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Effectivity and efficacy probiotics for Bacterial Vaginosis treatments:Meta-analysis

Infectious Disease Modelling 2022年第4期7卷 597-604页

作者： sri adila nurainiwati Mochammad Ma'roef Dwi Nurwulan Pravitasari Probo Yudha Pratama Putra Department Dermatology and Venereology Medical Faculty University of Muhammadiyah MalangMalangIndonesia Department Obstetric and Gynecology Medical FacultyUniversity of Muhammadiyah MalangMalangIndonesia Medical Faculty University of Muhammadiyah Malang MalangIndonesia

Introduction:Bacterial Vaginosis(BV)is the most common cause of vaginal ***,in some cases,side effects and resistance rates have been reported when anti-biotics are *** problem has prompted several investigations on the administration of probiotics as an adjunct therapy to treat this ***:This study aims to conduct a meta-analysis based on evidence to determine the efficacy and safety of probiotic and antibiotic ***:The meta-analysis was performed using PRISMA *** literature review was conducted in December 2020 using PubMed,Science Direct,Cochrane Library,and RevMan ***:The results showed a high and significant cure rate from the analysis of 1006 and 528 samples of probiotics and non-probiotics or control in 16 *** recurrence rate was statistically significant with probiotic ***,neither procedures nor therapy failure showed a significantly lower adverse event rate than the control ***:Probiotic shows better results compared to the control ***,both have the same occurrence of adverse event.

关键词： Antibiotics Bacterial Vaginosis Probiotics

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Efficacy,effectiveness,and safety of combination laser and tranexamic acid treatment for melasma:A meta-analysis

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第3期5卷 154-158页

作者： Arika Latashia Adelia sri adila nurainiwati Probo Yudha Pratama Putra Aulia Sita Hapsari Medical Faculty University of BrawijayaMalang 65145East JavaIndonesia Department of Dermatology and Venereology Medical FacultyUniversity of Muhammadiyah MalangMalang 65144East JavaIndonesia Medical Faculty University of Muhammadiyah MalangMalang 65144East JavaIndonesia

Background: Melasma is an acquired pigmentation condition characterized by its refractory nature and a high risk of recurrence. Treatment of melasma is challenging owing to its unclear etiology, stubborn resistance to treatment, and frequent relapses. Therefore, this study aimed to compare the efficacy, effectiveness, and safety of monotherapy and combination therapy(combination of laser and tranexamic acid(TXA)) for the treatment of melasma using a network ***: The PRISMA guidelines were used in this meta-analysis, with a literature search conducted in reputable sources, such as Cochrane, Science Direct, Pub Med, and Google ***: From the initial search, 1 504 relevant studies were identified. After careful analysis, three studies were included in the meta-analysis. The results showed no significant differences in the Melasma Area and Severity Index(MASI) score between monotherapy(control group) and a combination therapy of laser and TXA. The mean difference in MASI score was 1.87(95% confidence interval(CI),-0.78–4.52;P=0.17), indicating no significant difference between the two treatment approaches. Side effects were more common in the combination treatment group than in the control group. The odds ratio for experiencing side effects was 8.85(95% CI, 1.57–50.01;P=0.01).Conclusion: Both the monotherapy and combination therapy groups showed therapeutic improvement;however,the combination therapy group showed a higher incidence of side effects.

关键词： Laser Melasma Tranexamic acid

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