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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 3-5页

作者： Pi.zi.hetta M.A. Talami.i.R. Stanganelli I. 张宪旗 Di.. of Med. Oncol. C Prev. Oncology Ctro. Riferimento Oncologico Aviano Via Pedemontana Occidentale 12 I 33081 Aviano Italy

Background: Amelanoti. mali.nant melanoma i. a subtype of cutaneous melanoma wi.h li.tle or no pi.ment on vi.ual i.specti.n. i. may mi.i. beni.n and mali.nant vari.nts of both melanocyti. and nonmelanocyti. lesi.ns. Objecti.es: To evaluate whether dermoscopy i. also a useful techni.ue for the di.gnosi. of amelanoti./hypomelanoti. melanoma (AHM) . Methods: We conducted a retrospecti.e cli.i.al study of 151 amelanoti./hypomelanoti. ski. lesi.ns from 151 pati.nts wi.h a mean age of 47 years (±17.5 SD). Di.i.i.ed i.ages of amelanoti./hypomelanoti. ski. lesi.ns were converted to JPEG format and sent by e mai. from the fi.e parti.i.ati.g centres. Lesi.ns i.cluded 55 amelanoti./hypomelanoti. nonmelanocyti. lesi.ns (AHNML), 52 amelanoti./ hypomelanoti. beni.n melanocyti. lesi.ns (AHBML), and 44AHM, 10 (23%)-of whi.h were nonpi.mented, truly amelanoti. melanomas (AM). The 44 AHM lesi.ns were di.i.ed i.to thi. melanomas (TnM) ≤1 mm (29 cases) and thi.kmelanomas (TkM) > 1mm (15 cases), accordi.g to the Breslow i.dex. Fi.e cli.i.al features (elevati.n, ulcerati.n, shape, borders and colour) as well as 10 dermoscopi. cri.eri. (pi.ment network, pi.mentati.n, streaks, dots/globules, blue whi.i.h vei., regressi.n structures, hypopi.mentati.n, leaf li.e areas, multi.le grey blui.h globules, central whi.e patch) and ei.ht vascular patterns (comma, arbori.i.g, hai.pi., dotted, li.ear i.regular, dotted and li.ear i.regular vessels, and mi.ky red areas) were evaluated i. order to achi.ve cli.i.al and dermoscopi. di.gnoses. Stati.ti.al analyses were performed wi.h the χ2-test and Fi.hers exact test, when appropri.te. Results: The most frequent and si.ni.i.ant cli.i.al features for TnM and TkM were asymmetry and ulcerati.n (the latter only for TkM) compared wi.h AHBML. i.regular dots/globules (62%vs. 35%; P ≤0.03), regressi.n structures (48%vs. 27%; P ≤0.03), i.regular pi.mentati.n (41%vs. 11%; P ≤0.03) and blue whi.i.h vei. (10%vs. 0%; P ≤0.03) were the most relevant dermoscopi. cri.eri. for TnM i. compari.on wi.h AHBML. TkM di.fered

关键词：黑色素瘤色素性恶性黑素瘤点状血管多形性叶状有显著性差异临床信息白膜图像转换

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皮肤镜用于面部恶性雀斑样痣的早期检查

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 14-15页

作者： Stante M. Gi.rgi.V. Stanganelli I. 李晓莉冯义国 Department of Dermatology Universityof FlorenceViaAlfani37 50121 Florence Italy

Up unti. now, only lesi.ns selected on the basi. of thei. cli.i.al atypi. or whi.h appear equi.ocal on naked eye exami.ati.n have been shown to benefi. from the use of dermoscopy. i. our experi.nce, dermoscopi. evaluati.n of lesi.ns located on the face may requi.e a di.ferent approach, as a hi.topathologi.al di.gnosi. of mali.nancy i. not uncommon i. cli.i.ally tri.i.l lesi.ns (i.e. lesi.ns lacki.g the ABCD cri.eri. for cli.i.al suspi.i.n). Moreover, at thi. si.e dermoscopy reveals speci.i. cri.eri. accordi.g to the parti.ular hi.tologi.al archi.ecture shown by sun- damaged ski.. We report four cases of lenti.o mali.na (LM) of the face whose i.enti.i.ati.n depended on dermoscopi. exami.ati.n whi.h was performed routi.ely on all faci.llesi.ns,as the lesi.ns di. not show ABCD cli.i.al cri.eri. for mali.nancy. i. our experi.nce, the i.enti.i.ati.n of early si.ns of mali.nancy by dermoscopy may i.di.ate the exci.i.n of LM at an early phase, before the lesi.n i. associ.ted wi.h the ABCD si.ns of melanoma. Dermatologi.ts should avoi. the mi.take of i.medi.tely excludi.g a di.gnosi. of mali.nancy when exami.i.g an ABCD- negati.e pi.mented ski. lesi.n of the face.

关键词：恶性雀斑样痣早期检查黑素瘤色素性恶性诊断光损伤组织学结构诊断指标病理学诊断

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<i.gt;SEPT10</i.gt;Expressi.n i. Chroni. Lymphocyti. Leukemi.. Correlati.n wi.h Cli.i.al and Bi.logi.al Prognosti. Factors

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Open Journal of Blood Di.eases 2013年第3期3卷 11-16页

作者： Ana Travella Juli.ta Panero Carmen stanganelli Rai.undo Bezares i.ma Slavutsky Di.i.i.n Patología Molecular Instituto de Investigaciones Hematológicas Academia Nacional de Medi- cina Buenos Aires Argentina Laboratori. de Genéti.a de Neoplasi.s Li.foi.es Instituto de Medicina Experimental CONICET-Academia Nacional de Medicina Buenos Aires Argentina Servi.i. de Hematología Hospital General de Agudos “Dr Teodoro álvarez” Buenos Aires Ar- gentina.

Chroni. lymphocyti. leukemi. (CLL) i. characteri.ed by a hi.hly vari.ble cli.i.al course. Mi.roarray studi.s allowed hi.hli.ht genes di.ferenti.lly expressed i. thi. pathology. i. thi. study, we have evaluated the prognosti. si.ni.i.ance of SEPT10 expressi.n i. CLL pati.nts. Results were correlated wi.h i.munoglobuli. heavy-chai. vari.ble (i.HV) genes mutati.nal status, genomi. rearrangements and cli.i.al parameters. SEPT10 mRNA levels were determi.ed by quanti.ati.e real-ti.e PCR i. 70 newly di.gnosed CLL pati.nts consecuti.ely referred to our i.sti.uti.n. A wi.e heterogenei.y for SEPT10 expressi.n was found. Gene upregulati.n was observed i. 18.5% of cases. The uni.ari.te analysi. showed a posi.i.e associ.ti.n between gen expressi.n and platelet count (p 0.0001) and a negati.e correlati.n wi.h hemoglobi. levels (p = 0.0094). Although no si.ni.i.ant di.ferences were observed, mean treatment free survi.al was shorter i. pati.nts wi.h hi.h expressi.n (31 months) wi.h respect to those wi.h low mRNA levels (72 months). Cases wi.h abnormal karyotypes had i.creased expressi.n compared to those wi.h normal karyotypes and no associ.ti.n between gene expressi.n and Fi.H (fluorescence i. si.u hybri.i.ati.n) ri.k groups and i.HV mutati.nal status was found. Cases usi.g i.HV3-23 gene rearrangement had low SEPT10 expressi.n. Our results showed an associ.ti.n between SEPT10 expressi.n and features of adverse outcome but wi.hout i.dependent prognosti. value. The study of SEPT10 expressi.n may be i.portant for a better understandi.g of di.ease heterogenei.y, addi.g further i.formati.n to those provi.ed by establi.hed prognosti. factors.

关键词： Chroni. Lymphocyti. Leukemi. SEPT10 Expressi.n Fi.H Cytogeneti.s i.HV Mutati.nal Status

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