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Generalized Sampling in Shift Invariant Spaces with Frames

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1823-1844页

作者： stefan ERICSSON Department of Engineering Sciences and Mathematics Lule University of Technology

Generalized sampling in a shift invariant subspace V of l2（R） is considered. A function f in V is processed with different filters lm and then one tries to reconstruct f from the samples l^mf（j＇k）. We develop a theory of how to do this in the case when V possesses a shift invariant frame. Special attention is paid to the question： How to obtain dual frames with compact support？

关键词： Generalized sampling frames Riesz basis reproducing kernel shift invariant spaces

Carbon pool trends and dynamics within a subtropical peatland during long-term restoration

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Ecological Processes 2017年第1期6卷 449-462页

作者： Paul Julian II stefan Gerber Alan l.Wright Binhe Gu Todd Z.Osborne University of Florida Soil and Water Sciences DepartmentFt.PierceFL 34945USA. University of Florida Soil and Water Sciences DepartmentGainesvilleFL 32611USA. South Florida Water Management District Water Quality BureauWest Palm BeachFL 33406USA. University of Florida Whitney Laboratory for Marine BioscienceSt AugustineFL 32080USA.

Introduction:The Florida Everglades has undergone significant ecological change spanning the continuum of disturbance to *** the restoration effort is not complete and the ecosystem continues to experience short duration perturbations,a better understanding of long-term C dynamics of the Everglades is needed to facilitate new restoration *** study evaluated temporal trends of different aquatic carbon(C)pools of the northern Everglades Protection Area over a 20-year period to gauge historic C cycling *** inorganic C(DIC),dissolved organic C(DOC),particulate organic C(POC),and surface water carbon dioxide(pCO2(aq))were investigated between May 1,1994 and April 30,***:Annual mean concentrations of DIC,DOC,POC,and pCO2(aq)significantly decreased through time or remained constant across the Water Conservation Areas(WCAs).Overall,the magnitude of the different C pools in the water column significantly differed between *** of CO2 was dynamic across the Everglades ranging from 420 to 2001 kg CO2 year−***,the historic trend in CO2 flux from the marsh declined across our study area while pCO2(aq)largely remained somewhat constant with the exception of Water Conservation Area 2 which experienced significant declines in pCO2(aq).Particulate OC concentrations were consistent between WCAs,but a significantly decreasing trend in annual POC concentrations was ***:Hydrologic condition and nutrient inputs significantly influenced the balance,speciation,and flux of C pools across WCAs suggesting a subsidy-stress response in C dynamics relative to landscape scale responses in nutrient *** interplay between nutrient inputs and hydrologic condition exert a driving force on the balance between DIC and DOC production via the metabolism of organic matter which forms the base of the aquatic food *** the restoration trajectory as water quality and hydrology continues to improve,it is expect

关键词： Inorganic carbon Organic carbon Carbon dioxide Particulate carbon Hydrology Nutrients

A Design Concept and Kinematic Model for a Soft Aquatic Robot with Complex Bio-mimicking Motion

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Journal of Bionic Engineering 2022年第1期19卷 16-28页

作者： Shokoofeh Abbaszadeh Roberto leidhold stefan Hoerner Institute of Electrical Power Systems Department of Electrical Engineering and Information TechnologyOtto-Von-Guericke University of MagdeburgUniversitätsplatz 239106MagdeburgGermany Institute of Fluid Dynamics and Thermodynamics Department of Process and Systems EngineeringOtto-Von-Guericke University of MagdeburgUniversitätsplatz 239106MagdeburgGermany

Fish mortality assessments for turbine passages are currently performed by live-animal testing with up to a hundred thousand fish per year in Germany.A propelled sensor device could act as a fish *** this context,the study presented here investigates the state of the art via a thorough literature review on propulsion systems for aquatic *** evaluation of propulsion performance,weight,size and complexity of the motion achievable allows for the selection of an optimal concept for such a fish mimicking device carrying the *** the second step,the design of a bioinspired soft robotic fish driven by an unconventional drive system is *** is based on piezoceramic actuators,which allow for motion with five degrees of freedom(DOF)and the creation of complex bio-mimicking body motions.A kinematic model for the motion’s characteristics is developed,to achieve accurate position feedback with the use of strain *** measurements validate the complex deformation of the body and deliver the basis for the calibration of the kinematic ***,it can be shown,that the calibrated model presented allows the tracking of the deformation of the entire body with an accuracy of 0.1 mm.

关键词： Unconventional drive system Biologically inspired robots Biomimetics Flexible robots

Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure

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World Journal of Gastroenterology 2015年第7期21卷 2214-2219页

作者： Jan-Hendrik Bockmann Maura Dandri stefan lüth Nadine Pannicke Ansgar W lohse 1~(st) Deparment of Medicine University Medical Center Hamburg-Eppendorf

Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic *** recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is *** HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily ***,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis *** wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters.

关键词： Acute liver failure Hepatitis B virus Prednisolone

Identifying Novel Drug Targets by iDTPnd:A Case Study of Kinase Inhibitors

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 986-997页

作者： Hammad Naveed Corinna Reglin Thomas Schubert Xin Gao stefan T.Arold Michael l.Maitland Toyota Technological Institute at Chicago ChicagoIL 60637USA Department of Computer Science National University of Computer and Emerging SciencesIslamabad 44000Pakistan 2bind GmbH D-93053 RegensburgGermany King Abdullah University of Science and Technology(KAUST) Computational Bioscience Research Center(CBRC)ComputerElectrical and Mathematical Sciences and Engineering(CEMSE)DivisionThuwal 23955Saudi Arabia King Abdullah University of Science and Technology(KAUST) Computational Bioscience Research Center(CBRC)Biological and Environmental Sciences and Engineering(BESE)DivisionThuwal 23955Saudi Arabia Inova Center for Personalized Health and Schar Cancer Institute Falls ChurchVA 22042USA University of Virginia Cancer Center AnnandaleVA 22003USA

Current FDA-approved kinase inhibitors cause diverse adverse effects,some of which are due to the me-chanism-independent effects of these *** these mechanism-independent interactions could improve drug safety and support drug ***,we develop iDTPnd(integrated Drug Target Predictor with negative dataset),a computational approach for large-scale discovery of novel targets for known *** a given drug,we construct a positive structural signature as well as a negative structural signature that captures the weakly conserved structural features of drug-binding *** facilitate assessment of unintended targets,iDTPnd also provides a docking-based interaction score and its statistical *** confirm the interactions of sorafenib,imatinib,dasatinib,sunitinib,and pazopanib with their known targets at a sensitivity of 52%and a specificity of 55%.We also validate 10 predicted novel targets by using in vitro *** results suggest that proteins other than kinases,such as nuclear receptors,cytochrome P450,and MHC class I molecules,can also be physiologically relevant targets of kinase *** method is general and broadly applicable for the identification of protein–small molecule interactions,when sufficient drug–target 3D data are *** code for constructing the structural signatures is available at https://***/Documents/***.

关键词： Protein-drug interaction iDTPnd Kinase inhibitor Drug-binding site signature Drug repurposing

Innovative Analysis Ready Data(ARD)product and process requirements,software system design,algorithms and implementation at the midstream as necessary-but-notsuffcient precondition of the downstream in a new notion of Space Economy 4.0-Part 1:Problem background in Artificial General Intelligence(AGI)

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Big Earth Data 2023年第3期7卷 455-693页

作者： Andrea Baraldi luca D.Sapia Dirk Tiede Martin Sudmanns Hannah l.Augustin stefan lang Spatial Services GmbH SalzburgAustria CGI Italy FrascatiItaly Department of Geoinformatics-Z_GIS University of SalzburgSalzburgAustria

Aiming at the convergence between Earth observation(EO)Big Data and Artificial General Intelligence(AGI),this two-part paper identifies an innovative,but realistic EO optical sensory imagederived semantics-enriched Analysis Ready Data(ARD)productpair and process gold standard as linchpin for success of a new notion of Space Economy *** be implemented in operational mode at the space segment and/or midstream segment by both public and private EO big data providers,it is regarded as necessarybut-not-sufficient“horizontal”(enabling)precondition for:(I)Transforming existing EO big raster-based data cubes at the midstream segment,typically affected by the so-called data-rich information-poor syndrome,into a new generation of semanticsenabled EO big raster-based numerical data and vector-based categorical(symbolic,semi-symbolic or subsymbolic)information cube management systems,eligible for semantic content-based image retrieval and semantics-enabled information/knowledge discovery.(II)Boosting the downstream segment in the development of an ever-increasing ensemble of“vertical”(deep and narrow,user-specific and domain-dependent)value–adding information products and services,suitable for a potentially huge worldwide market of institutional and private end-users of space *** the sake of readability,this paper consists of two *** the present Part 1,first,background notions in the remote sensing metascience domain are critically revised for harmonization across the multidisciplinary domain of cognitive *** short,keyword“information”is disambiguated into the two complementary notions of quantitative/unequivocal information-as-thing and qualitative/equivocal/inherently ill-posed ***,buzzword“artificial intelligence”is disambiguated into the two better-constrained notions of Artificial Narrow Intelligence as part-without-inheritance-of ***,based on a betterdefined and better-understood vocabulary of multid

关键词： Artificial Narrow Intelligence big data cognitive science computer vision Earth observation essential climate variables Global Earth Observation System of(component)Systems inductive/deductive/hybrid inference Scene Classification Map Space Economy 4.0 radiometric corrections of optical imagery from atmospheric,topographic,adjacency and bidirectional reflectance distribution function effects semantic content-based image retrieval 2D spatial topology-preserving/retinotopic image mapping world ontology(synonym for conceptual/mental/perceptual model of the world)

The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond

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Neural Regeneration Research 2024年第8期19卷 1647-1648页

作者： Sven Marcel stefan Muhammad Rafehi Drug Development and Chemical Biology Lübeck Institute of Experimental Dermatology(LIED)University of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany Department of Pathology Section of NeuropathologyTranslational Neurodegeneration Research and Neuropathology LabUniversity of Oslo and Oslo University HospitalOsloNorway School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Institute of Clinical Pharmacology University Medical Center GöttingenGöttingenGermany Department of Medical Education Augsburg University MedicineAugsburgGermany

Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug ***,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted ***,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.

关键词： translation beyond likely

Promoting the production of challenging proteins via induced expression in CHO cells and modified cell-free lysates harboring T7 RNA polymerase and mutant eIF2α

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Synthetic and Systems Biotechnology 2024年第3期9卷 416-424页

作者： Jeffrey l.Schloßhauer lena Tholen Alexander Korner stefan Kubick Sofia Chatzopoulou Anja Honow Anne Zemella Fraunhofer Project Group PZ-Syn of the Fraunhofer Institute for Cell Therapy and Immunology-IZI Branch Bioanalytics and Bioprocesses-IZI-BBAm MühlenbergPotsdamGermany Fraunhofer Institute for Cell Therapy and Immunology-IZI Branch Bioanalytics and Bioprocesses-IZI-BBAm MühlenbergPotsdamGermany Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus-SenftenbergThe Brandenburg Medical School Theodor FontaneUniversity of PotsdamPotsdamGermany Institute for Chemistry and Biochemistry Laboratory of Protein BiochemistryFreie Universitat BerlinThielallee 6314195BerlinGermany Institute of Biotechnology Technische Universit¨at BerlinStraße des 17.Juni 13510623BerlinGermany New/era/mabs GmbH August-Bebel-Str.8914482PotsdamGermany

Chinese hamster ovary(CHO)cells are crucial in biopharmaceutical production due to their scalability and capacity for human-like post-translational ***,toxic proteins and membrane proteins are often difficult-to-express in living ***,cell-free protein synthesis can be *** study explores innovative strategies for enhancing the production of challenging proteins through the modification of CHO cells by investigating both,cell-based and cell-free approaches.A major result in our study involves the integration of a mutant eIF2 translation initiation factor and T7 RNA polymerase into CHO cell lysates for cell-free protein *** resulted in elevated yields,while eliminating the necessity for exogenous additions during cell-free production,thereby substantially enhancing ***,we explore the potential of the Rosa26 genomic site for the integration of T7 RNA polymerase and cell-based tetracycline-controlled protein *** findings provide promising advancements in bioproduction technologies,offering flexibility to switch between cell-free and cell-based protein production as needed.

关键词： Inducible expression CHO cells Cell-free protein synthesis CRISPR T7 RNA polymerase eIF2 Rosa26

Analysis of metabolic alterations in Arabidopsis following changes in the carbon dioxide and oxygen partial pressures

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Journal of Integrative Plant Biology 2014年第9期56卷 941-959页

作者： Alexandra Florian stefan Timm Zoran Nikoloski Takayuki Tohge Hermann Bauwe Wagner l.Araujo Alisdair R.Fernie Max Planck Institute for Molecular Plant Physiology Department of Plant Physiology University of Rostock Max-Planck Partner group at the Departament of Plant Biology Federal University of Vicosa

As sessile organisms,plants are subject to a multitude of environmental variations including several which directly affect their interaction with the *** the indiscriminant nature of Rubisco,the relative rates of photosynthesis and photorespiration are known to be responsive to changes in gas ***,comprehensive profiling methods have not yet been applied in order to characterize the wider consequences of these changes on primary metabolism in ***,although transcriptional profiling has revealed that a subset of photorespiratory enzymes are co-expressed,whether transcriptional responses play a role in short-term responses to atmospheric compositional changes remains *** address these questions,plants Arabidopsis thaliana（Arabidopsis） ecotype Columbia（Col-O） grown under normal air conditions were transferred to different CO_2 and O_2 concentrations and characterized at the physiological,molecular,and metabolic levels following this *** results reveal alterations in the components,which are directly involved in,or supporting,photorespiration,including transcripts and metabolite *** results further highlight that the majority of the regulation of these pathways is not mediated at the level of transcription and that the photorespiratory pathway is essential also in conditions in which flux through the pathway is minimized,yet suggest that flux through this pathway is not mediated at the level of transcription.

关键词： Carbon dioxide partial pressures gene expression metabolic profiling oxygen partial pressures