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Three-way Subsynchronous Torsional Interactions Between LCC HVDC,MMC HVDC and a Thermal Generator

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1331-1340页

作者： stefan Kovacevic Dragan Jovcic Pierre Rault Olivier Despouys School of Engineering University of AberdeenAberdeen AB243UEU.K. Réseau de Transport d’Électricité ParisFrance

This paper performs a study on three-way subsynchronous torsional interactions(SSTI)between a hybrid dual-infeed high-voltage direct current(HVDC)system and a nuclear *** test case is based on the French IFA2000 line commutated converter(LCC)HVDC(2 GW)and the new Eleclink modular multilevel converter(MMC)HVDC(1 GW)interacting with the Gravelines generator(1 GW).The analysis is performed by the means of the eigenvalue stability assessment on an analytical model,while the accuracy of the conclusions is verified using the detailed non-linear electromegnetic transient program(EMTP)*** study shows that the dual-infeed system may introduce higher risk of the SSTI compared with the point-to-point HVDC *** shows that MMC operating as static synchronous compensator(STATCOM)may further reduce the torsional damping at 6.3 Hz *** conclusion may be unexpected since it is known fact from literature that STATCOM has a beneficial impact on the transient performance of *** studies show that in a sequential HVDC loading,it may be beneficial to load the MMC HVDC ***,the risk of the SSTI may be minimized by changing HVDC controller gains,in particular,by increasing phaselocked-loop(PLL)gains on the LCC rectifier.

关键词： Subsynchronous torsional interaction(SSTI) eigenvalue stability hybrid dual-infeed high-voltage direct current(HVDC) line commutated converter(LCC) modular multilevel converter(MMC) nuclear generator

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Implementation and validation of a bonded particle model to predict rheological properties of viscoelastic materials

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Particuology 2024年第6期89卷 198-210页

作者： Michael Mascara Arno Mayrhofer stefan Radl Christoph Kloss Institute of Process and Particle Engineering Graz University of TechnologyInffeldgasse 13Graz8010Austria DCS Computing GmbH Industriezeile 35Linz4020Austria

This work focuses on implementing a particle-based method able to characterize viscoelastic materials whose rheological properties,such as storage modulus G′and loss modulus G″,are *** is based on the bonded particle model,with the elastic constitutive relation here substituted with a viscoelastic one to capture time-scale *** Burgers model,vastly used in literature to model viscoelastic systems,is discretized and *** test case used for calibration comprises of a cubic lattice,sheared with a periodic motion,to mimic the effect of a shear *** appropriate filtering of the stress response,the rheological properties are obtained,highlighting the effect of the lattice geometry,as well as the particle size,on the accuracy of the ***,the Burgers parameters are calibrated by analytically fitting the experimental dataset,showing the limitation of the Burgers *** micro-contact parameters are obtained from the macro parameters through appropriate *** completing a frequency sweep,the simulated G′and G″show a relatively large error,around 25%for G’for *** this reason,a more robust model,namely the generalized Maxwell model,has been *** calibration procedure is performed in the same fashion as for the Burgers ***,the tangential micro-contact parameters are scaled *** normal *** scaling parameter,calledα,is calibrated by minimizing the root mean square error between simulation and experimental data,giving errors below 10%in both G′and G″for a large ***,a full ring plate-plate rheometer setup is simulated,and the simulation is compared with the given experimental dataset,again finding a good agreement.

关键词： DEM Rheology Numerical modeling Viscoelasticity

Hydrogen effect on the mechanical behaviour and microstructural features of a Fe-Mn-C twinning induced plasticity steel

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 835-846页

作者： Xiaofei Guo stefan Zaefferer Fady Archie Wolfgang Bleck Steel Institute RWTH Aachen UniversityIntze-str.1Aachen 52072Germany Max-Planck-Institut für Eisenforschung GmbH Max-Planck-Straße 1Düsseldorf 40237Germany NLMK Europe Eutelis-Platz 2Ratingen 40878Germany

The influences of hydrogen on the mechanical properties and the fracture behaviour of Fe-22Mn-0.6C twinning induced plasticity steel have been investigated by slow strain rate tests and fractographic *** steel showed high susceptibility to hydrogen embrittlement,which led to 62.9%and 74.2%reduction in engineering strain with 3.1 and 14.4 ppm diffusive hydrogen,*** fracture surfaces revealed a transition from ductile to brittle dominated fracture modes with the rising hydrogen *** underlying deformation and fracture mechanisms were further exploited by examining the hydrogen effects on the dislocation substructure,stacking fault probability,and twinning behaviour in pre-strained slow strain rate test specimens and notched tensile specimens using coupled electron channelling contrast imaging and electron backscatter diffraction *** results reveal that the addition of hydrogen promotes planar dislocation structures,earlier nucleation of stacking faults,and deformation twinning within those grains which have tensile axis orientations close to//rolling direction and//rolling *** developed twin lamellae result in strain localization and micro-voids at grain boundaries and eventually lead to grain boundary decohesion.

关键词： twinning induced plasticity steel hydrogen mechanical behaviour dislocation twinning electron channelling contrast imaging

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Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4151-4153页

作者： Andreas Krämer stefan Knapp Institute of Pharmaceutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438Frankfurt am MainGermany Structural Genomics Consortium Buchmann Institute for Molecular Life SciencesGoethe-University FrankfurtMax-von-Laue-Str.1560438Frankfurt am MainGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)DTKT Site Frankfurt-Mainz69120HeidelbergGermany

A recent study published in Nature by Radko-Juettner and colleagues reports an unexpected mutant-specific synthetic lethality in which the E3 protein ubiquitin ligase DCAF5 specifically degrades mutant but not wild-type SWI/SNF chromatin remodeling complexes.1 DCAF5 contains a likely druggable WDR domain,providing a new avenue for the development of novel therapeutics for aggressive cancers with SMARCB1 loss of function mutations.

关键词： tumour likely complexes

POLIII-derived non-coding RNAs acting as scaffolds and decoys

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Journal of Molecular Cell Biology 2019年第10期11卷 880-885页

作者： HendrikTauber stefan Huttelmaier Marcel Kohn Institute of Molecular Medicine Section for Molecular Cell BiologyFaculty of MedicineMartin Luther University Halle-WittenbergCharles Tan ford Protein CentreKurt-Mothes-Str.3a06120 HalleGermany Julius Bernstein Institute of Physiology Faculty of MedicineMartin Luther University Halle-WittenbergCharles Tan ford Protein CentreKurt-Mothes-Str.3a06120 HalleGermany

A large variety of eukaryotic small structured POLIII-derived non-coding RNAs(ncRNAs)have been described in the ***,for only few,e.g.7SL and H1/MRP families,cellular functions are well *** the vast majority of these transcripts,cellular functions remain *** findings on the role ofY RNAs and other POLIII-derived ncRNAs suggest an evolutionarily conserved function of these ncRNAs in the assembly and function of ribonucleoprotein complexes(RNPs).These RNPs provide cellular‘machineries’,which are essential for guiding the fate and function of a variety of *** this review,we summarize current knowledge on the role of POLIII-derived ncRNAs in the assembly and function of *** propose that these ncRNAs serve as scaffolding factors that‘chaperone’RNA-binding proteins(RBPs)to form functional *** addition or associated with this role,some small ncRNAs act as molecular decoys impairing the RBP-guided control of RNA fate by competing with other RNA *** suggests that POLIII-derived ncRNAs serve essential and conserved roles in the assembly of larger RNPs and thus the control of gene expression by indirectly guiding the fate of mRNAs and IncRNAs.

关键词： ncRNA POLIII RBP scaffold RBP decoy

Why surgeons care about systemic chemotherapy for pancreatic cancer?

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 860-863页

作者： stefan Heinrich Department of General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany

Pancreatic adenocarcinoma(PDAC)has become the seventh most frequent cause of cancer death in the world with increasing incidence independent of patient sex and age with smoking and alcohol consumption being the most important risk factors(1).The high mortality rate is mainly attributed to the biological characteristics of this disease:even small tumors reveal perineural invasion or local spread into lymph and blood vessels resulting in systemic *** estimated risk of occult distant metastasis at the time of surgery is 28%and 94%for tumors with a diameter of 1 and 3 cm,respectively(2).Consequently,many patients present with disseminated or locally advanced disease and are at high risk for early tumor recurrence(3).

关键词： cancer invasion mortality

Neoadjuvant therapy for pancreatic ductal adenocarcinoma—real effects or patient selection?

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 289-291页

作者： stefan Heinrich Department of General Visceral and Transplantation Surgery University Hospital of Mainz Mainz Germany

Surgery is the only treatment with curative potential for patients with pancreatic ductal adenocarcinoma (PDAC).Unfortunately, the majority of patients do not qualify for curative resection due to locally advanced or ... 详细信息

关键词： adenocarcinoma Surgery curative

Age Structure and Growth of Degraded Populus euphratica Floodplain Forests in North-west China and Perspectives for Their Recovery

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Journal of Integrative Plant Biology 2008年第5期50卷 536-546页

作者： Janneke Westermann stefan Zerbe Dieter Eckstein Technical University of Berlin Institute of EcologyRothenburgstraβe 12D-12165 BerlinGermany University of Greifswald Institute of Botany and Landscape EcologyGrimmer Straβe 88D-17487 GreifswaldGermany University of Hamburg Department of Wood ScienceDivision of Wood BiologyLeuschnerstraβe 91D-21031 HamburgGermany

The Populus euphratica floodplain forests along the lower reaches of the Tarim River in continental-arid Xinjiang （northwest China） have been declining in recent decades as a result of dam constructions and the withdrawal of water from the river. Since 2000, controlled flooding has been carried out to counteract this process of degradation. However, the consequences of a changing water regime for the floodplain ecosystem are not yet sufficiently investigated. In 2004 we sampled a total of 150 P. euphratica trees along two transects at the middle and lower reaches of the Tarim River to compare the age structure and growth of these two tree populations. The anthropogenic drawdown of the groundwater table had no effect on the average growth of the trees at the lower reaches. However, tree growth abruptly increased after controlled flooding, thus showing distinct signs of recovery.

关键词： arid land controlled flooding Euphrates poplar human impact Populus euphratica tree rings.

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The current role of liver surgery in the treatment of colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 552-554页

作者： stefan Heinrich General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany

Since the establishment of a survival benefit for patientswith colorectal cancer liver metastases(CRLM)undergoingliver resection,perioperative outcome has continuouslyimproved,and surgery for CRLM is currently offered... 详细信息

关键词： colorectal surgery metastases