Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limit...
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Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.
Pancreatic ductal adenocarcinoma(PDAC)represents a challenging pathology with very poor outcomes and is increasing in incidence within the general *** majority of patients are diagnosed incidentally with insidious sym...
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Pancreatic ductal adenocarcinoma(PDAC)represents a challenging pathology with very poor outcomes and is increasing in incidence within the general *** majority of patients are diagnosed incidentally with insidious symptoms and hence present late in the disease *** significantly affects patient outcomes:the only cure is surgical resection but only up to 20%of patients present with resectable disease at the time of clinical *** use of“omic”technology is expanding rapidly in the field of personalised medicine-using genomic,proteomic and metabolomic approaches allows researchers and clinicians to delve deep into the core molecular processes of this difficult *** review gives an overview of the current findings in PDAC using these“omic”approaches and summarises useful markers in aiding clinicians treating *** strategies incorporating these findings and potential application of these methods are presented in this review article.
The research work presents,constrained network coding technique to ensure the successful data transmission based composite channel cmos technology using dielectric *** charge fragmentation and charge splitting are two...
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The research work presents,constrained network coding technique to ensure the successful data transmission based composite channel cmos technology using dielectric *** charge fragmentation and charge splitting are two components of the filtered switch domino(FSD)*** behavior of selected switching is achieved using generator called conditional pulse generator which is employed in Multi Dynamic Node Domino(MDND)*** FSD and MDND technique need wide area compared to existing single nodekeeper domino *** aim of this research is to minimize dissipation of power and to achieve less consumption of *** proposed research,works by introducing the method namely Interference and throughput aware Optimized Multicast Routing Protocol(IT-OMRP).The main goal of this proposed research method is to introduce the system which can forward the data packets towards the destination securely and *** achieve the bandwidth and throughput in optimized data transmission,proposed multicast tree is selected by Particle Swarm Optimization which will select the most optimal host node as the branches of multi cast *** node selection is done by considering the objectives residual energy,residual bandwidth and *** node selection multi cast routing is done with the concern of interference to ensure the reliable and successful data *** case of transmission range size is higher than the coverage sense range,successful routing is ensured by selecting secondary host forwarders as a backup which will act as intermediate relay *** NS2 simulator is used to evaluate research outcome from which it is proved that the proposed technique tends to have increased packet delivery ratio than the existing work.
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