检索结果-南通市图书馆

Treat to target in Crohn’s disease:A practical guide for clinicians

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： Ashish R srinivasan Department of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its *** highlights the need to describe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术的临床应用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

江苏大学学报（医学版） 2006年第3期16卷 229-231页

作者：曹彬 Vivek Jawali Murali Chakravarthy srinivasan kolar Murali Manohar 南京市鼓楼医院心胸外科 Wockhardt Hospital&Heart institute Bangalore Karnataka 560052India

目的:探索硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术临床应用的可行性。方法:在高位胸段硬膜外麻醉下对4例术前超声心动图显示主动脉瓣或二尖瓣狭窄和(或)关闭不全,冠状动脉造影显示多支病变的患者行心脏瓣膜替换合并冠... 详细信息

目的:探索硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术临床应用的可行性。方法:在高位胸段硬膜外麻醉下对4例术前超声心动图显示主动脉瓣或二尖瓣狭窄和(或)关闭不全,冠状动脉造影显示多支病变的患者行心脏瓣膜替换合并冠状动脉搭桥手术,均无气管内插管,所有病人在手术前晚行硬膜外置管。结果:行主动脉瓣替换术3例、二尖瓣替换术1例。冠状动脉搭桥9支(2支桥3例,3支桥1例)。无手术死亡或术中转为全身麻醉病例,术后在外科监护室和病房的住院时间分别为(10.6±8.4)h和(3.5±2.3)d。结论:本组的早期经验提示硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术避免了气管内插管全身麻醉,从而避免了全身麻醉对身体的伤害。

关键词：清醒病人硬膜外麻醉心脏瓣膜替换合并冠状动脉搭桥手术

Examining dietary interventions in Crohn’s disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第34期30卷 3868-3874页

作者： Lynna Chen Ashish srinivasan Abhinav Vasudevan Department of Gastroenterology and Hepatology Eastern HealthBox Hill 3128Australia Eastern Clinical School Monash UniversityBox Hill 3128Australia

This editorial builds on the article by Shakhshir et *** conducted an overview of evidence-based dietary interventions in adults with inflammatory bowel disease(IBD).In the IBD population,there may be a role for the Mediterranean diet due to its anti-inflammatory effects,long-term sustainability,and role in improving cardiovascular *** active Crohn’s disease,the use of exclusive enteral nutrition,the Crohn’s disease exclusion diet,or the specific carbohydrate diet may be used as a short-term adjunct to medical therapy and may improve mucosal *** low-FODMAP diet can assist in reducing symptoms for patients without evidence of active bowel *** interest in nutritional therapy increases amongst clinicians and patients alike,it is integral that dietary therapies are understood and discussed in routine management of patients with IBD as part of holistic care,ideally through a multidisciplinary setting with involvement of experienced *** serves to improve clinician-patient engagement and reduce complications of IBD including micro and micronutrient deficiencies.

关键词： Inflammatory bowel disease Nutrition Dietary therapies Inflammation Malnutrition

Synthesis and molecular docking of pyrimidine derivatives as antibacterial agents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Resources Conversion 2024年第3期7卷 32-40页

作者： Karthikeyan Elumalai Anandakumar Shanmugam Mahalakshmi Devaraji Sivaneswari srinivasan Department of Pharmaceutical Chemistry Saveetha Institute of Medical and Technical SciencesChennai-602105Tamil NaduIndia Department of Microbiology Dr.ALM Post Graduate Institute of Basic Medical SciencesUniversity of MadrasChennai-600010Tamil NaduIndia Department of Pharmaceutics KK College of PharmacyGerugambakkamChennai-600116India

In this study,we aimed to synthesise and evaluate the antimicrobial activity of sulphanilamide-condensed pyrimidine *** compounds were synthesised using a one-pot,three-component *** structures of the synthesised compounds were confirmed using spectroscopic techniques such as FT-IR,1H NMR,mass spectrometry,and elemental *** antibacterial activity of all the synthesised compounds was tested against Escherichia coli(***)and Bacillus subtilis(***),two types of Gram-positive *** thiamine-pyrophosphate riboswitch *** and the purine riboswitch *** were chosen as targets to determine how compounds bind to *** molecular docking data showed that compound 6f bound well and had the lowest binding energy in the active site areas of both *** was in line with the tests done in *** majority of the compounds have been demonstrated to be antibacterial.

关键词： Pyrimidine derivative Compounds Binding energy Active site Antibacterial activity

避免气管内插管硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术的临床应用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

避免气管内插管硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉...

Direct recycling of Li-ion batteries from cell to pack level:Challenges and prospects on technology,scalability,sustainability,and economics

第八届华东六省一市胸心血管外科学术会议

作者：曹彬 Vivek Jawali Murali Chakravarthy srinivasan kolar Murali Manohar 南京市鼓楼医院心胸外科 Wockhardt hospital & Heart institute Bangalore KarnatakaIndia

目的:探索硬膜外麻醉下清病人的心脏瓣膜替换合并冠状动脉搭桥手术临床应用的可行性。方法:2004年8月-10月在高位胸段硬膜外麻醉下对4例,女1例,男3例,平均年龄65±3．8岁。术前超声心动图显示主动脉瓣或二尖瓣狭窄和／或关闭不全。冠状...

目的:探索硬膜外麻醉下清病人的心脏瓣膜替换合并冠状动脉搭桥手术临床应用的可行性。方法:2004年8月-10月在高位胸段硬膜外麻醉下对4例,女1例,男3例,平均年龄65±3．8岁。术前超声心动图显示主动脉瓣或二尖瓣狭窄和／或关闭不全。冠状动脉造影显示多支病变。行心脏瓣膜替换合并冠状动脉搭桥手术,均无气管内插管,所有病人在手术前晚行硬膜外置管。结果:行主

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Carbon Energy 2024年第6期6卷 1-39页

作者： Joseph Jegan Roy Do Minh Phuong Vivek Verma Richa Chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi srinivasan Energy Research Institute@NTU(ERI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore CEA CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance School of Civil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore

Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent *** primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical *** technology's advantages over traditional pyrometallurgy and hydrometallurgy are costeffectiveness,energy efficiency,and sustainability,and it preserves the material structure and morphology and can shorten the overall recycling *** review extensively discusses the advancements in the direct recycling of LIBs,including battery sorting,pretreatment processes,separation of cathode and anode materials,and regeneration and quality enhancement of electrode *** encompasses various approaches to successfully regenerate high-value electrode materials and streamlining the recovery process without compromising their electrochemical ***,we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives:(1)battery design,(2)disassembling,(3)electrode delamination,and(4)commercialization and *** on these challenges and changing market trends,a few strategies are discussed to aid direct recycling efforts,such as binders,electrolyte selection,and alternative battery designs;and recent transitions and technological advancements in the battery industry are presented.

关键词： battery design cathode regeneration direct recycling graphite recycling lithium-ion battery,scaling-up

MXene-Based Elastomer Mimetic StretchableSensors: Design, Properties, and Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshbakht Marvi Sayan Ganguly Xiaowu(Shirley)Tang Bo Wang Seshasai srinivasan Amin Reza Rajabzadeh Andreas Rosenkranz School of Biomedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth School of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in human-machine *** of the motivating factors behind the progress of flexible sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have been draw-ing attention since the last decade due to their high electronic conduc-tivity,processability,mechanical robustness and chemical *** this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor ***,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,but also their future perspective and market throughout the *** our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

Optimizing Spatial Pattern Analysis in Serial Remote Sensing Images through Empirical Mode Decomposition and Ant Colony Optimization

在线全文

学校读者我要写书评

暂无评论

Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 52-60页

作者： J srinivasan S Uma Saleem Raja Abdul Samad Jayabrabu Ramakrishnan Department of Computer Applications Madanapalle Institute of Technology&Science(MITS)Madanapalle 517325Andhra PradeshIndia Department of Information Technology Panimalar Engineering CollegeChennai 600123India Information Technology Department College of Computing and Information SciencesUniversity of Technology and Applied Sciences-Shinas 324Sultanate of Oman Department of Information Technology and Security College of Computer Science and Information TechnologyJazan UniversityJazan 45142Kingdom of Saudi Arabia

Serial remote sensing images offer a valuable means of tracking the evolutionary changes and growth of a specific geographical area over *** the original images may provide limited insights,they harbor considerable potential for identifying clusters and *** aggregation of these serial remote sensing images(SRSI)becomes increasingly viable as distinct patterns emerge in diverse scenarios,such as suburbanization,the expansion of native flora,and agricultural *** a novel approach,we propose an innovative method for extracting sequential patterns by combining Ant Colony Optimization(ACD)and Empirical Mode Decomposition(EMD).This integration of the newly developed EMD and ACO techniques proves remarkably effective in identifying the most significant characteristic features within serial remote sensing images,guided by specific *** findings highlight a substantial improvement in the efficiency of sequential pattern mining through the application of this unique hybrid method,seamlessly integrating EMD and ACO for feature *** study exposes the potential of our innovative methodology,particularly in the realms of urbanization,native vegetation expansion,and agricultural activities.

关键词： spatial pattern analysis EMD ACO

在线全文

学校读者我要写书评

暂无评论

近海三角张力腿平台钢筋束假定失效研究

哈尔滨工程大学学报（英文版） 2024年第1期23卷 182-200页

作者： srinivasan Chandrasekaran Ganta Shanmukha Rao Department of Ocean Engineering Indian Institute of TechnologyMadras 600036India

Offshore triceratops is one of the successful manifestations of the form-dominant design approaches deployable in ultra-deepwater oil and gas *** deck’s geometric shape and partial isolation from the legs counteract lateral *** are position-restrained to the sea bed by taut-moored tendons,while ball joints partially isolate the deck from the buoyant ***,compliance in the horizontal plane imposes large displacements,intuiting the necessity to examine tendon *** analysis of triceratops under wave and wind combined action is carried out under the postulated conditions of a tendon failure.10-yr,100-yr,and 1000-yr post-Katrina hurricane conditions are assumed as loading to the *** confirm a marginal increase in the natural periods of stiff degrees of freedom even under postulated failure conditions,ensuring good adaptability to ultra-deep *** postulated failure,the tension of adjacent tendons varies significantly,causing a shift to the mean position of the *** life is significantly reduced under the postulated failure of tendons,making the platform free-floating without affecting its *** also show that the pitch response of the deck is a clear manifestation of the postulated failure,which is otherwise absent due to the presence of ball *** attempted study deliberates on the fatigue life of tendons,assessing the platform’s suitability to ultra-deep waters and identifying the vulnerable legs for the chosen load combinations.

关键词： Ball joints Tendons Buoyant legs Fatigue life Irregular waves Postulated failure