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Sympathetic skin response: simple test for evaluation of autonomic function in patients with diabetes mellitus?

Chinese Medical Journal 2005年第1期118卷 83-83页

作者： srinivasa jayachandra Maxim Pinto Urban J A D'Souza Monash Univ Dept Med Biosci Petaling Jaya 46150 Malaysia Wipro Technol Bangalore Karnataka India Univ Sains Malaysia Sch Med Sci Dept Physiol Kubang Kerian 16150 Malaysia

To the Editor: We read with interest the excellent article by Huang YN et al.1 This important and carefully conducted study illustrates the sympathetic skin response (SSR) test can detect early dysfunction of the smal... 详细信息

关键词： Diabetic Neuropathies Humans Skin Sympathetic Nervous System

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Fitness Sharing Chaotic Particle Swarm Optimization (FSCPSO): A Metaheuristic Approach for Allocating Dynamic Virtual Machine (VM) in Fog Computing Architecture

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Computers, Materials & Continua 2024年第8期80卷 2557-2578页

作者： Prasanna Kumar Kannughatta Ranganna Siddesh Gaddadevara Matt Chin-Ling Chen Ananda Babu jayachandra Yong-Yuan Deng Department of Computer Science&Engineering Ramaiah Institute of TechnologyBangalore560054India Department of Artificial Intelligence&Data Science Ramaiah Institute of TechnologyBangalore560054India School of Information Engineering Changchun Sci-Tech UniversityChangchun130600China Department of Computer Science and Information Engineering Chaoyang University of TechnologyTaichung41349Taiwan Department of Information Science and Engineering Malnad College of EngineeringHassan573202India

In recent decades,fog computing has played a vital role in executing parallel computational tasks,specifically,scientific workflow *** cloud data centers,fog computing takes more time to run workflow ***,it is essential to develop effective models for Virtual Machine(VM)allocation and task scheduling in fog computing *** task scheduling,VM migration,and allocation,altogether optimize the use of computational resources across different fog *** process ensures that the tasks are executed with minimal energy consumption,which reduces the chances of resource *** this manuscript,the proposed framework comprises two phases:(i)effective task scheduling using a fractional selectivity approach and(ii)VM allocation by proposing an algorithm by the name of Fitness Sharing Chaotic Particle Swarm Optimization(FSCPSO).The proposed FSCPSO algorithm integrates the concepts of chaos theory and fitness sharing that effectively balance both global exploration and local *** balance enables the use of a wide range of solutions that leads to minimal total cost and makespan,in comparison to other traditional optimization *** FSCPSO algorithm’s performance is analyzed using six evaluation measures namely,Load Balancing Level(LBL),Average Resource Utilization(ARU),total cost,makespan,energy consumption,and response *** relation to the conventional optimization algorithms,the FSCPSO algorithm achieves a higher LBL of 39.12%,ARU of 58.15%,a minimal total cost of 1175,and a makespan of 85.87 ms,particularly when evaluated for 50 tasks.

关键词： Fog computing fractional selectivity approach particle swarm optimization algorithm task scheduling virtual machine allocation

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Comparative Study of Antioxidant and Catalytic Activity of Silver and Gold Nanoparticles Synthesized From Costus pictus Leaf Extract

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Journal of Materials Science & Technology 2015年第10期31卷 986-994页

作者： jayachandra Reddy Nakkala Ekta Bhagat Kitlangki Suchiang Sudha Rani Sadras Department of Biochemistry and Molecular Biology School of Life SciencesPondicherry University

Biological synthesis of silver and gold nanoparticles using Costus pictus leaf extract （CPLE） and their potential in vitro antioxidant and catalytic activities were reported here. Formation of Costus pictus silver （CPAgNPs） and gold （CPAuNPs） nanoparticles was confirmed by UV-visible spectroscopy and their spherical shape by scanning electron microscopy. The synthesized nanoparticles gave strong signals for silver and gold in energy dispersive X-ray spectroscopy. The CPAgNPs and CPAuNPs had an average size of 46.7 and 37.2 nm, respectively, as determined by dynamic light scattering particle size analyzer. Fourier transform infrared spectroscopy （FTIR） analysis indicated involvement of amine and carbonyl groups in the formation of CPAgNPs and CPAuNPs. Thermal stability of synthesized nanoparticles was assessed by thermogravimetric analysis-differential scanning calorimetry. CPAgNPs, CPAuNPs and CPLE exhibited tremendous antioxidant activity when being assessed by various in vitro assays, and their activity was comparable to standard antioxidants. CPAgNPs, CPAuNPs and CPLE also caused degradation of dyes like methylene blue and methyl red. While CPAgNPs, CPAuNPs and CPLE caused respective 85%, 42% and 30% degradation of methylene blue, they showed less activity against methyl red. These observations signify that such green methods open up new avenues in nanobiotechnology for the synthesis of nanoparticles with extensive industrial and biomedical applications.

关键词： Costus pictusNanoparticles Antioxidants Methylene blue Methyl red

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Strategy and technology to prevent hospital-acquired infections:Lessons from SARS,Ebola,and MERS in Asia and West Africa

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Military Medical Research 2017年第4期4卷 229-235页

作者： Sanjeewa jayachandra Rajakaruna Wen-Bin Liu Yi-Bo Ding Guang-Wen Cao Department of Epidemiology Second Military Medical UniversityShanghai2oo433China

Hospital-acquired infections(HAIs) are serious problems for healthcare systems, especially in developing countries where public health infrastructure and technology for infection preventions remain undeveloped. Here, we characterized how strategy and technology could be mobilized to improve the effectiveness of infection prevention and control in hospitals during the outbreaks of Ebola, Middle East respiratory syndrome(MERS), and severe acute respiratory syndrome(SARS) in Asia and West Africa. Published literature on the hospital-borne outbreaks of SARS, Ebola, and MERS in Asia and West Africa was comprehensively reviewed. The results showed that healthcare systems and hospital management in affected healthcare facilities had poor strategies and inadequate technologies and human resources for the prevention and control of HAIs, which led to increased morbidity, mortality, and unnecessary costs. We recommend that governments worldwide enforce disaster risk management, even when no outbreaks are imminent. Quarantine and ventilation functions should be taken into consideration in architectural design of hospitals and healthcare facilities. We also recommend that health authorities invest in training healthcare workers for disease outbreak response, as their preparedness is essential to reducing disaster risk.

关键词： SARS Ebola MERS Infection control Hospital-acquired infections Strategy Technology

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Identification, Synthesis, Isolation and Spectral Characterization of Multidrug-Resistant Tuberculosis (MDR-TB) Related Substances

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Green and Sustainable Chemistry 2018年第2期8卷 190-207页

作者： Sureshbabu jayachandra Madhuresh Kumar Sethi Vipin Kumar Kaushik Vijayakrishna Ravi Saiprasad Kottolla Vikas Chandra Dev Purbita Chakraborty R & D Mylan Laboratories Ltd. Hyderabad India

Several related substances were detected at trace level in (2R)-2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl] phenoxy] methyl]imidazo[2, 1-b]oxazole drug substance by a newly developed high-performance liquid chromatography method. All related substances were characterized rapidly but some impurities were found to be intermediates. Proposed structures were further confirmed by characterization using NMR, FT-IR, and HRMS techniques. Based on the spectroscopic data;unknown related sub-stances were characterized as 1-(Methylsulfonyl)-4-[4-(trifluoromethoxy) phenoxy]piperidine;4-{4-[4-(Tri-fluoromethoxy)-phenoxy]piperidin-1-yl}phenol and 4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenyl methane sulfonate;4-Bromophenyl methane sulfonate, Ethyl 3,6-dihydro-1(2H)-pyridine carboxylate, (2S)-3-(4-Bromophenoxy)-2-hydroxy-2-methylpropyl methane sulfonate, (2S)-3-(4-Bromophenoxy)-2-methylpropane-1,2-diyldimethane-sulfonate, (2S)-2-Methyl-3-(4-{4-[4-(trifluoromethoxy) phenoxy]-piperidin-1-yl} phenoxy)-propane-1,2-diyldimethane sulfonate, (S)-3-(4-Bromophenoxy)-2-methyl-propane-1,2-diol and corresponding Enantiomer, (2R)-2-[(4-Bromo-phenoxy)methyl]-2-methyloxirane and (2R)-2-[(4-bromophenoxy)methyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole. A possible mechanism for the formation of these related substances is also proposed.

关键词： Asymmetric Synthesis Tuberculosis (TB) Human Immunodeficiency Virus (HIV) Mycobacterium tuberculosis Mycobacterium africanus Mycobacterium bovis Directly Observed Treatment Short (DOTS) High Prevalence of Multi-Drug-Resistant (MDR) and Extensively Drug Resistant (XDR)

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