检索结果-南通市图书馆

Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon(MPigut-IVM)

引用

Journal of Animal Science and Biotechnology 2021年第4期12卷 1428-1450页

作者： Raphaële Gresse Frédérique Chaucheyras-Durand Sylvain Denis Martin Beaumont Tom Van de Wiele Evelyne Forano st.phanie Blanquet-Diot UniversitéClermont Auvergne INRAEUMR 454 MEDISF-63000 Clermont-FerrandFrance Lallemand SAS F-31702 BlagnacCedexFrance GenPhySE Universitéde ToulouseINRAEENVTF-31326 Castanet-TolosanFrance Ghent University Center for Microbial Ecology and TechnologyB-9000 GhentBelgium

Background:Risk factors for the etiology of post-weaning diarrhea,a major problem in swine industry associated with enormous economic losses,remain to be fully *** concordance with the ethical concerns raised by animal experiments,we developed a new in vitro model of the weaning piglet colon(MPigut-IVM)including a mucin bead compartment to reproduce the mucus surface from the gut to which gut microbes can ***:Our results indicated that the MPigut-IVM is able to establish a representative piglet archaeal and bacterial colon microbiota in terms of taxonomic composition and *** MPigut-IVM was consequently used to investigate the potential effects of feed deprivation,a common consequence of weaning in piglets,on the *** lack of nutrients in the MPigut-IVM led to an increased abundance of Prevotellaceae and Escherichia-Shigella and a decrease in Bacteroidiaceae and confirms previous in vivo *** top of a strong increase in redox potential,the feed deprivation stress induced modifications of microbial metabolite production such as a decrease in acetate and an increase in proportional valerate,isovalerate and isobutyrate ***:The MPigut-IVM is able to simulate luminal and mucosal piglet microbiota and represent an innovative tool for comparative studies to investigate the impact of weaning stressors on piglet ***,weaning-associated feed deprivation in piglets provokes disruptions of MPigut-IVM microbiota composition and functionality and could be implicated in the onset of post-weaning dysbiosis in piglets.

关键词： Colon Dysbiosis In vitro gut model Microbiota Mucin Piglet Weaning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functionalized liposomes for targeted breast cancer drug delivery

引用

Bioactive Materials 2023年第6期24卷 401-437页

作者： Janske Nel Kamil Elkhoury Émilie Velot Arnaud Bianchi Samir Acherar Grégory Francius Ali Tamayol st.phanie Grandemange Elmira Arab-Tehrany Universitéde Lorraine LIBioF-54000NancyFrance LAAS-CNRS F-31400ToulouseFrance Universitéde Lorraine CNRSIMoPAF-54000NancyFrance Universitéde Lorraine CNRSLCPMF-54000NancyFrance Universitéde Lorraine CNRSLCPMEF-54000NancyFrance Department of Biomedical Engineering University of Connecticut Health CenterFarmingtonCT06030USA Universitéde Lorraine CNRSCRANF-54000NancyFrance

Despite the exceptional progress in breast cancer pathogenesis,prognosis,diagnosis,and treatment strategies,it remains a prominent cause of female mortality ***,although chemotherapies are effective,they are associated with critical limitations,most notably their lack of specificity resulting in systemic toxicity and the eventual development of multi-drug resistance(MDR)cancer *** have proven to be an invaluable drug delivery system but of the multitudes of liposomal systems developed every year only a few have been approved for clinical use,none of which employ active *** this review,we summarize the most recent strategies in development for actively targeted liposomal drug delivery systems for surface,transmembrane and internal cell receptors,enzymes,direct cell targeting and dual-targeting of breast cancer and breast cancer-associated cells,e.g.,cancer stem cells,cells associated with the tumor microenvironment,etc.

关键词： Liposomes Breast cancer Anti-cancer agents Targeted drug delivery Surface functionalization Receptor-targeted drug delivery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

La Belgique:réagir après les attentats

引用

法语学习 2016年第4期 61-63页

作者： st.phanie Crêteur 北京外国语大学

La Belgique a connu une période noire ces derniers mois:les perquisitions après les attentats en France,le niveau d’alerte au niveau maximal,le ?BelgianBashing?(les médias qui accusent le gouvernement belge de ne pas avoir pris les choses assez bien en main).Une période noire qui s’est provisoirement conclue par les attentats du *** Belgique est

关键词：法语阅读理解演讲稿

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Variability and Predictors of Mothers and Fathers’ Socialization Behaviors and Bidirectional Links with Their Preschoolers Socio-Emotional Competences

引用

Journal of Behavioral and Brain Science 2017年第12期7卷 621-653页

作者： st.phanie Mazzone Nathalie Nader-Grosbois Psychological Sciences Research Institute Chair Baron Frère in Specialized Education Université Catholique de Louvain Louvain-la-Neuve Belgium

In their Parental Socialization of Emotions model, Eisenberg, Cumberland and Spinrad (1998) differentiated parents’ Emotion-Related Socialization Behaviours (ERSBs) that support their child’s socio-emotional development: their reactions to their child’s emotions, their discussions about emotions with the child and the expressions of their own emotions in the family. The cross- sectional study focused on the variability of parents’ ERSBs according to children’s and parents’ characteristics (study 1) and included 167 mothers and 152 fathers of preschoolers. The short-term longitudinal study examined the interaction between parents’ ERSBs and children’s socio-emotional abilities (Theory of Mind, emotional regulation and social adjustment) (study 2) in 53 two-parent families and their children, with a 6 months interval. In study 1, parents’ ERSBs, their emotional competences and children’s personality were assessed by means of questionnaires. In study 2, we combined direct and indirect measures to assess children’s socio-emotional competences. Results of study 1 indicated that parental ERSBs were mainly predicted by children’s personality, such as emotional stability and parents’ emotional competences, such as communication about their own emotions. Moreover, we observed a differential sensitivity between mothers and fathers toward children’s personality. Results of study 2 revealed that both mothers and fathers socialized their children’s socio-emotional competences, particularly by the way of emotion-related conversations with their children. Mothers’ emotion-related conversations predicted children’s Theory of mind abilities and social adjustment, while fathers’ emotion-related conversations predicted children’s emotional regulation. In addition, fathers’ reactions to their children’s emotions were predicted by children’s socio-emotional competences. These studies highlighted bidirectional effects between parents’ behaviours and children’s development. They emphasize

关键词： Parental Emotion-Related Socialization Behaviours Preschool Period Socio-Emotional Competences

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Population isolation shapes plant genetics, phenotype and germination in naturally patchy ecosystems

引用

Journal of Plant Ecology 2017年第4期10卷 649-659页

作者： Laurent De Vriendt Marc-AndréLemay Martine Jean Sébastien Renaut st.phanie Pellerin Simon Joly François Belzile Monique Poulin Département de Phytologie Facultédes Sciences de l’Agriculture et de l’AlimentationUniversitéLaval2425 rue de l’agriculture QuébecQuébec G1V 0A6Canada Québec Center for Biodiversity Science Department of BiologyMcGill UniversityStewart Biology Building1205 Dr.Penfield AvenueMontréal H3A 1B1Canada Institut de Biologie Intégrative et des Systèmes(IBIS) UniversitéLaval1030 avenue de la MédecineQuébec G1V 0A6Canada Institut de recherche en biologie végétale Département des Sciences biologiquesUniversitéde Montréal4101 Sherbrooke EstMontréal H1X 2B2Canada Jardin botanique de Montréal 4101 Sherbrooke EstMontréal H1X 2B2Canada

Aims Habitat connectivity is important in conservation since isolation can diminish the potential of a population for adaptation and increase its risk of ***,conservation of naturally patchy ecosystems such as peatlands has mainly focused on preserving specific sites with exceptional characteristics,neglecting the poten-tial interconnectivity between *** order to better under-stand plant dynamics within a peatland network,we assessed the effect of population isolation on genetic distinctiveness,phenotypic variations and germination rates using the peatland-obligate white-fringed orchid(Platanthera blephariglottis).Methods Fifteen phenotypic traits were measured for 24 individuals per pop-ulation(20 distinct populations,Quebec,Canada)and germination rates of nearly 20000 seeds were *** distinctiveness was quantified for 26 populations using single nucleotide polymor-phism markers obtained via a pooled genotyping-by-sequencing *** isolation was measured as the distance to the nearest population and as the number of populations occurring in concentric buffer zones(within a radius of 2,5 and 10 km)around the studied *** Findings All phenotypic traits showed significant differences among *** results also indicated a pattern of isolation-by-distance,which suggests that seed and/or pollen exchange is restricted ***,all phenotypic traits,as well as a reduced germination rate,were correlated with either geographic isolation or genetic *** conclude that geographic iso-lation likely restricts gene flow,which in turn may affect ***,it is imperative that conservation programs take into account the patchy nature of such ecosystems,rather than targeting a few specific sites with exceptional character for preservation.

关键词： trait variation population genetics peatland orchid Platanthera blepharigottis genotyping by sequencing GBS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disrupted NF-κB activation after partial hepatectomy does not impair hepatocyte proliferation in rats

引用

World Journal of Gastroenterology 2005年第46期11卷 7345-7350页

作者： st.phanie Laurent Yves Horsmans Peter strkel Isabelle Leclercq Christine Sempoux Luc Lambotte GastroenterologyPathology and Experimental Surgery Laboratories Universite catholique de Louvain1200 BrusselsBelgium

AIM： To analyze the effects of NF-kB inhibition by antioxidant pyrrolidine dithiocarbamate （PDTC） or TNF inhibitor pentoxifylline （PTX） on liver regeneration after partial hepatectomy （PH）. METHODS： Saline, PDTC or PTX were injected 1 h before PH and rats were killed at 0.5 and 24 h after PH. Several control groups were used for comparison （injection control groups）. RESULTS： Compared to saline injected controls, NF-kB activation was absent 0.5 h after PH in rats treated with PDTC or PTX. At 24 h after PH, DNA synthesis and PCNA expression were identical in treated and control rats and thus occurred irrespectively of the status of NF-kB activation at 0.5 h. Signal transducer and activator of transcription 3 （stat3） acUvatJon was observed already 0.5 h after PH in saline, PDTC or PTX group and was similar to stat3 activation in response to injection without PH. CONCLUSION： These data strongly suggest that （1） NF-kB p65/p50 DNA binding produced in response to PH is not a signal necessary to initiate the liver regeneration, （2） star3 activation is a stress response unrelated to the activation of NF-kB. In conclusion, NF-kB activation is not critically required for the process of liver regeneration after PH.

关键词： Partial hepatectomy Nuclear factor kappa B Signal transducer and activator of transcription 3 Hepatocyte proliferation Antioxidant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander

引用

Neuroscience Bulletin 2013年第4期29卷 467-476页

作者： Jean-Marie Cabelguen st.phanie Chevallier Ianina Amontieva-Potapova Céline Philippe Neurocentre Magendie INSERM U 862 - Bordeaux University

Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the [e-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans.

关键词： salamander spinal cord locomotor recovery regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quiet in the nest:The nest environment attenuates song in a grassland songbird

引用

Avian Research 2023年第4期14卷 623-629页

作者： Sarah L.Dobney Mikayla M.K.Bornais D.Ryan Norris Amy E.M.Newman Heather Williams st.phanie M.Doucet Daniel J.Mennill Department of Integrative Biology University of WindsorWindsorOntarioN9B 3P4Canada Department of Integrative Biology University of GuelphGuelphOntarioN1G 2W1Canada Biology Department Williams CollegeWilliamstownMA01267USA

The nest environment may limit the ability of nest-bound birds to hear sounds from the outside *** vocal learning species,such as humans and songbirds,it is vital for young animals to hear the voices of conspecific animals early in *** songbirds,nest structure varies considerably across species,and the resulting impact on sound transmission may have consequences for vocal learning in *** this study,we tested the hypothesis that the nest environment attenuates song of Savannah Sparrows(Passerculus sandwichensis),grassland songbirds that build nests on the ground under cover of dense *** recorded live Savannah Sparrows singing at variable distances from 21 *** recorded songs using one microphone inside the nest(the typical position of a nestling)and another placed 1 m directly above the nest(a typical position of an adult).We found a substantial reduction in signal-to-noise ratio,where songs recorded inside the nest were an average of 11 dB lower than songs recorded directly above the *** estimate that the attenuation imposed by the nest reduced the maximum acoustic environment from 117.7 m(for recordings above the nest),to 78.6 m(for recordings within the nest),which is analogous to listening from a position 39.1 m farther away from the *** research estimated that song transmits up to 100 m in this species,so any adult male within 100 m of a young bird was previously considered a potential vocal *** reducing the nestling acoustic environment from 100 m to 78.6 m,the number of male tutors available to nestlings is reduced by an average of 27%.Given the growing evidence that song learning begins very early in life,future research on vocal development should account for how the structural properties of the natal environment affect the songs that nestlings hear.

关键词： Acoustic environment Nest environment Songbird Sound attenuation Vocal learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-photon photopolymerization directly initiated by spiropyran photochromic molecules

引用

Light(Advanced Manufacturing) 2023年第1期4卷 12-22页

作者： Dandan Ge Jean Aubard Erell Bodinier Safi Jradi st.phanie Lau-Truong Nordin Felidj Renaud Bachelot Anne-Laure Baudrion Light nanomaterialsnanotechnologies(L2n)LaboratoryCNRS EMR7004Universitéde Technologie de Troyes12 rue Marie Curie10004 Troyes CedexFrance UniversitéParis Cité CNRSITODYSF-75013 ParisFrance

Here,we report the ability of spiropyrans to initiate two-photon polymerization(TPP)for the first time in the *** comparison and synergies between the spiropyran photochromic molecule of interest,namely 6-nitro-BIPS,and well-known photoinitiators of radical photopolymerization have been *** spiropyran(SPy)molecule can initiate TPP in the presence of trifunctional acrylic monomers and create true 3D *** comparison with Irgacure 819,a well-known Type-I photoinitiator,shows that SPy has a comparable capability for *** addition,the combination of SPy with methyl diethanolamine increased the reactivity of both one-and two-photon *** the last section,we discuss which SPy isomer is the active photochromic species capable of generating radicals for initiating two-photon polymerization.

关键词： Spiropyran Direct laser writing Two-photon-photopolymerization Photochromism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Copper Adsorption from Wasterwater Using Bone Charcoal

引用

Advances in Materials Physics and Chemistry 2017年第5期7卷 139-147页

作者： Sana Ghrab Mourad Benzina st.phanie D. Lambert Laboratoire Eau Environnement Energie Ecole National d’Ingénieur Sfax Tunisie Department of Chemical Engineering University of Liège Liège Belgium

Bone charcoal (BC) is being developed as a treatment for decontamination of polluted water. In this study, bone charcoal was obtained by pyrolysis of cow bones and tested for the elimination of copper from aqueous solutions. The minimum time to reach the removal equilibrium by adsorption was 10 min with a maximum of copper removal equal to 9615 mg/g. Different kinetics models were applied to fit the experimental data: the pseudo second-order model correlated the results with a linear correlation coefficient equal to 1.

关键词： Adsorption Copper Bone Charcoal Wastewater

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：