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An axenic strain reveals the responses of Phaeodactylum tricornutum to external organic carbon

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Journal of Oceanology and Limnology 2024年第05期 1621-1633页

作者： Zhengfeng ZHU Zhichao HE Jian LI Chengxu ZHOU Yanrong LI Lin ZHANG Xiaohui LI spiros N.AGATHOS Jichang HAN College of Food and Pharmaceutical Sciences Ningbo University School of Biological and Chemical Engineering Panzhihua University Ningbo Institute of Oceanography School of Marine Life Ningbo University Earth & Life Institute Catholic University of Louvain

The model diatom Phaeodactylum tricornutum is considered a promising source of various high value bioproducts, and developing cultivation processes is crucial for its *** mixotrophy and heterotrophy have been recommended as effective strategies for microalgal cultivation, previous studies on P. tricornutum have yielded conflicting results in terms of cultivating this microalga. To verify the capacity of this microalga utilizing external organic carbon, both heterotrophic and mixotrophic cultivation with varied carbon sources were performed using an axenic strain. The results demonstrate that glycerol was the only organic carbon that substantially stimulated the growth of P. tricornutum in the presence of light. Sodium acetate(NaAc) at low concentrations could also promote growth, while at high concentrations led to severe inhibition under mixotrophic conditions. The addition of glucose imposed no appreciable impact on either cell density or biomass concentration, confirming that P. tricornutum cannot metabolize external glucose. Subsequently, a comparative analysis between mixotrophy and autotrophy was performed to reveal the influences of glycerol on the cellular metabolism based on growth performances, biochemical compositions, and chlorophyll fluorescence *** also indicate that the addition of glycerol did not have detrimental effects on the capacity of either pigments biosynthesis or photosynthesis, but enhanced the saturated fatty acids and reduced the unsaturated fatty acids.

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Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity,to curtail dependence on host tissue:molecular mode

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Cancer Biology & Medicine 2017年第3期14卷 254-270页

作者： spiros A.Vlahopoulos The First Department of Pediatrics University of AthensHoremeio Research LaboratoryAthens 11527Greece

The role of the transcription factor NF-κB in shaping the cancer microenvironment is becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF-κB function, and causes extensive changes in genomic chromatin that ultimately drastically alter cell-specific gene expression. NF-κB regulates the expression of cytokines and adhesion factors that control interactions among adjacent cells. As such, NF-κB fine tunes tissue cellular composition, as well as tissues' interactions with the immune system. Therefore, NF-κB changes the cell response to hormones and to contact with neighboring cells. Activating NF-κB confers transcriptional and phenotypic plasticity to a cell and thereby enables profound local changes in tissue function and composition. Research suggests that the regulation of NF-κB target genes is specifically altered in cancer. Such alterations occur not only due to mutations of NF-κB regulatory proteins, but also because of changes in the activity of specific proteostatic modules and metabolic pathways. This article describes the molecular mode of NF-κB regulation with a few characteristic examples of target genes.

关键词： Cytokine mucin chemokine IL-8/CXCL8 MUC1 NF-κB IL-6 TNFα

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Selection criteria for liver resection in patients with hepatocellular carcinoma and chronic liver disease

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World Journal of Gastroenterology 2008年第22期14卷 3452-3460页

作者： spiros G Delis Christos Dervenis 1st Surgical Clinic Liver Surgical Unit Kostantopouleio-Agia Olga HospitalAthens 14233 Greece

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual occurrence of one million new cases. An etiologic association between HBV infection and the development of HCC has been established with a relative risk 200-fold greater than in non-infected individuals. Hepatitis C virus is also proving an important predisposing factor for this malignancy with an incidence rate of 7% at 5 years and 14% at 10 years. The prognosis depends on tumor stage and degree of liver function, which affect the tolerance to invasive treatments. Although surgical resection is generally accepted as the treatment of choice for HCC, new treatment strategies, such as local ablative therapies, transarterial embolization and liver transplantation, have been developed nowadays. With increasing detection of small HCCs from screening programs for cirrhotic patients, it is foreseen that locoregional therapy will play an important role in the near future.

关键词： Hepatocellular carcinoma Hepatoma Resection Ablation Transplantation ICG clearance Remnant liver volume Milan criteria MELD score

Arsenic speciation in fish from Greek coastal areas

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Journal of Environmental Sciences 2017年第6期29卷 300-312页

作者： Ioanna Kalantzi Kyriaki Mylona Katerina Sofoulaki Manolis Tsapakis spiros A.Pergantis Institute of Oceanography Hellenic Centre for Marine Science(HCMR)PO Box 2214Heraklion 71003CreteGreece Environmental Chemical Processes Laboratory Department of ChemistryUniuersity of CreteHeraklion 71003CreteGreece

Arsenic speciation analysis was conducted on fish samples （sardine and anchovy） collected from six areas along the Greek coastline, i.e. Artemisium Straits, Thermaikos Gulf, Amvrakikos Gulf, Strymonian Gulf, Thracian Sea, and Elefsina Gulf. Total arsenic levels ranging from 11.8 to 62.6 mg As/kg dry weight were determined. Arsenobetaine, a non-toxic form of arsenic, was found to be the main arsenic species, present at 8.6 to 58.8 mg As/kg dry weight, accounting for 67--95% of the total arsenic. Also detected in all fish samples was dimethylarsinic acid, although at considerably lower concentrations, ranging from 0.072-3.956 mg As/kg dry weight. Monomethylarsonic acid was detected at low levels in all anchovy samples, and only in sardines from one area. Finally, inorganic arsenic in the form of arsenate was detected only in fish at one area, indicating the possible effect of an environmental parameter on its presence at detectable amounts. Statistical analysis revealed the environmental variables, such as salinity, total organic carbon and nitrogen, ammonium, phosphate, total phosphorus, dissolved oxygen and pressure index, are potentially correlated to As species concentrations. Furthermore, based on factor analysis, the biological parameters, such as fish weight, lipids, protein and ash content, that are correlated to As species concentrations of fish were also identified. The interrelationship of arsenobetaine and dimethylarsinic acid concentrations within each fish species was evaluated.

关键词： Arsenic speciationArsenobetaineDimethylarsinic acidArsenateFishEnvironmental and biologicalparameters

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Alignment calibration and performance study of the STAR PXL detector

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Nuclear Science and Techniques 2017年第2期28卷 61-69页

作者： Long Ma Xin Dong Hao Qiu spiros Margetis Yu-Gang Ma Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Purdue University West Lafayette IN 47907 USA Kent State University Kent OH 44242 USA ShanghaiTech University Shanghai 200031 China

We report in this paper the alignment calibration of the STAR pixel detector(PXL) prototype for the RHIC2013 run and performance study of the full PXL detector installed and commissioned in the RHIC 2014 run. PXL detector is the innermost two silicon layers of the STAR heavy flavor tracker aiming at high-precision reconstruction of secondary decay vertex of heavy flavor particles. To achieve the physics goals, the calibration work was done on the detector with high precision. A histogram-based method was successfully applied for the alignment calibration, and the detector efficiency after alignment was studied using both p t p collision data and cosmic ray data.

关键词： Alignment calibration Heavy flavor tracker STAR

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Technical note for intraoperative determination of proper acetabular cup size in primary total hip arthroplasty

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World Journal of Methodology 2024年第1期14卷 94-101页

作者： Panagiotis Karampinas John Vlamis Athanasios Galanis Michail Vavourakis Anastasia Krexi Evangelos Sakellariou Christos Patilas spiros Pneumaticos 3^(rd)Department of Orthopaedic Surgery National&Kapodistrian University of AthensKAT General HospitalAthens 14561Greece

BACKGROUND Selecting the optimal size of components is crucial when performing a primary total hip *** the accurate size of the acetabular component can occasionally be exacting,chiefly for surgeons with little experience,whilst the complications of imprecise acetabular sizing or over-reaming can be potentially *** To assist clinicians intraoperatively with a simple and repeatable tip in elucidating the ambivalence when determining the proper acetabular component size is not straightforwardly achieved,specifically when surgeons are inexperienced or preoperative templating is *** This method was employed in 263 operations in our department from June 2021 to December *** operations were performed by the same team of joint reconstruction surgeons,employing a typical posterior hip approach *** types of acetabular shells implanted were:The Dynasty®acetabular cup system(MicroPort Orthopedics,Shanghai,China)and the R3®acetabular system(Smith&Nephew,Watford,United Kingdom),which both feature cementless press-fit *** The mean value of all cases was calculated and collated with each *** distinguished as oversized an implanted acetabular shell when its size was>2 mm larger than the size of the acetabular size indicator reamer(ASIR)or when the implanted shell was larger than 4 mm compared to the preoperative planned *** median size of the implanted acetabular shell was 52(48–54)mm,while the median size of the preoperatively planned cup was 50(48–56)mm,and the median size of the ASIR was 52(50–54)*** correlation coefficient between ASIR size and implanted acetabular component size exhibited a high positive correlation with r=0.719(P<0.001).Contrariwise,intraoperative ASIR measurements precisely predicted the implanted cups’size or differed by only one size(2 mm)in 245 *** In our study,we demonstrated that the size of the first acetabular reamer not entering freely in the acetabular

关键词： Acetabular shell Total hip arthroplasty Hip Acetabulum Acetabular component Primary hip arthroplasty

On the electrical conductivity of alginate hydrogels

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Regenerative Biomaterials 2018年第5期5卷 293-301页

作者： Georgia Kaklamani Diana Kazaryan James Bowen Fabrice Iacovella spiros H.Anastasiadis George Deligeorgis Institute of Electronic Structure&Laser Foundation for Research&Technology HellasP.O.Box 138571110 HeraklionCreteGreece School of Engineering and Innovation The Open UniversityMilton Keynes MK76AAUK Department of Chemistry University of CreteP.O.Box 220871003 HeraklionCreteGreece

Hydrogels have been extensively used in the field of biomedical applications,offering customizable natural,synthetic or hybrid materials,particularly relevant in the field of tissue *** the bioelectronics discipline,hydrogels are promising mainly as sensing platforms with or without encapsulated cells,showing great potential in healthcare and ***,to date there is little data in the literature which characterizes the electrical properties of tissue engineering materials which are relevant to *** this work,we present electrical characterization of alginate hydrogels,a natural polysaccharide,using a four-probe method similar to electrical impedance *** acquired conductance data show distinct frequency-dependent features that change as a function of alginate and crosslinker concentration reflecting ion kinetics inside the measured ***,the presence of NIH 3T3 fibroblasts encapsulated in the hydrogels matrix was found to alter the artificial tissue’s electrical *** method used provides valuable insight to the frequency-dependent electrical response of the resulting *** is hoped that the outcome of this research will be of use in the development of cell/electronic interfaces,possibly toward diagnostic biosensors and therapeutic bioelectronics.

关键词： alginate bioelectronics conductivity hydrogel polysaccharide resistance fibroblasts

Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective

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Oncology Research 2022年第3期30卷 137-155页

作者： LOKMAN VARISLI VEYSEL TOLAN JIYAN H.CEN spiros VLAHOPOULOS OSMAN CEN Department of Molecular Biology and Genetics Science FacultyDicle UniversityDiyarbakir21280Turkey Cancer Research Center Dicle UniversityDiyarbakir21280Turkey Department of Chemical and Biomolecular Engineering University of IllinoisUrbanaIL61801USA First Department of Pediatrics National and Kapodistrian University of AthensAthens11527Greece Department of Microbiology and Immunology Feinberg School of MedicineNorthwestern UniversityChicagoIL60611USA Department of Natural Sciences and Engineering John Wood CollegeQuincyIL62305USA

Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing *** deprivation therapy has been used as a standard treatment approach for advanced prostate cancer for more than 80 *** primary aim of androgen deprivation therapy is to decrease circulatory androgen and block androgen *** a partly remediation is accomplished at the beginning of treatment,some cell populations become refractory to androgen deprivation therapy and continue to *** evidences suggest that androgen deprivation therapy may cause cadherin switching,from E-cadherin to N-cadherin,which is the hallmark of epithelial-mesenchymal *** direct and indirect mechanisms are involved in this switching and consequently,the cadherin pool changes from E-cadherin to N-cadherin in the epithelial *** E-cadherin represses invasive and migrative behaviors of the tumor cells,the loss of E-cadherin disrupts epithelial tissue structure leading to the release of tumor cells into surrounding tissues and *** this study,we review the androgen deprivation therapy-dependent cadherin switching in advanced prostate cancer with emphasis on its molecular basis especially the transcriptional factors regulated through TFG-βpathway.

关键词： Prostate cancer Androgen signaling Androgen deprivation therapy Cadherin switching

最小二乘谱及其在超导重力观测数据分析中的应用

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武汉大学学报（信息科学版） 2005年第7期30卷 613-616页

作者：尹晖 spiros D.Pagiatakis 武汉大学测绘学院武汉市珞喻路129号430079 约克大学地球与空间科学和工程系

运用投影理论和基于向量空间中最小二乘平差原理,介绍了最小二乘谱分析方法,给出了最小二乘谱的计算公式。利用加拿大超导重力观测数据实例,讨论了最小二乘谱分析的策略和步骤。

关键词：最小二乘谱超导重力仪数据分析