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Risk-Layering for Indirect Effects

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International Journal of Disaster Risk Science 2021年第5期12卷 770-778页

作者： stefan Hochrainer-Stigler Karina Reiter IIASA-International Institute for Applied Systems Analysis A-2361 Laxenburg.Austria

Environmental risks are one of the greatest threats in the twenty-first *** in the last years,the cascading impacts and risks associated with such events have received great attention as economic losses and consequences have mounted in their *** concerns about these ripple effects are rising,strategies to prevent and manage indirect risks are in urgent ***,such effects are currently barely considered in most countries and can seriously threaten global agendas such as achieving the Sustainable Development Goals by 2030 or the targets set out in the Sendai Framework for Disaster Risk Reduction *** discuss how the concept of risk-layering,which,though already applied in disaster risk management,could be expanded to include indirect *** point out some of the benefits,limitations,and ways forward for using this *** do so,we first delineate the transition of the risk-layering concept,which originated from the insurance industry,from its original use to its application in a wider *** bring special focus to the application of risk-layering in disaster risk management and identify strategies that allow for the inclusion of indirect *** main suggestion is that,while a probabilistic approach is appropriate for evaluating direct risks,a focus on connectedness is appropriate for indirect risks,which still allows for an easy link to direct ***,so we argue,facilitates more comprehensive risk management systems apt to deal with the multi-dimensional challenges ahead.

关键词： Connectedness Indirect risks Natural hazards and disasters Risk-layering Risk management

Pathological tumor response to neoadjuvant therapy in borderline resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 305-306页

作者： stefan Heinrich General Visceral and Transplantation Surgery University Hospital of Mainz

Surgery is the standard therapy for pancreatic ductal adenocarcinoma(PDAC).After the dramatic decline of operative mortality over the past decades,the indications for pancreas resections have been continuously extended:currently resections of the portal/superior mesenteric vein are considered standard by many centers,and even arterial resections are under *** these changes,different expert groups have defined resectability criteria containing a grey zone(“borderline resectable disease”)of tumors,which may be technically resectable with appropriate surgical expertise,but resection inherits an increased risk of an R1-resection[1].

关键词： Surgery mortality operative

Novel rodent models of penetrating traumatic brain injury

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Neural Regeneration Research 2015年第7期10卷 1047-1049页

作者： stefan Plantman Department of Neuroscience Retziusvag 8 Karolinska Institutet

A penetrating traumatic brain injury（pTBI）occurs when an object impacts the head with sufficient energy to penetrate skin,cranial bone and meninges to inflict injury directly to the brain *** type of injury is parti... 详细信息

关键词： TBI Novel rodent models of penetrating traumatic brain injury

Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols

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Journal of Bionic Engineering 2011年第2期8卷 114-121页

作者： Vuk Uskokovie Wu Li stefan Habelitz Division of Biomaterials and Bioengineering Department of Preventive and Restorative Dental Sciences University of Calil'ornia 707 Parnassus Avenue San Francisco CA 94143 USA Department of Orofacial Sciences University of California 513 Parnassus Avenue San Francisco CA 94143 USA

Human dental enamel forms over a period of 2 4 years by substituting the enamel matrix, a protein gel mostly composed of a single protein, amelogenin with fibrous apatite nanocrystals. Self-assembly of a dense amelogenin matrix is presumed to direct the growth of apatite fibers and their organization into bundles that eventually comprise the mature enamel, the hardest tissue in the mammalian body. This work aims to establish the physicochemical and biochemical conditions for the synthesis of fibrous apatite crystals under the control of a recombinant full-length human amelogenin rnatrix in combination with a pro- grammable titration system. The growth of apatite substrates was initiated from supersaturated calcium phosphate solutions in the presence of dispersed amelogenin assemblies. It was shown earlier and confirmed in this study that binding of amelogenin onto apatite surfaces presents the first step that leads to substrate-specific crystal growth. In this work, we report enhanced nucleation and growth under conditions at which amelogenin and apatite carry opposite charges and adsorption of the protein onto the apatite seeds is even more favored. Experiments at pH below the isoelectric point of amelogenin showed increased protein binding to apatite and at low Ca/P molar ratios resulted in a change in crystal morphology from plate-like to fibrous and rod-shaped. Concentrations of calcium and phosphate ions in the supernatant did not show drastic decreases throughout the titration period, indicating controlled precipitation from the protein suspension metastable with respect to calcium phosphate. It is argued that amelobtasts in the developing enamel may vary the density of the protein matrix at the nano scale by varying local pH, and thus control the interaction between the mineral and protein phases. The biomimetic experimental setting applied in this study has thus proven as convenient for gaining insight into the fundamental nature of the process ofamelogenesi

关键词： enamel amelogenin biomineralization apatite biomimetics

Managing stress granule disassembly with ubiquitin and its cousin

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3377-3378页

作者： stefan Müller Institute of Biochemistry II Gustav Embden ZentrumGoethe University FrankfurtFaculty of MedicineFrankfurtGermany

Recently,Maxwell et al.1 revealed a critical function of ubiquitylation in stress granule(SG)disassembly upon recovery from heat *** are continuously exposed to endogenous or environmental *** stress endangers DNA integrity,whereas proteotoxic stress causes an imbalance in protein homeostasis(proteostasis).Genotoxic insults activate DNA damage response pathways that halt the cell-cycle progression and initiate DNA *** quality control(PQC)systems in turn safeguard the integrity of the proteome and prepare for the restart of cellular activities upon stress *** genome and proteome integrity pathways are orchestrated by ubiquitin signaling and the ubiquitin-proteasome system(UPS).

关键词： stress aging integrity

Altered electroencephalographic networks in developmental dyslexia after remedial training:a prospective case-control study

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Neural Regeneration Research 2021年第4期16卷 734-743页

作者： Juliana A.Dushanova stefan ATsokov Institute of Neurobiology Bulgarian Academy of SciencesSofiaBulgaria

Electroencephalographic studies using graph theoretic analysis have found aberrations in functional connectivity in children with developmental ***,how the training with visual tasks can change the functional connectivity of the semantic network in developmental dyslexia is still *** looked for differences in local and global topological properties of functional networks between 21 healthy controls and 22 dyslexic children(8–9 years old)before and after training with visual tasks in this prospective case-control *** minimum spanning tree method was used to construct the subjects’brain networks in multiple electroencephalographic frequency ranges during a visual word/pseudoword discrimination *** found group differences in the theta,alpha,beta and gamma bands for four graph measures suggesting a more integrated network topology in dyslexics before the training compared to *** training,the network topology of dyslexic children had become more segregated and similar to that of the *** theθ,αandβ1-frequency bands,compared to the controls,the pre-training dyslexics exhibited a reduced degree and betweenness centrality of the left anterior temporal and parietal *** simultaneous appearance in the left hemisphere of hubs in temporal and parietal(α,β1),temporal and superior frontal cortex(θ,α),parietal and occipitotemporal cortices(β1),identified in the networks of normally developing children was not present in the brain networks of *** training,the hub distribution for dyslexics in the theta and beta1 bands had become similar to that of the *** summary,our findings point to a less efficient network configuration in dyslexics compared to a more optimal global organization in the *** is the first study to investigate the topological organization of functional brain networks of Bulgarian dyslexic *** for the study was obtained from the Ethics Committee of the Institute of Neur

关键词： adjusted post-training network developmental dyslexia EEG frequency oscillations functional connectivity visual training tasks visual word/pseudoword discrimination

Synthesis of luminescent KY_3F_(10) nanopowder multi-doped with lanthanide ions by a co-precipitation method

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Journal of Rare Earths 2016年第8期34卷 808-813页

作者： Szymon Goderski Marcin Runowski stefan Lis Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University

A series of KY3F10 nanophosphors doped with Gd3＋, Ce3＋ and Eu3＋ ions were obtained with the use of a co-precipitation method. The resulting products were white precipitates, consisting of spherical particles with diameter about 150-200 nm, which was confirmed using transmission electron microscopy （TEM） technique. Powder X-ray diffraction （XRD） and energy dispersive X-ray analysis （EDX） measurements confirmed appropriate structures of the nanoparticles obtained. Spectroscopic properties of the prod- ucts were examined on the basis of the measured excitation/emission spectra and luminescence decay curves. The synthesized sam- ples showed orange-red luminescence, characteristic for Eu3＋ ions. The reaction process was performed in required alkaline pH ad- justed with the use of ethylenediaminetetraacetic acid （EDTA） and potassium hydroxide. The samples containing large amounts of Gd3＋ dooant ions exhibited a tendencv to form nroducts with different momhologies.

关键词： : fluorides co-precipitation nanophosphors luminescence nanopowders Ce3+/Gd3+/Eu3+ doping rare earths

A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan

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Neural Regeneration Research 2022年第2期17卷 309-310页

作者： stefan Homentcovschi Ryo Higuchi-Sanabria Department of Molecular&Cellular Biology University of CaliforniaBerkeleyCAUSA

The ability to protect cellular components in the face of deleterious conditions, such as exposure to chemical poisons, damaging radiation, or excessive heat, is crucial to organismal viability.

关键词： autonomous delete exposure

A NEGATIVE ANSWER TO A PROBLEM OF FREMLIN AND MENDOZA

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Acta Mathematica Scientia 2007年第4期27卷 813-820页

作者：叶国菊 stefan Schwabik College of Science Hohai University Nanjing210098China Mater naticky ústav AV R itná 25 115 67 Praha 1Czech Republic

This article studies some convergence results for the McShane integral of functions mapping the interval [0, 1] into a Banach space X from the point of view of an open problem proposed by *** and J. Mendoza in [2], al... 详细信息

关键词： Abstract function Pettis integral McShane integral