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A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

Bone Research 2020年第3期8卷 356-364页

作者： Maria A.Christou Georgios ntritsos Georgios Markozannes Fotis Koskeridis spyros n.nikas David Karasik Douglas P.Kiel Evangelos Evangelou Evangelia E.ntzani Department of Hygiene and Epidemiology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrieli Faculty of Medicine Bar llan UniversitySafedIsrael Department of Epidemiology and Biostatistics Imperial College LondonLondonUK Department of Health Services Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural *** pleiotropy occurs when a single genetic element is associated with more than one *** aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association *** the discovery stage,the nHGRI-EBI Catalog was searched for genome-wide significant associations(P valueng bone-related *** was used to identify proxies of the significantly associated single nucleotide polymorphisms(SnPs)(r2=1).We then assessed putative genetic associations of this set of SnPs with femoral neck(Fn)and lumbar spine(LS)BMD data from the GEFOS *** variants were claimed at a false discovery raten-BMD andnetic markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound *** the discovery stage,72 BMD-related pleiotropic SnPs were identified,and 12 SnPs located in 11 loci on 8 chromosomes were replicated in the UK *** SnPs were associated,in addition to BMD,with 14 different *** pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological *** conclusion,12 BMD-related genome-wide significant SnPs showed pleiotropy with nonbone *** associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits.

关键词： magnesium globally Replication

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Laparoscopic cholecystectomy: A report from a single center

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World Journal of Gastroenterology 2006年第24期12卷 3887-3890页

作者： Konstantinos Vagenas Stavros n Karamanakos Charalambos Spyropoulos spyros Panagiotopoulos Menelaos Karanikolas Michalis Stavropoulos Department of Surgery School of Medicine University of PatrasRion University Hospital26500 PatrasGreece Department of Anaesthesiology and Critical Care Medicine School of Medicine University of PatrasRion University Hospital26500 PatrasGreece

AIM： To review and evaluate our experience in laparoscopic cholecystectomy. METHODS： A retrospective analysis was performed on data collected during a 13-year period （1992-2005） from 1220 patients who underwent laparoscopic cholecystectomy. RESULTS： Mortality rate was 0%. The overall morbidity rate was 5.08% （n = 62）, with the most serious complications arising from injuries to the biliary tree and the cystic artery. In 23 （1.88%） cases, cholecystectomy could not be completed laparoscopically and the operation was converted to an open procedure. Though the patients were scheduled as day-surgery cases, the average duration of hospital stay was 2.29 d, as the complicated cases with prolonged hospital stay were included in the calculation. COnCLUSIOn： Laparoscopic cholecystectomy is a safe, minimally invasive technique with favorable results for the patient.

关键词： Laparoscopy Cholecystectomy Minimallyinvasive

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Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient

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World Journal of Gastroenterology 2008年第26期14卷 4241-4244页

作者： Anastassios C Manolakis Andreas n Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos spyros P Potamianos Department of Gastroenterology University of ThessalySchool of Medicine Larissa 41447Greece

Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected.

关键词： Hemobilia Hemophilia Cholangiocarcinoma Cancer antigen 19-9 Cholangiopan-creatography

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Bacterial community in response to packaging conditions in farmed gilthead seabream

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Aquaculture and Fisheries 2023年第4期8卷 410-421页

作者： Apollon Thomas spyros J.Konteles Sotiris Ouzounis spyros Papatheodorou Aliki Tsakni Dimitra Houhoula Theofania Tsironi Department of Food Science and Technology Faculty of Food SciencesUniversity of West AtticaAthens11521Greece Medical Image and Signal Processing Laboratory Department of Biomedical EngineeringUniversity of West AtticaAthens11521Greece Laboratory of Food Process Engineering Department of Food Science and Human NutritionAgricultural University of AthensAthens11855Greece

The objective of this study was to evaluate the effect of modified atmosphere packaging(MAP)on fish skin,gills and intestines bacterial *** gilthead seabream was packed aerobically or under modified atmospheres(60%CO_(2),30%n_(2),10%O_(2))and stored isothermally at 0℃.next Generation Sequencing(nGS)analysis was applied for the characterization of fish microbiome on fish skin,gills,and intestines initially(time of packaging,1 day after harvesting)and after 10 days of isothermal storage at 0℃.nGS results indicated statistically significant differences in families’richness and diversity in the tested fish tissues between aerobic and MAP packaging during storage at 0℃.The most persistent bacteria were Proteobacteria for both packaging *** fish skin microbiota,the initially prevailing families were Comamonadaceae,Enterobacteriaceae and Moraxellaceae while in the intestines Comamonadaceae,Anaplasmataceae,Bacillaceae and Enterobacteriaceae were the dominant *** the end of storage period,the fish microbiota was dominated by psychotropic and psychrophilic families(Pseudoalteromonadaceae,Psychromonadaceae,and Shewanellaceae),while families such as Comamonadaceae were persistent under MAP *** 8 days of fish storage at 0℃,МАРsamples exhibited higher sensory scorings than the respective aerobically stored fish,indicating better retention of fish freshness and fish quality attributes under *** on the results of the study,MAP modified significantly the microbiological status and extended the shelf life of *** was a powerful tool that provided a more complete assessment compared to a culture-based analysis.

关键词： Fish Preservation next generation sequencing Modified atmosphere packaging Microbiome

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α2-Heremans-schmid glycoprotein(fetuin A)downregulation and its utility in inflammatory bowel disease

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World Journal of Gastroenterology 2017年第3期23卷 437-446页

作者： Anastassios C Manolakis Gregory Christodoulidis Andreas n Kapsoritakis Panagiotis Georgoulias Elisavet K Tiaka Kostas Oikonomou Varvara J spyros P Potamianos Department of Gastroenterology University of ThessalySchool of Medicine41110 LarissaGreece Department of Surgery University of ThessalySchool of Medicine41110 LarissaGreece Laboratory of nuclear Medicine University of ThessalySchool of Medicine41110 LarissaGreece

AIM To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein(AHSG/fetuin A) and potential associations with disease and patient *** AHSG serum levels were determined in treatment-na?ve newly-diagnosed patients, 96 with ulcerative colitis(UC), 84 with Crohn's disease (CD), 62 with diarrheapredominant or mixed irritable bowel syndrome (IBS, D- and M- types) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA).All patients were followed for a minimum period of 3 years at the Gastroenterology Department of the University Hospital of Larissa, Greece. C-reactive protein(CRP), anti-glycan antibodies, anti-Saccharomyces cerevisiae mannan antibodies Ig G, anti-mannobioside carbohydrate antibodies Ig G, anti-laminariobioside carbohydrate antibodies Ig G and anti-chitobioside carbohydrate antibodies Ig A were also determined via immunonephelometry and ELISA, *** The mean ± SE of serum AHSG, following adjustment for confounders, was 0.32 ± 0.02 g/L in IBD, 0.32 ± 0.03 g/L in CD and 0.34 ± 0.03 g/L in UC patients, significantly lower than in IBS patients(0.7 ± 0.018 g/L) and HC (0.71 ± 0.02 g/L) (P n all cases). AHSG levels were comparable between the CD and UC groups. Based on AHSG levels IBD patients could be distinguished from HC with about 90% sensitivity and specificity. Further adjusted analysis verified the inverse association between AHSG and penetrating, as well as stricturing CD (partial correlation coefficient: -0.45 and -0.33, respectively) (P ng for confounding factors, inverse correlations between AHSG and CRP and the need for anti-TnFα therapy or surgery, were found (partial correlation coefficients:-0.31,-0.33,-0.41, respectively, P n all cases). Finally, IBD individuals who were seropositive, for at least one marker, had AHSG levels falling within the two lower quartiles (OR = 2.86, 95%CI: 1.5-5.44, P < 0.001) while

关键词： Inflammatory bowel disease Irritable bowel syndrome Fetuin A

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Apalutamide for patients with metastatic castrationsensitive prostate cancer in East Asia:a subgroup analysis of the TITAn trial

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Asian Journal of Andrology 2022年第2期24卷 161-166页

作者： Byung Ha Chung Jian Huang Zhang-Qun Ye Da-Lin He Hirotsugu Uemura Gaku Arai Choung Soo Kim Yuan-Yuan Zhang Yusoke Koroki SuYeon Jeong Suneel Mundle spyros Triantos Sharon McCarthy Kim n Chi Ding-Wei Ye Department of Urology Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-roGangnam-guSeoul 135-271Korea Sun Yat-Sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Wuhan Tongji Hospital Tongji Medical CollegeWuhan 430030China First Affiliated Hospital of Xi’an Jiaotong University Xi’an 719054China Kindai University Hospital Ōsakasayama 589-8511Japan Dokkyo Medical University Saitama Medical Center Saitama 2-1-50Japan Asian Medical Center University of UlsanSeoul 138-040Korea Janssen Medical Affairs Department Beijing 100025China Janssen Medical Affairs Department Tokyo 101-0065Japan Janssen Medical Affairs Department Seoul 140-012Korea Janssen Global Medical Affairs Department HorshamPA 08869USA Janssen Research and Development Spring HousePA 19477USA Janssen Research and Development RaritanNJ 08869USA BC Cancer and Vancouver Prostate Centre VancouverBC V5Z 1G1Canada Fudan University Shanghai Cancer Center Shanghai 200032China

Ethnicity might be associated with treatment outcomes in advanced prostate *** study aimed to evaluate the efficacy and safety of androgen deprivation therapy(ADT)combined with apalutamide in East Asians with metastatic castration-sensitive prostate cancer(mCSPC).The original phase 3 Targeted Investigational Treatment Analysis of novel Anti-androgen(TITAn)trial was conducted at 260 sites in 23 *** subgroup analysis included patients enrolled in 62 participating centers in China,Japan,and *** progression-free survival(PFS),time to prostate-specific antigen(PSA)progression,and PSA changes from baseline were compared between groups in the East Asian *** intent-to-treat East Asian population included 111 and 110 participants in the apalutamide and placebo groups,*** 24-month radiographic PFS rates were 76.1%and 52.3%in the apalutamide and placebo groups,respectively(apalutamide vs placebo:hazard ratio[HR]=0.506;95%confidence interval[CI],0.302–0.849;P=0.009).Median time to PSA progression was more favorable with apalutamide than placebo(HR=0.210;95%CI,0.124–0.357;Pn maximum percentages of PSA decline from baseline were 99.0%and 73.9%in the apalutamide and placebo groups,*** most common adverse event(AE)was rash in the apalutamide group,with a higher rate than that in the placebo group(37.3%vs 9.1%).The most common grade 3 or 4 AEs were rash(12[10.9%])and hypertension(12[10.9%])for *** efficacy and safety of apalutamide in the East Asian subgroup of the TITAn trial are consistent with the global results.

关键词： apalutamide East Asia metastasis prostatic neoplasm survival

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Interferon-伪 plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B

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World Journal of Gastroenterology 2005年第37期11卷 5882-5887页

作者： Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos Department of Gastroenterology Polyclinic General Hospital Athens Greece Hepato-Gastroenterology Unit Department of Internal Medicine University of Ioannina School of Medicine Ioannina Greece Department of Gastroenterology Polyclinic General Hospital Athens Greece Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece Hepato-Gastroenterology Unit Department of Internal Medicine University of Ioannina School of Medicine Ioannina Greece 2~(nd) Department of Internal Medicine Propaedeutic Athens University Athens Greece 2~(nd) Department of Gastroenterology"Evangelismos" General Hospital Athens Greece 2~(nd) Department of Internal Medicine Propaedeutic Athens University Athens Greece

AIM： To investigate the efficacy of combination treatment of IFn-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAgnegative hepatitis B patients. METHODS： Fifty consecutive patients were randomly assigned to receive IFn-α-2b （5 MU thrice per week, n = 24） plus lamivudine （100 mg daily） or lamivudine only （n = 26） for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response （undetectable serum HBV DnA concentrations） and or sustained biochemical response （transaminase levels within normal range） at 30 mo （6 mo after the end of therapy）. Secondary end-points were timed from initial virological （biochemical） response to VBR （BBR, respectively） and the emergence of YMDD mutants across the two arms. RESULTS： Five of twenty-four （21%） patients in the combination arm vs 3/26 （12%） in the lamivudine arm had sustained response （i.e., normal serum transaminase levels and undetectable HBV DnA by PCR assay） 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receMng combination treatment （10% vs46% , P= 0.01 and 14% vs46% , P= 0.03, respectively）. Time from initial virologic response to virologic breakthrough （VBR） was greater among initial responders receiving combination treatment compared to those receiving lamivudine （22.9 mo vs 15.9 mo, respectively; P = 0.005）.COnCLUSIOn： Our results demonstrate that IFn-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However, combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development.

关键词： Interferon Lamivudine Hepatitis B Combination therapy

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The effect of high-flow oxygen via tracheostomy on respiratory pattern and diaphragmatic function in patients with prolonged mechanical ventilation:A randomized,physiological,crossover study

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Journal of Intensive Medicine 2024年第2期4卷 202-208页

作者： Elena Lytra Stelios Kokkoris Ioannis Poularas Dimitrios Filippiadis Demosthenes Cokkinos Dimitrios Exarhos spyros Zakynthinos Christina Routsi 1st Department of Intensive Care Medical SchoolNational and Kapodistrian University of AthensEvangelismos HospitalAthensGreece Radiology Department Evangelismos HospitalAthensGreece 2nd Radiology Department Medical SchoolNational and Kapodistrian University of AthensAttikon HospitalAthensGreece

Background Compared to conventional oxygen devices,high-flow oxygen treatment(HFOT)through the nasal cannulae has demonstrated clinical *** data exist on whether such effects are also present in HFOT through ***,we aimed to examine the short-term effects of HFOT through tracheostomy on diaphragmatic function and respiratory parameters in tracheostomized patients on prolonged mechanical *** A randomized,crossover,physiological study was conducted in our ICU between December 2020 and April 2021,in patients with tracheostomy and prolonged mechanical *** patients underwent a 30-min spontaneous breathing trial(SBT)and received oxygen either via T-piece or by HFOT through tracheostomy,followed by a washout period of 15-min breathing through the T-piece and receipt of 30-min oxygen with the other modality in a randomized crossover *** the start and end of each session,blood gasses,breathing frequency(f),and tidal volume(VT)via a Wright's spirometer were measured,along with diaphragm ultrasonography including diaphragm excursion and diaphragmatic thickening fraction,which expressed the inspiratory muscle *** Eleven patients were enrolled in whom 19 sessions were uneventfully completed;eight patients were studied twice on two different days with alternate sessions;and three patients were studied *** were randomly assigned to start the SBT with a T-piece(n=10 sessions)or with HFOT(n=9 sessions).With HFOT,VT and minute ventilation(VE)significantly increased during SBT(from[465±119]mL to[549±134]mL,Pnd from[12.4±4.3]L/min to[13.1±4.2]L/min,Pnot change significantly during SBT with T-piece(from[495±132]mL to[461±123]mL and from[12.8±4.4]mL to[12.0±4.4]mL,respectively);f/VT decreased during HFOT(from[64±31]breaths/(min∙L)to[49±24]breaths/(min∙L),Pnot change significantly during SBT with T-piece(from[59±28]breaths/(min∙L)to[64±33]breaths/(m

关键词： Diaphragm Diaphragm ultrasonography High-flow oxygen Prolonged mechanical ventilation Tracheostomy

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Exchange 2000与***——Microsoft的邮件服务器开始展现.net的特色

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软件 2001年第12期22卷 90-94页

作者： spyros Sakellariadis Janathan ZucK 谢合宜 Enterprise Applications Business Unit for USlnternelworking Association for Competitive Technology 台湾育荟数位科技公司

本篇文章是讨论Exchange 2000就目前技术层面的考虑,是否能成为***平台的一员。通过对***的解释,从管理人员与程序设计人员的角度来做讨论。目前Exchange 2000支持Front-End/Back-End来扩展架构,程序设计方面支持XML与WebDAV,而SOAP部... 详细信息

本篇文章是讨论Exchange 2000就目前技术层面的考虑,是否能成为***平台的一员。通过对***的解释,从管理人员与程序设计人员的角度来做讨论。目前Exchange 2000支持Front-End/Back-End来扩展架构,程序设计方面支持XML与WebDAV,而SOAP部分则可通过SOAP Toolkit for Visual Studio 6来提供支持。多方面的讨论也可让读者多了解.nET的观念。

关键词：电子邮件邮件服务器 Exchange2000 ***

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