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Por.hyr.monas gingivalis r.sistance to Polymyxin B Is Deter.ined by the Lipid A 4’-Phosphatase, PGN_0524

Inter.ational Jour.al of Or.l Science 2009年第3期1卷 126-135页

作者： ste.he. r. coats Thao T. To Sumita Jain Pamela H. Br.ham r.char. P. Dar.eau Depar.ment of Per.odontics School of Dentistry University of Washington Seattle USA

Aim To elucidate the genetic basis for.the pr.nounced r.sistance that the or.l pathogen, Por.hyr.monas gingivalis （P. gingivalis）, exhibits towar.s the cationic antimicr.bial peptide, polymyxin B. Methodology A genetic scr.en of P. gingivalis clones gener.ted by a Tn4400-based r.ndom inser.ion mutagenesis str.tegy was per.or.ed to identify bacter.a har.or.ng novel genetic mutations that r.nder.P. gingivalis susceptible to killing by the cationic antimicr.bial peptide, polymyxin B （PMB, 50μg·mL^-1）. r.sults P. gingivalis （ATCC 33277） is unusually r.sistant to the cationic antimicr.bial peptide, PMB at r.latively high concentr.tions （200μg·mL^-1）. Appr.ximately 2,700 independent Tn4400 ＇-der.ved mutants ofP. gingivalis wer. examined for.incr.ased sensitivity to PMB killing at a r.latively low dose （50 μg·mL^-1）. A single PMB-sensitive mutant was obtained in this phenotypic scr.en. We deter.ined that the Tn4400＇ tr.nsposon was integr.ted into the gene encoding the lipid A 4＇-phosphatase, PGN 0524, demonstr.ting that this inser.ion event was r.sponsible for.its incr.ased susceptibility of this clone to PMB-dependent killing. The r.sulting mutant str.in, designated 0524-Tn4400＇, was highly sensitive to PMB killing r.lative to wild-type P. gingivalis, and exhibited the same sensitivity as the pr.viously char.cter.zed str.in, 0524KO, which bear. a genetically engineer.d deletion in the PGN_0524 locus. Positive ion mass spectr.metr.c str.ctur.l （MALDI-TOF MS） analyses r.vealed that lipid A isolates fr.m 0524-Tn4400＂ and 0524KO str.ins displayed str.kingly similar.MALDI-TOF MS spectr. that wer. substantially differ.nt fr.m the wildtype P gingivalis lipid A spectr.m. Finally, intact 0524- Tn4400＇ and 0524KO mutant bacter.a, as well as their.cor.esponding LPS isolates, wer. significantly mor. potent in stimulating Toll-like r.ceptor.4 （TLr.）-dependent E-selectin expr.ssion in human endothelial cells r.lative to intact wild-type P.. gingivalis or.its cor.esponding LPS isolate.

关键词： P. gingivalis antimicr.bial peptide lipid A phosphatase polymyxin B tr.nsposon lipopolysacchar.de

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成人刀砍样线状硬皮病伴癫痫发作及类coats样表现1例并文献复习

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中华神经科杂志 2024年第3期57卷 273-282页

作者：盛西西朱旭贞贺忠延薛丹张蕊浙江中医药大学附属杭州市中医院神经内科杭州310007 浙江中医药大学附属杭州市中医院皮肤科杭州310007 浙江中医药大学附属杭州市中医院眼科杭州310007

目的通过报道1例刀砍样线状硬皮病患者的临床特点及诊治经过,并进行相关文献回顾,旨在为刀砍样线状硬皮病的早期诊断及治疗提供依据。方法总结2022年9月22日就诊于杭州市中医院的1例刀砍样线状硬皮病患者的临床资料和诊治过程,同时系统... 详细信息

目的通过报道1例刀砍样线状硬皮病患者的临床特点及诊治经过,并进行相关文献回顾,旨在为刀砍样线状硬皮病的早期诊断及治疗提供依据。方法总结2022年9月22日就诊于杭州市中医院的1例刀砍样线状硬皮病患者的临床资料和诊治过程,同时系统性分析国内外与刀砍样线状硬皮病伴癫痫发作或类coats样表现相关的病例报道或病例系列研究,总结该类型患者的性别、年龄、发病时间、临床表现、治疗及预后等情况。结果本例患者为22岁女性,有头皮斑片样脱发和同侧额部刀砍样皮损病史10余年,5年前因右眼视力下降诊断为coats病,现已失明。本次因"发作性意识丧失2 h余"就诊。患者入院时伴有癫痫样发作及左眼类coats样表现,接受抗癫痫药物、糖皮质激素、免疫抑制剂治疗,效果尚可。分析国内外文献报道的全部20例刀砍样线状硬皮病患者的临床资料,其发病年龄为11.00(6.75,20.50)岁,男女比例为1∶1,刀砍样线状硬皮病伴癫痫发作患者的影像学结果多表现为病灶侧颅内多发钙化灶、病灶侧软组织萎缩、颅骨变薄。刀砍样线状硬皮病伴coats样表现患者眼底及荧光素血管造影检查主要表现为渗出性炎症、视网膜脱离,其中1例患者的头颅影像学提示脑血管炎。对刀砍样线状硬皮病伴癫痫发作患者多予抗癫痫药物、激素联合免疫抑制剂、白细胞介素6抑制剂托珠单抗等药物治疗,也有患者予手术治疗。刀砍样线状硬皮病伴类coats样表现患者多予玻璃体内贝伐珠单抗治疗,同时联合激素及免疫抑制剂治疗或视网膜靶向光凝治疗或局部激光和曲安奈德治疗。上述治疗可以有效控制患者的难治性癫痫,改善患者的视力下降。结论刀砍样线状硬皮病主要表现为眼睑以上额面部刀砍样皮损伴色素沉着,可伴有眼部类coats样表现、癫痫发作及颅内影像学异常,上述临床特征可先后出现,也可同时出现,严重时可导致失明及难治性癫痫。应尽早予激素联合免疫抑制剂治疗,玻璃体内贝伐单抗治疗可以改善患者的视力下降。

关键词：硬皮病局限性癫痫视网膜毛细管扩张神经影像学

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Phylogenetic r.lationships of native and intr.duced Bemisia tabaci (Homopter.:Aleyr.didae) fr.m China and India based on mtCOI DNA sequencing and host plant compar.sons

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Pr.gr.ss in Natur.l Science:Mater.als Inter.ational 2007年第6期17卷 645-654页

作者： Susan A.coats Ali M.Idr.s Judith K.Br.wn Depar.ment of Plant Sciences The University of ArizonaTucsonAZ 85721USA

Phylogenetic r.lationships for.Bemisia tabaci wer. r.constr.cted by analysis of a ～780 bp fr.gment of the mitochondr.al cytochr.me oxidase I (mtCOI) gene with an emphasis on geogr.phic r.nge and distr.bution among eight eudicot plant families that ar. common hosts of B. tabaci wor.dwide to elucidate key phylogeogr.phic linkages between populations extant in China (n=31) and India (n=34). Bootstr.p values for.the Maximum Par.imony tr.e wer. highly r.bust for.all major.nodes involving the major.Asian clade, subgr.ups, and sister.gr.ups within, at 92%—100%. Between-clade distances for.the Southeast Asia and thr.e other.major.clades, e.g. fr.m sub-Sahar. Afr.ca, Nor.h Afr.ca-Mediter.anean, and the Amer.cas, wer. appr.ximately >16% diver.ent. Two major.Asian subgr.ups (I, II) wer. r.solved, which r.pr.sented populations indigenous to the r.gion, compr.sing two (I a, I b) and five (II a—e) sister.gr.ups, r.spectively, which diver.ed by 11%. Two distinct populations fr.m sunflower.in Hyder.bad gr.uped separ.tely within the two Asian subgr.ups. All other.populations gr.uped uniquely within Asian subgr.up II or.I. The "B" biotype was identified in 23 collections fr.m China at 97.3%—99.5% nucleotide identity with "B" biotype r.fer.nce sequences; it was not identified in collections fr.m India. The major.ty of haplotypes wer. associated with 3—4 plant families, with one exception that for.sister.gr.up IId (sesame, India), it might be monophagous. Thus, B. tabaci fr.m the southeaster. and near.easter. r.gions of the Asian continent compr.se of a lar.e number.of ancestr.l, r.chly diver.ent, mostly polyphagous populations. This r.gion is ther.for. hypothesized to constitute an impor.ant Old Wor.d center.of diver.ification for.the B. tabaci complex, together.with sub-Sahar.n Afr.ca.

关键词： Bemisia tabaci complex cytochr.me oxidase I host r.nge phylogenetic r.lationship

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Why Does the Wor.d Need a r.ser.e Asset with a Har. Anchor.,

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Fr.ntier. of Economics in China-Selected Publications fr.m Chinese Univer.ities 2017年第4期12卷 545-570页

作者： Dongsheng Di War.en coats Yuxuan Zhao School of Inter.ational Studies Renmin University of China Beijing 100872 China Inter.ational Monetar. Institute of r.nmin Univer.ity of China SDr.Division of the Finance Depar.ment IMF Agr.cultur. Global Pr.ctice International Bank for Reconstruction and Development (IBRD)Washington DC USA

Fr.m the 1970s, the global cur.ency system has two featur.s： the use of one or.a few sover.ign cur.encies as the global r.ser.e asset and the floating exchange r.te r.gime between major.cur.encies. This paper.points out that the costs of the dollar.s use as an inter.ational r.ser.e cur.ency exceed the benefits for.both the US and the r.st of the wor.d. These costs include the expor.ing of Amer.can manufactur.ng as a bypr.duct of its cur.ent account deficit needed to supply its cur.ency to the r.st of the wor.d. In addition to the detr.ment to tr.de fr.m unpr.dictable exchange r.te fluctuations, the ter.ination of the U.S. obligation to r.deem its cur.ency for.gold also r.moved an impor.ant r.str.int on deficit financing for.the US and many other.countr.es in the shor.-r.n, thus pr.moting excessive lever.ge that was a major.contr.butor.to the 2008 financial cr.sis. The paper.suggests r.placing sever.l main countr.es＇ cur.encies in inter.ational r.ser.es with a r.al Special Dr.wing r.ght （SDr. issued accor.ing to cur.ency boar. r.les.

关键词： r.ser.e cur.ency exchange r.te volatility exor.itant pr.vilege,fiscal discipline har. anchor balance of payments r.al SDr

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Mother. in childr.n's and young adult liter.tur.

Mothers in children's and young adult literature

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作者： Fr.ustino Lisa r.we (1963-)coats Kar.n

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A par.metr.c study of the hydr.dynamic r.ughness pr.duced by a wall coating layer.of heavy oil

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Petr.leum Science 2017年第1期14卷 155-166页

作者： S. r.shd r. S. Sander. Depar.ment of Chemical and Mater.als Engineer.ng University of Alberta Edmonton AB Canada

In water.lubr.cated pipeline tr.nspor.ation of heavy oil and bitumen, a thin oil film typically coats the pipe wall. A detailed study of the hydr.dynamic effects of this fouling layer.is cr.tical to the design and oper.tion of oil-water.pipelines, as it can incr.ase the pipeline pr.ssur. loss （and pumping power.r.quir.ments） by 15 times or.mor.. In this study, a par.metr.c investigation of the hydr.dynamic effects caused by the wall coating of viscous oil was conducted. A custom-built r.ctangular.flow cell was used. A validated CFD-based pr.cedur. was used to deter.ine the hydr.dynamic r.ughness fr.m the measur.d pr.ssur. losses. A similar.pr.cedur. was followed for.a set of pipe loop tests. The effects of the thickness of the oil coating layer. the oil viscosity, and water.flow r.te on the hydr.dynamic r.ughness wer. evaluated. Oil viscosities fr.m 3 to 21300 Pa s wer. tested. The r.sults show that the equivalent hydr.dynamic r.ughness pr.duced by a wall coating layer.of viscous oil is dependent on the coating thickness but essentially independent of oil viscosity. A new cor.elation was developed using these data to pr.dict the hydr.dynamic r.ughness for.flow conditions in which a viscous oil coating is pr.duced on the pipe wall.

关键词： Pipeline tr.nspor.ation - heavy oil Wallfouling Lubr.cated pipe flow CFD simulation

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Pest management with biopesticides

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Fr.ntier. of Agr.cultur.l Science and Engineer.ng 2018年第3期5卷 295-300页

作者： James N.SEIBEr.Joel coats ste.he. O.DUKE Aar.n D.Gr.SS Depar.ment of Envir.nmental Toxicology University of CaliforniaDavis Depar.ment of Entomology Iowa State University Natur.l Pr.ducts Utilization r.sear.h Agricultural Research Service United States Department of AgricultureUniversityMS Depar.ment of Entomology Virginia Polytechnic Institute and State University

Biopesticides ar. attr.cting inter.st as alter.atives to conventional pesticides but without many of the non-tar.et effects, pr.mising a better.r.cor. of safety and sustainability in pest contr.l pr.ctices. In this ar.icle we summar.ze and discuss the cur.ent status and futur. pr.mise of biopesticides, including how biopesticides use may incr.ase the quality and safety of the food supply.

关键词： biopesticide GMO cr.ps pest management

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胆囊切除术与消化道癌症的风险:一项系统性综述

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中国微创外科杂志 2017年第1期17卷 27-32页

作者：郭绍红 Mar.a coats Sami M Shimi 南京医科大学附属明基医院肝胆胰外科南京210019 Depar.ment of Sur.er. Ninewells Hospital and Medical SchoolUniversity of Dundee

目的研究胆囊切除术与胃肠道(gastr.-intestinal tr.ct,GIT)癌症的关系。方法我们遵循Pr.SMA(译者注)指南进行了这项系统性综述。借助Medline用预设检索标准对有关胆囊切除与GIT癌症的英文文献进行检索。通过手工查询参考文献的方法得... 详细信息

目的研究胆囊切除术与胃肠道(gastr.-intestinal tr.ct,GIT)癌症的关系。方法我们遵循Pr.SMA(译者注)指南进行了这项系统性综述。借助Medline用预设检索标准对有关胆囊切除与GIT癌症的英文文献进行检索。通过手工查询参考文献的方法得到其他文献。所有文献都得到了全文。从中提取的数据包括:研究类型、病例数、对照、国家、效度、混杂因素的校正和文献质量。采用STr.BE(译者注)核查表对文献质量进行评分。GIT每个部位的数据录入不同的表格。结果有75项研究和5项meta分析符合预选标准进入这项综述。入选的研究结果相互矛盾,没有强的证据表明胆囊切除与食管癌(腺癌)、胰腺癌、小肠癌以及右半结肠癌有关。高质量的研究中,胆囊切除与食管鳞癌、胃癌、肝癌、胆管癌、小肠癌、左半结肠癌没有关系。同样,远端结肠癌和直肠癌也没有观察到与胆囊切除有关。文献提出了一些致癌或促癌的机理,这些机理集中在胆汁酸盐对一些潜在突变分子的致癌作用以及作用于GIT代谢激素,这些代谢激素信号可以导致细胞增殖或癌症生成。结论这是一项关于胆囊切除与GIT癌症关系的综合性综述,结果没有显示胆囊切除与GIT癌症之间有明确的联系。

关键词：胆囊切除癌症胃肠道致癌作用

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唐代女性半臂的变化研究

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服装设计师 2024年第5期 58-61页

作者：钱秋月王翮大连工业大学服装学院

以唐代穿着半臂的女性形象为研究对象,详细探讨唐代各个时期女性半臂的特点,辅以考古学、图像学、文史学等相关资料,总结归纳唐代女性半臂的演变特征。将唐代女性半臂款式的变迁划分为初唐、盛唐、中晚唐3个时期,结合唐代的时代背景、... 详细信息

以唐代穿着半臂的女性形象为研究对象,详细探讨唐代各个时期女性半臂的特点,辅以考古学、图像学、文史学等相关资料,总结归纳唐代女性半臂的演变特征。将唐代女性半臂款式的变迁划分为初唐、盛唐、中晚唐3个时期,结合唐代的时代背景、政治因素、社会风尚、审美诉求,归纳出女性半臂在唐代各分期的不同表达。

关键词：唐代女性半臂服饰形制

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Cholecystectomy and the r.sk of alimentar. tr.ct cancer.:A systematic r.view

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Wor.d Jour.al of Gastr.enter.logy 2015年第12期21卷 3679-3693页

作者： Mar.a coats Sami M Shimi Depar.ment of Sur.er. Ninewells Hospital and Medical School University of Dundee

AIM: To investigate the association between cholecystectomy and gastr.-intestinal tr.ct(GIT) ***: We conducted a systematic r.view accor.ing to the Pr.SMA guidelines. A MEDLINE sear.h was per.or.ed with pr.defined sear.h cr.ter.a for.English Language ar.icles on the association between cholecystectomy and GIT cancer.. Additional ar.icles wer. r.tr.eved by manual sear.h of r.fer.nces. All r.levant ar.icles wer. accessed in full text. Data onstudy type; cases; contr.ls; countr.; effect estimate; adjustments for.confounder. and quality of publication wer. extr.cted. The quality of the publications wer. scor.d by adher.nce to the STr.BE checklist. The data for.each par. of the GIT wer. pr.sented in separ.te ***: Seventy-five studies and 5 meta-analyses satisfied the pr.defined cr.ter.a for.inclusion and wer. included in this r.view. Ther. wer. inconsistent r.por.s and no str.ng evidence of an association between cholecystectomy and cancer. of the oesophagus(Adenocar.inoma), pancr.as, small bowel and r.ghtsided colon cancer.. In squamous cancer.of the oesophagus, cancer. of the stomach, liver. bile ducts, small bowel and left sided colon cancer., good quality studies suggested a lack of association with cholecystectomy. Equally, distal colon and r.ctal cancer. wer. found not to be associated with cholecystectomy. Sever.l mechanisms for.car.inogenesis/pr.motion of car.inogensis have been pr.posed. These have focused on a r.le for.bile salts in car.inogenesis with sever.l potential mutagenic molecular.events and gut metabolic hor.ones signaling cell pr.lifer.tion or.initiation of ***: This is a compr.hensive r.view of the association between GIT cancer. and cholecystectomy. This r.view found no clear.association between cholecystectomy and GIT cancer..

关键词： Cholecystectomy Cancer Gastr.-intestinal tr.ct Car

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