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Development of NK cell-based cancer immunotherapies through receptor engineering

Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey Page Nicolas Chuvin Jenny Valladeau-Guilemond stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

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Could near infrared spectroscopy be the new weapon in our understanding of the cerebral and muscle microvascular oxygen demand during exercise?

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Journal of Sport and Health Science 2024年第4期13卷 457-458页

作者： stephane Perrey EuroMov Digital Health in Motion University of MontpellierIMT Mines AlesMontpellier 34090France

Near-infrared spectroscopy(NIRS)has been increasingly utilized in both sport and health sciences to assess various physiological parameters related to exercise performance.1 NIRS methods coupled with the recent development of portable and wearable devices suitable for field-based measurements have revolutionized the study of exercise physiology and the determinants of exercise performance by providing real-time,non-invasive,and spatially localized measurements of tissue oxygenation dynamics.

关键词： cerebral utilized exercise

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Association between Fetal Heart Rate Monitoring during Labor and Neonatal Acidosis in Full-Term Newborns: A Retrospective Multicenter Cohort study

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Open Journal of Obstetrics and Gynecology 2020年第9期10卷 1265-1278页

作者： Anne-Charlotte Faivre Salma Tazi Jan Chrusciel stéphane sanchez Nathalie Bednarek René Gabriel Perrine Moussy Olivier Graesslin Department of Gynecology and Obstetrics Institute Alix de Champagne University Hospital Reims France Department of Medical Information Evaluation and Performance Centre Hospitalier Troyes Troyes France Neonatal Intensive Care Unit American Memorial Hospital Reims France

Introduction: Fetal heart rate monitoring during labor is used to study fetal well-being and predict neonatal acidosis of newborn. Fetal heart rate monitoring is analyzed by the obstetrical team and categorized accord... 详细信息

strong>Introduction: strong>Fetal heart rate monitoring during labor is used to study fetal well-being and predict neonatal acidosis of newborn. Fetal heart rate monitoring is analyzed by the obstetrical team and categorized according to the FIGO guidelines. An important limitation of this diagnostic tool is an inter- and intra-observer variability, leading to subjective cardiotocography interpretation and classification. Our objective was to study the association between the categories of fetal heart rate analysis (according to FIGO classification) and neonatal acidosis of full-term newborns. Study design: This is a multicenter retrospective cohort study conducted between 2014 and 2018 in the Grand-Est region. We searched and included retrospectively children hospitalized in a pediatric intensive care unit in one of the participating hospitals with an ICD-10 coding type “P91.6” corresponding to “Hypoxic Ischemic Encephalopathy”. Maternal, pregnancy, delivery, and newborn characteristics were collected and compared by univariate logistic regression with multiple imputation. Odds Ratio and 95% confidence intervals (CI) were calculated using the model and presented. Multiple imputation with m = 100 imputations was tested, using Rubin rules to combine the results. Results: 55 patients were included in the study. Fetal heart rate tracings classified in Category 3 as “pathological” according to FIGO guidelines were significantly associated with an increased risk of severe neonatal acidosis. Late decelerations and bradycardia during labor were associated with severe neonatal acidosis. Conclusion:style="font-family:Verdana;"> Severe neonatal acidosis may be suspected b

关键词： Fetal Heart Rate Neonatal Acidosis Third stage of Labor Newborn

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Geophysical evidence of large-scale silica-rich fluid flow above the continental subduction interface

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Science China Earth Sciences 2024年第9期67卷 2796-2809页

作者： Yuantong MAO Liang ZHAO Marco G.MALUSA stefano SOLARINO Silvia PONDRELLI Baolu SUN Coralie AUBERT Simone SALIMBENI Elena EVA stéphane GUILLOT state Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Earth and Environmental Sciences University of Milano-BicoccaMilan 20126Italy Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di BolognaBologna 40127Italy Université Grenoble Alpes Université Savoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

Fluids in subduction zones can have major effects on subduction ***,geophysical constraints on the scale and impact of fluid flow during continental subduction are still *** we analyze the VP/VS ratios in the Western Alpine region,hosting one of the best-preserved fossil continental subduction zones worldwide,to investigate the impact of fluid flow during continental *** found a belt of high VP/VS ratios>1.9 on the upper-plate side of the subduction zone,consistent with a partially serpentinized upper-plate mantle,and a belt of unusually low VP/VS ratiosst fluid flow along the continental subduction *** results suggest that past fluid flow may have reduced the effective stress along the subduction interface thus favoring continental subduction.

关键词： Western Alps Crustal structure Receiver function Vp/Vs ratio Silica enrichment

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Spatial Analysis of structural Changes and Floristic Distribution of Forest Landscapes in the Centre-West Region of Burkina Faso

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Journal of Geoscience and Environment Protection 2024年第9期12卷 246-268页

作者： stéphane Koudougou Oumar Kaboré Space and Society Dynamics Laboratory Université Joseph KI-ZERBO Ouagadougou Burkina Faso National Center for Scientific and Technological Research/Institute for Environment and Agricultural Research (CNRst/INERA) Space and Society Dynamics Laboratory of Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Land use and occupation dynamics impact landscape structure, diversity, richness and balance of vegetation cover. The aim of this study is to describe the process of fragmentation of the forest landscape from 1990 to 2020 and its effects on the degradation of the floristic characteristics of the vegetation in the Central West region of Burkina Faso. To achieve this, satellite data were collected and processed as part of a mapping approach to describing the landscape and the different types of landscape fragmentation. Mapping indices of landscape fragmentation (relative richness, change process, patch zones, Shannon diversity index) were also calculated. These indices were programmed in Idrisi Selva’s Landscape Pattern and change process analysis module. Spatio-temporal analysis revealed that in 1990, the landscape was dominated by natural vegetation formations, covering 66.33% of the territory. By 2020, these had been degraded to 44.80% by farmlands. The mapping analysis of indices also showed that the study area is characterized by four types of landscape fragmentation, including attrition, aggregation, creation and dissection. We also observed an abundant homogeneity, diversity and richness of conservation areas with legal and land tenure status. However, the structure is heterogeneous in landscapes outside protected areas and in areas under human occupation. This shows the crucial role played by conservation areas in preserving and balancing the diversity of vegetative cover in the study area.

关键词： Change Process Fragmentation Remote Sensing Landscape Burkina Faso

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Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine Henry Dario A.Fioretto Lorenzo M.Procopio stéphane Monfray Frédéric Boeuf Laurent Vivien Eric Cassan Carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine Nadia Belabas Institut Polytechnique de Paris LTCITélécom ParisPalaiseauFrance Université Paris-Saclay CNRSCentre for Nanosciences and NanotechnologyUMR 9001PalaiseauFrance Weizmann Institute of Science RehovotIsrael stMicroelectronics SAS CrollesFrance

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability,noise resilience,parallelization,and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave ***,state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation,and efficient photon pair *** have developed silicon ring resonators with a footprint below 0.05 mm^(2)providing more than 70 frequency channels separated by 21 *** exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic *** fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state *** demonstrate for the first time,we believe,a fully connected five-user quantum network in the frequency *** results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology,for applications in quantum computing and secure communications.

关键词： integrated photonics frequency domain quantum gates quantum networks

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What If the Protection against Oxidation of Chromia-Forming Alloys Was Not Always Due to the Chromia Layer?

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American Journal of Analytical Chemistry 2024年第9期15卷 286-302页

作者： Boris Contri stéphane Valette Marina Soustre Pierre Lefort IRCER European Ceramics Centre UMR CNRS 7315 University of Limoges 12 rue Atlantis Limoges Cedex France

Chromia-forming alloys have good resistance to oxidizing agents such as O2, CO2, … It is accepted that the protection of these alloys is always due to the chromia layer formed at the surface of the alloys, which acts as a barrier between the oxidizing gases and the alloy substrates, forming a diffusion zone that limits the overall reaction rate and leads to parabolic kinetics. But this was not verified in the study devoted to Inconel®625 the oxidation in CO2 that was followed by TGA, with characterizations by XRD, EDS and FIB microscopy. Contrary to what was expected and accepted in similar studies on other chromia-forming alloys, it was shown that the diffusion step that governs the overall reaction rate is not located inside the chromia layer but inside the alloy, precisely inside a zone just beneath the interface alloy/chromia, this zone being depleted in chromium. The chromia layer, therefore, plays no kinetic role and does not directly protect the underlying alloy. This result was demonstrated using a simple test that consisted in removing the chromia layer from the surface of samples partially oxidized and then to continue the thermal treatment: insofar as the kinetics continued without any change in rate, this proved that this surface layer of oxide did not protect the substrate. Based on previous work on many chromia-forming alloys, the possibility of a similar reaction mechanism is discussed. If the chromia layer is not the source of protection for a number of chromia-forming alloys, as is suspected, this might have major consequences in terms of industrial applications.

关键词： Chromia-Forming Alloys Chromia Layer Oxidation Protection Inconel®625 Kinetics

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Epidemiology and Prognosis of Hepatocellular Carcinoma (HCC) in the Internal Medicine Department of the Bouake University Hospital (Côte d’Ivoire)

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Open Journal of Gastroenterology 2024年第9期14卷 289-299页

作者： Nguessan Michel Konan stéphane Yapa Lauret Kouassi Tiépé Rokia Ouattara Kadidiata Touré Fiacre Abbé Georges stéphane Koffi Bourhaïma Ouattara Department of Internal Medicine Treichville Teaching Hospital Abidjan Cte dIvoire Medical Sciences Training and Research Unit Flix Houphouet Boigny University Abidjan Cte dIvoire Department of Internal Medicine Teaching Hospital of Bouake Bouake Cte dIvoire Medical Sciences Training and Research Unit Alassane Ouattara University Bouake Cte dIvoire

Background and Objective: Hepatocellular carcinoma (HCC) is a public health problem due to its high incidence and high mortality rate. The epidemiology and prognosis of this disease is poorly documented in Bouake. The aim of the study was to describe the epidemiological aspects and identify the predictors of death in patients hospitalized for HCC in the Internal Medicine Department of the Bouake University Hospital in order to improve patient management. Material and Methods: We conducted a cross-sectional study from 1 January 2020 to 31 December 2022 in the Internal Medicine Department of Bouake University Hospital, involving 160 patients. Results: The prevalence of HCC was 3.6%, the mean age was 48.86 ± 14.5 years with extremes of 14 and 90 years and the sex ratio was 2.90. Viral hepatitis B was observed in 81% of patients, with HBs Ag positivity in 71.2%. The performance status of WHO was ≥ 2 in 93.2% of cases. HCC was discovered at advanced stage respectively in 51% for BCLC C and 47.8% for BCLC D stage. The nodules were multiple (89.3%), and superior to 3 cm. The hospital mortality was 20% and BCLC D stage of HCC was significantly associated with death (p = 0.04) in the univariate analysis. The BCLC D stage of HCC was significantly associated with death. Length of stay inferior to 5 days (OR = 0.77;CI 95: 0.61 - 0.96) and hepatic encephalopathy (OR = 1.39;CI 95: 1.10 - 1.77), were the two independent predictors of mortality. Conclusion: HCC mainly affected young men infected with chronic viral hepatitis B. Short length of stay and hepatic encephalopathy were independent predictors of mortality.

关键词： Liver Cancer Viral Hepatitis Death West Africa

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An ethically guided preclinical device for phenotyping H_(2)production in laboratory rodents

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Animal Models and Experimental Medicine 2024年第4期7卷 553-561页

作者： Victor Pascal-Moussellard Emilie Boucher stéphane Tanguy Philippe Cinquin Pierre-Alain Barraud ChloéDavin Cordélia Salomez-Ihl Dalil Hannani François Boucher Jean-Pierre Alcaraz University Grenoble Alpes CNRSUMR 5525VetAgro SupGrenoble INPTIMCGrenobleFrance

Background:Dihydrogen(H_(2))is produced endogenously by the intestinal microbiota through the fermentation of diet *** the past few years,numer-ous studies have demonstrated the significant therapeutic potential of H_(2)in various pathophysiological contexts,making the characterization of its production in labora-tory species of major preclinical ***:This study proposes an innovative solution to accurately monitor H_(2)pro-duction in free-moving rodents while respecting animal welfare *** devel-oped device consisted of a wire rodent cage placed inside an airtight chamber in which the air quality was maintained,and the H_(2)concentration was continuously *** the airtightness and efficiency of the systems used to control and maintain air quality in the chamber were checked,tests were carried out on rats and mice with different metabolic phenotypes,over 12 min to 1-h experiments and repeatedly.H_(2)production rates(HPR)were obtained using an easy calculation algorithm based on a first-order moving ***:HPR in hyperphagic Zucker rats was found to be twice as high as in control Wistar rats,respectively,2.64 and 1.27 nmol.s^(−1)per *** addition,the ingestion of inulin,a dietary fiber,stimulated H_(2)production in *** were 0.46 nmol.s^(−1)for animals under control diet and 1.99 nmol.s^(−1)for animals under inulin ***:The proposed device coupled with our algorithm enables fine analysis of the metabolic phenotype of laboratory rats or mice with regard to their endogenous H_(2)production.

关键词： hydrogen therapy laboratory rodents microbiota molecular hydrogen noninvasive monitoring device

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Trombe walls with porous medium insertion and their influence on thermal comfort in flats in Cusco,Peru

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Energy and Built Environment 2024年第2期5卷 194-210页

作者： Patrick Facelli sanchez Lisset Mercado Hancco Department of Civil Engineering Faculty of Architecture and Civil EngineeringUniversidad Nacional de San Antonio Abad del Cusco08003 CuscoPeru

The Trombe wall is a passive indirect heating system which should be used in Cusco,Peru to improve thermal conditions against the typical frosts and low temperatures during winter in the high Andean *** to this problem,the use of a modified Trombe wall with insertion of porous medium is proposed to improve thermal comfort in flat buildings in *** research aims to analyse and compare the performance of dwellings without Trombe wall,with traditional Trombe wall,and with Trombe wall with glass and plastic pellets insertion in thermal comfort ***■CFD was used to simulate and analyse the *** simulation was performed with three prototype flats(55 m^(2),75 m^(2) and 95 m^(2))for six months of the *** the results obtained,the level of thermal comfort in the traditional scenarios is low with an average PMV of-1.86,in the scenarios with Trombe wall is good and in the scenarios with Trombe wall with insertion of porous medium is slightly better than the previous one,reaching an average PMV of+0.10 and a temperature of 21.90℃.The study carried out is important because it represents an efficient eco-sustainable heating alternative that improves the thermal comfort sensation in houses during the coldest months of the year.

关键词： Trombe wall thermal comfort porous medium residential buildings computational fluid dynamics

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