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Specific alterations of regional myocardial work in strength-trained athletes using anabolic androgenic steroids compared to athletes with genetic hypertrophic cardiomyopathy

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Journal of Sport and Health Science 2023年第4期12卷 477-485页

作者： Antoine Grandperrin Frédéric Schnell Erwan Donal Elena Galli Christophe Hedon Olivier Cazorla stéphane Nottin Avignon University LaPEC UPR 4278Avignon F-84000France Rennes University CHU RennesInsermLTSI-UMR 1099Rennes F-35000France Montpellier University PhyMedExpINSERMCNRSPhysiology and Experimental Heart and Muscle MedicineMontpellier 34295France

Background:strength-trained athletes using anabolic androgenic steroids(AAS)have left ventricular(LV)hypertrophy and myocardial fibrosis that can lead to sudden cardiac death.A similar feature was described in athletes with hypertrophic cardiomyopathy(HCM),which complicates the diagnosis for *** this context,we aimed to compare the LV function of the 2 populations by measuring global and regional strain and myocardial work using speckle-tracking ***:Twenty-four strength-trained asymptomatic athletes using AAS(AAS-Athletes),22 athletes diagnosed with HCM(HCM-Athletes),and 20 healthy control athletes(Ctrl-Athletes)underwent a resting echocardiography to assess LV *** evaluated LV global and regional strains and myocardial work,with an evaluation of the constructive work(CW),wasted work,and work efficiency(WE).Results:Compared to Ctrl-Athletes,both AAS-Athletes and HCM-Athletes had a thicker interventricular septum,with maj ored values in *** strain was reduced in AAS-Athletes and even more in ***,global WE was significantly diminished in both AAS and HCM-Athletes(93%±2%in Ctrl-Athletes,90%±4%in AAS-Athletes,and 90%±5%in HCM-Athletes(mean±SD);pstructive work and WE regional analysis showed specific alterations,with the basal septal segments preferentially affected in AAS-Athletes,and both septal and apical segments affected in ***:The regional evaluation of myocardial work reported specific alterations of the major LV hypertrophy induced by the regular use of AAS compared to the LV hypertrophy due to *** finding could help clinicians to differentiate between these 2 forms of pathological hypertrophy.

关键词： Anabolic androgenic steroids Hypertrophic cardiomyopathy Left ventricular function Myocardial work Speckle-tracking echocardiography

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Production of liquid bio-fuel from catalytic de-oxygenation:Pyrolysis of beech wood and flax shives

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燃料化学学报 2019年第2期47卷 153-166页

作者： Chetna Mohabeer Luis Reyes Lokmane Abdelouahed stéphane Marcotte Jean-Christophe Buvat Lucette Tidahy Edmond Abi-Aad Bechara Taouk Normandie Univ INSA Rouen NormandieUNIROUENLaboratoire de Sécurité des Procédés Chimiques Normandie Univ INSA Rouen NormandieUNIROUEN Université du Littoral Cte d'Opale Unité de Chimie Environnementale et Interactions sur le Vivant

This study presents a detailed analysis of the catalytic de-oxygenation of the liquid and gaseous pyrolytic products of two biomasses (beech wood and flax shives) using different catalysts (commercial HZSM-5 and H-Y,and lab-synthesised Fe-HZSM-5,Fe-H-Y,Pt/Al2O3 and CoMo/Al2O3). The experiments were all conducted in a semi-batch reactor under the same operating conditions for all feed materials. BET specific surface area,BJH pore size distribution and FT-IR technologies have been used to characterise the catalysts,while gas chromatography-mass spectrometry (GC-MS),flame ionisation detection (GC-FID) and thermal conductivity detection (GC-TCD) were used to examine the liquid and gaseous pyrolytic products. It was firstly seen that at higher catalyst-to-biomass ratios of 4∶1,de-oxygenation efficiency did not experience any further significant improvement. FeHZSM-5 was deemed to be the most efficient of the catalysts utilised as it helped reach the lowest oxygen contents in the bio-oils samples and the second best was HZSM-5. It was also found that HZSM-5 and H-Y tended to privilege the decarbonylation route(production of CO),whilst their iron-modified counterparts favoured the decarboxylation one (production of CO2) for both biomasses studied. It was then seen that the major bio-oil components (carboxylic acids) underwent almost complete conversion under catalytic treatment to produce mostly unoxygenated aromatic compounds,phenols and gases like CO and CO2. Finally,phenols were seen to be the family most significantly formed from the actions of all catalysts.

关键词： pyrolysis biomass catalytic treatment de-oxygenation bio-oil upgrading

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Towards an integrated framework for the risk assessment of coastal structures exposed to earthquake and tsunami hazards

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Resilient Cities and structures 2022年第2期1卷 57-75页

作者： Cláudia Reis Mário Lopes Maria Ana Baptista stéphane Clain Civil Engineering Research and Innovation for Sustainability CERISInstituto Superior TécnicoUniversidade de LisboaAvenida Rovisco Pais1Lisboa 1049-001Portugal Instituto Superior de Engenharia de Lisboa Instituto Politécnico de LisboaR.Conselheiro Navarro 1Lisboa 1959-007Portugal Departamento de Matemática Centro de FísicaUniversidade do MinhoCampus de GualtarBraga 4710-057Portugal

The spatial distribution of the world population is uneven,with a density of about 40%living in coastal *** trend is expected to continue in both demographic indicators and urban development rate,being many coastal cities in seismic-and tsunami-prone regions and built through informal and unplanned settlements,exposing their population and assets to such *** tectonic-triggered events raised awareness of the cascading earthquake and tsunami threat and highlighted the paucity of structural design criteria considering the cumulative effects of *** being exposed to the ground-motion,the structures’resistance may decrease and become residual/non-existent to support the incoming tsunami,implying an underestimation of the *** management can benefit from reinforcing the ties between natural hazards and engineering practitioners,linking science and industry,and promoting dialogue between risk analysts and *** by the expansion plans of an internationally-sized deep-water port located in a tsunami-prone region,a reflection on the work needed to perform a multi-risk assessment and the challenges yet to overcome is introduced to emphasize the challenge of combining safety requirements with financial and ecologic concerns.A conceptual interdisciplinarybased methodology is proposed to support uncertainty-aware,systematic and informed decisions.

关键词： Cascading earthquake and tsunami Multi-hazard structural vulnerability to earthquake and derivative tsunami Performance-based engineering to cascading ground motion and tsunami

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How does chronic dry eye shape peripheral and central nociceptive systems?

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Neural Regeneration Research 2021年第2期16卷 306-307页

作者： Adrian Guerrero-Moreno Darine Fakih stéphane Melik Parsadaniantz Annabelle Réaux-Le Goazigo Sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Dry eye disease(DED)is a multifactorial disease characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms,in which tear film instability and hyperosmolarity,ocular surface inflammation... 详细信息

关键词： homeostasis al. ocular

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T-lymphoblastic lymphoma with cutaneous involvement

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World Journal of Clinical Cases 2015年第8期3卷 727-731页

作者： Emmanuelle Ginoux Fanny Julia Brigitte Balme Luc Thomas stéphane Dalle Department of Dermatology Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Université Claude Bernard Lyon 1 Unit of Pathology Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Cancer Research Center of Lyon

To study dermatological manifestation of T-lymphoblastic lymphoma and to help clinicians in the diagnosis, we report here the case of a 75-year-old patient who presented with violaceous nodules acquired during the last 4 wk and affecting the scalp and right arm. The diagnosis of systemic lymphoma was suggested upon the appearance of cutaneous tumors, palpable lymph nodes and general symptoms including asthenia and weight-loss. The pathology features: positive immunostaining for CD3 and terminal deoxynucleotidyl transferase(Td T) and staging, led us to the final diagnosis of T-lymphoblastic lymphoma(T-LBL) with cutaneous involvement. He received a CHOP regimen as first-line treatment. Unfortunately, the patient relapsed and died 8 mo after the treatment initiation. T-LBL may be diagnosed by skin lesions. Additional immunostaining including Td T and experienced histopathologists are needed to correctly classify this aggressive disease and discuss the correct management including bone-marrow transplantation where appropriate.

关键词： Cutaneous lymphoma Lymphoblastic lymphoma Skin

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Development of a multiprimer metabarcoding approach to understanding trophic interactions in agroecosystems

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Insect Science 2022年第4期29卷 1195-1210页

作者： Ivan Batuecas Oscar Alomar Cristina Castañe Josep Piñol stéphane Boyer Lorena Gallardo-Montoya Nuria Agustí IRTA Sustainable Plant ProtectionCabrilsBarcelonaSpain Universitat Autònoma Barcelona Cerdanyola del VallèsSpain CREAF Cerdanyola del VallèsSpain Institut de Recherche sur la Biologie de l'Insecte(IRBI) Tours UniversityToursFrance

To understand trophic interactions and the precise ecological role of each predatory species,it is important to know which arthropod and plant resources are used by generalist predators in *** approaches,such as the use of high-throughput sequencing(HTS),play a key role in identifying these *** study develops a multiprimer metabarcoding approach for screening the most common trophic interactions of two predatory arthropods with contrasting morphologies,Rhagonycha fulva(Coleoptera:Cantharidae)and Anthocoris nemoralis(Hemiptera:Anthocoridae)collected from a peach *** reduce the time and cost of this metabarcoding approach,we first evaluated the effect of using two different predator-pools of different size(10 and 23 individuals of the same species).We also used our system to analyze the performance of one and two primer pairs in the same *** results show that the analysis of 23 individuals together with the use of two primer pairs in the same library optimize the HTS *** these best-performing conditions,we then analyzed the entire bodies of field-collected predators as well as the washing solutions used to clean the insect *** were able to identify both gut content(i.e.,diet)and external pollen load(i.e.,on the insects’bodies).This study also demonstrates the importance of washing predatory insects’bodies prior to HTS analysis when the target species have a considerable size(>10 mm)and hairy *** metabarcoding approach has significant potential for the study of trophic links in agriculture,revealing expected and unexpected trophic relationships.

关键词： high-throug hput sequencing metabarcoding molecular diet analysis multiprimer approach predatory arthropods trophic interactions

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New perspectives for investigating respiratory failure induced by cervical spinal cord injury

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Neural Regeneration Research 2014年第22期9卷 1949-1951页

作者： Marcel Bonay stéphane Vinit Université de Versailles Saint-Quentin-en-Yvelines Unité End:icapUFR des Sciences de la Santé–Simone Veil78180 Montigny-le-BretonneuxFrance Service de Physiologie-Explorations Fonctionnelles H?pital Ambroise Paré Assistance Publique-H?pitaux de Paris(AP-HP)Groupe Hospitalier Paris Ile-de-France Ouest92104 BoulogneBillancourtFrance

Traumatic cervical spinal cord injury （SCI）, with an annual incidence of 12,000 new cases in USA （NSCISC 2013）, causes devastating locomotor and respiratory paralysis and unfortunately compromises the human patient＇s lifespan. The severity of the injury depends on the degree and the extent of the initial trauma. In fact, respiratory failure is the leading cause of mortality following upper cervical SCI. However, 80% of the injuries are incomplete, allowing some modest spontaneous recovery. To date, no effective treatment is available in order to restore the loss of function.

关键词： SCI New perspectives for investigating respiratory failure induced by cervical spinal cord injury CPP

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state-of-the-art on theories and applications of cable-driven parallel robots

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Frontiers of Mechanical Engineering 2022年第3期17卷 35-57页

作者： Zhaokun ZHANG Zhufeng SHAO Zheng YOU Xiaoqiang TANG Bin ZI Guilin YANG Clément GOSSELIN stéphane CARO state Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Precision/Ultra-Precision Manufacturing Equipment and Control Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA Department of Precision Instrument Tsinghua UniversityBeijing 100084China School of Mechanical Engineering Hefei University of TechnologyHefei 230009China Ningbo Institute of Industrial Technology Chinese Academy of Sciences(CAS)Ningbo 315201China Department of Mechanical Engineering UniversitéLavalQuebec QC G1V 0A6Canada Laboratory of Digital Sciences of Nantes National Centre for Scientific ResearchNantes 44321France

Cable-driven parallel robot(CDPR)is a type of high-performance robot that integrates cable-driven kinematic chains and parallel mechanism *** inherits the high dynamics and heavy load capacities of the parallel mechanism and significantly improves the workspace,cost and energy efficiency *** a result,CDPRs have had irreplaceable roles in industrial and technological fields,such as astronomy,aerospace,logistics,simulators,and *** follow the cutting-edge trend of rigid-flexible fusion,reflect advanced lightweight design concepts,and have become a frontier topic in robotics *** paper summarizes the kernel theories and developments of CDPRs,covering configuration design,cable-force distribution,workspace and stiffness,performance evaluation,optimization,and motion *** modeling,workspace analysis,and cable-force solution are *** and dynamic modeling methods are *** further promote the development,researchers should strengthen the investigation in configuration innovation,rapid calculation of workspace,performance evaluation,stiffness control,and rigid-flexible coupling *** addition,engineering problems such as cable materials,reliability design,and a unified control framework require attention.

关键词： cable-driven parallel robot kinematics optimization dynamics control

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Hepatitis C virus: Virology, diagnosis and management ofantiviral therapy

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World Journal of Gastroenterology 2007年第17期13卷 2461-2466页

作者： stéphane Chevaliez Jean-Michel Pawlotsky French National Reference Center for Viral Hepatitis B C and deltaDepartment of Virology & INSERM U841 Henri Mondor Hospital University of Paris XII Créteil France

Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection in order to diagnose infection, guide treatment decisions and assess the virological response to antiviral therapy. Anti- HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. The HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment, the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection, and molecular assays are used to assess the end-of-treatment and, most importantly the sustained virological response, i.e. the endpoint of therapy.

关键词： Hepatitis C virus serological tests HepatitisC virus genotype HCV RNA quantification Interferon alpha Ri-bavirin-

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Diesel engine exhaust exposures in two underground mines

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International Journal of Mining Science and Technology 2017年第4期27卷 641-645页

作者： Debia Maximilien Couture Caroline Njanga Pierre-Eric Neesham-Grenon Eve Lachapelle Guillaume Coulombe Hugo Hallé stéphane Aubin Simon Department of Environmental and Occupational Health School of Public Health Universite de Montreal 2375 chemin de la Cote Ste-Catherine Montreal H3T IA8 Canada Department of Mechanical Engineering F.cole de Technologie Superieure 1100 rue Notre-Dame Ouest Montreal H3C 1K3 Canada Health and Safety Agnico Eagie Mines 145 King Street East Suite 400 Toronto MSC 2Y7 Canada Health and Safety Westwood Mine (IAMGOLD) Chemin Arthur Doyon PreissacJOY 2EO Canada Institut de recherche Robert-Sauve en sante et en securite du travail (IRSst) 505 Boul. de Maisonneuve Ouest Montreal H3A 3C2 Canada

Exposure to diesel engine exhaust(DE) is a major concern in underground mines. It has been linked to cardiopulmonary diseases and is classified as a human carcinogen. The goal of this study is to assess DE exposures in workers at two underground gold mines, to compare exposure levels within and between the mines, and to compare different methods of measuring DE exposures, namely respirable combustible dust(RCD), elemental carbon(EC) and total carbon(TC). Ambient and personal breathing zone(PBZ) measurements were taken. Side-by-side monitoring of RCD and of the respirable fraction of EC and TC(EC_Rand TC_R) was carried out in the workers' breathing zone during full-shift *** ambient measurements, in addition to EC_R, TC_Rand RCD, a submicron aerosol fraction(less than 1 mm) of EC and TC was also sampled(EC_1and TC_1). Average ambient results of 240 mg/m^3 in RCD, 150 mg/m^3 in EC_Rand 210 mg/m^3 in TC_Rare obtained. Average PBZ results of 190 mg/m^3 in RCD,84 mg/m^3 in EC3Rand 150 mg/min TC_Rare obtained. Very good correlation is found between EC_Rand EC_1 with a Pearson correlation coefficient of 0.99(p st exposures are reported for loadhaul-dump(LHD) and jumbo drill operators and conventional miners. Significant exposure differences are reported between mines for truck and LHD operators(p < 0.01). The average TC_R/EC_Rratio is 1.6 for PBZ results, and 1.3 for ambient results. The variability observed in the TC_R/EC_Rratio shows that interferences from non-diesel related organic carbon can skew the interpretation of results when relying only on TC data.

关键词： Diesel exposure Underground mine Respirable combustible dust Elemental carbon Total carbon Diesel particulate matter Similar exposure groups

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