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Integrated genomics provides insights into the evolution of the polyphosphate accumulation trait of ***

Environmental Science and Ecotechnology 2024年第4期20卷 131-144页

作者： Xiaojing Xie Xuhan Deng Liping Chen Jing Yuan Hang Chen Chaohai Wei Xianghui Liu stefan Wuertz Guanglei Qiu School of Environment and Energy South China University of TechnologyGuangzhou510006China Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological UniversitySingapore637551Singapore School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore639798Singapore Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling Guangzhou510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou510006China

Candidatus Accumulibacter,a prominent polyphosphate-accumulating organism(PAO)in wastewater treatment,plays a crucial role in enhanced biological phosphorus removal(EBPR).The genetic underpinnings of its polyphosphate accumulation capabilities,however,remain largely ***,we conducted a comprehensive genomic analysis of ***-PAOs and their relatives within the Rhodocyclaceae family,identifying 124 core genes acquired via horizontal gene transfer(HGT)at its least common *** analysis of an enrichment culture of *** revealed active transcription of 44 of these genes during an EBPR cycle,notably including the polyphosphate kinase 2(PPK2)gene instead of the commonly recognized polyphosphate kinase 1(PPK1)***,the phosphate regulon(Pho)genes showed minimal transcriptions,pointing to a distinctive fact of Pho dysregulation,where PhoU,the phosphate signaling complex protein,was not regulating the high-affinity phosphate transport(Pst)system,resulting in continuous phosphate *** prevent phosphate toxicity,*** utilized the laterally acquired PPK2 to condense phosphate into polyphosphate,resulting in the polyphosphate-accumulating *** study provides novel insights into the evolutionary emergence of the polyphosphate-accumulating trait in ***,offering potential advancements in understanding the PAO phenotype in the EBPR process.

关键词： Candidatus Accumulibacter Comparative genomics Horizontal gene transfer(HGT) PhoU Polyphosphate kinase 2(PPK2)

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Tailoring the microstructure， tensile properties， and creep resistance of additively manufactured Inconel 718 superalloy by post-processing

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Transactions of Nonferrous Metals Society of China 2024年

作者： Sajad Ghaemifar Milad Roostaei Mohammad Reza Zamani stefan Wurster Hamed Mirzadeh School of Metallurgy and Materials Engineering， College of Engineering， University of Tehran Erich Schmid Institute of Materials Science， Austrian Academy of Sciences Department of Materials Science， Chair of Materials Physics， Montanuniversit?t Leoben

Effects of post-processing heat treatments on the microstructure， aging kinetics， and room/elevated temperature mechanical properties of additively manufactured Inconel 718 superalloy were investigated. Scanning electron microscopy (SEM)， electron backscattered diffraction (EBSD)， and X-ray diffraction (XRD)， as well as hardness， tensile， and creep testing were used for characterization. At temperatures higher than 1100 °C， homogenization treatment resulted in the appearance of equiaxed grains by recrystallization and diminishing the dislocation density. The precipitation activation energy for the homogenized aged condition was obtained as 203 kJ/mol， which was higher than the value of ～160 kJ/mol for the as-built IN718 superalloy. Therefore， direct aging resulted in a faster aging response， which led to a significant improvement in tensile properties， as rationalized by the strengthening mechanisms. Direct aging treatment resulted in a higher elevated-temperature ultimate tensile strength (UTS) as well as the optimum creep life and lowest minimum creep rate in comparison with other heat treating routes， which were attributed to the presence of fine and uniformly dispersed strengthening precipitates in conjunction with the high dislocation density.

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Spatiotemporal drivers of Nature's contributions to people:A countylevel study

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Environmental Science and Ecotechnology 2024年第4期20卷 323-332页

作者： Wei Jiang Bojie Fu Zhongguo Shu Yihe Lv Guangyao Gao Xiaoming Feng stefan Schüler Xing Wu Cong Wang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesNo.18 Shuangqing Road100085BeijingChina Functional Agrobiodiversity Georg-August-Universit€at G€ottingenGrisebachstraße 637077G€ottingenGermany

Nature's contributions to people(NCP)encompass both the beneficial and detrimental effects of living nature on human quality of life,including regulatory,material,and non-material ***,vital NCPs have been deteriorating,accelerated by changes in both natural and anthropogenic drivers over recent *** the often inevitable trade-offs between NCPs due to their spatially and temporally uneven distributions,few studies have quantitatively assessed the impacts of different drivers on the spatial and temporal changes in multiple NCPs and their *** we evaluate the effects of precipitation,temperature,population,gross domestic product,vegetation restoration,and urban expansion on four key regulatory NCPs-habitat maintenance,climate regulation,water quantity regulation,and soil protection-in Nei Mongol at the county *** observe increasing trends in climate regulation and soil protection from 2000 to 2019,contrasted with declining trends in habitat maintenance and water quantity *** have identified the dominant positive and negative drivers influencing each NCP across individual counties,finding that natural drivers predominantly overpowered anthropogenic ***,we discover significant spatial disparities in the tradeoff or synergy relationships between NCPs across the *** findings illustrate how the impacts of various drivers on NCPs and their interrelationships can be quantitatively evaluated,offering significant potential for application in various spatial *** an understanding of trade-offs and scale effects,these insights are expected to support and inform policymaking at both county and provincial levels.

关键词： Potential regulating contributions Natural and anthropogenic drivers Path analysis Trade-off or synergy relationship China

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Role of immunotherapy in gastric cancer with liver metastasis

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World Journal of Clinical Oncology 2024年第11期15卷 1383-1389页

作者： Bogdan Gafton stefan Morarasu Gabriel Dimofte Department of Oncology Regional Institute of OncologyIasi 700483Romania Department of Oncology Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Second Department of Surgical Oncology Regional Institute of OncologyFaculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Surgery University of Medicine and Pharmacy Grigore T.Popa IaşiRegional Institute of Oncology IasiIasi 700483Romania

Gastric cancer continues to be a significant issue for public health,marked by its widespread occurrence and high mortality rates,even as the incidence of the disease shows a declining *** liver is the primary site for metastatic spread,with the peritoneum,lungs,and bones also being common *** the advent of biologic treatments and the introduction of immunotherapy for patients with metastatic conditions,the options to treat metastatic gastric cancer have *** diversified therapeutic approach is designed to enhance patient quality of life and prolong survival,showcasing the progress in treatment modalities for individuals with gastric cancer and liver metastases.

关键词： Gastric cancer Immunotherapy Liver metastases Metastatic gastric cancer Oncology Surgical oncology

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Alkali Metal Ion Substituted Carboxymethyl Cellulose as Anode Polymeric Binders for Rapidly Chargeable Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第1期7卷 77-82页

作者： Seoungwoo Byun Zhu Liu Dong Ok Shin Kyuman Kim Jaecheol Choi Youngjoon Roh Dahee Jin Seungwon Jung Kyung-Geun Kim Young-Gi Lee stefan Ringe Yong Min Lee Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Intelligent Sensors Research Section Electronics and Telecommunications Research Institute(ETRI)Daejeon 34129Korea Department of Advanced Device Technology University of Science and Technology(UST)Daejeon 34113Korea Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science University of WollongongWollongong NSW 2522Australia Department of Chemistry Korea UniversitySeoul 02841Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea

The increasing demand for short charging time on electric vehicles has motivated realization of fast chargeable lithium-ion batteries(LIBs).However,shortening the charging time of LIBs is limited by Li^(+)intercalation process consisting of liquid-phase diffusion,de-solvation,SEI crossing,and solid-phase ***,we propose a new strategy to accelerate the de-solvation step through a control of interaction between polymeric binder and solvent-Li^(+)*** this purpose,three alkali metal ions(Li^(+),Na^(+),and K^(+))substituted carboxymethyl cellulose(Li-,Na-,and K-CMC)are prepared to examine the effects of metal ions on their *** lowest activation energy of de-solvation and the highest chemical diffusion coefficient were observed for ***,Li-CMC cell with a capacity of 3 mAh cm^(-2)could be charged to>95%in 10 min,while a value above>85%was observed after 150 ***,the presented approach holds great promise for the realization of fast charging.

关键词： de-solvation digital twins fast charging graphite anodes polymeric binders

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Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

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Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg Alexander Becker Sebastian Keppler Guillaume Duchateau stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing Alexander Kessler Franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensities<10^(16)W/cm^(2).Single-shot near-infrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

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Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus Ioannis Belios stefan Bonn Ania C.Muntau Kurt Hecher Anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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Septic shock due to Capnocytophaga canimorsus treated with IgM-enriched immunoglobulin as adjuvant therapy in an immunocompetent woman

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Journal of Intensive Medicine 2024年第2期4卷 265-268页

作者： Josephine Braunsteiner Stephanie Siedler Dominik Jarczak stefan Kluge Axel Nierhaus Department of Intensive Care Medicine University Medical Centre Hamburg-EppendorfHamburgGermany

Background Capnocytophaga canimorsus(***)belongs to the family *** is a facultative anaerobic Gram-negative bacillus and belongs to the normal oral microbiota of some mammals,such as cats and *** to humans can occur through the skin after skin abrasion caused by a scratch or a bite.[1]Based on polymerase chain reaction(PCR)analysis,*** is present in saliva in 70%-74%of dogs and 55%-57%of cats.

关键词： belongs enriched scratch

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Platelet-rich plasma treatment for chronic wounds:A case report and literature review

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World Journal of Clinical Cases 2024年第33期12卷 6635-6643页

作者： Ana Dimova Martin Boroš stefan Dimov Janja Konjevod Maja Svetec Department of Surgery Zabok General Hospital and the Croatian Veterans HospitalZabok 49210Croatia Department of Surgery St Catherine Specialty HospitalZagreb 10000Croatia Department of Emergency Medicine Zabok General Hospital and the Croatian Veterans HospitalZabok 49210Croatia

BACKGROUND Wound healing is a complicated process that can be heavily influenced by patient comorbidities,in some cases leading to a chronic non-healing *** presented in the medical literature supporting the clinical use of autologous platelet-rich plasma(PRP)in treatment of such wounds is becoming increasingly *** involved include complex interactions between the patient’s thrombocytes,cytokines,and growth *** SUMMARY We present a case of a 72-year-old male patient with a long-standing chronic wound and multiple *** the course of more than 7 months,the patient was unsuccessfully treated with all routinely used measures,including different dressing *** antibiotic regimens were administered for wound infection,with repeated evaluation of microbiological swab ***,after three PRP applications,the wound showed clinical improvement with complete restitution of the epithelial layer of the *** PRP treatment may be beneficial to reduce healing time in chronic wounds.

关键词： Wound healing Platelet-rich plasma Growth factors Antibiotics Wound Infection Case report

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Exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

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High Power Laser Science and Engineering 2024年第2期12卷 24-32页

作者： Petrisor Gabriel Bleotu Radu Udrea Alice Dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei Daniel Ursescu stefan Irimiciuc Valentin Craciun Extreme Light Infrastructure-Nuclear Physics(ELI-NP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania National Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(E).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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