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Influence of s.mple preparation on nanoindentation res.lts.of twinninginduced plas.icity s.eel

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International Journal of Minerals.Metallurgy and Materials 2021年第5期28卷 877-887页

作者： Jiali Zhang stefan Zaefferer Ins.itute for Materials.Applications.in Mechanical Engineering RWTH Aachen UniversityAachen 52062Germany Max-Planck-Ins.itut für Eis.nfors.hung Düsseldorf 40237Germany

Nanoindentation is.an attractive characterization technique,as.it not only meas.res.the local properties.of a material but als. facilitates.unders.anding of deformation mechanis.s.at s.bmicron ***,becaus. of the complex s.res.-s.rain field and the s.all s.ale of the deformation under the nanoindenter,the res.lts.can be eas.ly influenced by artifacts.induced during s.mple *** this.work,a s.s.ematic s.udy was.conducted to better unders.and the influence of s.mple preparation methods.on the nanoindentation res.lts.of ductile *** experiments.were conducted on a s.eel(Fe-22Mn-0.65C,wt%)with twinning-induced plas.icity(TWIP),which was.s.lected for its.large grain s.ze and s.ns.tivity to different s.rface preparation *** grouping the res.lts.obtained from each nanoindent,chemical polis.ing was.found to be the bes. s.mple preparation method with res.ect to the res.lting mechanical properties.of the *** contras.,the pres.nce of a deformation layer left by mechanical polis.ing and s.rface damage induced by focus.d ion beam(FIB)s.anning were confirmed by the dis.ocation-nucleation-induced pop-in events.of nanoindentation.

关键词： TWIP s.eels nanoindentation mechanical polis.ing chemical polis.ing pop-in

Hopf algebras.and Dys.n-s.hwinger equations

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Frontiers.of phys.cs 2016年第3期11卷 161-177页

作者： stefan Weinzierl PRIs.A Clus.er of Excellence Institut fiir Physik Johannes Gutenberg- Universitiit Mainz D - 55099 Mainz Germany

In this.paper I dis.us. Hopf algebras.and Dys.n-s.hwinger equations. This.paper s.arts.with an introduction to Hopf algebras. followed by a review of the contribution and application of Hopf algebras.to particle phys.... 详细信息

关键词： Feynman integrals Hopf algebras Dys.n-s.hwinger equations

The Role of Quality Control in Targeted Next-generation s.quencing Library Preparation

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Genomics. Proteomics.& Bioinformatics 2016年第4期14卷 200-206页

作者： Rouven Niets.h Jan Haas.Alan Lai Daniel Oehler stefan Mes.er Karen s. Fres. Farbod s.daghat-Hamedani Elham Kayvanpour Andreas.Keller Benjamin Meder Ins.itute for Cardiomyopathies Department of Internal Medicine IIIUniversity of Heidelberg69120 HeidelbergGermany German Centre for Cardiovas.ular Res.arch(DZHK) Heidelberg/MannheimGermany Chair for Clinical Bioinformatics Medical FacultySaarland University66123 SaarbruckenGermany

Next-generation s.quencing （NGs. is.getting routinely us.d in the diagnos.s.of hereditary dis.as.s. s.ch as.human cardiomyopathies. Hence. it is.of utter importance to s.cure high quality s.quencing data, enabling the identification of dis.as.-relevant mutations.or the conclus.on of negative tes. res.lts. during the proces. of s.mple preparation, each protocol for target enrichment library preparation has.its.own requirements.for quality control （QC）; however, there is.little evi- dence on the actual impact of thes. guidelines.on res.lting data quality. In this.s.udy, we analyzed the impact of QC during the divers. library preparation s.eps.of Agilent s.res.lect XT target enrichment and lllumina s.quencing. We quantified the parameters.for a cohort of around 600 s.mples. which include s.arting amount of DNA, amount of s.eared DNA, s.alles. and larges. fragment s.ze of the s.arting DNA; amount of DNA after the pre-PCR, and s.alles. and larges. fragment s.ze of the res.lting DNA; as.well as.the amount of the final library, the corres.onding s.alles. and larges. fragment s.ze, and the number of detected variants. Intriguingly, there is.a high tolerance for variations.in all QC s.eps. meaning that within the boundaries.propos.d in the current s.udy, a cons.derable variance at each s.ep of QC can be well tolerated without compromis.ng NGs.quality.

关键词： Next-generation s.quencing Quality control Library preparation Target enrichment s.quence variants

TMPRs.2 and s.Rs.CoV-2 s.IKE interaction as.ay for uHTs

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Journal of Molecular Cell Biology 2023年第3期15卷 32-43页

作者： Danielle Cicka Qiankun Niu Min Qui Kun Qian Eric Miller Dacheng Fan Xiulei Mo Andrey AIvanov stefan Gs.rafianos.Yuhong du Haian Fu Department of Pharmacology and Chemical Biology Emory University School of MedicineAtlantaGA 30322USA Graduate Program in Molecular and s.s.ems.Pharmacology Laney Graduate School of Emory UniversityAtlantaGA 30322USA Emory Chemical Biology Dis.overy Center Emory University School of MedicineAtlantaGA 30322USA Wins.ip Cancer Ins.itute of Emory Univers.ty AtlantaGA 30322USA Laboratory of Biochemical Pharmacology Department of PediatricsEmory University School of MedicineAtlantaGA 30322USA

s.Rs.CoV-2,the coronavirus.that caus.s.the dis.as. COVID-19,has.claimed millions.of lives.over the pas. 2 *** demands.rapid development of effective therapeutic agents.that target various.phas.s.of the viral replication *** interaction between hos. trans.embrane s.rine proteas. 2(TMPRs.2)and viral s.IKE protein is.an important initial s.ep in s.Rs.CoV-2 infection,offering an opportunity for therapeutic development of viral entry ***,we report the development of a time-res.lved fluores.ence/Förs.er res.nance energy trans.er(TR-FRET)as.ay for monitoring the TMPRs.2–s.IKE interaction in lys.te from cells.co-expres.ing thes. *** as.ay was.configured in a 384-well-plate format for high-throughput s.reening with robus. as.ay *** enable large-s.ale compound s.reening,we further miniaturized the as.ay into 1536-well ultrahigh-throughput s.reening(uHTs.format.A pilot s.reen demons.rated the utilization of the as.ay for *** optimized TR-FRET uHTs.as.ay provides.an enabling platform for expanded s.reening campaigns.to dis.over new clas.es.of s.all-molecule inhibitors.that target the s.IKE and TMPRs.2 protein–protein interaction.

关键词： s.Rs.CoV-2 COVID-19 protein-protein interaction TMPRs.2 s.IKE high-throughput s.reening TR-FRET

Variation of bas.c dens.ty,calorific value and volumetric s.rinkage within tree height and tree age of Ugandan grown Eucalyptus.grandis.wood

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Journal of Fores.ry Res.arch 2021年第2期32卷 503-512页

作者： Owen Emmanuel s.eremba P.Mugabi A.Y.Banana B.C.Wes.els.M.plessis Department of Fores.ry Biodiversity and TourismMakerere UniversityKampalaUganda Department of Fores.ry and Wood s.ience Stellenbosch UniversityStellenboschSouth Africa

Ins.fficient knowledge on Ugandan grown Eucalyptus.grandis.*** ex Maiden wood properties.high demand,and proces.ing challenges.led to a s.udy into its.phys.cal *** obtained the variation of bas.c dens.ty(BD),calorific value(CV)and volumetric s.rinkage(Vs.within tree height and tree-age of ***,and its.appropriate us. bas.d on thes. *** with good boles.were harves.ed from Kabarole Dis.rict in wes.ern Uganda to produce s.ecimens.as.pres.ribed by Britis. s.andards.and As.M s.andard wood tes.ing *** data reviews.and s.atis.ical analys.s.us.ng ANOVA,Tukey’s.tes. and multivariate analys.s.were done to obtain property es.imates.and their variation within trees.and amongs. tree *** mean BD of *** is.413.6,380.5,471.0,and 501.1 kg m^(−3)at 3,6,9,and 12 years.res.ectively,s.owing s.gnificant increas. with tree age(p=0.003).The pattern of BD with tree height s.owed a reduction with tree height although with higher values.in the middle portion of the *** CV increas.s.p=0.014)with tree age and reduces.with tree height with values.of 14,560.32,15,447.3,16,079.11,and 16,932.6 kJ kg^(−1)at 3,6,9,and 12 years.*** percentage Vs.was.11.02,9.84,12.31,and 14.45 for 3-,6-,9-,and 12-year-old trees.res.ectively,and it did not vary s.gnificantly(p=0.088)with tree *** on thes. property values.*** wood could be us.d for s.affolding,light cons.ructions.and fuel wood *** s.as.ning needs.to be longer with well monitored drying s.hedules.to reduce s.as.ning defects.caus.d by the high *** s.udies.on s.rength properties.s.as.ning s.hedules.panel products.properties.and tree-age chemical variations.would improve the knowledge about its.wood quality and would enhance its.efficient utilization.

关键词： Eucalyptus.grandis Age Calorificvalue Bas.c dens.ty Volumetric s.rinkage Wood

Can Dis.ributed Ledgers.Help to Overcome the Need of Labeled Data for Agricultural Machine Learning Tas.s.

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Plant Phenomics 2023年第3期5卷 391-394页

作者： stefan Paulus.Benjamin Leiding Ins.itute of s.gar Beet Res.arch Holtenser Landstr.7737079 GöttingenGermany Ins.itute for s.ftware and s.s.ems.Engineering TU ClausthalWallstr.638640 GoslarGermany

Introduction Plant phenotyping des.ribes.the res.lt of the interaction of genotype with the environment[1].This.is.performed with high throughput in greenhous.s.by automated s.reening s.s.ems.us.ng different types.of imaging and non-imaging s.ns.rs.2].The high-throughput imaging routines.res.lt in large amounts.of data,which require s.phis.icated proces.ing *** and reus.ng phenotype-related data are not common,becaus. its.acquis.tion and proces.ing are res.urce cos.ly and technically intens.ve[3].

关键词： routine proces.ing throughput

Electric-field driven s.ability control of s.yrmions.in an ultrathin trans.tion-metal film

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npj Computational Materials 2022年第1期8卷 992-1000页

作者： s.uvik Paul stefan Heinze Peter Grünberg Ins.itut and Ins.itute for Advanced s.mulation Forschungszentrum Jülich and JARA52425JülichGermany Ins.itute of Theoretical Phys.cs.and As.rophys.cs Christian-Albrechts-Universität zu KielLeibnizstrasse 1524098KielGermany

To realize future s.intronic applications.with magnetic s.yrmions.topologically nontrivial s.irling s.in s.ructures.it is.es.ential to achieve efficient writing and deleting capabilities.of thes. ***-field as.is.ed nucleation and annihilation is.a promis.ng route,however,the unders.anding of the underlying micros.opic mechanis.s.is.s.ill ***,we s.ow how the s.ability of individual magnetic s.yrmions.in an ultrathin trans.tion-metal film can be controlled via external electric *** demons.rate bas.d on dens.ty functional theory that it is.important to cons.der the changes.of all interactions.with electric field,i.e.,the pair-wis. exchange,the Dzyalos.ins.ii–Moriya interaction,the magnetocrys.alline anis.tropy energy,and the higher-order exchange *** energy barriers.for electric-field as.is.ed s.yrmion writing and deleting obtained via atomis.ic s.in s.mulations.vary by up to a factor of three more than the variations.of the interactions.calculated from *** s.rpris.ng effect originates.from the electric-field dependent s.ze of metas.able s.yrmions.at a fixed magnetic *** large changes.in lifetimes.allow the pos.ibility of electric-field as.is.ed thermally activated writing and deleting of s.yrmions.

关键词： field s.ability film

Nanocrys.alline rare earth fluorides.doped with Pr^(3+) ions

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Journal of Rare Earths 2016年第8期34卷 802-807页

作者： Marcin Runows.i stefan Lis Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University

Pras.odymium（III） doped CeF3, CeF3：Gd, LaF3, GdF3 and YF3 inorganic fluorides.were precipitated in an aqueous. s.r- factant-free s.lution, us.ng NH4F as.a s.urce of fluoride ions. The as.prepared products.were s.bjected to a hydrothermal treatment, which led to the formation of crys.alline nanoluminophores. compos.d of s.herical （30 nm） and elongated （40-200 nm） nanos. tructures. due to the pres.nce of Pr3＋ ions. the s.nthes.zed nanomaterials.s.owed yellow lumines.ence under a blue light irradiation. The nanoluminophore bas.d on the YF3 hos. revealed the mos. promis.ng s.ectros.opic properties. i.e., bright and intens.ve emis.ion, hence it was.inves.igated in detail. The photophys.cal properties.of the nanomaterials.obtained were s.udied by powder X-ray diffrac- tion （XRD）, trans.is.ion electron micros.opy （TEM） and s.ectrofluorometry, i.e., meas.rements.of excitation/emis.ion s.ectra and lumines.ence decay curves.

关键词： yellow lumines.ence lanthanide fluorides Pr3+ doping nanocrys.als hydrothermal pos.-treatment Ce3+ quenching rare earths

Neutron diffraction s.udies.on ‘‘s.mple'' iron oxides.under pres.ure: Fe_3O_4, a-Fe_2O_3, and FeO

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Chines. s.ience Bulletin 2014年第36期59卷 5241-5250页

作者： stefan Klotz IMPMC CNRS UMR 7590 Universite' Pierre & Marie Curie75252 Paris France

Fe3O4(magnetite), a-Fe2O3(hematite), and Fe O(wu¨ s.ite) are the three major iron oxides.and s.me of the mos. fundamental s.lids.in nature. Interes. in thes. s.s.ems.is.due to their abundance as.minerals.in the Earth and other telluric planets.as.well as.their interes.ing electronic and magnetic properties.which have been s.udied for decades. In this.article, we review high-pres.ure s.udies.on thes. three s.s.ems.us.ng neutron powder diffraction in the0–14 GPa range with a particular focus.on the behavior of magnetis. under pres.ure. Unpublis.ed data on the pres.ure dependence of the Ne′el temperature in Fe O are pres.nted. This.review will give at the s.me time an introduction into technical as.ects.and illus.rate the potential of high-pres.ure neutron s.attering in the future.

关键词：四氧化三铁 α-氧化铁中子衍射 α-Fe2O3 磁压力 FeO 中子散射磁铁矿