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In vitro effec. of pantoprazole on lower esophageal sphinc.er tone in rats

World Journal of Gastroenterology 2011年第46期17卷 5105-5109页

作者： Mustafa Duman Mahmut zer Enver Rean Yeliz Demirc. Ali E Atιc. Tahsin Dalgι Erdal B Bostanc. Ec. Gen Department of Gastrointestinal Surgery Kartal Kosuyolu Education and Research Hospital Department of Pharmac.logy Medical SchoolYeditepe University

AIM:To investigate the in vitro effec.s of pantoprazole on rat lower esophageal sphinc.er(LES)***:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Researc. c.nter(Yü-DETAM),were used throughout the *** were anesthetized before *** tissues whose muc.sal lining were removed were plac.d in a stan-dard 30-mL organ bath with a modif ied Krebs solution and c.ntinuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room *** tissues were allowed to stabilize for 60 ***-sequently,the c.ntrac.ile response to 10-6 mol/L carba-c.ol was *** c.nc.ntrations of freshly prepared pantoprazole were added direc.ly to the tis-sue bath to generate c.mulative c.nc.ntrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/***-ties were rec.rded on an online c.mputer via a 4-c.anneltransduc.r data ac.uisition system using the software BSL PRO v 3.7,whic. also analyzed the ***:Pantoprazole at 5×10-6 mol/L c.used a small,but statistic.lly insignif ic.nt,relaxation in the car-bac.ol-c.ntrac.ed LES(2.23% vs 3.95%).The 5×10-5 mol/L c.nc.ntration,however,c.used a signif ic.nt relax-ation of 10.47% c.mpared with the c.ntrol.1.5×10-4 mol/L c.nc.ntration of pantoprazol c.used a 19.89% relaxation in the carbac.ol c.ntrac.ed LES(Pc.Nc.USION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effec. in isolated *** results might have signif ic.nt c.inic.l implic.tions for the subset of patients using proton pump inhibitors who do not rec.ive full symptomatic.alleviation from gastroesophageal reflux disease.

关键词： Pantoprazole Lower esophageal sphinc.er,Gastroesophageal reflux disease

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