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Diabetic kidney disease:Are the reported associations with singlenucleotide polymorphisms disease-specific?

World Journal of Diabetes 2021年第10期12卷 1765-1777页

作者： Marek Saracyn Bartłomiej Kisiel Maria Franaszczyk Dorota Brodowska-Kania WawrzyniecŻmudzki Robert Małecki Longin niemczyk Przemysław Dyrla Grzegorz Kamiński RafałPłoski stanisław niemczyk Department of Internal Diseases Nephrology and DialysisMilitary Institute of MedicineWarsaw 04-141Poland Department of Endocrinology and Isotope Therapy Military Institute of MedicineWarsaw 04-141Poland Clinical Research Support Center Military Institute of MedicineWarsaw 04-141Poland Department of Medical Biology Molecular Biology LaboratoryInstitute of CardiologyWarsaw 04-628Poland Department of Nephrology Międzyleski Specialist Hospital in WarsawWarsaw 04-749Poland Department of Nephrology Dialysis and Internal DiseasesWarsaw Medical UniversityWarsaw 02-097Poland Department of Gastroenterology Military Institute of MedicineWarsaw 04-141Poland Department of Medical Genetics Medical University of WarsawWarsaw 02-106Poland

BACKGROUND The genetic backgrounds of diabetic kidney disease(DKD)and end-stage kidney disease(ESKD)have not been fully *** To examine the individual and cumulative effects of single-nucleotide polymorphisms(SNPs)previously associated with DKD on the risk for ESKD of diabetic etiology and to determine if any associations observed were specific for *** Fourteen SNPs were genotyped in hemodialyzed 136 patients with diabetic ESKD(DKD group)and 121 patients with non-diabetic ESKD(NDKD group).Patients were also re-classified on the basis of the primary cause of chronic kidney disease(CKD).The distribution of alleles was compared between diabetic and nondiabetic groups as well as between different *** weighted multilocus genetic risk score(GRS)was calculated to estimate the cumulative risk conferred by all *** GRS distribution was then compared between the DKD and NDKD groups as well as in the groups according to the primary cause of *** One SNP(rs841853;SLC2A1)showed a nominal association with DKD(P=0.048;P>0.05 after Bonferroni correction).The GRS was higher in the DKD group(0.615±0.260)than in the NDKD group(0.590±0.253),but the difference was not significant(P=0.46).The analysis of associations between GRS and individual factors did not show any significant ***,the GRS was significantly higher in patients with glomerular disease than in those with tubulointerstitial disease(P=0.014)and in those with a combined group(tubulointerstitial,vascular,and cystic and congenital disease)(P=0.018).CONCLUSION Our results suggest that selected SNPs that were previously associated with DKD may not be specific for DKD and may confer risk for CKD of different etiology,particularly those affecting renal glomeruli.

关键词： Diabetic kidney disease Chronic kidney disease End-stage kidney disease Single-nucleotide polymorphism Diabetes mellitus

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DEVELOPMENT AND STATUS OF IFP IN POLAND

DEVELOPMENT AND STATUS OF IFP IN POLAND

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International Conference on Integrated Fruit Production

作者： Edmund niemczyk Research Institute of Pomology and Floriculture PL-96100 SkierniewicePoland

The official establishmend of Integrated Fruit Production(IFP) in an organized form commenced in Poland in *** now(1995) IFP has been practised in all over the country only in apple orchards on a total area of 4239 ha...

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处于欧洲领先地位的回收浆车间废渣处理系统

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中华纸业 2004年第8期25卷 28-29页

作者： Bernhard niemczyk Gisbert Wünsche

介绍了Voith造纸技术控股股份有限公司近期研发的新技术和新装备,包括CompactPulper损纸碎浆机,经过优化设计的回收浆车间废渣处理系统,适合于所有纸种脱水的靴式压榨技术——NipcoFlex和TissueFlex,PrintFlex P压榨毛布,VTT真空引纸系... 详细信息

介绍了Voith造纸技术控股股份有限公司近期研发的新技术和新装备,包括CompactPulper损纸碎浆机,经过优化设计的回收浆车间废渣处理系统,适合于所有纸种脱水的靴式压榨技术——NipcoFlex和TissueFlex,PrintFlex P压榨毛布,VTT真空引纸系统,Duoshake摇振器,Strato系列橡胶包覆层新品种等。

关键词：欧洲回收浆废渣处理系统造纸工业粗渣处理

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THE INFLUENCE OF DIFFERENT UNDER-GROWTH AND IPM SPRAY SCHEDULES ON APPLE DAMAGE,FRUIT QUALITY AND YIELD.

THE INFLUENCE OF DIFFERENT UNDER-GROWTH AND IPM SPRAY SCHEDU...

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International Conference on Integrated Fruit Production

作者： E.niemczyk R.W.Olszak R.Z.Zajac Research Institute of Pomology and Floriculture PL-96100 Skierniewice Poland

＜正＞In a young apple orchards divided into seven plots,on 6 plots the several insecticides recomended in IPM control method was *** plot 7（check） was sprayed with non selective insecticides. The apple damage caused by insect pests decreased with the years,from 21.5%in 1992, 12.3%in 1993 and 1.7%in *** first 2 years the highest apple damage caused leaf rollers, bugs and large *** moth and apply sawfly affected few fruits only. The quality of apples harvested on "IPM plots" was pretty high,but compering to "check fruits" slightly lower or lower. The yield from "IPM plots"-compering to the crop harvested from the check trees-was the same,little lower or lower depending on the plot.

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废纸回收车间的废渣处理

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华东纸业 2005年第3期 100-101+97页

作者： GISBERT WüNSCHE,BERNHARD niemczyk Meri Entsorgungstechik公司

排出废渣的处理成本占纸张生产利润高达5%。直到现在,投入回报(ROI)一直是决定对废渣处理系统投资的唯一定夺标准。一旦对废渣处理要求更加严励的法律在德国(从2005年6月开始)和欧洲生效后,这种情况将有所改变。

关键词：废渣处理废物处理碎浆机纸张生产车间

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