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Optimal duration for dual antiplatelet therapy with COMBO dual therapy stent

Journal of Geriatric Cardiology 2019年第11期16卷 840-843页

作者： Aydin Huseynov Michael Behnes Uzair Ansari stefan baumann Dirk Lossnitzer Ibrahim El-Battrawy Christian Fastner Martin Borggrefe Ibrahim Akin First Department of Medicine University Medical Centre Mannheim (UMM) University of Heidelberg

The COMBO stent(OrbusNeich Medical BV,the Netherlands)is a stainless-steel platform with the biodegradable abluminal coating containing antiproliferative sirolimus(5 mg/mm)and the luminal stent surface covered with anti-CD-34 *** CD-34 antibodies essentially capture endothelial progenitor cells resulting in rapid re-endothelialization of the treated segment.

关键词： Adverse events Antiplatelet therapy Combo stent

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Clinical and echocardiographic analysis of patients suffering from recurrent takotsubo cardiomyopathy

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Journal of Geriatric Cardiology 2016年第11期13卷 888-893页

作者： Ibrahim El-Battrawy Uzair Ansari Michael Behnes Dennis Hillenbrand Katja Schramm Darius Haghi Ursula Hoffmann Theano Papavassiliu Elif Elmas Christian Fasmer Tobias Becher stefan baumann Christina Dosch Felix Heggemann Jurgen Kuschyk Martin Borggrefe Ibrahim Akin First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM) University of Heidelberg Mannheim Germany DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg-Mannheim Mannheim Germany

Background Recurrence of takotsubo cardiomyopathy （TTC） is a well-known complication. However, current literature lists only a few isolated cases. We aimed to determine the incidence and clinical significance of recurrent TTC. Methods ＆ Results Our institutional database constituted a collective of 114 patients diagnosed with TTC since 2003. Close follow-up of these patients revealed a recurrence of TTC in seven of these （6.1%）. The time interval between the index event and its recurrence varied between six months and six years. Arterial hypertension was more revealed in the recurrence group of TTC compared to non-recurrence group, （P = 0.02）. Chronic obstructive pulmo- nary disease and/or asthma was more diagnosed in the recurrence group, （P = 0.04）. Clinical events like fight ventficular involvement, TTC related complications such as life-threatening arrhythmias, pulmonary congestion and in hospital death were observed more frequently in the recurrent episode. Over a mean follow-up of one year the mortality rate was similar in both groups. Conclusions Recurrence of TTC within six years after index event is not an uncommon phenomenon. In the event of right ventricular involvement in the relapse phase, it might be associated with a higher complication rate. TTC recurrence should be the first differential diagnosis in patients with a past history of TTC.

关键词： Biventricular takotsubo cardiomyopathy Recurrent takotsubo cardiomyopathy Takotsubo cardiomyopathy related complication

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Instantaneous wave-free ratio(iFR) to determine hemodynamically significant coronary stenosis: A comprehensive review

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World Journal of Cardiology 2018年第12期10卷 267-277页

作者： stefan baumann Leonard Chandra Elizaveta Skarga Matthias Renker Martin Borggrefe Ibrahim Akin Dirk Lossnitzer First Department of Medicine-Cardiology University Medical Center MannheimMannheim Germany and DZHK (German Center for Cardiovascular Research) partner site Heidelberg/Mannheim Department of Cardiology Kerckhoff-Klinik GmbH

Coronary angiography is considered to be the gold standard in the morphological evaluation of coronary artery stenosis. The morphological assessment of the severity of a coronary lesion is very subjective. Thus, the invasive fractional flow reserve(FFR) measurement represents the current standard for estimation of the hemodynamic significance of coronary artery stenosis. The FFR-guided revascularization strategy was initially classified as a Class-IA-recommendation in the 2014 European Society of Cardiology/European Association for Cardio-Thoracic Surgery guidelines on myocardial revascularization. Both the Deferral vs Performance of Percutaneous Coronary Intervention of Functionally Non-Significant Coronary Stenosis and Flow Reserve vs Angiography for Multivessel Evaluation studies showed no treatment advantage for hemodynamically insignificant stenoses. With the help of FFR(and targeted interventions), clinical results could be improved; however, the use in clinical practice is still limited due to the need of adenosine administration and a significant prolongation of the length of the procedure. Instantaneous wave-free ratio(iFR~) is a new innovative approach for the determination of the hemodynamic significance of coronary stenosis, which can be obtained at rest without the use of vasodilators. Regarding the periprocedural complications as well as prognosis, iFR~ showed non-inferiority to FFR in the SWEDEHEART and DEFINE-FLAIR trials. Furthermore, iFR~, enhanced by iFR~-pullback, provides the possibility to display the iFR~-change over the course of the vessel to create a hemodynamic map.

关键词： Coronary stenosis Coronary angiography Fractional flow reserve Instantaneous wave-free ratio Myocardial ischemia Coronary revascularization

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欧洲中央银行（ECB）

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城市环境设计 2020年第4期126卷 162-173页

作者：沃尔夫·狄·普瑞克斯 Magdalena Baczkowska Markus baumann Michael Beckert Johannes Behrens Hilde Benda Marcelo Bernardi Nico Boyer Jan Brosch Timo Carl Anna Rita Cedroni Jasmin Dieterle Sabrina Dlugosch Jan Ruben Fischer Brigitte Fuchs Sergio Gonzales Gesine G?rlich Martin Gruber Guthu Hallstein Sebastian Haffner Simone Hainz Sascha Hempel Rob Henderson Emanuele Iacono Martin Jelinek Rashmi Krishna Jois Ivana Jug Frank Pascal Kaul Matt Kirkham Daniela Kr?hnert Bernward Krone Christian Labud Anke Lammert Monika Lyzyczka Steven M Christian Maeder Dimitra Mamou Ariane Marx Christoph Maurer Matthias Niemeyer Martin Oberascher Ross Olson Renate Ott Gerhard Pfeiler Ellen Pietrzyk James Pike Robert Pippan Jakob Przybylo Anna Ptaszynska Stephanie Rathgeber Carmen Renz Salome Reves Donna Riedel Akvile Rimantaite Pete Rose Penelope Rüttimann stefan Rutzinger Oliver Sachse Kristina Schinegger Benjamin Schmidt Marita Schnepper Thomas Siegl Ebru Simsek-Lenk Denise Sokolowski Augustin Solorzano Anja Sorger Andrea St?llenwerk Ernst Stockinger Crystal K.H Tang Jürgen Tiltmann Markus Tritthart Josef Tr?ster Günther Weber Andreas Weissenbach Clemens Werb Judith Werkh?user Markus Wings Eva Wolf Barbara Zeleny Thomas Zengger Zeyneb Badur Fabien Barthelemey Oliver Cassik Alejandro Corena Alexander Daxb?ck Mario Dign?ss Helmut Fr?tscher Annegret Haider Christian Halm Gregor Kassl Gernot K?fer Alexander Laber Anita Lischka Rangel Malinov Oliver Martinz Philipp Munz Barbara Roller Nicole Rumpler Wolfgang Ruthensteiner stefan Salchinger stefan Schadenb?ck Thomas Schwed Hannes Schwed Eckart Schwerdtfeger Sylvia Spernbauer Christoph Treberspurg Johannes Weigl Paul Raftery European Central Bank/RobertMetsch Markus Pillhofer

项目大事记/CHRONOLOGY竞赛/Competition:第一阶段/Phase 1:2003;第二阶段/Phase 2:2003-2004;修改阶段/Revision Phase:2004;优化阶段/Optimization Phase:2005规划设计起始时间/Start of Planning:2005前期工程/Preliminary Site Works:2008主体施工/Main Construction Works:2010竣工/Completion:2014项目参数/PROJECT DATA用地面积/Site Area:120 000m2建筑毛面积/Gross Floor Area:185 000m2

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