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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion spencer.j.Allen Stephanie M.Ntoukas Gordon j.Bell jessica McNeil Qinggang Wang Margaret L.McNeely jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau john R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(p<0.001),poor sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(p<0.001),and multiple symptoms(p<0.001).VO_(2peak)demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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Development of a Balanced Adaptive Time‑Stepping Strategy Based on an Implicit jFNK‑DG Compressible Flow Solver

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Communications on Applied Mathematics and Computation 2022年第2期4卷 728-757页

作者： Yu Pan Zhen‑Guo Yan joaquim Peiró spencer.j.Sherwin Department of Aeronautics Imperial College LondonLondonUK State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000SichuanChina

A balanced adaptive time-stepping strategy is implemented in an implicit discontinuous Galerkin solver to guarantee the temporal accuracy of unsteady simulations.A proper relation between the spatial,temporal and iterative errors generated within one time step is *** an estimate of temporal and spatial error using an embedded RungeKutta scheme and a higher order spatial discretization,an adaptive time-stepping strategy is proposed based on the idea that the time step should be the maximum without obviously infuencing the total error of the *** designed adaptive time-stepping strategy is then tested in various types of problems including isentropic vortex convection,steady-state fow past a fat plate,Taylor-Green vortex and turbulent fow over a circular cylinder at Re=*** results indicate that the adaptive time-stepping strategy can maintain that the discretization error is dominated by the spatial error and relatively high efciency is obtained for unsteady and steady,well-resolved and under-resolved simulations.

关键词： Adaptive time-stepping Unsteady simulations High order Discontinuous Galerkin Implicit time integration

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Cs_(3)Bi_(2)l_(9)-hydroxyapatite composite waste forms for cesium and iodine immobilization

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journal of Advanced Ceramics 2022年第5期11卷 712-728页

作者： Kun YANG Yachun WANG junhua SHEN spencer M.SCOTT Brian j.RILEY john D.VIENNA jie LIAN Department of Mechanical Aerospaceand Nuclear EngineeringRensselaer Polytechnic InstituteTroyUSA Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyUSA Savannah River National Laboratory AikenUSA Pacific Northwest National Laboratory RichlandUSA

Perovskite-based ceramic composites were developed as potential waste form materials for immobilizing cesium(Cs)and iodine(I)with high waste loadings and chemical *** perovskite Cs_(3)Bi_(2)I_(9)has high Cs(22 wt%)and I(58 wt%)content,and thus can be used as a potential host phase to immobilize these critical *** this work,the perovskite Cs_(3)Bi_(2)I_(9)phase was synthesized by a cost effective solution-based approach,and was embedded into a highly durable hydroxyapatite matrix by spark plasma sintering to form dense ceramic composite waste *** chemical durabilities of the monolithic Cs_(3)Bi_(2)I_(9)and Cs_(3)Bi_(2)I_(9)-hydroxyapatite composite pellets were investigated by static and semi-dynamic leaching tests,*** and I are incongruently released from the matrix for both pure Cs_(3)Bi_(2)I_(9)and composite *** normalized Cs release rate is faster than that of I,which can be explained by the difference in the strengths between Cs-I and Bi-I bonds as well as the formation of insoluble micrometer-sized BiOI *** activation energies of elemental releases based on dissolution and diffusion-controlled mechanisms are determined with significantly higher energy barriers for dissolution from the composite versus that of the monolithic Cs_(3)Bi_(2)I_(9).The ceramic-based composite waste forms exhibit excellent chemical durabilities and waste loadings,commensurate with the state-of-the-art glass-bonded perovskite composites for I and Cs immobilization.

关键词： cesium(Cs) iodine(Ⅰ) perovskite nuclear waste hydroxyapatite

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Regulatory role of NFAT1 signaling in articular chondrocyteactivities and osteoarthritis pathogenesis

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BIOCELL 2023年第10期47卷 2125-2132页

作者： MINGCAI ZHANG TANNER CAMPBELL spencer FALCON jINXI WANG Harrington Laboratory for Molecular Orthopedics Department of Orthopedic SurgeryUniversity of Kansas Medical CenterKansas CityUSA

Osteoarthritis (OA), the most common form of joint disease, is characterized clinically by joint pain, stiffness,and deformity. OA is now considered a whole joint disease;however, the breakdown of the articular cartilage remains themajor hallmark of the disease. Current treatments targeting OA symptoms have a limited impact on impeding orreversing the OA progression. Understanding the molecular and cellular mechanisms underlying OA development isa critical barrier to progress in OA therapy. Recent studies by the current authors’ group and others have revealedthat the nuclear factor of activated T cell 1 (NFAT1), a member of the NFAT family of transcription factors, regulatesthe expression of many anabolic and catabolic genes in articular chondrocytes of adult mice. Mice lacking NFAT1exhibit normal skeletal development but display OA in both appendicular and spinal facet joints as adults. Thisreview mainly focuses on the recent advances in the regulatory role of NFAT1 transcription factor in the activities ofarticular chondrocytes and its implication in the pathogenesis of OA.

关键词： Osteoarthritis Chondrocyte NFAT1 Transcription factor Regulation of gene expression

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Technical and conceptual considerations forusing animated stimuli in studies of animalbehavior

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Current Zoology 2017年第1期63卷 5-19页

作者： Laura CHOUINARD-THULY Stefanie GIERSZEWSKI Gil G. ROSENTHAL Simon M. READER Guillaume RIEUCAU Kevin L. Woo Robert GERLAI Cynthia TEDORE spencer.j. ingley john R. STOWERS joachim G.FROMMENI Francine L. DOLINS Klaudia WITTE Department of Biologv McGill University 1205 Docteur Penfield Montreal Quebec Canada H3A 1B1 Research Group of Ecology and Behavioral Biology Institute of Biology University of Siegen Adolf-Reichwein Str. 2 Siegen 57068 Germany Ecology & Evolutionary Biology Texas A&M University 3258 TAMU College Station TX 77843 USA Centro de Investigaciones Cientfficas de las Huastecas "Aguazarca" Calnali Hidalgo Mexico Departmentof Biological Sciences Florida International University 3000 Northeast 151 Street North Miami FL 33181 USA SUNY Empire State College Metropolitan Center 325 Hudson Street New York NY 10013-1005 USA Departmentof Psychology University of Toronto Mississauga 3359 Mississauga Road Mississauga Ontario Canada L5L 1C6 Lund Vision Group Department of Biology Lund University SSIvegatan 35 Lund 22362 Sweden Department of Biology University of North Carolina at Chapel Hill CB#3280 Coker Hall Chapel Hill NC 27599 USA Research Institute of Molecular Pathology IMP Vienna Biocenter VBC Dr. Bohr-Gasse 7 Vienna 1030 Austria loopbiogmbh Hauptstrasse 93 Kritzendorf 3420 Austria Department of Behavioural Ecology Institute of Ecology and Evolution University of Bern Wohlenstrasse 50a Hinterkappelen 3032 Switzerland Department of Behavioral Sciences University of Michigan-Dearborn 4901 Evergreen Road Dearborn MI 48128 USA

Rapid technical advances in the field of computeropened new avenues in animal behavior *** （CA） and virtual reality （VR） haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby＂reducing＂ and ＂replacing＂ the animals used, and ＂refining＂ the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical *** this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss （I） the creation, （11） the presentation, and （111） the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior.

关键词： animal behavior, animated stimulus, computer animation, experimental design, virtual reality, visual communication.

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Himalayan Tectonics:Preface

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Geoscience Frontiers 2019年第3期10卷 791-792页

作者： Kyle Larson Christopher j. spencer Tectonics and Geodynamics Earth Environmental and Geographical Sciences IKBSAS University of British Columbia Earth Dynamics Research Group The Institute for Geoscience Research (TIGeR) Department of Applied Geology Curtin University

The Himalayan-Tibetan orogen system serves as the modern paradigm for understanding convergence-related processes in orogenic belts. The advancements made studying the region have been applied to other ancient orogenic belts leading not only to a better understanding of their development, but also of secular changes in collisional processes. As more advanced methodologies are introduced and utilized in geological research, the type, scale, and quality of data available enable quantification of geological processes not previously possible. These complex and robust datasets now form the core of many of the research projects undertaken across the Himalaya and continue to provide unprecedented insight into the myriad different aspects of the evolution of the collisional system.

关键词： Himalayan-Tibetan system evolution

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Visualising data distributions with kernel density estimation and reduced chi-squared statistic

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Geoscience Frontiers 2017年第6期8卷 1247-1252页

作者： C.j.spencer C.Yakymchuk M.Ghaznavi Earth Dynamics Research Group The Institute of Geoscience ResearchDepartment of Applied GeologyCurtin UniversityPerthAustralia Department of Earth and Environmental Sciences University of WaterlooWaterlooCanada David R.Cheriton School of Computer Science University of WaterlooWaterlooCanada

The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret *** commonly used tools are the kernel density estimation and reduced chi-squared statistic used in combination with a weighted *** to the wide applicability of these tools,we present a java-based computer application called KDX to facilitate the visualization of data and the utilization of these numerical tools.

关键词： Data visualisation Kernel density estimation Reduced chi-squared statistic Mean square weighted deviation Geostatistics

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Novel directions of precision oncology:circulating microbial DNA emerging in cancer-microbiome areas

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Precision Clinical Medicine 2022年第1期5卷 46-62页

作者： Liting You juan Zhou Zhaodan Xin j.spencer Hauck Feifei Na jie Tang Xiaohan Zhou Zichen Lei Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Pathology Duke University School of MedicineDurhamNC 27710USA Department of Thoracic Cancer West China HospitalSichuan UniversityChengdu 610041China Department of Clinical Laboratory Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000China

Microbiome research has extended into the cancer area in the past *** can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect ***-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and ***,the cancermicrobiome has recently been *** identification of intra-tumoral microbes and cancer-related circulating microbial DNA(cmDNA)has promoted novel research in the cancer–microbiome *** this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid *** outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field.

关键词： circulating microbial DNA liquid biopsy cancer-microbiome-immunity intra-tumor microbiome cancer precision diagnosis and therapy

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Strategies towards statistically robust interpretations of in situ U-Pb zircon geochronology

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Geoscience Frontiers 2016年第4期7卷 581-589页

作者： Christopher j.spencer Christopher L.Kirkland Richard j.M.Taylor The Institute of Geoscience Research(TIGeR) Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Centre for Exploration Targeting-Curtin Node Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Australian Research Council Centre of Excellence for Core to Crust Fluid SystemsPerthWA 6102Australia

Zircon U-Pb geochronology has become a keystone tool across Earth science, arguably providing the gold standard in resolving deep geological time. The development of rapid in situ analysis of zircon （via laser ablation and secondary ionization mass spectrometry） has allowed for large amounts of data to be generated in a relatively short amount of time and such large volume datasets offer the ability to address a range of geological questions that would otherwise remain intractable （e.g. detrital zircons as a sedi- ment fingerprinting method）. The ease of acquisition, while bringing benefit to the Earth science com- munity, has also led to diverse interpretations of geochronological data. In this work we seek to refocus U -Pb zircon geochronology toward best practice by providing a robust statistically coherent workflow. We discuss a range of data filtering approaches and their inherent limitations （e.g. discordance and the reduced chi-squared; MSWD）. We evaluate appropriate mechanisms to calculate the most geologically appropriate age from both 238U/206pb and 207pb/206pb ratios and demonstrate the cross over position when chronometric power swaps between these ratios. As our in situ analytical techniques become progressively more precise, appropriate statistical handing of U-Pb datasets will become increasingly pertinent.

关键词： Zircon Geochronology U-Pb Geostatistics MSWD

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Timescales of geological processes: Preface

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Geoscience Frontiers 2019年第1期10卷 1-3页

作者： Andrew Putnis Christopher j.spencer Tom Raimondo The Institute for Geoscience Research School of Earth and Planetary Science Curtin University School of Natural and Built Environments University of South Australia

*** One of the major challenges in Geoscience is to understand how the formation and evolution of the Earth System are governed by timescales-that is,how the various geological processes that continue to contribute to its present-day structure and composition operated in the deep *** traditional view of such processes refers to events that occur at immense spatial scales and over hundreds of millions of years,constrained in most cases by the ages of rocks determined using isotopic dating methods or the fossil ***,the modern view of geological processes has increasingly acknowledged that their durations can be significantly shorter than previously thought possible,or indeed detectable without recent analytical *** are a prime example of rapid,high energy and episodic events that have a profound effect on subsequent processes such as metamorphism,fluid transport,and ore formation e the evidence of which is written in microstructures,compositional zoning,and P-T *** studies have also revealed that the reaction rates between fluids and rocks can be extremely rapid relative to geological *** has led to the notion that geological processes are not necessarily continuous over millions of years but may,in fact,be sporadic,with long periods where essentially no reactions take place punctuated by periods of intense activity.

关键词： In Preface Timescales of geological processes

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