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The Largest Chinese Cohort Study Indicates Homologous Recombination Pathway Gene Mutations as Another Major Genetic Risk Factor for Colorectal Cancer with Heterogeneous Clinical Phenotypes

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Research 2024年第3期6卷 191-203页

作者： Yun Xu Kai Liu Cong Li Minghan Li Fangqi Liu Xiaoyan Zhou Menghong Sun Megha ranganathan Liying Zhang Sheng Wang Xin Hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Tissue BankFudan University Shanghai Cancer CenterShanghaiP.R.China Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Precision Cancer Medical Center Fudan University Shanghai Cancer CenterShanghaiP.R.China

While genetic factors were associated with over 30% of colorectal cancer (CRC) patients, mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients. Besides, previous studies on hereditary CRC were largely designed to analyze germline mutations in patients with single genetic high-risk factor, which limited understanding of the association between genotype and phenotypes. From January 2015 to December 2018, we retrospectively enrolled 2,181 patients from 8,270 consecutive CRC cases, covering 5 categories of genetic high-risk factors. Leukocyte genomic DNA was analyzed for germline mutations in cancer predisposition genes. The germline mutations under each category were detected and analyzed in association with CRC susceptibility, clinical phenotypes, and prognoses. A total of 462 pathogenic variants were detected in 19.3% of enrolled CRC patients. Mismatch repair gene mutation was identified in 9.1% of patients, most prevalent across all high-risk groups. Homologous recombination (HR) gene mutations were detected in 6.5% of cases, penetrated in early-onset and extra-colonic cancer risk groups. Mutations in HR genes, including BARD1, RAD50, and ATM, were found to increase CRC risk with odds ratios of 2.8-, 3.1-, and 3.1-fold, respectively. CRC patients with distinct germline mutations manifested heterogeneous phenotypes in clinicopathology and long-term prognoses. Thus, germline mutation screenings should be performed for CRC patients with any of those genetic risk factors. This study also reveals that HR gene mutations may be another major driver for increased CRC risk.

关键词： susceptibility category Major

Fuzzy Multi-Criteria Decision Support System for the Best Anti-Aging Treatment Selection Process through Normal Wiggly Hesitant Fuzzy Sets

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Computers, Materials & Continua 2024年第9期80卷 4947-4972页

作者： Daekook Kang Ramya Lakshmanaraj Samayan Narayanamoorthy Navaneethakrishnan Suganthi Keerthana Devi Samayan Kalaiselvan ranganathan Saraswathy Dragan Pamucar Vladimir Simic Department of Industrial and Management Engineering Institute of Digital Anti-Aging Health CareInje UniversityGimhae-si50834Republic of Korea Department of Mathematics Bharathiar UniversityCoimbatore641046India Department of SocialWork SRMV Collge of Arts and ScienceCoimbatore641020India Department of Radiology Karpagam Medical College and HospitalCoimbatore641032India Department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia College of Engineering Department of Industrial Engineering and ManagementYuan Ze UniversityTaoyuan City320315Taiwan Department of Mechanics and Mathematics Western Caspian UniversityBakuAZ1001Azerbaijan Faculty of Transport and Traffic Engineering University of BelgradeBelgrade11000Serbia Department of Computer Science and Engineering College of InformaticsKorea UniversitySeoul02841Republic of Korea

This socialized environment among educated and developed people causes themto focusmore on their appearance and health,which turns them towards medical-related treatments,leading us to discuss anti-aging treatment methods for each age group,particularly for urban people who are interested in *** anti-aging therapies are used to address the alterations brought on by aging in human life without the need for surgery or negative *** anti-aging therapies such as microdermabrasion or dermabrasion,laser resurfacing anti-aging skin treatments,chemical peels,dermal fillers for aged skin,and botox injections are considered in this *** on the criteria of safety risk,investment cost,customer happiness,and side effects,the optimal alternative is *** a result,a NormalWiggly Hesitant Pythagorean Fuzzy Set(NWHPFS)is constructed and used in Multi-Criteria Decision-Making(MCDM)using traditional wavy mathematical *** entropy approach is utilized to determine weight values,and the Normal Wiggly Hesitant Pythagorean-VlseKriterijumska Optimizacija I Kompromisno Resenje(NWHPF-VIKOR)method is utilized to rank alternatives using MCDM *** analysis and comparative analysis were performed to ensure the robustness and reliability of the proposed *** smart final choice will undoubtedly assist Decision Makers(DM)in making the right judgments,and the MCDM approach will undoubtedly assist individuals in understanding the medicine.

关键词： Normal wiggly hesitant pythagorean fuzzy set hesitant pythagorean fuzzy set anti-aging treatment entropy VIse Kriterijumska Optimizacija I Kompromisno Resenje

How Marie Sklodowska-Curie Doctoral Networks Can Support European Refractory Ecosystem in Context of The European Green Deal

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China's Refractories 2024年第2期33卷 1-9页

作者： Marc HUGER Glyn DERRICK Mossaab MOUIYA Andrea SALERNO Kwasi Addo BOATENG Hrikeshava ranganathan Amit Kumar GOPE Institute of Research for Ceramics(IRCER-UMR CNRS 7315) University of LimogesLimoges 87000France

The movement of the Iron&Steelmaking(I&S)industry towards Net-Zero emissions and digitalized processes through disruptive,breakthrough technologies will be achieved through the use of *** biggest challenge for the refractory industry is to continue to meet the performance expectations while,at the same time,moving to a more sustainable production *** complexity and urgency of these technological changes,highlighted by the European Green Deal,requires ambitious,international,interdisciplinary and intersectoral projects,bringing together institutes from across the global value chain,to carry out cutting edge *** European Union,through its flagship doctoral training program,MSCA,has,and continues to support research and development as well as the promotion of the refractory industry in *** introduction to two MSCA projects and some of the results achieved are highlighted within this article.

关键词： FIRE network Horizon 2020 Horizon Europe Marie Sklodowska-Curie Actions Doctoral networks European Green Deal

Two-Dimensional Lattice Boltzmann Model for Droplet Impingement and Breakup in Low Density Ratio Liquids

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Communications in Computational Physics 2011年第8期10卷 767-784页

作者： Amit Gupta ranganathan Kumar Department of Mechanical Engineering Indian Institute of TechnologyNew DelhiIndia 110016 Department of Mechanical Materials and Aerospace EngineeringUniversity of Central FloridaOrlandoFL 32816USA

A two-dimensional lattice Boltzmann model has been employed to simulate the impingement of a liquid drop on a dry *** a range of Weber number,Reynolds number and low density ratios,multiple phases leading to breakup have been *** analytical solution for breakup as function of Reynolds and Weber number based on the conservation of energy is shown to match well with the *** the moment breakup occurs,the spread diameter is maximum;it increases with Weber number and reaches an asymptotic value at a density ratio of *** breakup is found to be more viable for the case when the wall is non-wetting or neutral as compared to a wetting *** breakup,the distance between the daughter droplets is much higher for the case with a non-wetting wall,which illustrates the role of the surface interactions in the outcome of the impact.

关键词： Lattice Boltzmann droplet impingement spread factor breakup

Paddy Husk as Support for Solid State Fermentation to Produce Xylanase from Bacillus pumilus

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Rice science 2011年第1期18卷 36-45页

作者： ranganathan KAPILAN Vasanthy ARASARATNAM Department of Botany Faculty of Science Thirunelvely University of Jaffna Department of Biochemistry Faculty of Medicine University of Jaffna

To optimize culture conditions for xylanase production by solid state fermentation （SSF） using Bacillus pumilus, with paddy husk as support, solid medium contained 200 g of paddy husk with 800 mL of liquid fermentation medium [xylan, 20.0 g/L; peptone, 2.0 g/L; yeast extract, 2.5 g/L; K2HPO4, 2.5 g/L; KH2PO4, 1.0 g/L; NaCl, 0.1 g/L; （NH4）2SO4, 2.0 g/L, CaCl2-2H2O, 0.005 g/L; MgCl2.6H2O, 0.005 g/L; and FeCI3, 0.005 g/L] at pH 9.0 was applied. The highest xylanase activity （142.0 ±0.47 U/g DM] was obtained on the 6th day at 30℃ The optimized paddy husk to liquid fermentation medium ratio was 2：9, and the optimized culture temperature was 40℃. When commercial Birchwood xylan was replaced with different concentrations of corncob, xylanase production was maximized （224.2 U/g DM） in the medium with 150 g/L corncob. Xylanase production was increased by sucrose, fructose and arabinose, whereas reduced by glucose, galactose, lactose and amylose. When organic nitrogen sources were replaced with locally available nitrogen sources such as groundnut powder or sesame seedcake powder or coconut seedcake powder or soy meal powder, the highest xylanase production （290.7 U/g DM） was obtained in the medium with soy meal powder and 16.0 g/L of soy meal powder was the optimum （326.5±0.34 U/g DM）. Based on the optimization studies, B. pumilus produced 2.3 times higher xylanase activity. The medium cost was reduced from 2 458.3 to 178.3 SLR/kg and the total activity which could be obtained from 1 kg of the medium was increased from 48 624 to 220 253 Units.

关键词： Bacillus pumilus solid state fermentation xylanase paddy husk xylan corncob soymeal

Origin of Excellent Charge Storage Properties of Defective Tin Disulphide in Magnesium/Lithium-Ion Hybrid Batteries

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Nano-Micro Letters 2022年第11期14卷 87-106页

作者： Xin Fan Mike Tebyetekerwa Yilan Wu Rohit ranganathan Gaddam Xiu Song Zhao School of Chemical Engineering The University of QueenslandSt LuciaBrisbaneQLD 4072Australia School of Material Science and Technology North University of ChinaTaiyuan 030051ShanxiPeople’s Republic of China Dow Centre for Sustainable Engineering Innovation School of Chemical EngineeringThe University of QueenslandSt LuciaBrisbaneQLD 4072Australia Department of Chemical Engineering Indian Institute of Science Education and ResearchBhopalIndia

Lithium-ion batteries(LIBs)are excellent electrochemical energy sources,albeit with existing challenges,including high costs and safety ***-ion batteries(MIBs)are one of the potential ***,the performance of MIBs is poor due to their sluggish solid-state Mg^(2+) diffusion kinetics and severe electrode *** magnesium-ion/lithium-ion(Mg^(2+)/Li^(+))hybrid batteries(MLHBs)with Mg^(2+) and Li+as the charge carriers create a synergy between LIBs and MIBs with significantly improved charge transport kinetics and reliable safety ***,MLHBs are yet to reach a reasonable electrochemical performance as *** work reports a composite electrode material with highly defective two-dimensional(2D)tin sulphide nanosheets(SnS_(x))encapsulated in three-dimensional(3D)holey graphene foams(HGF)(SnS_(x)/HGF),which exhibits a specific capacity as high as 600 mAh g^(−1) at 50 mA g^(−1) and a compelling specific energy density of~330 Wh kg^(−1).The excellent electrochemical performance surpasses previously reported hybrid battery systems based on intercalation-type cathode materials under comparable *** role played by the defects in the SnS_(x)/HGF composite is studied to understand the origin of the observed excellent electrochemical *** is found that it is closely related to the defect structure in SnS_(x),which offers percolation pathways for efficient ion transport and increased internal surface area assessable to the charge *** defective sites also absorb structural stress caused by Mg^(2+) and Li+*** work is an important step towards realizing high-capacity cathode materials with fast charge transport kinetics for hybrid batteries.

关键词： Defects Tin disulphide Magnesium/lithium-ion hybrid batteries 2D materials

Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 141-147页

作者： Mariappan BALAMURUGAN Kasi PARTHASARATHI Lalpet Souri ranganathan Edwin L. COOPER Division of Vermibiotechnology Department of Zoology Annamalai University Annamalai Nagar-608002 India VLB Janakiammal College of Arts and Science Kovaipudur Coimbatore-641042 India Laboratory of Comparative Immunology Department of Neurobiology UCLA Medical Centre University of California Los Angeles California 90095-1763 USA

The hepatoprotective potential of earthworm extract (EE) (Lampito mauritii, Kinberg) was evaluated against paracetamol-induced liver injury in Wistar albino rat, in comparison with silymarin, the standard hepatoprotective drug. We observed a reduction in liver antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) and in serum total protein, and an increase in serum alkaline phosphatase (ALP), serum aspertate aminotranferase (AST), serum alanine aminotranferase (ALT), bilirubin and liver thiobarbituric acid reactive substances (TBARS) due to liver injury in the paracetamol-administered rats (2 g/kg). On the contrary, increased activities of liver GSH, SOD, GPx, CAT and serum total protein level, and decrease in the contents of serum ALP, AST, ALT, bilirubin and liver TBARS were observed in rats administered with different doses of EE (100, 200 and 300 mg/kg), which are similar to the activities of hepato-protective drug silymarin (150 mg/kg). The mode of action of EE as evidenced by the above parameters may suggest that EE, on the one hand, prevents the formation of the reactive oxygen groups, or scavenges these groups, thereby preventing the damage on the hepatic cells, and, on the other hand, modulates the genes responsible for synthesis of antioxidant enzymes such as GPx, CAT and SOD in liver tissue and decreases the serum enzymatic activities such as ALP, AST and ALT.

关键词： Earthworm extract Hepatoprotective potential Antioxidant Paracetamol Lipid peroxidation

Interface Engineering of NixSy@MnOxHy Nanorods to Efficiently Enhance Overall-Water-Splitting Activity and Stability

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Nano-Micro Letters 2022年第7期14卷 246-262页

作者： Pan Wang Yuanzhi Luo Gaixia Zhang Zhangsen Chen Hariprasad ranganathan Shuhui Sun Zhicong Shi Institute of Batteries School of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006People’s Republic of China Énergie Matériaux Télécommunications Research Centre Institut National de La Recherche Scientifique(INRS)VarennesQuébec J3X 1P7Canada The Key Laboratory of Fuel Cell Technology of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641People’s Republic of China

Exploring highly active and stable transition metal-based bifunctional electrocatalysts has recently attracted extensive research interests for achieving high inherent activity, abundant exposed active sites, rapid mass transfer, and strong structure stability for overall water splitting. Herein, an interface engineering coupled with shell-protection strategy was applied to construct three-dimensional(3D) core-shell NixSy@MnOxHy heterostructure nanorods grown on nickel foam(NixSy@MnOxHy/NF) as a bifunctional electrocatalyst. NixSy@MnOxHy/NF was synthesized via a facile hydrothermal reaction followed by an electrodeposition process. The X-ray absorption fine structure spectra reveal that abundant Mn-S bonds connect the heterostructure interfaces of N ixSy@MnOxHy, leading to a strong electronic interaction, which improves the intrinsic activities of hydrogen evolution reaction and oxygen evolution reaction(OER). Besides, as an efficient protective shell, the MnOxHy dramatically inhibits the electrochemical corrosion of the electrocatalyst at high current densities, which remarkably enhances the stability at high potentials. Furthermore, the 3D nanorod structure not only exposes enriched active sites, but also accelerates the electrolyte diffusion and bubble desorption. Therefore, NixSy@MnOxHy/NF exhibits exceptional bifunctional activity and stability for overall water splitting, with low overpotentials of 326 and 356 mV for OER at 100 and 500 mA cm^(–2), respectively, along with high stability of 150 h at 100 mA cm^(–2). Furthermore, for overall water splitting, it presents a low cell voltage of 1.529 V at 10 mA cm^(–2), accompanied by excellent stability at 100 mA cm^(–2) for 100 h. This work sheds a light on exploring highly active and stable bifunctional electrocatalysts by the interface engineering coupled with shell-protection strategy.

关键词： Interface engineering Protective shell Manganese compound Nickel sulfides Bifunctional Water splitting

Magnesium/Lithium Hybrid Batteries Based on SnS_(2)-MoS_(2) with Reversible Conversion Reactions

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Energy Material Advances 2022年第1期2022卷 118-131页

作者： Xin Fan Mike Tebyetekerwa Yilan Wu Rohit ranganathan Gaddam Xiu Song Zhao School of Chemical Engineering The University of QueenslandSt.LuciaBrisbane 4072Australia School of Material Science and Technology North University of ChinaShanxiTaiyuan 030051China Dow Centre for Sustainable Engineering Innovation School of Chemical EngineeringThe University of QueenslandSt.LuciaBrisbane QLD 4072Australia Department of Chemical Engineering Indian Institute of Science Education and ResearchBhopalIndia

The magnesium/lithium hybrid batteries(MLHBs)featuring dendrite-less deposition with Mg anode and Li-storage cathode are a promising alternative to Li-ion batteries for large-scale energy ***,their limited energy density limits their practical *** improve this,beyond the commonly proposed intercalation compounds,high-capacity conversion-type cathodes based on heterostructures of tin sulphide-molybdenum disulphide(SnS_(2)-MoS_(2))are proposed in this *** SnS_(2) is already a promising high-capacity electrode material for multivalent batteries and undergoes conversion reactions during the ion storage *** introduction of S-deficient MoS_(2) enhances the reversibility of SnS_(2) in the conversion reaction via strong polysulfide anchoring and catalytic *** results show that the SnS_(2)-MoS_(2) electrode achieves a high charge capacity of~600 mAhg^(-1) at 50mAg^(-1) and an excellent rate capability of 240mAhg^(-1) at 1000mAhg^(-1) with a negligible capacity fading rate of 0.063%per cycle across 1000 *** results highlight a new direction toward designing 2D heterostructures as high-capacity cathodes beyond intercalation-type cathodes for multivalent-ion batteries.

关键词： electrode Reversible magnesium