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Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy

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World Journal of Gastroenterology 2012年第16期18卷 1915-1920页

作者： Khaleel R Fareed Irshad N Soomro Khalid Hameed Arvind Arora Dileep N Lobo Simon L Parsons srinivasan madhusudan Laboratory of Molecular Oncology Academic Unit of OncologySchool of Molecular Medical SciencesFaculty of Medicine and Health SciencesUniversity of Nottingham Nottingham University Hospitals Nottingham NG5 1PBUnited Kingdom Department of Pathology Nottingham University HospitalsNottingham NG5 1PBUnited Kingdom Division of Gastrointestinal Surgery Nottingham Digestive Diseases CentreNIHR Biomedical Research UnitNottingham University HospitalsNottingham NG7 2UHUnited Kingdom Department of Surgery Nottingham University HospitalsNottingham NG5 1PBUnited Kingdom

AIM:To examine cytokeratin-18(CK-18) and caspasecleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade(TRG) ***:Formalin-fixed human gastro-oesophageal cancers were constructed into tissue *** first set consisted of 122 gastric/gastro-oesophageal cancer cases not exposed to neoadjuvant chemotherapy and the second set consisted of 97 gastric/gastrooesophageal cancer cases exposed to pre-operative platinum-based *** of CK-18 and caspase-cleaved CK-18 was investigated using ***:CK18 was commonly expressed in gastrooesophageal tumours(92.6%).Fifty-six point seven percent of tumours previously exposed to neoadjuvant chemotherapy were positive for caspase-cleaved CK-18 expression compared to only 24.6% of tumours not previously exposed to neoadjuvant chemotherapy(P = 0.009).In patients who received neoadjuvant chemotherapy,caspase-cleaved cytokeratin-18 expression correlated with favourable TRG response(TRG 1,2 or 3,P = 0.043).CONCLUSION:This is the largest study to date of CK-18 and caspase-cleaved CK-18 expression in gastrooesophageal *** provide the first evidence that caspase-cleaved CK-18 predicts tumour regression with neoadjuvant chemotherapy.

关键词：细胞角蛋白蛋白酶食管癌肿瘤化疗胃癌 caspase 回归

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Treat to target in Crohn’s disease:A practical guide for clinicians

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World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： Ashish R srinivasan Department of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its *** highlights the need to describe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

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Direct recycling of Li-ion batteries from cell to pack level:Challenges and prospects on technology,scalability,sustainability,and economics

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Carbon Energy 2024年第6期6卷 1-39页

作者： Joseph Jegan Roy Do Minh Phuong Vivek Verma Richa Chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi srinivasan Energy Research Institute@NTU(ERI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore CEA CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance School of Civil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore

Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent *** primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical *** technology's advantages over traditional pyrometallurgy and hydrometallurgy are costeffectiveness,energy efficiency,and sustainability,and it preserves the material structure and morphology and can shorten the overall recycling *** review extensively discusses the advancements in the direct recycling of LIBs,including battery sorting,pretreatment processes,separation of cathode and anode materials,and regeneration and quality enhancement of electrode *** encompasses various approaches to successfully regenerate high-value electrode materials and streamlining the recovery process without compromising their electrochemical ***,we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives:(1)battery design,(2)disassembling,(3)electrode delamination,and(4)commercialization and *** on these challenges and changing market trends,a few strategies are discussed to aid direct recycling efforts,such as binders,electrolyte selection,and alternative battery designs;and recent transitions and technological advancements in the battery industry are presented.

关键词： battery design cathode regeneration direct recycling graphite recycling lithium-ion battery,scaling-up

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MXene-Based Elastomer Mimetic StretchableSensors: Design, Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshbakht Marvi Sayan Ganguly Xiaowu(Shirley)Tang Bo Wang Seshasai srinivasan Amin Reza Rajabzadeh Andreas Rosenkranz School of Biomedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth School of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in human-machine *** of the motivating factors behind the progress of flexible sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have been draw-ing attention since the last decade due to their high electronic conduc-tivity,processability,mechanical robustness and chemical *** this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor ***,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,but also their future perspective and market throughout the *** our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

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近海三角张力腿平台钢筋束假定失效研究

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哈尔滨工程大学学报（英文版） 2024年第1期23卷 182-200页

作者： srinivasan Chandrasekaran Ganta Shanmukha Rao Department of Ocean Engineering Indian Institute of TechnologyMadras 600036India

Offshore triceratops is one of the successful manifestations of the form-dominant design approaches deployable in ultra-deepwater oil and gas *** deck’s geometric shape and partial isolation from the legs counteract lateral *** are position-restrained to the sea bed by taut-moored tendons,while ball joints partially isolate the deck from the buoyant ***,compliance in the horizontal plane imposes large displacements,intuiting the necessity to examine tendon *** analysis of triceratops under wave and wind combined action is carried out under the postulated conditions of a tendon failure.10-yr,100-yr,and 1000-yr post-Katrina hurricane conditions are assumed as loading to the *** confirm a marginal increase in the natural periods of stiff degrees of freedom even under postulated failure conditions,ensuring good adaptability to ultra-deep *** postulated failure,the tension of adjacent tendons varies significantly,causing a shift to the mean position of the *** life is significantly reduced under the postulated failure of tendons,making the platform free-floating without affecting its *** also show that the pitch response of the deck is a clear manifestation of the postulated failure,which is otherwise absent due to the presence of ball *** attempted study deliberates on the fatigue life of tendons,assessing the platform’s suitability to ultra-deep waters and identifying the vulnerable legs for the chosen load combinations.

关键词： Ball joints Tendons Buoyant legs Fatigue life Irregular waves Postulated failure

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Intelligent Energy Utilization Analysis Using IUA-SMD Model Based Optimization Technique for Smart Metering Data

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 90-98页

作者： K.Rama Devi V.srinivasan G.Clara Barathi Priyadharshini J.Gokulapriya Department of Information Technology Panimalar Engineering CollegeChennaiTamil Nadu 600029India Department of Computer Applications Dayananda Sagar College of EngineeringBengaluru 560078KarnatakaIndia Department of Computer Appliations Karpagam Academy of Higher EducationCoimbatoreTamil Nadu 641021India Department of Computer Science Rathinam College of Arts and ScienceCoimbatoreTamil Nadu 641021India

Smart metering has gained considerable attention as a research focus due to its reliability and energy-efficient nature compared to traditional electromechanical metering systems. Existing methods primarily focus on data management,rather than emphasizing efficiency. Accurate prediction of electricity consumption is crucial for enabling intelligent grid operations,including resource planning and demandsupply balancing. Smart metering solutions offer users the benefits of effectively interpreting their energy utilization and optimizing costs. Motivated by this,this paper presents an Intelligent Energy Utilization Analysis using Smart Metering Data(IUA-SMD)model to determine energy consumption patterns. The proposed IUA-SMD model comprises three major processes:data Pre-processing,feature extraction,and classification,with parameter optimization. We employ the extreme learning machine(ELM)based classification approach within the IUA-SMD model to derive optimal energy utilization labels. Additionally,we apply the shell game optimization(SGO)algorithm to enhance the classification efficiency of the ELM by optimizing its parameters. The effectiveness of the IUA-SMD model is evaluated using an extensive dataset of smart metering data,and the results are analyzed in terms of accuracy and mean square error(MSE). The proposed model demonstrates superior performance,achieving a maximum accuracy of65.917% and a minimum MSE of0.096. These results highlight the potential of the IUA-SMD model for enabling efficient energy utilization through intelligent analysis of smart metering data.

关键词： electricity consumption predictive model data analytics smart metering machine learning

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Epidemiology of EGFR Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis

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Advances in Lung Cancer 2024年第1期13卷 1-21页

作者： Ankita Jain Kumar Prabhash Venkatraman Radhakrishnan Shashank srinivasan Pfizer Products India Private Limited Mumbai India Tata Memorial Hospital Mumbai India Cancer Institute (W.I.A.) Chennai India

Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.

关键词： Epidemiology Epidermal Growth Factor Receptor Adenocarcinoma Non-Small Cell Lung Cancer India

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Optimizing Spatial Pattern Analysis in Serial Remote Sensing Images through Empirical Mode Decomposition and Ant Colony Optimization

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 52-60页

作者： J srinivasan S Uma Saleem Raja Abdul Samad Jayabrabu Ramakrishnan Department of Computer Applications Madanapalle Institute of Technology&Science(MITS)Madanapalle 517325Andhra PradeshIndia Department of Information Technology Panimalar Engineering CollegeChennai 600123India Information Technology Department College of Computing and Information SciencesUniversity of Technology and Applied Sciences-Shinas 324Sultanate of Oman Department of Information Technology and Security College of Computer Science and Information TechnologyJazan UniversityJazan 45142Kingdom of Saudi Arabia

Serial remote sensing images offer a valuable means of tracking the evolutionary changes and growth of a specific geographical area over *** the original images may provide limited insights,they harbor considerable potential for identifying clusters and *** aggregation of these serial remote sensing images(SRSI)becomes increasingly viable as distinct patterns emerge in diverse scenarios,such as suburbanization,the expansion of native flora,and agricultural *** a novel approach,we propose an innovative method for extracting sequential patterns by combining Ant Colony Optimization(ACD)and Empirical Mode Decomposition(EMD).This integration of the newly developed EMD and ACO techniques proves remarkably effective in identifying the most significant characteristic features within serial remote sensing images,guided by specific *** findings highlight a substantial improvement in the efficiency of sequential pattern mining through the application of this unique hybrid method,seamlessly integrating EMD and ACO for feature *** study exposes the potential of our innovative methodology,particularly in the realms of urbanization,native vegetation expansion,and agricultural activities.

关键词： spatial pattern analysis EMD ACO

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Strength Characteristics of Treated Soil with Proposed Layer Formation

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 117-135页

作者： N Sivakumar A Mandal srinivasan venkatraman Department of Civil Engineering Visvesvaraya National Institute of TechnologyNagpur-440010India

The engineering characteristics of the soil,soil-fly ash and fly ash-lime,were examined to utilize as base layer material in civil *** influence of fly ash percentage and the effect of curing on California bearing ratio(CBR)and unconfined compressive strength(UCS),of soil and soil-fly ash mixing and layered system were examined to estimate the optimum *** volumetric swelling of the optimal mixture was estimated to be within the allowable *** microscope analysis and X-ray diffraction tests were performed.A model test analyses with three layers were conducted by finite element method and stress-strain behavior was observed.

关键词： Scanning electron microscopy simulation sustainable materials waste reduction X-ray diffraction

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Secured Vehicle Life Cycle Tracking Using Blockchain and Smart Contract

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Computer Systems Science & Engineering 2022年第4期41卷 1-18页

作者： srinivasan Ananthanarayanan Bragadeesh Arumugam Umamakeswari School of Computing SASTRA Deemed UniversityThanjavur613401India

Life Cycle Tracking(LCT)involves continuous monitoring and analy-sis of various activities associated with a *** crucial factor in the LCT is to ensure the validity of gathered data as numerous supply chain phases are involved and the data is assessed by multiple *** and swindling activities can be prevented if the history of the vehicles is made available to the interested *** provides a way of enforcing trustworthiness to the supply chain participants and the data associated with the various actions *** learning techniques when combined decentralized nature of blockchains can be used to develop a robust Vehicle LCT *** the proposed work,Harmonic Optimized Gradient Descent andŁukasiewicz Fuzzy(HOGD-LF)Vehicle Life Cycle Tracking in Cloud Environment is proposed and it involves three ***,the Progressive Harmonic Optimized User Registra-tion and Authentication model is designed for computationally efﬁcient registra-tion and ***,for the authentic user,the Gradient Descent Blockchain-based SVM Data Encryption model is designed with minimum CPU ***,Łukasiewicz Fuzzy Smart Contract Veriﬁcation is per-formed with encrypted data to ensure accurate and precise fraudulent activity *** experimental analysis shows that the proposed method achieves signiﬁcant performance in terms of life cycle’s prediction time,overhead,and accuracy for a different number of users.

关键词： Vehicle life cycle tracking progressive harmonic optimization blockchain gradient descent Łukasiewicz fuzzy smart contract

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