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TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro

中国科学：生命科学英文版 2010年第2期53卷 223-228页

作者： SUN Peng1,ZHANG Qing2,HAN JiYuan1,TIAN Yuan3 & ZHANG JingHui3 1Department of Emergency,Union Hospital,Tongji Medical College,Huazhong university of Science and technology,Wuhan 430022,china 2Department of Anesthesia,Union Hospital,Tongji Medical College,Huazhong university of Science and technology,Wuhan 430022,china 3Department of General Surgery,Union Hospital,Tongji Medical College,Huazhong university of Science and technology,Wuhan 430022,china 1. Department of Emergency Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China2. Department of Anesthesia Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China3. Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Both TLR4 and TLR2 participated in the mediation of the inflammatory injury in the process of partial cerebral ischemia/***,it still remains unclear whether a crosstalk exists between TLR2 and TLR4 in ischemic cerebral *** the present study,we investigated the effect of TLR4 signaling on TLR2 expression during mimic cerebral I/R in ***-2 cells were cultured and treated with ischemia/reperfusion,then transfected with the plasmid pEGFP-H1/TLR4-siRNA,the plasmid pEGFP-H1/control sequence-siRNA and the blank plasmid,***,the expression of TLR2 and TLR4 mRNA and protein,NF-κB p65 mRNA and supernatant TNF-α level were significantly higher in ischemia/reperfusion treated cells than those lack of ischemia/reperfusion treatment,and as compared with those in ischemia/reperfusion treated cells without transfection,no significant differences about the above mentioned gene and protein expression were found in the blank plasmid tranfected cells and the plasmid pEGFP-H1/control sequence-siRNA transfected cells respectively,while the expression levels in the plasmid pEGFP-H1/TLR4-siRNA transfected cells were significantly ***,in order to determine the effects of pyrrolidinediethyldithiocarbamate (PDTC),an NF-κB inhibitor,on the TLR4-induced TLR2 expression in BV-2 cells treated with ischemia/reperfusion,it was found that TLR4 and TLR2 mRNA expressions in PDTC pretreated cells were significantly lower in comparison with normal saline pretreated cells and non-pretreated *** data suggested that TLR2 activation,signaled by TLR4 and regulated by NF-κB,might be directly involved play an important role in ischemia/reperfusion induced brain damage.

关键词： Toll-like receptor 4 Toll-like receptor 2 cerebral ischemia/reperfusion microglia

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Atomic Force Microscopy-based Cell Nanostructure for Ligand-conjugated Quantum Dot Endocytosis

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Acta Biochimica et Biophysica Sinica 2006年第9期38卷 646-652页

作者： Yun-Long PAN~1* Ji-Ye CAI~2 Li QIN~3 Hao WANG~4 1 The First Affiliated Hospital of Jinan university,Guangzhou 510632,china 2 College of Life Science and technology,Jinan university,Guangzhou 510632,china 3 Department of Histology and Embryology,Medical College of Jinan university,Guangzhou 510632,china 4 Information and Optoelectronic Science and Engineering.south china Normal university,Guangzhou 510631,china TheFirstAffiliatedHospitalofJinanuniversity Guangzhou510632China CollegeofLifeScienceandtechnology JinanUniversity.Guangzhou510632China DepartmentofHistologyandEmbryology.MedicalCollegeofJinanuniversity

While it has been well demonstrated that quantum dots (QDs) play an important role inbiological labeling both in vitro and in vivo,there is no report describing the cellular nanostructure basis ofreceptor-mediated ***,nanostructure evolution responses to the endocytosis of transferrin(Tf)-conjugated QDs were characterized by atomic force microscopy (AFM).AFM-based nanostructureanalysis demonstrated that the Tf-conjugated QDs were specifically and tightly bound to the cell receptorsand the nanostructure evolution is highly correlated with the cell membrane receptor-mediated ***,confocal microscopic and flow cytometry results have demonstrated the specificity anddynamic property of Tf-QD binding and *** found that the internalization of Tf-QD is linearlyrelated to ***,while the nanoparticles on the cell membrane increased,the endocytosis was stillvery active,suggesting that QD nanoparticles did not interfere sterically with the binding and function ***,ligand-conjugated QDs are potentially useful in biological labeling of cells at a nanometerscale.

关键词： quantum dot endocytosis nanostructure atomic force microscopy

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The Researches on Path Independence Problem

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Journal of Systems Engineering and Electronics 1998年第2期9卷 19-22页

作者： Luo Yunfeng Xiao Renbin & Zhu Mingfu(Institute of Systems Engineering, Huazhong university of Science and technology,Wuhan 430074, P. R. china) Institute of Systems Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China

Rationality condition is imposed in Arrow's General Possibility Theorem in order for social choice to be independent of the path of choice. In this Paper, emphasis is laid on the analysis of the relevance of path independence and rationality condition. Two kinds of Path independence, i.e., Plott's path independence and Bandyopadhyay's sequential path independence, are shown, and their meanings with respect to the problem are investigated.

关键词： Social choice Rationality condition Path independence Sequential path independence

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EXPERT SYSTEM FOR CONTROLLING THE STATE OF SINTERING PROCESS

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Journal of Central south university 1999年第1期11卷 42-43页

作者： Wang Haidong Jiang Bo (Department of Mineral Processing Engineering,Central south university of technology,Changsha 410083, china)

In order to control sintering process,improve permeability and stabilize burn through point, a control scheme which combines thermal state with permeability state is proposed, and an expert system for controlling sintering process state is developed, the software which includes about 1000 expert rules is successfully applied to off line control of sintering process.

关键词： sintering process state control expert system

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Significance of stress on mobilization of ore-forming materials

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Chinese Science Bulletin 1999年第S2期44卷 139-141页

作者： MA Rui and JIANG Qigang Research Center of Metamorphic Dynamics of Changchun university of Science and technology, Changchun 130061, china Research Center of Metamorphic Dynamics Changchun University of Science and Technology Changchun 130061 China

METALLOGENIC processes represent migration and concentration of useful elements, which are controlled by a number of factors. Among varied geological factors, stress is very improtant. Stress could not only causethe fracture and deformation, but also is closely related to the mobilization and migration of ore-formingmaterials, especially for hydrothermal deposits. Varied experiments have been carried out to showthe above phenomenon. The sample is carbonaceous slate collected from the Taiyangding Group of the Nuo ’ ergai area,Sichuan Province. The rock is fresh, creckless, containing 40×10-9 of gold and high content of organiccarbon. Under a microscope, it is black. A group of state cleavage is observed, fine quartz and uniformily distributed carbonaceous materials. The quartz is<0.01 mm in diametre. Using high temperature

关键词： stress mobilization ore-formmg material.

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Enhanced Terahertz Fingerprint Detection beyond Refractive Index Sensing in a Periodic Silicon Waveguide Cavity

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Journal of Electronic Science and technology 2018年第2期16卷 105-109页

作者： Bei Zhu Zhanghua Han College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310018 Advanced Launching Co-Innovation Center Naniing University of Science and TechnologyNanjing 210094

Resonance shifting due to refractive index changes is used quite often in terahertz sensing, but it does not show the advantages of substance identification of terahertz technology. Different from that approach, we explored the use of a cavity to enhance the sensitivity of terahertz sensing while retaining the original capability of substance identification. The defect mode of a one-dimensional photonic crystal cavity composed of periodic holes etched into a silicon wire wavegnide was investigated for this purpose. The resonance of the defect mode was designed to match one characteristic absorption frequency of the sample. Due to the high dependence of the defect mode transmission on the material loss, the transmission sensitivity to the quantity of target was amplified significantly. The detection of alactose was used as an example, which demonstrates steady detection with its thickness of a few microns.

关键词： Detection photonic crystal terahertz sensing waveguide

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Special magnetic phenomena in heavily doped La_(0.7-x)Dy_xSr_(0.3)MnO_3 system

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Science china(Physics,Mechanics & Astronomy) 2008年第1期51卷 90-97页

作者： LIU Ning 1,2 ,YAN GuoQing 1,3 ,CAI ZhiRang 1 ,PI Li 2 ,ZHANG Bei 2 &TONG Wei 2 1 Department of Physics,Suzhou College,Suzhou 234000,china 2 Structure Research Laboratory,university of Science and technology of china,Hefei 230026,china 3 National Laboratory of Solid State Microstructures,Physics Department,Nanjing university,Nanjing 210093,china 1. Department of Physics Suzhou College Suzhou 234000 China 2. Structure Research Laboratory University of Science and Technology of China Hefei 230026 China 3. National Laboratory of Solid State Microstructures Physics Department Nanjing University Nanjing 210093 China

The magnetism in heavily Dy doped La0.7-xDyxSr0.3MnO3(0.40≤x≤0.70)system is studied in this *** M-T relation seems to be complicated with the increase of *** sample with x=0.40,AFM behavior exists at T≤TN and M-T curves under zero field cooling(ZFC)and field cooling(FC)exhibit typical behavior of spincluster glass state above *** the sample with x=0.50,the M-T curve under ZFC exhibits a valley at a low temperature while the M-T curve under FC exhibits the negative magnetization below *** samples with x=0.60,0.70,their ZFC M-T curves are similar to that of x=0.50,but the FC M-T curves do not exhibit negative values any *** the peculiar phenomena above are well explained by Néel double-lattice model combined with M-H relation at typical *** molecular field theory fits well the negative magnetization for x=0.50.

关键词： heavily doped special magnetic phenomena double-lattice model

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Nonlinear Combination Forecasting Model and Its Application

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Systems Science and Systems Engineering 1998年第2期8卷 124-128页

作者： ZHOU Chuanshi\ LIU Yongqing (Ins.of System Engineer, south china Univ. of Science technology,Guangzhou 510641)

This paper mainly discusses the nonlinear combination forecasting model and states that the nonlinear combination forecasting model is better than linear combination forecasting model in many aspect.

关键词： nonlinear combination forecasting model precision.

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south china's Gondwana connection in the Paleozoic:Paleomagnetic evidence

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Progress in Natural Science:Materials International 2004年第1期14卷 86-91页

作者： ZHANG Shihong*(School of Earth Sciences and Resources, china university of Geosciences, Beijing 100083, china) china Univ Geosci Sch Earth Sci & Resources Beijing 100083 Peoples R China

The reconstruction in which the south china Block (SCB) lies along the Great India Australia region of Gondwana margin is tested by using existing Paleozoic paleomagnetic data. Under the proposed reconstruction, all six high quality paleopoles from the SCB between the Early Cambrian and late Early Devonian (～400 Ma) are in good agreement with coeval paleopoles from Gondwana. Thereafter, the apparent polar wander paths for the SCB and Gondwana diverge markedly. This indicates that the SCB had been part of Gondwana and the connection was intact from at least Early Cambrian until late Early Devonian, but they began to separate by late Middle Devonian (～375 Ma).

关键词： south china block Gondwana paleomagnetism reconstruction

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Biomimetic synthesis of calcium-strontium apatite hollow nanospheres

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Science china Chemistry 2010年第8期53卷 1723-1727页

作者： GAN Yong,HAN DongMei,GU FuBo,WANG ZhiHua & GUO GuangSheng State Key Laboratory of Chemical Resource Engineering,Beijing university of Chemical technology,Beijing 100029,china 1. State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China

In this work,calcium-strontium apatite (Sr-HA) hollow nanospheres were synthesized by a facile biomimetic *** structure and property of Sr-HA were characterized by FESEM,TEM,HRTEM,XRD and FT-IR *** influences of different ratios of calcium and strontium on the morphologies of the Sr-HA products were *** experimental results revealed that the hollow spherical Sr-HA,with a size of 30-120 nm in diameter,could be synthesized when the molar ratio of Ca/Sr was 1:*** possible formation mechanism of the hollow Sr-HA was *** drug release experiments indicated that the hollow spherical Sr-HA had the property of sustained release.

关键词： calcium-strontium apatite hollow nanosphere biomimetic synthesis

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