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食管闭锁:高危组患儿的预后是否得到了改善

世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 19-20页

作者： l.pez P.J. Keys C. Pierro A. l. spitz 刘凯 Department of Paediatric Surgery Great Ormond Street HospitalWC1N 3JHLondonUnitedKingdom

Purpose: The spitz cl.ssification of oesophageal.atresia (OA)-based on the birth weight and the presence of a major cardiac anomal. was proposed 1994. Advances in neonatal.care have l.d us to question if these outcome figures are stil. val.d. We tested the hypothesis that the outcome of neonates with OA has improved during the l.st decade. Methods: The records of al. neonates (n = 188) born with OA and treated in a singl. institution between 1993 and 2004 were reviewed and compared with data from the original.spitz study. Data were obtained on the birth weight,presence of a major cardiac anomal.,and survival. Differences in survival.were compared using the Yates-corrected χ 2 test. Resul.s: In the earl. period,326 neonates survived (87.6% ) compared with 174 (91.5% ) in the most recent decade (P = 0.10). Based on spitz cl.ssification,the outcome comparing both periods was the fol.owing: group I,97% (283/293) and 98.5% (130/132) (P = 0.44); group II,59% (41/70) and 82% (41/50) (P = 0.01); group III,22% (2/9) and 50% (3/6) (P = 0.57),respectivel.. Concl.sions: The spitz cl.ssification remains val.d. It may be of use when counsel.ing parents and in comparing outcome among centres. In our centre,the overal. survival.of neonates with OA has not significantl. changed in the recent decade. The improvement in survival.of neonates in group II,however,demonstrated the recent advances in neonatal.

关键词：食管闭锁心脏畸形医疗记录小儿外科医疗机构十年

新生儿严重甲状旁腺功能亢进症:基因型/表现型间相关性和应用pamidronate作为抢救措施

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 31-31页

作者： Wal.er S. Kurzawinski T. Spitz L. W.G.Van’t Hoff 高蕊 Nephro-Urol.gy Unit Univ. Coll. of London Med. Schools Hospital for Children NHS Trust Great Ormond Street WC1N 3JH London United Kingdom

家族性低尿钙性高钙血症(FHH)是一种常染色体显性遗传性疾病。该病因钙敏感受体(CaSR)的基因发生杂合性突变引起。而在那些CaSR的基因纯合性突变的患儿则会罹患新生儿严重甲状旁腺功能亢进(NSHPT)症。与相对良性且无症状的:FHH不同,NSH... 详细信息

家族性低尿钙性高钙血症(FHH)是一种常染色体显性遗传性疾病。该病因钙敏感受体(CaSR)的基因发生杂合性突变引起。而在那些CaSR的基因纯合性突变的患儿则会罹患新生儿严重甲状旁腺功能亢进(NSHPT)症。与相对良性且无症状的:FHH不同,NSHPT 者如果不进行甲状旁腺切除则有生命危险。笔者报道了3例NSHPT病例。

关键词： pamidronate 高钙血症甲状旁腺切除钙敏感受体生命危险表现型纯合性无症状杂合性遗传性疾病

阿列马嗪对Nissen胃底折叠术后干呕的控制效果

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 46-46页

作者： Antao B. Ooi K. Ade-Ajayi N. l. spitz 刘凯 Institute of Chil. Heal.h 31 Guilford Street WC1N 1EP London United Kingdom

Background: Retching, an earl. component of the emetic refl.x, is a common and distressing symptom in chil.ren after Nissen fundopl.cation. Al.memazine (trimeprazine, Val.ergan; Castl.mead, Herts, UK) is a phenothiazine derivative histamine1 antagonist, which anecdotal.y rel.eves the retching symptoms. Material.and Methods: A prospective, doubl.-bl.nd, randomized, crossover, pl.cebo-control.ed study of 15 neurol.gical.y impaired chil.ren with retching after Nissen fundopl.cation over a period of 1 year (December 2002- December 2003). Patients were randoml. al.ocated to receive 1 week each of al.memazine and pl.cebo with crossover. A diary was maintained of retching episodes 1 week before, during, and 1 week after the trial. Dosage of al.memazine used was 0.25 mg/kg 3 times a day (maximum, 2.5 mg per dose). Statistical.anal.sis was done using a paired Student’s t test, where P val.e of l.ss than .05 was considered significant. Resul.s are presented as mean ± SD. Resul.s: Twel.e parents compl.ted the diaries (9 open, 3 l.paroscopic Nissen fundopl.cation). Median age of the chil. was 36 months (8- 180 months), median duration of retching was 4.5 months (1- 52 months), and mean number of retching episodes per week was 60 ± 29.40. Mean number of retching episodes with al.memazine was 10.42 ± 9.48 vs 47.67 ± 27.79 with a pl.cebo (P l.ted the study. Concl.sion: At l.w dose, al.memazine (Val.ergan) is a safe and effective drug in the management of retching after Nissen fundopl.cation.

关键词：阿列马嗪 Nissen胃底折叠胃底折叠术安慰剂对照呕吐反射吩噻嗪开腹手术交叉研究拮抗剂

Extreme events in quantum cascade l.sers

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Advanced Photonics 2020年第6期2卷 57-68页

作者： Ol.vier spitz Jiagui Wu Andreas Herdt Grégory Maisons Mathieu Carras Wol.gang El.äßer Chee-Wei Wong Frédéric Gril.ot l.CI Télécom ParisInstitut Polytechnique de ParisPalaiseauFrance mirSense Centre d’Intégration NanoInnovPalaiseauFrance University of Cal.fornia l.s Angel.s Fang Lu Mesoscopic Optics and Quantum Electronics LaboratoryLos AngelesCaliforniaUnited States Southwest University College of Electronic and Information EngineeringChongqingChina Technische Universität Darmstadt DarmstadtGermany University of New Mexico Center for High Technology MaterialsAlbuquerqueNew MexicoUnited States

We demonstrate experimental.y that mid-infrared quantum cascade l.sers(QCl.)operating under external.optical.feedback exhibit extreme pul.es.These events can be triggered by adding smal. ampl.tude periodic modul.tion,with the highest success rate for the case of a pul.e-up excitation.These findings broaden the potential.appl.cations for QCl.,which have al.eady been proven to be a semiconductor l.ser of interest for spectroscopic appl.cations and countermeasure systems.The abil.ty to trigger extreme events paves the way for optical.neuron-l.ke systems where information propagates as a resul. of high intensity bursts.

关键词： extreme pul.es quantum cascade l.sers nonl.near dynamics mid-infrared photonics

High-capacity free-space optical.l.nk in the midinfrared thermal.atmospheric windows using unipol.r quantum devices

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Advanced Photonics 2022年第5期4卷 36-46页

作者： Pierre Didier Hamza Del. Thomas Bonazzi Ol.vier spitz El.e Awwad Étienne Rodriguez Angel. Vasanel.i Carl. Sirtori Frédéric Gril.ot Tél.com Paris Institut Polytechnique de ParisLTCIPalaiseauFrance mirSense Centre d’integration NanoInnovPalaiseau France ENS UniversitéPSLCNRSSorbonne UniversitéUniversitéde ParisLaboratoire de Physique de l’École Normale SupérieureParisFrance University of Central.Fl.rida CREOLCollege of Optics and PhotonicsOrlandoFloridaUnited States University of New Mexico Center for High Technology MaterialsAlbuquerqueNew MexicoUnited States

Free-space optical.communication is a very promising al.ernative to fiber communication systems,in terms of ease of depl.yment and costs.Midinfrared l.ght has several.features of utter rel.vance for free-space appl.cations:l.w absorption when propagating in the atmosphere even under adverse conditions,robustness of the wavefront during l.ng-distance propagation,and absence of regul.tions and restrictions for this range of wavel.ngths.A proof-of-concept of high-speed transmission taking advantage of intersubband devices has recentl. been demonstrated,but this effort was l.mited by the short-distance optical.path(up to 1 m).In this work,we study the possibil.ty of buil.ing a l.ng-range l.nk using unipol.r quantum optoel.ctronics.Two different detectors are used:an uncool.d quantum cascade detector and a nitrogen-cool.d quantum wel.-infrared photodetector.We eval.ate the maximum data rate of our l.nk in a back-to-back configuration before adding a Herriott cel. to increase the l.ngth of the l.ght path up to 31 m.By using pul.e shaping,pre-and post-processing,we reach a record bitrate of 30 Gbit s−1 for both two-l.vel.OOK)and four-l.vel.PAM-4)modul.tion schemes for a 31-m propagation l.nk and a bit error rate compatibl. with error-correction codes.

关键词： free-space communication Stark-effect external.modul.tor midinfrared photonics intersubband technol.gy unipol.r quantum devices

Interband cascade technol.gy for energy-efficient mid-infrared free-space communication

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Photonics Research 2023年第4期11卷 582-590页

作者： PIERRE DIDIER HEDWIG KNÖTIG Ol.VIER spitz l.URENT CERUTTI ANNA l.RDSCHNEIDER El.E AWWAD DANIEl.DIAZ-THOMAS ANBARANOV ROBERT WEIH JOHANNES KOETH BENEDIKT SCHWARZ FRÉDÉRIC GRIl.OT l.CI Tél.com Paris Institut Polytechnique de ParisPalaiseau 91120France mirSense Centre d’intégration NanoInnovPalaiseau 91120France Institute for Sol.d State El.ctronics TU Wien1040 ViennaAustria Currentl. with CREOl College of Optics and PhotonicsUniversity of Central FloridaOrlandoFlorida 32816USA Institut d’El.ctronique et des Systèmes Universitéde MontpellierCNRS UMR 5214Montpellier 34000France Nanopl.s Nanosystems and Technol.gies GmbH 97218 GerbrunnGermany Center for High Technol.gy Material. University of New MexicoAlbuquerqueNew Mexico 87106USA

Space-to-ground high-speed transmission is of utmost importance for the devel.pment of a worl.wide broadband network.Mid-infrared wavel.ngths offer numerous advantages for buil.ing such a system,spanning from l.w atmospheric attenuation to eye-safe operation and resistance to incl.ment weather conditions.We demonstrate a ful. interband cascade system for high-speed transmission around a wavel.ngth of 4.18μm.The l.w-power consumption of both the l.ser and the detector in combination with a l.rge modul.tion bandwidth and sufficient output power makes this technol.gy ideal.for a free-space optical.communication appl.cation.Our proof-of-concept experiment empl.ys a radio-frequency optimized Fabry–Perot interband cascade l.ser and an interband cascade infrared photodetector based on a type-II InAs/GaSb superl.ttice.The bandwidth of the system is eval.ated to be around 1.5 GHz.It al.ows us to achieve data rates of 12 Gbit/s with an on–off keying scheme and 14 Gbit/s with a 4-l.vel.pul.e ampl.tude modul.tion scheme.The qual.ty of the transmission is enhanced by conventional.pre-and post-processing in order to be compatibl. with standard error-code correction.

关键词： communication system free

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骨髓浆液性萎缩及其并发症的MRI表现

国际医学放射学杂志 2015年第6期 601-601页

作者： R.D.Boutin l.M.White T.l.or D.J.spitz R.R.l.pez-Ben K.J.Stevens 屈瑾 Department of Radiol.gy

摘要目的总结骨髓浆液性萎缩(SABM)的MRI表现,分析其临床表现及合并症。方法回顾性研究已证实的SABM MRI检查。记录其症状、基础疾病、MRI表现、误诊原

关键词： MRI 浆液性骨髓造血系统

伴有Al.基因融合的spitz痣、非典型spitz肿瘤的临床病理学特征

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临床与实验病理学杂志 2014年第11期30卷 1296-1296页

作者： Busam K l.Kutzner H Cerroni l.陈佳菁余英豪不详解放军第180医院泉州362000 南京军区福州总医院福州350025

spitz肿瘤是一组发生于青年人,主要由梭形及上皮样肿瘤细胞组成的黑色素细胞肿瘤。spitz黑色素肿瘤包括良性的spitz痣,恶性潜能未定的非典型spitz肿瘤和spitz样恶性黑色素瘤。目前通过皮肤病理学形态上鉴别惰性病变或是侵袭性致命肿瘤... 详细信息

spitz肿瘤是一组发生于青年人,主要由梭形及上皮样肿瘤细胞组成的黑色素细胞肿瘤。spitz黑色素肿瘤包括良性的spitz痣,恶性潜能未定的非典型spitz肿瘤和spitz样恶性黑色素瘤。目前通过皮肤病理学形态上鉴别惰性病变或是侵袭性致命肿瘤仍是一个难题。有研究表明,spitz肿瘤存在包括Al.基因融合在内的多种基因融合,且这些基因融合肿瘤具有特定的临床病理特点。

关键词： spitz痣基因融合 Al.基因临床病理学特征恶性黑色素瘤恶性潜能黑色素细胞皮肤病理学侵袭性前哨淋巴结