检索结果-南通市图书馆

Neuroimaging in atypical normal tension glaucoma:debating routine implementation in the absence of classic neurological findings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 509-517页

作者： Umay Güvenç Gülizar Demirok Güner Üney Selma Uzman Ophthalmology Department Ankara Training and Research HospitalAnkara 06230Turkey

●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTG)who do not exhibit typical glaucoma manifestations.●METHODS:A retrospective analysis was conducted on 90 atypical NTG patients who underwent cranial magnetic resonance imaging(MRI)due to atypical *** demographic characteristics,clinical parameters,and radiological findings were recorded.●RESULTS:Among the patients,66.7%had abnormal radiology results,with the most common findings being gliosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benign intracranial mass lesions(11%).Non-glaucomatous visual field defects were more frequently observed in patients with abnormal neuroimaging ***,there were no significant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiological *** mean age of the patients was ***,there was a significant age difference,with the abnormal radiology group having a higher median age(P=0.021).●CONCLUSION:The study highlights the importance of cranial imaging in older NTG patients to detect underlying pathologies and prevent *** suggests that neuroimaging may be warranted in NTG patients with atypical visual field defects incompatible with ***,routine neuroimaging in all NTG patients without classic neurological signs may not be necessary.

关键词： normal tension glaucoma neuroimaging atypical visual field defects

Development of NK cell-based cancer immunotherapies through receptor engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey Page Nicolas Chuvin Jenny Valladeau-Guilemond stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

Could near infrared spectroscopy be the new weapon in our understanding of the cerebral and muscle microvascular oxygen demand during exercise?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第4期13卷 457-458页

作者： stephane Perrey EuroMov Digital Health in Motion University of MontpellierIMT Mines AlesMontpellier 34090France

Near-infrared spectroscopy(NIRS)has been increasingly utilized in both sport and health sciences to assess various physiological parameters related to exercise performance.1 NIRS methods coupled with the recent development of portable and wearable devices suitable for field-based measurements have revolutionized the study of exercise physiology and the determinants of exercise performance by providing real-time,non-invasive,and spatially localized measurements of tissue oxygenation dynamics.

关键词： cerebral utilized exercise

维普期刊数据库

The interaction of the structure-directing agent with the zeolite framework determines germanium distribution in SCM-15 germanosilicate

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第5期18卷 105-114页

作者： stoyan P.Gramatikov Petko st.Petkov Zhendong Wang Weimin Yang Georgi N.Vayssilov Faculty of Chemistry and Pharmacy University of Sofia1126 SofiaBulgaria state Key Laboratory of Green Chemical Engineering and Industrial Catalysis Sinopec Shanghai Research Institute of Petrochemical Technology Co.Ltd.Shanghai 201208China

We report results from computational modeling of the relative stability of germanosilicate SCM-15 structure due to different distribution of germanium heteroatoms in the double four-member rings(D4Rs)of the framework and the orientation of the structure directing agent(SDA)molecules in the as-synthesized *** calculated relative energies of the bare zeolite framework suggest that structures with germanium ions clustered in the same D4Rs,e.g.,with large number of Ge–O-Ge contacts,are the most *** simulations of various orientations of the SDA in the pores of the germanosilicate zeolite show different stability order-the most stable models are the structures with germanium spread among all ***,for SCM-15 the stabilization due to the presence of the SDA and their orientation,is thermodynamic factor directing both the formation of specific framework type and Ge distribution in the framework during the *** relative stability of bare structures with different germanium distribution is of minor *** differs from SCM-14 germanosilicate,reported earlier,for which the stability order is preserved in presence of ***,even for zeolites with the same chemical composition and SDA,the characteristics of their framework lead to different energetic preference for germanium distribution.

关键词： zeolite density functional theory structure-directing agent SCM-15

Empowerment in chronic wound care——exploring the scope for patient contribution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Nursing 2024年第1期11卷 1-16页

作者： Benedikt Hackert Ewa Klara stürmer Ulrich Weger Department of Psychology and Psychotherapy University of Witten/HerdeckeAlfred-Herrhausen-Straße 5058448 WittenGermany Department for Vascular Medicine University Heart and Vascular Center HamburgUniversity Medical Center Hamburg-EppendorfMartinistreet 5220246 HamburgGermany

Objective:In this study,we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom(DOF):that is,shaping of everyday wound care tasks initiated by patients and based on their wishes,mostly in terms of patients executing treatment steps,requesting or directing health care professionals to under take changes,or modifications of internal ***:As a first step,we conducted a systematic literature search,followed by an inductive form of qualitative content analysis,which resulted in the identification of 5 dimensions as main elements of empowerment:education and shared decision making,adherence to self-care behaviors,responsibility and control,general call for empowerment,and ***,the latter are noticeably absent in the *** investigate patients'freedom in shaping the wound care process,we conducted a second literature ***:A number of possibilities for patients to influence the wound care process could be identified,but experimental or clinical evidence about their effects is missing,their variety is limited,and they are only inadequately ***:However,DOF should be an indispensable aspect of genuine empowerment,since they allow patients to occupy the role of the agent in the treatment process and give rise to the subjective experience of feeling ***,in the third part,we develop a research proposal on how to investigate and include DOF in the clinical practice of wound ***,limitations about implementations are discussed(e.g.,patients being reluctant to overcome their passive role,resulting in frustration for health care professionals).

关键词： adherence chronic wounds control degrees of freedom empowerment shared decision making

维普期刊数据库

Effect of Thermal Cycles on Creep Behavior of Bituminous Binder in Hot Regions

在线全文

学校读者我要写书评

暂无评论

Journal of Civil Engineering and Architecture 2024年第7期18卷 334-339页

作者： Bachir Glaoui Mahdjoub Bendjima M'hamed Merbouh Martin Van de ven Laboratoire de la Fiabilité des Matériaux et structures en Régions Sahariennes(FIMAS) Université de Béchar B.P.417Béchar08000Algérie Laboratory of Road and Railway Engineering TU DelftP.O.Box 50482600 GA DelftThe Netherlands

This research is devoted to the study of creep behavior of asphalt binder in hot *** binder was subjected to thermal cycles due to the variation of temperature from day to *** cycles produce a heating-cooling *** evaluate the effect of climate change in laboratory,the DSR(dynamic shear rheometer)was used,and the results found with the nine samples were *** thermal cycles led to aging and therefore hardening of the ***,a rheological model was proposed that can represent the curves obtained experimentally,where it is able to describe the creep behavior of binders tested.A new model is proposed that correlates well with the experimental curves,which is called A+2 K.

关键词： Bitumen temperature heating/cooling DSR BBR model

新与旧的碰撞捷克Ro?nov pod Radho?těm市立图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

室内设计与装修 2024年第8期 30-35页

作者： ?TY?stěN ?TY?stěN

捷克Ro?nov pod Radho?těm市立图书馆位于市区的一处十字路口,一侧是居民区、学校、公交站台和综合诊所,另一侧是艺术小学和市中心。图书馆紧邻城镇公园和一条主干道,其全新设计的馆前公共空间点缀着2条繁忙的道路,成为Bezru?ova街文...

捷克Ro?nov pod Radho?těm市立图书馆位于市区的一处十字路口,一侧是居民区、学校、公交站台和综合诊所,另一侧是艺术小学和市中心。图书馆紧邻城镇公园和一条主干道,其全新设计的馆前公共空间点缀着2条繁忙的道路,成为Bezru?ova街文化区的庄严入口。扩大图书馆的容量,使其能在不限制学校教育计划的情况下,为老年人和带孩子的父母提供早间便利服务。另外,拓展青少年的阅读空间,为青少年提供一个安全的聚会场所。

关键词：

Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in Southern China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第3期44卷 586-594页

作者： YIN Lingjia st?LSBY LUNDBORG Cecilia WU Darong YANG Jinghua ALVESSON Helle M?lsted CAI Jianxiong LU Taoying XIE Qianwen MARRONE Gaetano Department of Global Public Health Karolinska Institutet state Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Outcome Assessment Research Team in Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Health Construction Administration Centre Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Pediatrics the Second Affiliated Hospital of Guangzhou University of Chinese Medicine

OBJECTIVE: To determine the effectiveness of pediatric Tuina(PT) in preventing recurrent acute respiratory tract infections(ARTIs) in children. METHODS: This is a retrospective cohort study based on the electronic medical records of children with recurrent ARTIs in 2016. Children were divided into a PT group or a non-PT group, according to whether they had received PT or not in 2016. The primary outcome was the number of ARTI episodes in 2017 and 2018. The secondary outcomes were the number of ARTIs leading to outpatient department visits and outpatient antibiotic prescriptions due to ARTIs in the same time period. Negative binomial regressions were used to detect the association between PT and the outcomes. RESULTS: A total of 2303 children were included in the analysis, including 94 in the PT group and 2209 in the non-PT group. Children who received PT six or more times in 2016 had fewer episodes of ARTIs in 2017 [incidence rate ratio(IRR): 0.59, 95% confidence interval(CI)(0.42-0.84)] and 2018 [IRR: 0.58, 95% CI(0.36-0.94)] and fewer outpatient department visits due to ARTIs in 2017 [IRR: 0.56, 95% CI(0.38-0.83)] than children who had not received PT in 2016. There was no significant difference in the number of outpatient antibiotic prescriptions between the two groups. CONCLUSIONS: Receiving PT six or more times within one year is associated with a decrease in recurrent ARTIs in children in the following two years. Randomized controlled trials are needed for effect evaluation prior to establishing PT as a method for preventing recurrent ARTIs among children.

关键词： child massage pediatric Tuina respiratory tract infections

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

锦凌水库移民后期扶持实施效果评价

水利技术监督 2024年第5期 70-74页

作者：文丹大连金普新区现代农业生产发展服务中心辽宁大连116100

以小凌河中下游锦凌水库为例,结合水库移民系统信息的复杂性、不确定性特征及移民后期扶持监测数据,从收入结构、社会保障、生活条件、生产条件和基础设施5方面选择指标,运用熵值法与灰色系统模型评价移民后期扶持实施效果。结果表明:... 详细信息

以小凌河中下游锦凌水库为例,结合水库移民系统信息的复杂性、不确定性特征及移民后期扶持监测数据,从收入结构、社会保障、生活条件、生产条件和基础设施5方面选择指标,运用熵值法与灰色系统模型评价移民后期扶持实施效果。结果表明:锦凌水库后期扶持政策的实施明显提升了移民的生产生活水平,灰色系统模型可以全面真实地反映水库移民后期扶持效果情况,实际应用时具有较强科学合理性,可为科学编制水库移民安置规划及促进移民后续稳定发展提供依据。

关键词：灰色系统理论水库移民扶持效果锦凌水库

维普期刊数据库