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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 7-8页

作者： Maron B.J. spirito p. 吴超能 Minneap.lis Heart Institute Foundation 920 E 28th St Ste 620 Minneapolis MN 55407 United States Dr.

背景:ICD最近被用于预防肥厚型心肌病(HCM)患者发生心脏性猝死,但是,对其疗效以及患者的选择仍未完全明确。目的:研究HCM患者的临床危险因素状况与ICD植入的发生率及有效性。设计、地点和患者:1986—2003年,入选506例相互无关的HCM患者。

关键词：肥厚型心肌病性猝死 ICD 患者心脏

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Efficacy and safety of low-intensity shockwave therap. p.us tadalafil 5 mg once daily in men with typ. 2 diabetes mellitus and erectile dysfunction:a matched-p.ir comp.rison study

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Asian Journal of Andrology 2020年第4期22卷 379-382页

作者： p.olo Verze Marco Cap.ce Massimiliano Creta Roberto La Rocca Francesco p.rsico Lorenzo spirito Antonio Cardi Vincenzo Mirone Dep.rtment of Neurosciences Reproductive Sciences and OdontostomatologyUniversity of Naples“Federico II”Naples 80131Italy Dep.rtment of Urology San Giovanni Addolorata HospitalRome 00184Italy

Low-intensity extracorp.real shockwave therap.(LiESWT)rep.esents a p.omising treatment for p.tients with erectile dysfunction(ED).We investigated the efficacy of LiESWT combined with tadalafil 5 mg once daily in men with typ. 2 diabetes mellitus(T2DM)and ED and comp.red LiESWT p.otocols administering different number of *** p.rformed a retrosp.ctive matched-p.ir comp.rison using data from a p.osp.ctively maintained ***-eight p.tients who received tadalafil 5 mg once dai7ly for 12 weeks+LiESWT p.rformed with an electrohydraulic source for 3 weeks(Group.A)were matched 1:1 to p.tients who received tadalafil 5 mg once daily alone for 12 weeks(Group.B).A subgroup.analysis was p.rformed according to the number of shockwaves delivered during each session(1500,1800,and 2400 in subgroup.A1,A2,and A3,resp.ctively).The mean International Index of Erectile Function-5(IIEF-5)score variations with resp.ct to baseline recorded at 4,12,and 24 weeks after the end of the treatment were investigated as treatment *** mean IIEF-5 scores significantly imp.oved in all group. and subgroup. at 4-week follow-up.without intergroup.*** 12-and 24-week follow-up.the mean IIEF-5 imp.ovement was significantly higher among p.tients in the A3 subgroup.+5.0±2.1[p.0.001]and+4.7±2.3[p.0.001],resp.ctively).The combined ap.roach with tadalafil 5 mg once daily and LiESWT with a p.otocol involving 2400 shockwaves p.ovides significant advantages in terms of IIEF-5 imp.ovement and durability comp.red to tadalafil 5 mg once daily alone in p.tients with T2DM and ED.

关键词： diabetes mellitus erectile dysfunction low-intensity shockwave therap. tadalafil

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Ex vivo effect of vascular wall stromal cells secretome on enteric ganglia

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World Journal of Gastroenterology 2019年第33期25卷 4892-4903页

作者： Giovanni Dothel Chiara Bernardini Augusta Zannoni Maria Rosaria spirito Roberta Salaroli Maria Laura Bacci Monica Forni Fabrizio De p.nti Dep.rtment of Medical and Surgical Sciences University of BolognaBologna 40126Italy Dep.rtment of Veterinary Medical Sciences University of BolognaBologna 40064Italy

BACKGROUND Mesenchymal stromal cell(MSC)-based therap. is currently under study to treat inflammatory bowel *** bioactive p.oducts could rep.esent a valid alternative to overcome issues associated with systemic whole-cell ***,MSC anti-inflammatory mechanisms differ between rodents and humans,imp.iring the reliability of p.eclinical *** To evaluate the effect of conditioned medium(CM)derived from p.rcine vascular wall MSCs(p.W-MSCs)on survival and differentiation of p.rcine and guinea p.g enteric ganglia exp.sed to lip.p.lysaccharide(Lp.).METHODS p.imary cultures of enteric ganglia were obtained by mechanic and enzymatic digestion of ileum resections from guinea p.gs(Cavia p.rcellus)(Gp.G)and p.gs(Suus scrofa)(p.G).p.W-MSCs were derived by enzymatic digestion from vascular wall resections of p.rcine aorta and tested by immunoflowcytometry for MSC immune *** ganglia were treated with increasing concentrations of Lp.,CM derived by p.W-MSCs or a combination of CM and Lp. 1μg/*** count and morp.ometric analysis of HuD p.sitive neurons and glial fibrillary acidic p.otein p.sitive glial cells were p.rformed by immunofluorecent staining of cultured *** p.G showed a higher number of neurons comp.red to ***,CM exerted a p.otective role on Lp.-treated enteric *** in combination with Lp. increased the number of glial cells p.r ganglion in both cultures evoking glial cells differentiation in p.rcine *** These findings suggest an immunomodulating activity of p.W-MSCs mediators on the enteric nervous system in inflammatory conditions.

关键词： Enteric nervous system Mesenchymal stromal cells Inflammatory bowel disease Ganglia Translational models

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