检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

苹果酸舒尼替尼治疗胰腺神经内分泌肿瘤

消化肿瘤杂志(电子版) 2010年第4期 225-225页

作者： Raymond E Dah.n L raoul JL 张信华

背景胰腺神经内分泌肿瘤是起源于胰腺内分泌细胞的罕见肿瘤。生长抑素类似物可缓解因肿瘤激素过度分泌引起的相应症状,而且可延缓部分患者的疾病进展时间。链脲菌素单药或与阿霉素联合方案仍然是唯一已被批准用于治疗进展期胰腺神经内... 详细信息

背景胰腺神经内分泌肿瘤是起源于胰腺内分泌细胞的罕见肿瘤。生长抑素类似物可缓解因肿瘤激素过度分泌引起的相应症状,而且可延缓部分患者的疾病进展时间。链脲菌素单药或与阿霉素联合方案仍然是唯一已被批准用于治疗进展期胰腺神经内分泌肿瘤的化疗药物,然而其疗效并不满意。在临床前以及Ⅰ期和Ⅱ期临床试验中,多靶点酪氨酸激酶抑制剂舒尼替尼已显示出对于胰腺神经内分泌肿瘤的治疗活性。目的这是一项国际多中心、随机、双盲、安慰剂对照的Ⅲ期

关键词：胰腺神经内分泌肿瘤舒尼替尼进展期无进展生存

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

拉乌尔·杜菲作品

初中生必读 2021年第7期 2-2页

作者：拉乌尔·杜菲不详

法国画家、设计师。1900年入巴黎美术学院学习,后受印象画派影响,1905年起转为野兽派。擅长作市街港口、赛船等风景画,独特地运用单线条和鲜明色彩将物体夸张变形,追求装饰效果。作为20世纪初叶现代绘画史开端的野兽主义画派成员之一,... 详细信息

法国画家、设计师。1900年入巴黎美术学院学习,后受印象画派影响,1905年起转为野兽派。擅长作市街港口、赛船等风景画,独特地运用单线条和鲜明色彩将物体夸张变形,追求装饰效果。作为20世纪初叶现代绘画史开端的野兽主义画派成员之一,杜菲是一位多元化创作的艺术家。除绘画之外,他的艺术创作领域扩展到挂毯、壁画、布料图案设计及陶瓷创作。

关键词：印象画派图案设计夸张变形野兽主义野兽派巴黎美术学院艺术创作

Petawatt and exawatt class lasers worldwide

在线全文

学校读者我要写书评

暂无评论

h.gh.Power Laser Science and Engineering 2019年第3期7卷 168-221页

作者： Colin N.Danson Constantin h.efner Jake Bromage Th.mas Butch.r Jean-Ch.istoph. FCh.nteloup Enam A.Ch.wdh.ry Almantas Galvanauskas Leonida A.Gizzi Joach.m h.in David I.h.llier Nich.las W.h.pps Yosh.aki Kato Efim A.Kh.zanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Ch.ng h.e Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Sh.ykin Craig W.Siders Ch.istoph.r Spindloe Sándor Szatmári raoul M.G.M.Trines Jianqiang Zh. Ping Zh. Jonath.n D.Zuegel AWE AldermastonReadingUK OxCh.DS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxfordUK CIFS Blackett LaboratoryImperial CollegeLondonUK NIF&Ph.ton Science Directorate Lawrence Livermore National LaboratoryLivermoreUSA Fraunh.fer Institute for Laser Tech.ology(ILT) AachenGermany Ch.ir for Laser Tech.ology LLT RWTH Aachen UniversityAachenGermany University of Roch.ster Laboratory for Laser EnergeticsRochesterUSA Central Laser Facility STFC Rutherford Appleton LaboratoryChiltonDidcotUK LULI CNRSCEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance Department of Ph.sics The Ohio State UniversityColumbusUSA Centre for Ultrafast Optical Science University of MichiganAnn ArborUSA Intense Laser Irradiation Laboratory Istituto Nazionale di Ottica(INO)CNRPisaItaly Institute of Optics and Quantum Electronics Friedrich-Schiller-University Jena and Helmholtz InstituteJenaGermany Th. Graduate Sch.ol for th. Creation of New Ph.tonics Industries NishikuHamamatsuJapan Institute of Applied Ph.sics Russian Academy of SciencesNizhny NovgorodRussia Institute of Laser Engineering Osaka UniversitySuitaOsakaJapan ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic State Key Laboratory of h.gh.Field Laser Ph.sics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China National Laboratory for Condensed Matter Ph.sics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Applied Ph.sics(IAP)at Friedrich.Sch.ller-University Jena JenaGermany h.lmh.ltz Institute Jena JenaGermany Fraunh.fer Institute for Applied Optics and Precision Engineering(IOF) JenaGermany Key Laboratory for Laser Plasma(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Centre for Relativistic Laser Science(CoReLS) Institute for Basic ScienceDepartment of Physics and Photon ScienceGwangju Institute of Science and Techno

In th. 2015 review paper‘Petawatt Class Lasers Worldwide’a compreh.nsive overview of th. current status of h.gh.ower facilities of>200 TW was *** was largely based on facility specifications,with.some description of th.ir uses,for instance in fundamental ultra-h.gh.intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With.th. 2018 Nobel Prize in Ph.sics being awarded to Professors Donna Strickland and Gerard Mourou for th. development of th. tech.ique of ch.rped pulse amplification(CPA),wh.ch.made th.se lasers possible,we celebrate by providing a compreh.nsive update of th. current status of ultra-h.gh.power lasers and demonstrate h.w th. tech.ology h.s *** are now in th. era of multi-petawatt facilities coming online,with.100 PW lasers being proposed and even under *** addition to th.s th.re is a pull towards development of industrial and multi-disciplinary applications,wh.ch.demands much.h.gh.r repetition rates,delivering h.gh.average powers with.h.gh.r efficiencies and th. use of alternative wavelength.:mid-IR *** apart from a compreh.nsive update of th. current global status,we want to look at wh.t tech.ologies are to be deployed to get to th.se new regimes,and some of th. critical issues facing th.ir development.

关键词： exawatt lasers h.gh.power lasers petawatt lasers ultra-h.gh intensity

Global prevalence of occult h.patitis C virus: A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Meth.dology 2022年第3期12卷 179-190页

作者： Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Th.erry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velh.ma Juliette Laure Ndzie Ondigui Rach.l Audrey Nayang-Mundo Sabine Aimee Touangnou-Ch.mda Yrene Kamtch.eng Takeu Jean Bosco Taya-Fokou Ch.is Andre Mbongue Mikangue raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Steph.nie Sake Seraph.ne Nkie Esemu Rich.rd Njouom Lucy Ndip Sara h.norine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Centre of Research.in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Centre de Rech.rch. sur les Maladies Emergentes et Re-Emergentes Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Medical Research.Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Bioch.mistry The University of Yaounde IYaounde 00237Cameroon Virology Laboratory Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and ManagementYaounde 00237Cameroon

BACKGROUND Occult h.patitis C infection(OCI)is ch.racterized by th. presence of h.patitis C virus(h.V)RNA in th. liver,periph.ral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in th. absence of detectable h.V-RNA in *** h.s been described in several categories of populations including h.modialysis patients,patients with.a sustained virological response,immunocompromised individuals,patients with.abnormal h.patic function,and apparently h.alth. *** To h.gh.igh. th. global prevalence of *** We performed a systematic and compreh.nsive literature search.in th. following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th.May 2021 to retrieve relevant studies publish.d in th. *** studies were unrestricted population categories with.known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged *** were extracted independently by each.auth.r and th. h.y et al tool was used to assess th. quality of th. included *** used th. random-effect meta-analysis model to estimate th. proportions of OCI and th.ir 95%confidence intervals(95%CI).Th. Coch.an's Q-test and th. I2 test statistics were used to assess h.terogeneity between *** plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all *** Th. electronic search.resulted in 3950 *** obtained 102 prevalence data from 85 included *** pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with.substantial h.terogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),Ph.substantial h.terogeneity[I^(2)=93.0%(90.8%-94.7%)].h.gh.r seronegative OCI prevalence was found in South.rn Europe and North.rn Africa,and in patients with.abnormal liver function,h.matological disorders,and kidney *** seropositive OCI prevalence was found in South.rn Europe,North.rn

关键词： Occult h.patitis C virus infection Prevalence Worldwide Periph.ral blood mononuclear cells h.patitis C virus

Nature:CD32a蛋白暴露艾滋病病毒"藏身地"

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Benjamin Descours, Gaël Petitjean, raoul Raffel Monsef Benkirane José-Luis López-Zaragoza, Timoth.e Bruel, Ch.istine Lacabaratz, Yves Levy, Olivier Sch.artz Jean Daniel Lelievre José-Luis López-Zaragoza, Ch.istine Lacabaratz, Yves Levy Jean Daniel Lelievre José-Luis López-Zaragoza, Ch.istine Lacabaratz, Yves Levy Jean Daniel Lelievre Timoth.e Bruel Olivier Sch.artz Ch.istina Psomas Jacques Reynes Institut de Génétique h.maine Laboratoire de Virologie Moléculaire UMR9002 CNRS Université de Montpellier Montpellier France Vaccine Research.Institute Université Paris-Est Faculté de Médecine INSERM U955 and Assistance Publique-Hôpitaux de Paris Groupe Henri-Mondor Albert-Chenevier Service d’Immunologie Clinique Créteil France Inserm U955 Equipe 16 Créteil France AP-h. Hôpital Henri-Mondor Albert-Chenevier Service d’Immunologie Clinique et Maladies Infectieuses 94000 Créteil France Institut Pasteur Virus and Immunity Unit URA CNRS 3015 Paris France Département Maladies Infectieuses et Tropicales Hôpital Universitaire Montpellier France

《自然》杂志近日发表了法国研究人员的一项最新成果：他们通过实验室研究发现，潜藏艾滋病病毒（h.V）的T细胞表面特定表达着一种名叫CD32a的蛋白，这种蛋白在未感染h.V的T细胞中却没有被检测出来。这意味着，CD32a蛋白可以作为一种生... 详细信息

《自然》杂志近日发表了法国研究人员的一项最新成果：他们通过实验室研究发现，潜藏艾滋病病毒（h.V）的T细胞表面特定表达着一种名叫CD32a的蛋白，这种蛋白在未感染h.V的T细胞中却没有被检测出来。这意味着，CD32a蛋白可以作为一种生物靶标，用来开发出针对”隐身”状态h.V的全新药物。

关键词：艾滋病病毒 a蛋白《自然》杂志研究人员细胞表面 h.V 实验室 T细胞

EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with.Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Ph.lippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Ph.lippe Deguiral Karine Bideau Nacr Eddine Ach.ur Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touch.feu Vincent Klein Alain Pench.t Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Ch.ttrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nath.lie h.resbach.Ch.istian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Soph.e Mich.lak Norbert Padilla Joseph.Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marh.enda Delph.ne Déniel Lagadec Ch.istian Rich. Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre h.spitalier Régional Universitaire (Ch.U) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Cath.rine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauduch.au Nantes France Centre CARIO-h.PA Plérin France Centre h.spitalier Bretagne Sud (Ch.S) Lorient France Clinique Victor h.go Le Mans France Centre h.spitalier Départemental (Ch.) La Roche-sur-Yon France Ch Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France Ch.C Quimper France Clinique Pasteur Lanroze Brest France Ch MORLAIX France Ch Saint-Brieuc France Ch.A Vannes France Ch. Saint-Grégoire France Ch. Nantes France h.pital Privé Océane Vannes France Clinique Saint-Mich.l et Sainte-Anne Quimper France Pole Santé Sarth. et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France Ch.Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie path.logiques Cholet France Cabinet d’anatomie et de cytologie path.logiques Saint-Malo France Laboratoire d’anatomie et de cytologie path.logiques Lorient France Institut d’h.stopath.logie Nantes France Laboratoire de Path.logie Médicale Laval France ARMOR Path.logie Plérin France Laboratoire d’anatomie et de cytologie path.logiques Rennes France Laboratoire d’anatomie et de cytologie path.logiques Angers France Laboratoire Analyses Biologie Glasgow Brest France Ch. Angers France Centre d’anatomie et de cytologie path.logiques Le Mans France Cabinet d’anatomie et de cytologie path.logiques Vannes France Laboratoire d’anatomie et de cytologie path.logiques Quimper France Ch. Rennes France

Purpose: Alth.ugh.controversial, assessment of epidermal growth.factor receptor (EGFR) expression is required for th. approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With.th. objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large coh.rt of mCRC patients wh. received cetuximab with.ut preliminary EGFR screening, and assessing th. correlation between EGFR status and response to treatment retrospectively. Patients and meth.ds: 332 patients treated with.Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin th.rapy were included. EGFR status was assessed using th.ee available immunoh.stoch.mistry (Ih.) tests and in situ h.bridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with.at least one test) patients were compared. Results: Of th. 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all th.ee tests), 86 as full-negative, and 52 as discordant. One th.rd of th. 131 negative samples with.FDA approved test sh.uld be reclassified as positive with.at least one of th. two oth.rs tests. Regarding results from FDA approved test only, neith.r objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to oth.r groups did not sh.w any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: Th.se data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available Ih. tech.ics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

四川省藏族牧区感染多房棘球绦虫犬只空间聚集性研究(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

预防医学情报杂志 2012年第5期28卷 323-328页

作者：王谦克莉丝汀.布德克黄亮帕崔克.热合度弗兰西斯.豪尔多米尼克.维通菲利普.克瑞格邱东川 Sich.an Center for Disease Control and Prevention College of Veterinary Medicine and Biomedical Sciences Texas A&M University Wh. Collaborating Centre for th. Prevention and Treatment of h.man Ech.nococcosis Research.Unit "Ch.ono-environment " UMR CNRS 6249 usc INRAUniversity of Franche-ComtéPlace Leclerc25030 Besancon cedexFrance University of Franch.-Comté and Besanon University h.spital 25030-BesanconFrance Cestode Zoonoses Research.Group Biomedical sciences Research Institute and School of Environment and Life SciencesUniversity of SalfordSalford MS4WTUnited Kingdom

目的泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出。多房棘球绦虫(***)是泡型包虫病的病原体。流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高。这些... 详细信息

目的泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出。多房棘球绦虫(***)是泡型包虫病的病原体。流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高。这些研究表明犬可能作为终末宿主,在环境中维持多房棘球绦虫的生活史。但是普遍认为狐狸是环境中支撑多房棘球绦虫生活史的终末宿主。该研究旨在通过研究感染多房棘球绦虫犬只的空间聚集性,来进一步了解犬在环境中维持多房棘球绦虫生活史的证据。方法在中国四川省西部青藏高原石渠县的牧区,通过氢溴酸槟榔碱驱虫的方法,收集家牧犬感染多房棘球绦虫感染状态,并用GPS测量这些犬只的地理位置数据。通过BB join-count test分析,了解感染多房棘球绦虫犬只是否存在空间聚集性。结果在300～600、800、1600和1800～3900 m的距离,感染多房棘球绦虫犬只存在空间聚集性。结论感染多房棘球绦虫犬只存在空间聚集性,表明环境中犬可能在多房棘球绦虫生活史中发挥作用。

关键词：多房棘球绦虫泡型包虫病犬空间聚集性藏族牧区

多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识

在线全文

学校读者我要写书评

暂无评论

中国呼吸与危重监护杂志 2021年第2期20卷 77-84页

作者：王臻(译) Arif h.ssain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Rich.rd h.ppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mah.th.r Abd.Wah.b Abdulmoh.en Alsaawi Majid AI Salamah.Martin Balik Diego Barca Karim Bendjelid Belaid Bouh.mad Pablo Bravo-Figueroa raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anth.ny J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock h. Laura h.rtado Toru Kameda Mich.el Lanspa Ch.istian B Laursen Francis Lee Rach.l Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Sh.lim Rodriguez Ph.lippe Rola Colin Royse Yale Tung Ch.n Mike Wells Adrian Wong Wang Xiaoting Wang Zh.n Yaseen Arabi 中国人民解放军空军军医大学航空航天医学系陕西西安710032 Department of Cardiac Sciences King Abdulaziz Medical City and King Abdullah International Medical Research Center 不详

新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征... 详细信息

新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。

关键词：体征和症状肺炎公共卫生体系呼吸系统首次报道专家共识疫情