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Pre-treatment platelet counts as a prognostic and predictive factor in stage Ⅱ and Ⅲ rectal adenocarcinoma

World Journal of Gastrointestinal Oncology 2017年第1期9卷 42-49页

作者： Morgan steele Ioannis A Voutsadakis Clinical Trials Unit Sault Area Hospital Division of Medical Oncology Department of Internal Medicine Sault Area Hospital Division of Clinical Sciences Northern Ontario School of Medicine

AIM To investigate if pre-treatment platelet counts could provide prognostic information in patients with rectal adenocarcinoma that received neo-adjuvant treatment. METHODS Platelet number on diagnosis of stage II and III rectal cancer was evaluated in 51 patients receiving neoadjuvant treatment and for whom there were complete follow-up data on progression and survival, as well as pathologic outcome at the time of surgery. Pathologic responses on the surgical specimen of patients with lower platelet counts(150-300 × 10~9/L) were compared with these of patients with higher platelet counts(> 300 × 10~9/L) by the χ~2 test. Overall and progression free survival Kaplan-Meier curves of the two groups were constructed and compared with the Log-Rank *** A significant difference was present between the two groups in regards to pathologic response with patients with lower platelet counts being more likely to exhibit a good or complete response to neo-adjuvant treatment than patients with higher platelet counts(P = 0.015). Among other factors evaluated, there was also a significant difference between the carcinoembryonic antigen(CEA) at presentation of patients that exhibited a good or complete response and those that had no response or a minimal to moderate response. Patients with a good or complete response were more likely to present with a CEA of less than 5 μg/L(P = 0.00066). There was no significant difference in overall and progression free survival between the two platelet count groups(Log-Rank tests P = 0.42 and P = 0.35, respectively).CONCLUSION In this retrospective analysis of stage II and III rectal cancer patients, platelet counts at the time of diagnosis had prognostic value for neo-adjuvant treatment pathologic response. Pre-treatment CEA also held prognostic value in regards to treatment effect.

关键词： Rectal cancer Platelets Prognosis Treatment response neo-adjuvant Chemoradiation

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Rapid conversion of cellulose to 5-hydroxymethylfurfural using single and combined metal chloride catalysts in ionic liquid

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燃料化学学报 2013年第2期41卷 214-222页

作者： Hussein Abou-Yousef El Barbary Hassan Philip steele Department of Forest Products Mississippi State University Cellulose & Paper Department National Research CenterDokkiCairoEgypt

Direct conversion of cellulose into 5-hydroxymethylfurfural(HMF) was performed by using single or combined metal chloride catalysts in 1-ethyl-3-methylimidazolium chloride(Cl) ionic *** study demonstrated formation of 2-furyl hydroxymethyl ketone(FHMK),and furfural(FF) simultaneously with the formation of *** reaction parameters were addressed to optimize yields of furan derivatives produced from cellulose by varying reaction temperature,time,and the type of metal chloride *** reaction by using FeCl3 resulted in 59.9% total yield of furan derivatives(HMF,FHMK,and FF) from ***3 was the most effective catalyst for selective conversion of cellulose into HMF(35.6%) with less concentrations of FHMK,and *** the yields of furans produced from cellulose could be achieved via reactions catalyzed by different combinations of two metal *** optimization was carried out to produce total furans yield 75.9% by using FeCl3/CuCl2 ***3/CuCl2 was the most selective combination to convert cellulose into HMF(39.9%) with total yield(63.8%) of furans produced from the *** temperature and time of the catalytic reaction played an important role in cellulose conversion,and the yields of *** the reaction temperature could enhance the cellulose conversion and HMF yield for short reaction time intervals(5~20 min).

关键词：化学动力学燃料化学理论 EMIM HMF

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Plant-animal interactions: patterns and mechanisms in terrestrial ecosystems

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Integrative Zoology 2018年第3期13卷 225-227页

作者： Michael A.steele Xianfeng YI Hongmao ZHANG Department of Biology Wilkes UniversityUSA College of Life Sciences Jiangxi Normal UniversityChina School of Life Sciences Central China Normal UniversityChina

From the early work of Darwin,then Ehrlich and Raven(1964),to the recent novel contribution of mutualistic networks developed by Jordano and colleagues(Bascompte and Jordano 2007,Nuismer et al.2013,Guimarães et al.2017),it is clear that plant-animal interactions—especially those involving herbivory,seed dispersal,seed predation and pollination—are significant drivers of ecological processes and the evolution and maintenance of *** vast majority of plant species,for example,are influenced by animal-mediated seed dispersal and pollination.

关键词： Ehrlich terrestrial

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Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1980-1995页

作者： Koki Nishihara Clothilde Villot Lautaro Cangiano Le Luo Guan Michael steele Department of Animal Biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Faculty of Land and Food Systems The University of British ColumbiaVancouverBC V6T 1Z4Canada Present Address:Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life,understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal *** probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune *** objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune *** Twenty Holstein bull calves received no supplementation(CON)or Saccharomyces cerevisiae boulardii(SCB)from birth to 5 d of *** tissue biopsies were taken within 2 h of life(D0)before the first colostrum feeding and 3 h after the morning feeding at d 5 of age(D5)to analyze mucosa-attached bacteria and colon *** sequencing showed that there was no difference inαandβdiversity of mucosa-attached bacteria between day and treatment,but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to *** addition,q PCR indicated that the absolute abundance of Escherichia coli(***)decreased in the colon mucosa on D5 compared to D0;however,that of Bifidobacterium,Lactobacillus,and Faecalibacterium prausnitzii,which could competitively exclude ***,increased in the colon mucosa on D5 compared to ***-sequencing showed that there were no differentially expressed genes between CON and SCB,but suggested that pathways related to viral infection such as“Interferon Signaling”were activated in the colon mucosa of D5 compared to *** Growth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB *** early life,opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune *** activation

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

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Revisiting 1-＋ Light Hybrid from Monte-Carlo Based QCD Sum Rules

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Chinese Physics Letters 2014年第5期31卷 26-30页

作者：张珠峰金洪英 T. G. steele Department of Physics Ningbo University Ningbo 315211 Zhejiang Institute of Modern Physics Zhejiang University Hangzhou 310027 Department of Physics and Engineering Physics University of Saskatchewan Saskatoon S7N 5E2 Canada

We reanalyze the 1 ＋ light hybrid from QCD sum rules with a Monte-Carlo based on uncertainty analysis. With 30% uncertainties in the accepted central values for QCD condensates and other input parameters, we obtain a prediction on the 1-＋ hybrid mass of 1.71 ± 0.22 GeV, which covers the mass of 7rl （1600）. We also study the correlations between the input and output parameters of QCD sum rules.

关键词： Uncertainty analysis

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Evolving screening and surveillance techniques for Barrett's esophagus

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World Journal of Gastroenterology 2019年第17期25卷 2045-2057页

作者： David steele Kondal Kyanam Kabir Baig Shajan Peter Basil Hirschowitz Endoscopic Centre of Endoscopic Excellence Division of Gastroenterology and HepatologyUniversity of Alabama at Birmingham

Barrett's esophagus(BE) is a change in the esophageal lining and is known to be the major precursor lesion for most cases of esophageal adenocarcinoma(EAC).Despite an understanding of its association with BE for many years and the falling incidence rates of squamous cell carcinoma of the esophagus, the incidence for EAC continues to rise exponentially. In association with this rising incidence, if the delay in diagnosis of EAC occurs after the onset of symptoms,then the mortality at 5 years is greater than 80%. Appropriate diagnosis and surveillance strategies are therefore vital for BE. Multiple novel optical technologies and other advanced approaches are being utilized to assist in making screening and surveillance more cost effective. We review the current guidelines and evolving techniques that are currently being evaluated.

关键词： Barrett’s esophagus Screening Surveillance New techniques Endoscopy Imaging Radiofrequency ablation Narrow band imaging

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Neurosurgical treatment for addiction: lessons from an untold story in China and a path forward

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National Science Review 2020年第3期7卷 702-712页

作者： Shuo Ma Chencheng Zhang Ti-fei Yuan Douglas steele Valerie Voon Bomin Sun Department of Functional Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine Co-innovation Center of Neuroregeneration Nantong University Division of Imaging Science and Technology Medical School University of Dundee Department of Psychiatry University of Cambridge

Addiction is a major public-health crisis associated with significant disability and mortality. Although various pharmacological and behavioral treatments are currently available, the clinical efficacy of these treatments is limited. Given this situation, there is a growing interest in finding an effective neurosurgical treatment for addiction. First, we discuss the use of ablative surgery in treating addiction. We focus on the rise and fall of nucleus accumbens ablation for addiction in China. Subsequently, we review recent studies that have explored the efficacy and safety of deep-brain-stimulation treatment for addiction. We conclude that neurosurgical procedures, particularly deep-brain stimulation, have a potentially valuable role in the management of otherwise intractable addictive disorders. Larger well-controlled clinical trials, however, are needed to assess clinical efficacy and safety. We end by discussing several key issues involved in this clinical field and identifying some areas of progress.

关键词： drug addiction psychosurgery ablative surgery deep-brain stimulation medical ethics

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Could titin have a role in strain-induced injuries？

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Journal of Sport and Health Science 2017年第2期6卷 143-144页

作者： Craig Perrin Kazunori Nosaka James steele School of Sport Health and Social SciencesSouthampton Solent University Ringgold Standard InstitutionSouthamptonS014 OYNUK School of Exercise and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia

It has been known for some time that strain injuries occur through the excessive lengthening of a muscle.^(1–3)However,the precise mechanism for strain injury remains elusive and has been the subject of recent debate in the Journal of Sport and Health Science,^(4–9)but it seems sensible to consider mechanisms at the level of the muscle *** was previously believed that damage was the result of non-uniform stretching of

关键词：肌联蛋白损伤机制应变诱导肌肉纤维最佳长度肌原纤维最大变形力曲线

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Determining future high speed rail review topics through bibliometric analysis

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High-Speed Railway 2024年第1期2卷 17-29页

作者： Heather steele Marcelo Blumenfeld Paul Plummer Birmingham Centre for Railway Research and Education School of Engineering University of BirminghamBirmingham B152TTUK

As High Speed Rail(HSR)has proliferated globally,so has a related research field dedicated to exploring and addressing its unique ***,studies to understand and classify the HSR research domain are *** paper addresses the gap,using bibliometric analysis to identify future research areas and 20 candidate topics for literature review based on keyword analysis through *** and review papers related to HSR published in the last 20 years(2003-2022)were retrieved from Scopus,and then analyzed to determine the split in knowledge between languages,the collaboration between countries and institutions,highly productive and cited journals,and research topics which have and have not been *** 30%of the search results were published exclusively in Chinese,highlighting the importance of extending the evaluation to cover both *** is a novel aspect of the work,which has enabled the recognition of potential knowledge *** is recommended that future reviews incorporate works in both languages,possibly through international *** in China and other countries that are strong collaborators have been identified,as well as relevant,highly cited journals.

关键词： High speed rail Literature review Bibliometric analysis Vosviewer Keyword co-occurrence

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Effects of insect infestation on rodent-mediated dispersal of Quercus aliena:results from field and enclosure experiments

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Integrative Zoology 2019年第1期14卷 104-113页

作者： Bo ZHANG Xiaoning CHEN Michael A.steele Jingang LI Gang CHANG College of Life Sciences Shaanxi Normal UniversityXi’anChina Shaanxi Institute of Zoology Xi’anChina and Department of Biology Wilkes UniversityWilkes-BarrePennsylvaniaUSA

Rodents influence plant establishment and regeneration by functioning as both seed predators and ***,these rodent-plant interactions can vary significantly due to various environmental conditions and the activity of other insect seed ***,we use a combination of both field and enclosure(*** cage and semi-natural enclosure)experiments,to determine whether rodents can distinguish sound seeds from those infested with *** also demonstrate how such responses to insects are influenced by food abun-dance and other environmental *** presented rodents with 2 kinds of Quercus aliena seeds(sound and insect-infested seeds)in a subtropical forest in the Qinling Mountains,central China,from September to No-vember of 2011 to *** results showed that rodents preferred to hoard and eat sound seeds than infested seeds in the field and semi-natural enclosure,while they preferred to eat infested seeds over sound seeds in the individual *** addition,both hoarding and eating decisions were influenced by food *** hoarded more sound seeds in years of high food abundance while they consumed more acorns in years of food *** with field results,rodents reduced scatter-hoarding behavior in semi-natural enclosures and ate more insect-infested seeds in smaller individual *** results further confirm that rodents distinguish infested seeds from non-infested seeds but demonstrate that this behavior varies with conditions(***-ment and food abundance).We suggest that such interactions will influence the dispersal and natural regenera-tion of seeds as well as predation rates on insect larvae.

关键词： food abundance infested seeds larder hoarding scatter hoarding seed dispersal semi-natural enclosure

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