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The Digital Mapping of Ukrainian Soils on the Base of High Resolution Space Images

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Journal of Geodesy and Geomatics Engineering 2015年第1期2卷 59-62页

作者： stanislav Truskavetsky National Scientific Center "Institute for Soil Science and Agrochemistry Research named after O.N. Sokolovsky" Kharkiv 61024 Ukraine

The first Ukrainian using experience of multispectral space scanning for digital soil mapping is described in this paper. Methodical approaches for detailed soil observation of Ukrainian forest regions are elaborated based on modem mapping principles. For the first time in Ukraine, digital soil maps based on GIS （geographic information system） were obtained for individual farms. In GIS based on space images and digital relief models, the medium-scale and large-scale soil maps were created by geo-statistical methods. According to elaborated methods, modem digital soil mapping should provide all combined works： remote sensing and traditional soil observations. The modem digital soil mapping should be based just on quantitative principles： on remote sensing data, geomorphologic field parameters, and chemical analyses. The methodological approaches, which were used for the first time in Ukraine during digital soil mapping by remote sensing methods, are described in this paper.

关键词： Digital soil map remote sensing space image GIS-technologies digital relief model.

Poly(1-vinylimidazole) Prospects in Gene Delivery

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Chinese Journal of Polymer Science 2019年第7期37卷 637-645页

作者： Elena N.Danilovtseva stanislav N.Zelinskiy Viktor A.Pal'shin Gayathri Kandasamy Uma Maheswari Krishnan Vadim V.Annenkov Limnological Institute of the Siberian Branch of the Russian Academy of Sciences 3Ulan-Batorskaya St.P.O. Box 278Irkutsk 664033Russia Centre for Nanotechnology &Advanced Biomaterials (CeNTAB) School of Chemical and BiotechnologySASTRA UniversityThanjavur 613401 Tamil NaduIndia

Polymeric amines are being studied intensively as components of systems for gene delivery in genetic engineering and gene therapy of genetic disorders, including cancer. Despite remarkable achievements in the field, polymeric amines, such as polyethyleneimine, show some disadvantages. Strong interaction between the amine-containing polymer and nucleic acid hampers the release of nucleic acid in the cell cytoplasm. Amine groups can interact with the cell membrane which results in cell death. These limitations of polymeric amines stimulated an investigation of new structures for gene delivery. Imidazole-containing polymers have attracted attention as lesser basic substances, while they are able to interact with polymeric acids. Further development of imidazole-based gene delivery agents requires knowledge about some fundamental aspects of interaction between nucleic acids, and polymeric imidazoles. In this work, we studied the complexation of poly(1-vinylimidazole) and oligomeric DNA. We found that the number of active sites capable of binding with negatively charged phosphate groups is comparable with the number of protonated imidazole units in the case of high molecular weight polymer. The increase in polymer charge by 1-bromopropane quaternizating 1%?5% imidazole units or by decreasing the pH to 6.5?7 considerably increased the ability of poly(1-vinylimidazole) to interact with oligonucleotides. The pH sensitivity of this interaction is interesting for cancer gene therapy because the tumours have a lowered intercellular pH (stable oligonucleotide complex) and a higher extracellular pH which can lead to complex dissociation. Minimal critical length for complexation of quaternized poly(1-vinylimidazole) and DNA is below eight units which corresponds to polymers with amine groups. Fluorescence-tagged poly(1-vinylimidazole) samples were obtained and their potential for monitoring the polymer and polymer-oligonucleotide complex internalization into living cells was demo

关键词： Polymeric amines Oligonucleotides Fluorescence Poly(1-vinylimidazole) Gene delivery

Testing the Association Between TRPM6 rs2274924 Gene, Metabolic Syndrome and Staphylococcus Aureus in Patients With Type 2 Diabetes Mellitus

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Journal of Life Sciences 2021年第1期15卷 20-29页

作者： stanislav Alexandra Alina Clinical Laboratory-Bacteriology Giurgiu County Emergency HospitalGiurgiu 080306Romania

The TRPM6 gene is associated with multifactorial diseases:diabetes mellitus,obesity,hypertension,components of the metabolic *** aim of this study is to test the association between TRPM6 rs2274924 gene,metabolic syndrome and *** based on clinical data and biochemical,haematological,microbiological and genetic laboratory investigations in patients with type 2 diabetes *** TRPM6 gene sequencing was performed by the Advanced NGx assay based on clinical and laboratory data,on 152 subjects from Giurgiu County Emergency *** results were processed by the graph Pad prism 7 program,*** conclusion,the TRPM6 rs2274924 gene is associated with metabolic syndrome and ***.

关键词： TRPM6 gene metabolic syndrome hypertension diabetes S.aureus

Ethylene and jasmonate as stimulants of latex yield in rubber trees(Hevea brasiliensis):Molecular and physiological mechanisms.A systematic approximation review

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Advanced Agrochem

Advanced Agrochem 2024年第4期3卷 279-288页

作者： Nixon Florez-Velasco Vanessa Florez Ramos stanislav Magnitskiy Helber Balaguera-López Sistema de Investigación Desarrollo Tecnologico e Innovación Complejo Tecnológico para la Gestión AgroempresarialServicio Nacional de AprendizajeAntioquiaColombia Departamento de Agronomía Facultad de Ciencias AgrariasUniversidad Nacional de ColombiaBogotáColombia

The rubber tree Hevea brasiliensis(*** *** Juss.)Müell Arg.]is an important source of latex for the production natural *** rubber is an important biopolymer used in various industries,but aspects related to hormonal regulation in biosynthesis are still unknown,which would allow optimizing its *** review the molecular and physiological mechanisms of increases latex regeneration and flow by the stimulation of rubber trees with exogenous applications of ethylene and *** found that the increase in latex regeneration by ethylene is due to the increase in gene level expression and enzymatic activity of key photosynthesis and glycolysis enzymes for the generation of precursors in the first phase of rubber *** flow is supported by up-regulated genes in sucrose metabolism such as invertases,induction of sucrose transporters(SUT),and aquaporins(PIP)to maintain flow and turgor pressure in ***,the increase in latex yield mediated by jasmonate may be due to the induction of laticifer differentiation in the long term and in the short term be mediated by the induction of small rubber particles(SRPP)as non-enzymatic cofactors in the production of *** information contributes to the knowledge of latex biosynthesis,which allows for a greater support for the exogenous application of jasmonates and ethylene to regulate its production.

关键词： Rubber tree Sucrose Tapping Ethephon Laticifers Natural rubber Stimulation Plant secondary metabolites

***: a materials informatics web app platform for materials discovery and survey of state-of-the-art

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npj Computational Materials 2022年第1期8卷 605-616页

作者： Jianjun Hu stanislav Stefanov Yuqi Song Sadman Sadeed Omee Steph-Yves Louis Edirisuriya M.D.Siriwardane Yong Zhao Lai Wei Department of Computer Science and Engineering University of South Carolina550 Assembly StreetColumbiaSC29201USA Department of Physics University of ColomboPO Box 1490Colombo 00300Sri Lanka

The availability and easy access of large-scale experimental and computational materials data have enabled the emergence of accelerated development of algorithms and models for materials property prediction,structure prediction,and generative design of ***,the lack of user-friendly materials informatics web servers has severely constrained the wide adoption of such tools in the daily practice of materials screening,tinkering,and design space exploration by materials *** we first survey current materials informatics web apps and then propose and develop ***,a web-based materials informatics toolbox for materials discovery,which includes a variety of routinely needed tools for exploratory materials discovery,including material’s composition and structure validity check (*** neutrality,electronegativity balance,dynamic stability,Pauling rules),materials property prediction (*** gap,elastic moduli,hardness,and thermal conductivity),search for hypothetical materials,and utility *** user-friendly tools can be freely accessed at http://*** argue that such materials informatics apps should be widely developed by the community to speed up materials discovery processes.

关键词： Atlas web prediction

Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma:Relation to the immune cycle

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World Journal of Gastroenterology 2021年第31期27卷 5259-5271页

作者： Artem Mashukov Dmytro Shapochka Oleksii Seleznov Nazarii Kobyliak Tetyana Falalyeyeva stanislav Kirkilevsky Roman Yarema Oksana Sulaieva Department of Oncology Odessa National Medical UniversityOdessa 65082Ukraine Department of Molecular Pathology and Genetics Medical Laboratory CSDKyiv 03022Ukraine Department of Pathology Medical Laboratory CSDKyiv 03022Ukraine Department of Endocrinology Bogomolets National Medical UniversityKyiv 01601Ukraine Biomedicine Educational-Scientific Center"Institute of Biology and Medicine"Taras Shevchenko National University of KyivKyiv 01601Ukraine Department of Thoracic Tumors National Cancer InstituteKyiv 03022Ukraine Department of Oncology and Medical Radiology Danylo Halytsky Lviv National Medical UniversityLviv 79010Ukraine

BACKGROUND Various histological types of gastric carcinomas(GCs)differ in terms of their pathogenesis and their preexisting background,both of which could impact the tumor immune microenvironment(TIME).However,the current understanding of the immune contexture of GC is far from *** To clarify the tumor-host immune interplay through histopathological features and the tumor immune cycle *** In total,50 GC cases were examined(15 cases of diffuse GC,31 patients with intestinal-type GC and 4 cases of mucinous GC).The immunophenotype of GC was assessed and classified as immune desert(ID),immune excluded(IE)or inflamed(Inf)according to CD8+cell count and spatial *** addition,CD68+and CD163+macrophages and programmed death-ligand 1(PD-L1)expression were *** We found that GCs with different histological differentiation demonstrated distinct immune *** intestinal-type GCs had inflamed TIMEs rich in both CD8+cells and *** contrast,more aggressive diffuse-type GC more often possessed ID characteristics with few CD8+lymphocytes but abundant CD68+macrophages,while mucinous GC had an IE-TIME with a prevalence of CD68+macrophages and CD8+lymphocytes in the peritumor ***-L1 expression prevailed mostly in intestinal-type Inf-GC,with numerous CD163+cells ***,GCs of different histological patterns have specific mechanisms of immune *** intestinal-type GC was more often related to PD-L1 expression,diffuse and mucinous GCs possessing more aggressive behavior demonstrated low immunogenicity and a lack of tumor antigen recognition or immune cell recruitment into the tumor *** These data help to clarify the links between tumor histogenesis and immunogenicity for a better understanding of GC biology and more tailored patient management.

关键词： Gastric carcinoma Tumor immune microenvironment Tumor infiltrating lymphocytes Tumor associated macrophages

Philosophical Study of Scientific Proof

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Journal of Philosophy Study 2015年第1期5卷 24-28页

作者： Bondarenko stanislav Borisovich Kursk Filial at Plekhanov Russian University of Economics

The scientific proof is the highest type of the rational proof. The mankind is looking for the best technology of the reasonable demonstration. What is a proof？. What is a scientific proof？. Philosophical investigations of proofs have the long history. Philosophy is exploring physics, mathematics, astronomy, biology, history, and so on. Science demands strict proofs. Science uses the specific methods as the optimum technologies for the achievement of the truth. Strictness of the proof depends on the aim algorithm： the distribution of the functions between parts of the proof. The beginning stage, the middle parts, and the ending stage are the unit of the proof. Philosophy can make the correct model of the scientific proof only! Science and its methodology develop and the growth of knowledge has not the finish. The rational ideals improve continually. Science is looking for the criterion of the demonstrative strictness. The adaptation algorithm of the scientific method is the best technology for the achievement of the truth.

关键词： science proof model method unit algorithm

Hamiltonian of Acoustic Phonons in Inhomogeneous Solids

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Journal of Modern Physics 2013年第3期4卷 373-379页

作者： stanislav Minarik Vladimir Labas Department of Physics Faculty of Education Catholic University Ruzomberok Slovak Republic

Theoretical solid-state physicists formulate their models usually in the form of a Hamiltonian. In quantum mechanics, the Hamilton operator (Hamiltonian) is of fundamental importance in most formulations of quantum theory. Mentioned operator corresponds to the total energy of the system and its spectrum determines the set of possible outcomes when one measures the total energy. Interpretation of results obtained by the applying of models based on the Hamiltonian indicates very specific mechanisms of some observed phenomena that are not fully consistent with the experience. Such approach may occasionally lead to surprises when obtained results are confronted with expectations. The aim of this work is to find Hamilton operator of acoustic phonons in inhomogeneous solids. The transport of energy in the vibrating crystal consisting of ions whose properties differ over long distances is described in the work. We modeled crystal lattice by 1D “inhomogeneous” ionic chain vibrating by acoustic frequencies and found the Hamiltonian of such system in the second quantization. The influence of long-distance inhomogeneities on the acoustic phonons quantum states can be discussed on basis of our results.

关键词： Phonons Mass Density Elastic Coefficient Energy States Inhomogeneities 1D Ionic Chain Hamiltonian

A New Fairness-Oriented Packet Scheduling Scheme with Reduced Channel Feedback for OFDMA Packet Radio Systems

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International Journal of Communications, Network and System Sciences 2009年第7期2卷 608-618页

作者： stanislav NONCHEV Mikko VALKAMA 不详

In this paper, we propose a flexible and fairness-oriented packet scheduling approach for 3GPP UTRAN long term evolution (LTE) type packet radio systems, building on the ordinary proportional fair (PF) scheduling principle and channel quality indicator (CQI) feedback. Special emphasis is also put on practical feedback reporting mechanisms, including the effects of mobile measurement and estimation errors, reporting delays, and CQI quantization and compression. The performance of the overall scheduling and feedback re-porting process is investigated in details, in terms of cell throughput, coverage and resource allocation fairness, by using extensive quasistatic cellular system simulations in practical OFDMA system environment with frequency reuse of 1. The performance simulations show that by using the proposed modified PF ap-proach, significant coverage improvements in the order of 50% can be obtained at the expense of only 10-15% throughput loss, for all reduced feedback reporting schemes. This reflects highly improved fairness in the radio resource management (RRM) compared to other existing schedulers, without essentially com-promising the cell capacity. Furthermore, we demonstrate the improved functionality increase in radio re-source management for UE’s utilizing multi-antenna diversity receivers.

关键词： Radio Resource Management Packet Scheduling Proportional-Fair Channel Quality Feedback Throughput Fairness