restore and even enhance neuronal connectivity in the presence of amyloid-β.In summary,this study not only presents a novel culture approach that offers insights into the biological process of neurite growth and inhibition,but also proposes a specific mechanism for reduced neural connectivity in the presence of amyloid-βpeptides,along with potential intervention points to restore neurite ***,we aim to establish a culture system that has the potential to serve as an assay for measuring preclinical,predictive outcomes of drugs and their ability to promote neurite outgrowth,both generally and in a patie

关键词： Alzheimer's disease induced pluripotent stem cell neurite outgrowth neuron Nogo Rho A ROCK stem cell three-dimensional culture

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Enhancing the OGC WPS interface with GeoPipes support for real-time geoprocessing

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International journal of Digital Earth 2018年第1期11卷 48-63页

作者： stefan Herle jörg Blankenbach Geodetic Institute and Chair for Computing in Civil Engineering and Geo Information Systems RWTH Aachen UniversityAachenGermany

Real-time geospatial information is used in various applications such as risk management or alerting ***,the rise of new sensing technologies also increases the demand for processing the data in real ***’s spatial data infrastructures,however,do not meet the requirements for real-time *** OpenGIS®Web Processing Service(WPS)is not designed to process real-time *** has some major drawbacks in asynchronous processing and cannot handle(geo)data streams out of the *** previous papers,we introduced the GeoPipes approach to share spatiotemporal data in real *** implemented the concept extending the Message Queue and Telemetry Transport(MQTT)protocol by a spatial and temporal dimension,which we call *** this paper,we demonstrate the integration of the GeoPipes idea in the WPS interface to expose standardized real-time geoprocessing *** proof of the concept is illustrated in some exemplary real-time geo processes.

关键词： Real-time geoprocessing web processing service sensor web Internet-ofthings GeoPipes

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In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz j.T.Huber stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

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Micropatterning of Superhydrophobic Silicone Nanofilaments by a Near-Ultraviolet Nd:YAG Laser

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Nano Research 2010年第12期3卷 889-894页

作者： Ana Stojanovic Georg R.j.Artus stefan Seeger Institute of Physical Chemistry University of ZurichWinterthurerstrasse 1908057 ZürichSwitzerland

We demonstrate that a recently developed coating composed of superhydrophobic silicone nanofilaments can be selectively functionalized to yield well defined micron-scale patterns of contrasting wettabilities(superhydrophobic/hydrophilic and amphiphobic/amphiphilic).Nanofilament ablation was performed using a near-ultraviolet(UV)laser with a wavelength of 355 nm and a repetition rate of 10 *** is a highly promising approach for open channel microfluidics and microarray analysis due to its simplicity,the chemical and environmental stability of the coating,and the low cost.

关键词： Superhydrophobic ultraviolet(UV)laser ablation wettability open channels

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Generalized Sampling in Shift Invariant Spaces with Frames

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1823-1844页

作者： stefan ERICSSON Department of Engineering Sciences and Mathematics Lule University of Technology

Generalized sampling in a shift invariant subspace V of L2（R） is considered. A function f in V is processed with different filters Lm and then one tries to reconstruct f from the samples L^mf（j＇k）. We develop a theory of how to do this in the case when V possesses a shift invariant frame. Special attention is paid to the question： How to obtain dual frames with compact support？

关键词： Generalized sampling frames Riesz basis reproducing kernel shift invariant spaces

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Constitutive relations for the shear band evolution in granular matter under large strain

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Particuology 2008年第6期6卷 501-505页

作者： stefan Luding Multi Scale Mechanics TS CTW UTwente P.O. Box 217 7500 AE Enschede Netherlands

A so-called ＂split-bottom ring shear cell＂ leads to wide shear bands under slow, quasi-static deformation. Unlike normal cylindrical Couette shear cells or rheometers, the bottom plate is split such that the outer part of it can move with the outer wall, while the other part （inner disk） is immobile. From discrete element simulations （DEM）, several continuum fields like the density, velocity, deformation gradient and stress are computed and evaluated with the goal to formulate objective constitutive relations for the powder flow behavior. From a single simulation, by applying time- and （local） space-averaging, a non-linear yield surface is obtained with peculiar stress dependence. The anisotropy is always smaller than the macroscopic friction coefficient. However, the lower bound of anisotropy increases with the strain rate, approaching the maximum according to a stretched exponential with a specific rate that is consistent with a shear path of about one particle diameter.

关键词： Ring shear cell Shear bands DEM simulation Micro-macro transition Objective constitutive relations Yield stress fluid

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Influence of sample preparation on nanoindentation results of twinninginduced plasticity steel

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International journal of Minerals,Metallurgy and Materials 2021年第5期28卷 877-887页

作者： jiali Zhang stefan Zaefferer Institute for Materials Applications in Mechanical Engineering RWTH Aachen UniversityAachen 52062Germany Max-Planck-Institut für Eisenforschung Düsseldorf 40237Germany

Nanoindentation is an attractive characterization technique,as it not only measures the local properties of a material but also facilitates understanding of deformation mechanisms at submicron ***,because of the complex stress-strain field and the small scale of the deformation under the nanoindenter,the results can be easily influenced by artifacts induced during sample *** this work,a systematic study was conducted to better understand the influence of sample preparation methods on the nanoindentation results of ductile *** experiments were conducted on a steel(Fe-22Mn-0.65C,wt%)with twinning-induced plasticity(TWIP),which was selected for its large grain size and sensitivity to different surface preparation *** grouping the results obtained from each nanoindent,chemical polishing was found to be the best sample preparation method with respect to the resulting mechanical properties of the *** contrast,the presence of a deformation layer left by mechanical polishing and surface damage induced by focused ion beam(FIB)scanning were confirmed by the dislocation-nucleation-induced pop-in events of nanoindentation.

关键词： TWIP steels nanoindentation mechanical polishing chemical polishing pop-in

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Experimental investigation on slip conditions during thread rolling with flat dies

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Friction 2024年第1期12卷 136-143页

作者： stefan VOLZ Peter GROCHE Institute for Production Engineering and Forming Machines Technical University DarmstadtOtto-Berndt Straße 2Darmstadt 64287Germany

The process design of flat die rolling operations can be a tedious and costly process due to the challenges posed by small process *** this work,an effort is made to closely investigate and understand the process limits caused by excessive slippage of the *** measurements are carried out to capture the characteristics of excessive slippage and the influence of the stroke rate and the tribological system on this process *** differences in slippage were observed,depending on the tribological *** systems with polymer based lubricants showed excessive slippage at low stroke rates,systems using oil or no lubricant endured higher stroke rates before process limits were *** optical measurements revealed three major forms of slippage:successful rolling without slippage,failure due to excessive slippage at process start,and failure due to excessive slippage at around one workpiece rotation.

关键词： rolling incremental forming thread rolling slippage profile rolling

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Hopf algebras and Dyson-Schwinger equations

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Frontiers of physics 2016年第3期11卷 161-177页

作者： stefan Weinzierl PRISMA Cluster of Excellence Institut fiir Physik Johannes Gutenberg- Universitiit Mainz D - 55099 Mainz Germany

In this paper I discuss Hopf algebras and Dyson-Schwinger equations. This paper starts with an introduction to Hopf algebras, followed by a review of the contribution and application of Hopf algebras to particle physi... 详细信息

关键词： Feynman integrals Hopf algebras Dyson-Schwinger equations

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Optical inline analysis and monitoring of particle size and shape distributions for multiple applications: Scientific and industrial relevance

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Chinese journal of Chemical Engineering 2019年第2期27卷 257-277页

作者： j?rn Emmerich Qiao Tang Yundong Wang Peter Neubauer stefan j.nne Sebastian Maa? Bioprocess Engineering Department of Biotechnology Technische Universit?t Berlin SOPAT GmbH The State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University

Particles occur in almost all processes in chemical and life sciences. The particle size and shape influence the process performance and product quality, and in turn they are influenced by the flow behavior of the particles during production. Monitoring and controlling such characteristics in multiphase systems to obtain sufficient qualities will greatly facilitate the achievement of reproducible and defined distributions. So far, obtaining this information inline has been challenging, because existing instruments lack measurement precision, being unable to process overlapping signals from different particle phases in highly concentrated multiphase systems. However, recent advances in photo-optics made it possible to monitor such features(particle size distribution(PSD), aspect ratio and particle concentration) with advanced image analysis(IA) in real-time. New analysis workflows as well as single feature extractions from the images using multiple image analysis algorithms allowed the precise real-time measurements of size, shape and concentration of particle collectives even separated from each other in three phase systems. The performances, advantages and drawbacks with other non-photo-optical methods for assessing the particle size distribution are compared and discussed.

关键词： Particle Multiphase flow Algorithm Inline Photo-optical Concentration

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