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Anti-inflammatory,analgesic and antipyretic potentials of marine sponge Sigmadocia pumila

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Journal of Coastal Life Medicine 2016年第4期4卷 273-276页

作者： devaraj Isaac Dhinakaran Aaron Premnath Lipton Centre for Marine Science and Technology Manonmaniam Sundaranar UniversityRajakkamangalam 629502Kanyakumari DistrictTamil NaduIndia Marine Biotechnology Laboratory Central Marine Fisheries Research InstituteVizhinjam 695521ThiruvananthapuramKeralaIndia

Objective:To study the pharmacological properties of Sigmadocia pumila(***),a marine sponge,through in-vivo ***:The anti-inflammatory activity was determined by the carrageenan-induced rat paw edema *** analgesic activity was analyzed by tail immersion *** activity was done by using Brewer’s yeast induced hyperpyrexia ***:The anti-inflammatory activity using methanol extracts in *** at the concentrations of 100 mg/kg and 200 mg/kg,(p.o.)on rats showed significant decrease in the paw thickness at the 5th h of *** was denoted that the *** exerted more analgesic *** for the antipyretic activity during the 2nd and 3rd h,the 3rd and 4th group of rats showed the reduction in temperature in *** at 100 mg/kg and 200 mg/kg ***:The present study concludes that the marine sponge *** acts as a vital role in exhibiting pharmaceutical *** could be used to produce novel drugs.

关键词： Sigmadocia pumila Anti-inflammatory Analgesic Antipyretic

Plant derived antioxidants and antifibrotic drugs:past,present and future

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Journal of Coastal Life Medicine 2014年第9期 738-745页

作者： devaraj Ezhilarasan Etienne Sokal Sivanesan Karthikeyan Mustapha Najimi Institut de Recherche Expérimentale et Clinique Laboratory of Pediatric Hepatology and Cell TherapyUniversitéCatholique de LouvainBrusselsBelgium Department of Pharmacology and Environmental Toxicology Food and Hepatotoxicology LaboratoryDr.ALM Post Graduate Institute of Basic Medical SciencesUniversity of MadrasChennaiIndia

Hepatic fibrosis occurs as a wound-healing process after several forms of chronic hepatic *** and proliferation of hepatic stellate cells play pivotal role in the pathogenesis of hepatic *** researchers,from the therapeutic perspective,have focused their attention on searching for novel agents with inhibitory effects on hepatic stellate cells proliferation and activation to prevent hepatic fibrogenesis and a number of plant derived antioxidants have been tested as anti-fibrogenic agents,they generally suppress proliferation and collagen *** remain an imperative source of novel drugs,novel drug leads and new chemical *** plant based drug discovery resulted primarily in the development of antioxidant,anti-cancer and other anti-infectious agents and continues to contribute to the new leads in clinical *** review summarizes some of those most important plant derived anti-fibrotic drugs and their beneficial effects on experimentally induced hepatic fibrosis in vitro and in *** plant derived antioxidant compounds described herein are curcumin,silymarin,silibinin,baicalein,resveratrol,salvianolic acids,tetrandine,quercetin and *** from ours and as demonstrated by pervious workers much information has been accumulated over the past two decades through in vivo and in *** light of those studies,it has been confirmed that plants derived antioxidants,particularly flavanoids,show a significant influence to block hepatic fibrosis regardless of any *** review outlines recent progress in the use of plant derived drugs against experimentally induced liver fibrosis by in vitro and in vivo studies and summarizes the possible mechanisms anti-fibrotic effects of these compounds.

关键词： Curcumin Hepatic stellate cells Hepatic fibrosis Antioxidant Silibinin

Proteomic profiling of various human dental stem cells-a systematic review

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World Journal of Stem Cells 2020年第10期12卷 1214-1236页

作者： Jagadish Hosmani Khalil Assiri Hussain Mohammed Almubarak Master Luqman Mannakandath Ahmed Al-Hakami Shankargouda Patil Deepa Babji Sachin Sarode Anantharam devaraj Harish C Chandramoorthy Diagnostic Dental Sciences College of DentistryKing Khalid UniversityAbha 61471AsirSaudi Arabia Diagnostic Dental Sciences King Khalid UniversityAbha 61471AsirSaudi Arabia Center for Stem Cell Research and Department of Microbiology and Clinical Parasitology King Khalid UniversityAbha 61421AsirSaudi Arabia Maxillofacial Surgery and Diagnostic Sciences Division of oral PathologyJazan 45142JazanSaudi Arabia Department of Oral Pathology and Microbiology Maratha Mandal's NG Halgekar Institute of Dental Sciences and Research CentreBelgaun 590010KarnatakaIndia Department of Oral Pathology Y Patil Dental College and HospitalPune 411018MaharashtraIndia

BACKGROUND The proteomic signature or profile best describes the functional component of a cell during its routine metabolic and survival *** complexity in differentiation and maturation is observed in stem/progenitor *** role of functional proteins at the cellular level has long been attributed to anatomical niches,and stem cells do not deflect from this *** dental stem cells(hDSCs),on the whole,are a combination of mesenchymal and epithelial coordinates observed throughout craniofacial bones to *** To specify the proteomic profile and compare each type of hDSC with other mesenchymal stem cells(MSCs)of various ***,we analyzed the characteristics of the microenvironment and preconditioning changes associated with the proteomic profile of hDSCs and their influence on committed lineage *** Literature searches were performed in PubMed,EMBASE,Scopus,and Web of Science databases,from January 1990 to December *** extra inquiry of the grey literature was completed on Google Scholar,ProQuest,and *** MeSH terms(PubMed)and keywords related to dental stem cells were used independently and in *** The initial search resulted in 134 *** the 134 full-texts assessed,96 articles were excluded and 38 articles that met the eligibility criteria were *** overall assessment of hDSCs and other MSCs suggests that differences in the proteomic profile can be due to stem cellular complexity acquired from varied tissue sources during embryonic ***,our comparison of the proteomic profile suffered inconsistencies due to the heterogeneity of various *** believe that the existence of a heterogeneous population of stem cells at a given niche determines the modalities of regeneration or tissue *** prominences to the differences present between various hDSCs have been reasoned *** Systematic review on proteomic studies of various hDS

关键词： Apical papilla stem cells Dental follicle stem cells Dental pulp stem cells Periodontal ligament stem cells Proteomics

α—生育酚+硒与多种抗氧化剂抑制血浆、LDL及全身氧化作用的比较

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α—生育酚+硒与多种抗氧化剂抑制血浆、LDL及全身氧化作用的比较

Determination of the major geochemical processes of groundwater along the Cretaceous-Tertiary boundary of Trichinopoly,Tamilnadu,India

第二届中日维生素国际学术研讨会

作者： MarangonK devaraj S.Jialall 临床生化及人体新陈代谢研究小组德克萨斯大学达拉斯西南医学研究中心病理学系临床生化及人体新陈代谢研究小组德克萨斯大学达拉斯西南医学研究中心病理学系临床生化及人体新陈代谢研究小组德克萨斯大学达拉斯西南医学研究中心病理学系

＜正＞有实验证明氧化了的LDL可以导致动脉粥样化;动物实验已证实,象α-生育酚（AT）和类胡萝卜素等抗氧化剂可以降低LDL的氧化作用,减缓动脉粥样硬化的恶化.每种抗氧化剂抑制LDL氧化的作用已有报道,但对于含有多种抗氧化物的复合补充剂...

＜正＞有实验证明氧化了的LDL可以导致动脉粥样化;动物实验已证实,象α-生育酚（AT）和类胡萝卜素等抗氧化剂可以降低LDL的氧化作用,减缓动脉粥样硬化的恶化.每种抗氧化剂抑制LDL氧化的作用已有报道,但对于含有多种抗氧化物的复合补充剂和AT之间的比较实验数据较少.因此,本实验就着眼于AT+硒补充剂与复合的微量营养

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Acta Geochimica 2020年第5期39卷 760-781页

作者： N.devaraj S.Chidambaram U.Vasudevan K.Pradeep M.Nepolian M.V.Prasanna V.S.Adithya R.Thilagavathi C.Thivya Banajarani Panda Department of Earth Sciences Annamalai UniversityChidambaramTamilnadu 608002India Water Research Centre Kuwait Institute for Scientific ResearchKuwait CityKuwait Department of Applied Geology Faculty of Engineering and ScienceCurtin University Malaysia.CDT 25098009 MiriSarawakMalaysia

The hydrogeochemical variations in groundwater are mainly influenced by lithology,residence time of water in the aquifer matrix,and anthropogenic *** study was focused on the geochemical variations of groundwater in different lithological units(Archaean,Cretaceous,Tertiary,and Quaternary)by understanding the major factors governing the geochemical variations in each *** 71 groundwater samples were collected from these rock types,namely,Archaean(14),Cretaceous(37),Tertiary(11),Quaternary(9).The collected samples were measured for major ions and they were used for preparation of standard geochemical plots and ionic *** analysis and factor score were used to identify the major factors controlling the hydrochemistry and their spatial distribution in the study *** addition,geochemical model,WATEQ 4 F was used to determine the saturation condition of carbonate and sulphate minerals in the ***–Cl and mixed Ca–Na–HCO3 were the dominant hydrochemical facies irrespective of lithological *** overall interpretation of geochemical data revealed that leaching of secondary salts,weathering and ion exchange reaction along the groundwater flow path through various lithological units,and anthropogenic influence from domestic sewages and agricultural activities constitute the major geochemical processes in the study ***,this study brings out the multiple hydrogeochemical process in the complex geological terrain along the Cretaceous-Tertiary boundary.

关键词： Groundwater Geochemical process Major ions Correlation Factor analysis

Toxicological effects of ammonia on gills of Cyprinus carpio ***(Linn.)

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Journal of Coastal Life Medicine 2014年第2期2卷 94-98页

作者： Senthamilselvan devaraj Chezhian Arulprakasam Arul Pandian Kandhan Kabilan Neelamegam Rajalakshmi Kalaiselvan Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai-608502Tamil NaduIndia

Objective:To monitor the response of gills of Cyprinus carpio var. communis to LC_(50) levels of ammonia over a period of 96 h by bath exposure, using scanning electron microscopy (SEM). Methods: Cyprinus carpio procured from a local fish farm in Vadalore, Cuddalore District, Tamil Nadu, India were acclimatized under laboratory conditions for 20 d. Fish were placed into experimental tanks with 20 L of water and 22 mg/L ammonia. A total of 10 fish were collected from each experimental tank every 24 h for histopathological studies. Results:Histopathological studies showed these changes in the gills:secondary lamellar fusion, haemorrhage, oedema, epithelial hyperplasia, and chloride cell proliferation. Occasionally, multifocal necrosis of inter-lamellar regions of gill filaments but with no apparent haemorrhage was observed under electron microscopy. Conclusion:The present study shows that histopathological and ultrastructural alterations in gills are useful indicators for ammonia toxicity in Cyprinus carpio.

关键词： Ammonia toxicity Gill histology scanning electron microscopy Cyprinus carpio

Slurry Erosive Wear Behavior of Plasma Sprayed Inconel-718 Coatings on Al6061 Alloy

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Journal of Minerals and Materials Characterization and Engineering 2011年第5期10卷 445-453页

作者： C.S. Ramesh Suresh Kumar D.S. devaraj R. Keshavamurthy Department of Mechanical Engineering PES Institute of Technology Bangalore KarnatakaIndia Department of Mechanical Engineering SBMJCE Ramanagaram District. Karnataka India

Plasma Sprayed coatings provide protection against corrosion, erosion and wear. Inconel- 718 is a metallic coating which has good wear and erosion resistance. This is plasma sprayed on to Al6061 substrate and then subjected to slurry erosive wear tests. It is observed that the slurry wear rates of Al6061 decreased on coating the substrate material with Inconel- 718.

关键词： Plasma spray Inconel- 718 Al6061 Erosion.

使用体积法确定肺小结节生长：一项“跨时间一致性”CT研究结果，并对当前结节管理指南具有启示意义

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国际医学放射学杂志 2022年第3期 367-367页

作者： E.C.Bartlett S.V.Kemp B.Rawal A.devaraj 刘柱娜

摘要目的容积CT扫描肺结节体积的增加可能代表结节真实的生长或测量变化。在结节指南中，经常使用结节体积增加25%来确定其已经生长，这是基于肺转移性结节的重

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Impact of technology on indications and limitations for transanal surgical removal of rectal neoplasms

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World Journal of Surgical Procedures 2015年第1期5卷 1-13页

作者： Bikash devaraj Andreas M Kaiser Department of Colorectal Surgery Keck School of MedicineUniversity of Southern California

Transanal surgery has and continues to be well accepted for local excision of benign rectal disease not amenable to endoscopic resection. More recently, there has been increasing interest in applying transanal surgery to local resection of early malignant disease. In addition, some groups have started utilizing a transanal route in order to accomplish total mesorectal excision(TME) for more advanced rectal malignancies. We aim to review the role of various transanal and endoscopic techniquesin the local resection of benign and malignant rectal disease based on published trial data. Preliminary data on the use of transanal platforms to accomplish TME will also be highlighted. For endoscopically unresectable rectal adenomas, transanal surgery remains a widely accepted method with minimal morbidity that avoids the downsides of a major abdomino-pelvic operation. Transanal endoscopic microsurgery and transanal minimally invasive surgery offer improved visualization and magnification, allowing for finer and more precise dissection of more proximal and larger rectal lesions without compromising patient outcome. Some studies have demonstrated efficacy in utilizing transanal platforms in the surgical management of early rectal malignancies in selected patients. There is an overall higher recurrence rate with transanal surgery with the concern that neither chemoradiation nor salvage surgery may compensate for previous approach and correct the inferior outcome. Application of transanal platforms to accomplish transanal TME in a natural orifice fashion are still in their infancy and currently should be considered experimental. The current data demonstrate that transanal surgery remains an excellent option in the surgical management of benign rectal disease. However, care should be used when selecting patients with malignant disease. The application of transanal platforms continues to evolve. While the new uses of transanal platforms in TME for more advanced rectal malignancy ar

关键词： Transanal surgery Transanal endoscopic microsurgery Endoscopic mucosal resection Transanal total mesorectal excision Transanal minimally invasive surgery Robotic transanal surgery Local excision rectal neoplasms