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Long-term opioid therapy and functional status

中华物理医学与康复杂志 2017年第10期39卷 789-789页

作者： Hoffman EM Watson jC st sauver j

BACKGROUND AND OBjECTIVE While opioids appeared to be effective for the treatment of non-cancer pain in short durations,the long-term efficacy of these medications is not well *** a longitudinal cohort format,this study followed patients with polyneuropathy,in order to examine the relationship between the duration of opioid therapy and functional status.

关键词：药物治疗状态治疗时间神经病多发性

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维普期刊数据库

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非酒精性脂肪肝疾病自然史:一项基于大样本人群队列研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 28-29页

作者： Adams L.A. Lymp j.F. st. sauver j. P. Angulo 王志宇 Division of Gastroenterology and Hepatology Mayo Clinic 200 First St. SW Rochester MN 55905 United States Dr.

Background & Aims: The natural history of nonalcoholic fatty liver disease (NAFLD) in the community remains unknown. We sought to determine survival and liver- related morbidity among community- based NAFLD patients. Methods: Four hundred twenty patients diagnosed with NAFLD in Olmsted County, Minnesota, between 1980 and 2000 were identified using the resources of the Rochester Epidemiology Project. Medical records were reviewed to confirm diagnosis and determine outcomes up to 2003. Overall survival was compared with the general Minnesota population of the same age and sex. Results: Mean (SD) age at diagnosis was 49 (15) years; 231 (49% ) were male. Mean follow- up was 7.6 (4.0) years (range, 0.1- 23.5) culminating in 3192 person- years follow- up. Overall, 53 of 420 (12.6% ) patients died. Survival was lower than the expected survival for the general population (standardized mortality ratio, 1.34; 95% CI, 1.003- 1.76; P = .03). Higher mortality was associated with age (hazard ratio per decade, 2.2; 95% CI, 1.7- 2.7), impaired fasting glucose (hazard ratio, 2.6; 95% CI, 1.3- 5.2), and cirrhosis (hazard ratio, 3.1, 95% CI, 1.2- 7.8). Liver disease was the third leading cause of death (as compared with the thirteenth leading cause of death in the general Minnesota population), occurring in 7 (1.7% ) subjects. Twenty- one (5% ) patients were diagnosed with cirrhosis, and 13 (3.1% ) developed liver- related complications, including 1 requiring transplantation and 2 developing hepatocellular carcinoma. Conclusions: Mortality among community- diagnosed NA- FLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis. Liver- related death is a leading cause of mortality, although the absolute risk is low.

关键词：酒精性脂肪肝疾病自然史队列研究样本人群标化死亡率肝脏疾病肝纤维化空腹血糖受损自然病史血糖过高

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