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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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BASIc FORMULATION OF STATIc AND DYNAMIc BEHAVIOURS OF SOIL AND OTHER POROUS MEDIA

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Applied Mathematics and Mechanics(English Edition) 1982年第4期3卷 457-468页

作者： 0.c.Zienkiewicz University of Wales. Swansea. U. K. Department of civil Engineering

This paper treats the soil and rock or concrete as a two-phasemedium composed of a solid skeleton and an interstitial ***-der the unsaturated condition of interstitial fluid,the thirdphase is taken into consideration. In this paper. we consider theconstitutive relation,dynamic and kinematic relations,and also va-rious approximations with their limits of *** thoseof most practical engineering situations such as the consolidationproblem and the undrained behaviour. The finite element discreti-zation and the time dependent solution of various classes of soilproblem are also discussed.

关键词： BASIc FORMULATION OF STATIc AND DYNAMIc BEHAVIOURS OF SOIL AND OTHER POROUS MEDIA

Implementing Symmetries of a Free Bose field via White Noise Operators

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Acta Mathematica Sinica,English Series 2003年第1期19卷 147-158页

作者： ShunLongLU0 InstituteofAppliedMathematics AcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing1

Linear symmetries of a free Bose field are exploited in the framework of Hida's white noise functionals triple. General symplectic automorphisms on the single particle space are implemented by generalized operators. The intertwining operators are constructed in a physically intuitive way, characterized analytically in terms of symbols, and factorized into three fundamental parts according to Wick ordering procedure. In particular, the classical Shale's theorem is rederived.

关键词： free Bose field Symplectic automorphisms symbols gaussian Kernel operators Signs and symbols bose white noise

A New Approach to Nonlinear Partial Differential Equations

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communications in Nonlinear Science and Numerical Simulation 1997年第4期2卷 230-235页

作者： Jihuan HE (Shanghai University,Shanghai Institute of Applied Mathematics and Mechanics,Shanghai 2 0 0 0 72 ,china) Shanghai University Shanghai Institute of Applied Mathematics and Mechanics Shanghai 200072 China

In this paper,a novel method called variational iteration method is proposed to solve nonlinear partial differential equations without linearization or small *** this method,a correction functional is constructed by a general Lagrange multiplier,which can be identified via variational *** analytical solution can be obtained from its trial- function with possible unknown constants,which can be identified by imposing the boundary conditions,by successively iteration.

关键词： Nonlinear Problems Partial Differential Equations Variational Iteration Method Variational Theory

Valued Gabriel quiver of a wedge product and semiprime coalgebras

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Frontiers of Mathematics in china 2013年第5期8卷 1157-1183页

作者： Gabriel NAVARR0 Department of computer Sciences and AI University of Granada E1 Greco s/n E-51002Ceuta Spain

We describe the valued Gabriel quiver of a wedge product of coalgebras and study the category of comodules of a semiprime coalgebra. In particular, we prove that any monomial semiprime k-tame fc-tame coalgebra is string. We also prove a version of Eisenbud-Griffith theorem for coalgebras, namely, any hereditary semiprime strictly quasi-finite coalgebra is serial.

关键词： Wedge product semiprime coalgebras representation theory,valued Gabriel quiver

Variational Iteration Method for Delay Differential Equations

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communications in Nonlinear Science and Numerical Simulation 1997年第4期2卷 235-236页

The variational iteration method is shown to be applicable to delay differential equations for analytical approximate solutions

关键词： Variational Iteration Method for Delay Differential Equations

Numerical simulations for G-Brownian motion

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Frontiers of Mathematics in china 2016年第6期11卷 1625-1643页

作者： Jie YANG Weidong ZHA0 School of Mathematics & Finance Institute Shandong University Jinan 250100 China

This paper is concerned with numerical simulations for the G- Brownian motion （defined by S. Peng in Stochastic Analysis and Applications, 2007, 541-567）. By the definition of the G-normal distribution, we first show that the G-Brownian motions can be simulated by solving a certain kind of Hamilton-Jacobi-Bellman （HJB） equations. Then, some finite difference methods are designed for the corresponding HJB equations. Numerical simulation results of the G-normal distribution, the G-Brownian motion, and the corresponding quadratic variation process are provided, which characterize basic properties of the G-Brownian motion. We believe that the algorithms in this work serve as a fundamental tool for future studies, e.g., for solving stochastic differential equations （SDEs）/stochastic partial differential equations （SPDEs） driven by the G-Brownian motions.

关键词： Nonlinear expectation G-Brownian motion G-normal distribu- tion Hamilton-Jacobi-Bellman (HJB) equation

Projected area and drag coefficient of high velocity irregular fragments that rotate or tumble

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Defence Technology（防务技术） 2017年第4期13卷 269-280页

作者： John F. Moxnes 0yvind Fr0 yland Ivar J. 0ye Tom I. Brate Eva Friis Gard 0degardstuen Tallak H. Risdal Norwegian Defence Research Establishment Land Systems Division P.O. Box 25 2027 Kjeller Norway Nammo Raufoss AS P.O. Box 162 2831 Raufoss Norway HPVisTech AS Bj0rnstadgutua 21 2092 Minnesund Norway

3 degrees of freedom(DOF)exterior ballistic computer models are used in fragment studies to calculate individual trajectories of each fragment based on drag coefficient and the projected(presented)area in the direction of velocity of center of *** expectation of a randomly distributed projected area is commonly used for fragments that tumble(random rotation)during *** forecast a model where the expected drag coefficient is dependent of shape and Mach *** or tumbling only affects the expected projected *** of projected areas during tumbling and rotation are *** examination of the data by Mc cleskey(1988)indicates that the volume of the fragment to the power of2/3 is a better parameter to characterize the drag coefficient of the fragments than the maximum projected *** simulations are used to verify results and to study projected area and drag coefficient of fragments.

关键词： Fragments Form factor Mach number Drag coefficient cauchy area Tumbling

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