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Sonographic signs of neutropenic enterocolitis

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World Journal of Gastroenterology 2006年第9期12卷 1397-1402页

作者： Christoph F Dietrich Stella Hermann stefan klein Barbara Braden Department of Internal Medicine Cari-tas Hospital Bad Mergentheim Bad MergentheimGermany Medical Department University Hospital Frankfurt/MainGermany

AIM： To investigate the sonographic features at time of diagnosis and follow-up in patients with neutropenic enterocolitis. METHODS： The sonographic findings in 14 patients with neutropenic enterocolitis were described and evaluated regarding symptoms and clinical outcome. RESULTS： In all patients with neutropenic enterocolitis, the ileocoecal region was involved with wall thickening 〉10 mm. A transmural inflammatory pattern, hypervascularity of the thickened bowel wall and free abdominal fluid were the common findings. The sonographically revealed thickness of the bowel wall was associated with lethal outcome （P〈0.03）. In the 11 surviving patients, the improvement of clinical symptoms was accompanied by progressive reduction of intestinal wall thickness. CONCLUSION： High-end sonography of the bowel is a helpful tool for diagnosis, assessment of prognosis and follow-up of patients with neutropenic enterocolitis. The ultrasonographically revealed bowel thickness reflects the severity and the course of the disease, and seems to be predictive for the clinical outcome.

关键词： Neutropenia Bowel wall thickness Ultrasonography

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北京鸭种鸭需要给予特殊的管理

国外畜牧学（猪与禽） 2008年第2期28卷 17-21页

作者：张劳 Hermann klein-hessling 国际家禽咨询服务公司

北京鸭的种鸭生产是商用家禽生产中一个高度专业的领域,其父母代种群的繁殖率很高,介于蛋鸡和肉用种鸡之间。然而,在北京鸭的管理中存在着许多特殊要求,实施这些管理措施能将北京鸭饲养成令人感兴趣的具有卓越生产性能的家禽。

关键词：北京鸭管理种鸭家禽生产肉用种鸡生产性能繁殖率父母代

饲料加工厂面临饲用玉米干酒糟及其可溶物带来的挑战

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国外畜牧学（猪与禽） 2009年第1期29卷 55-57页

作者：张贤群 Hermann klein-hessling

根据最近的研究成果，家禽日粮中添加高达20％的玉米干酒糟及其可溶物（Distillers Dried Grains with Soluble，DDGS）是切实可行的。然而，为能取得最佳添加效果，必须对影响其质量的各种因素进行仔细监测。

关键词：玉米干酒糟可溶物饲料加工厂饲用研究成果家禽日粮添加效果

Grb-2-associated binder 1(Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

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Grb-2-associated binder 1(Gab1) regulates postnatal ischemic...

Heterosis in plants:Manifestation in early seed development and prediction approaches to assist hybrid breeding

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： stefan klein-Heβling Masabumi Shibuya Department of Molecular Pathology Institute of PathologyUniversity of WiirzburgD-97080 WiirzburgGermany Department of Molecular Oncology Tokyo Medical and Dental UniversityTokyo 113-8510Japan

The intracellular signaling mechanisms underlying postnatal angiogenesis are incompletely understood. Herein we show that Grb-2-associated binder 1(Gab1) plays a critical role in ischemic and VEGF-induced ***-specific Gab1 KO(EGKO) mice displayed impaired angiogenesis in the ischemic hindlimb despite normal induction of VEGF *** plugs with VEGF implanted in EGKO mice induced fewer capillaries than those in control *** vessels and endothelial cells(ECs) derived from EGKO mice were defective in vascular sprouting and tube formation induced by VEGF. Biochemical analyses revealed a substantial reduction of endothelial NOS(eNOS) activation in Gab1-deficient vessels and ECs following VEGF ***,the phosphorylation of Akt,an enzyme known to promote VEGF-induced eNOS activation,was increased in Gab1-deficient vessels and ECs whereas protein kinase A(PKA) activity was significantly *** of an active form of PKA rescued VEGF-induced eNOS activation and tube formation in EGKO *** of WT or mutant Gab1 molecules in EGKO ECs revealed requirement of Gab1/Shp2 association for the activation of PKA and *** together,these results identify Gab1 as a critical upstream signaling component in VEGF-induced eNOS activation and tube formation,which is dependent on *** note,this pathway is conserved in primary human ECs for VEGFinduced eNOS activation and tube formation,suggesting considerable potential in treatment of human ischemic diseases.

关键词： Gabl protein complex collateralization Tie2-Cre PKA substrate

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Chinese Science Bulletin 2009年第14期54卷 2363-2375页

作者： THIEMANN Alexander MEYER Stephanie SCHOLTEN stefan Developmental Biology and Biotechnology Biocenter Klein FlottbekUniversity HamburgOhnhorststraβe 1822609 HamburgGermany Developmental Biology and Biotechnology Biocenter Klein FlottbekUniversity HamburgOhnhorststraβe 18 22609 HamburgGermany

Heterosis, or hybrid vigour, describes the superior performance of heterozygous hybrid individuals compared with their homozygous parental inbred lines. Although heterosis has been intensively used in plant breeding, the molecular and genetic mechanism underlying the phenomenon remains largely unknown. During the last years numerous laboratories initiated genomic approaches with new, often genome wide tools toward the elucidation of the molecular basis of heterosis. Various studies described differences in genome organization and gene expression of hybrids and their parental inbred lines. In maize, a considerable loss of co-linearity at many loci between different inbred lines was observed. Expression profile comparisons between inbred lines and hybrids revealed complex transcriptional networks specific for different developmental stages and tissues mainly in maize (Zea mays), rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana). Allele-specific expression data resolved the relative parental contributions and allowed figuring out the regulatory basis for expression variation in hybrids. Integrating all these complex expression data might help to get an idea about the molecular basis of heterosis. Thereby molecular processes during early seed development shortly after fertilization might be of particular importance, because the allelic interplay has to be coordinated after the unification of two diverse genomes and these processes might contribute to establish the basis for future performance of the sporophyte. Besides these fundamental interests in the molecular basis and manifestation of hybrid vigour applied aspects of the phenomenon are of high importance to support plant breeding and agriculture. Prediction methods are of special interest to identify the most promising parental lines of hybrid varieties, greatly reducing the financial effort and increasing the efficiency to develop new hybrid cultivars. Until now, most prediction approaches were based on g

关键词：植物育种方法水稻基因表达

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诗意的宇宙

作者： (奥)斯特凡·克莱因(stefan klein)

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用于燃油位置传感器的厚膜浆料(英文)

电子工业专用设备 2007年第3期36卷 53-60页

作者： stefan Flick Roland Kersting 罗庆生 Randy klein 贺利氏上海工业技术材料有限公司

现今的燃油传感器要求在汽车汽油箱的苛刻的化学环境里有低的电子噪声,长的耐磨寿命和高的信号传递。虽然燃油传感器基板的设计师通过结构设计和选择触点、电刷的安装等能够较大的提高性能,但厚膜导体必须符合相关要求。导体浆料是贵重... 详细信息

现今的燃油传感器要求在汽车汽油箱的苛刻的化学环境里有低的电子噪声,长的耐磨寿命和高的信号传递。虽然燃油传感器基板的设计师通过结构设计和选择触点、电刷的安装等能够较大的提高性能,但厚膜导体必须符合相关要求。导体浆料是贵重金属粉末混合物(例如Ag,Pd,Au,Pt和它们的合金、以及玻璃或氧化物粉末)悬浮于有机载体中而形成的。这些燃油传感器基板必须在包含水、酒精、有机酸、硫化合物、氟素的燃油中工作,要满足抗银离子迁移、抗化学腐蚀和耐磨性这些重要的特性。论述了一种应用于燃油传感器厚膜电路需求的导体浆料,以及工艺、机械和化学上的要求。并给出了详细的耐磨性、耐硫化及抗化学腐蚀的讨论,讨论了金属合金在导体中的作用,并用微结构分析和化学分析来评估材料。

关键词：厚膜燃油传感器耐磨性抗化学腐蚀

Assessment of regional ventilation distribution:Comparison of vibration response imaging with electrical impedance tomography

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Assessment of regional ventilation distribution:Comparison o...

Gabl regulates postnatal ischemic and VEGF-induced angiogenesis via activation of the PKA-eNOS pathway

中国毒理学会第六届全国毒理学大会

作者： SHI Chang stefan BOEHME Alexander H BENTLEY Erik K HARTMANN Klaus U klein Marc BODENSTEIN Roman ULLRICH Klaus MARKSTALLER Department of Anaesthesiology Medical Centre of the Johannes Gutenberg-University Mainz National Beijing Center for Drug Safety Evaluation and Research Beijing Institute of Pharmacology and Toxicology

＜正＞OBJECTIVE Vibration response imaging（VRI） is a new bedside technology to monitor ventilation by detecting lung sound *** is currently unknown whether VRI is able to accurately monitor the local distribution of ventilation within the *** therefore compared VRI to electrical impedance tomography（EIT）,an established technique used for the assessment of regional ventilation. METHODS For peer review,simultaneous EIT and VRI measurements were performed in the healthy and injured lungs（ALI;induced by saline lavage） at different PEEP levels（0,5,10,15 mbar） in nine *** energy amplitude（VEA） by VRI,and amplitudes of relative impedance changes（rel. AZ） by EIT,were evaluated in seven regions of interest（ROIs）.To assess the distribution of VT by VRI and EIT,absolute values were normalized to the VT obtained by simultaneous spirometry measurements. RESULTS Redistribution of ventilation by ALI and PEEP was detected by VRI and *** linear correlation between pooled VT by VEA and *** was R =***-Altman analysis showed a bias of -1.07±24.71 ml and limits of agreement of -49.05 to +47.36 *** the different ROIs, correlations of VT - distribution by EIT and VRI ranged between R values ofO.29 and *** and PEEP did not alter the agreement of VT between VRI and *** Measurements of regional ventilation distribution by VRI are similar to those obtained by EIT.

关键词： electrical impedance lung injury ventilation vibration imaging

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Gabl regulates postnatal ischemic and VEGF-induced angiogene...