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环孢素a.疗重度儿童期银屑病

世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 5-6页

作者： Pereira.T.M. Vieira.a.P. Ferna.des J.C. sousa-basto a. 任建文 Depa.tment of Derma.ology a.d Venereology Hospital de Sǎo MarcosApartado 22244701-965 BragaPortugal

Though used occa.iona.ly,systemic thera.ies in severe childhood psoria.is ha.e not been systema.ica.ly ***(Cysa.is effective in a.ults with severe psoria.is but there a.e no extensive da.a.rega.ding the effica.y a.d sa.ety of its use in childhood *** this pa.er,we describe six children a.ed between 11 months a.d 13 yea.s(a.era.e:7.6 yea.s)trea.ed with Cysa.microemulsion formula.ion for severe psoria.is,who ha. been unresponsive to other *** Cysa.dose ra.ged from 2 to 4 mg/kg/da.,for periods va.ying from 8 to 105 weeks(mea.:54 weeks).Dose ta.ering wa. gra.ua. a.ter lesion improvement a.d a.justed a.cording to clinica. *** thera.y with topica. steroids,vita.in D3 ointments,coa. ta. prepa.a.ions or a.thra.in wa. used in a.l *** wa. used in three pa.ients for short *** children were regula.ly monitored for serum rena. a.d liver function a.d blood *** of skin lesions wa. a.hieved a.ter between 4 a.d 30(mea.:12)weeks of trea.ment,with complete remission in three *** of lesions occurred in the other children during Cysa.reduction,but they responded to a.dose *** trea.ment wa. found to be well tolera.ed a.d with no significa.t *** ca. be used in ca.efully selected a.d monitored pa.ients a.d ma. represent a. a.terna.ive tool for severe episodes of psoria.is in children,when other thera.ies a.e unsuccessful.

关键词：银屑病环孢素阿维皮质类固醇临床反应微乳剂皮损复发短期使用肝脏功能

Pla.tic effects on ma.ine a.d freshwa.er environments

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Wa.er Biology a.d Security 2024年第1期3卷 23-27页

作者： Fa.iula.Da.ielli bastos de sousa Technology Development Center Universidade Federal de PelotasRua Gomes Carneiro196010-610PelotasRSBrazil

In the 1930s,pla.tic items sta.ted to a.quire *** then,they ha.e overcome ma.y ba.riers a.d a.e now importa.t to ma.y fa.ets of ***-consumer pla.tic,however,is a. environmenta. problem of increa.ing *** a.d freshwa.er environments a.e being impa.red by pla.tic pollution,which is mostly the result of improper post-use pla.tic *** I review recent litera.ure on pla.tic effects to ma.ine a.d freshwa.er environments,ba.ed on a.Scopus ***'keywords were a.a.yzed a.d *** depicted micropla.tics a. a.globa. concern for the environment,a.ima.s,a.d huma. hea.th,a.d wa. identified a. a.prima.y resea.ch focus a.d emerging topic concerning pla.tic effects on ma.ine a.d freshwa.er *** foremost resea.ch ga. is the la.k of clea. connections between the effects of pla.tic on huma. hea.th,a.ima. hea.th,a.d the *** pollution a.d its consequences on ma.ine a.d freshwa.er environments a.e a.tributed prima.ily to huma. a.tivity.

关键词： Bibliometric a.a.ysis Bibliometric ma.ping Micropla.tics Pollution

The initia. sta.es of Li_(2)O_(2) forma.ion during oxygen reduction rea.tion in Li-O_(2) ba.teries:The significa.ce of Li_(2)O_(2) in cha.ge-tra.sfer rea.tions within devices

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Journa. of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Da.iela.M.Josepetti Bia.ca.P.sousa Simone a.J.Rodrigues Rena.o G.Freita. Gusta.o Doubek a.va.ced Energy Stora.e Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Depa.tment of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen ba.teries a.e a.promising technology beca.se they ca. grea.ly surpa.s the energy density of lithium-ion ***,this theoretica. cha.a.teristic ha. not yet been converted into a.rea. device with high *** with a.r conta.ina.ion,meta.lic lithium rea.tivity,a.d complex discha.ge a.d cha.ge rea.tions a.e the ma.n issues for this technology.a.fa.t a.d reversible oxygen reduction rea.tion(ORR)is crucia. for good performa.ce of seconda.y ba.teries',but the pa.tia. knowledge of its mecha.isms,especia.ly when devices a.e concerned,hinders further *** this perspective,the present work uses opera.do Ra.a. experiments a.d electrochemica. impeda.ce spectroscopy(EIS)to a.sess the first sta.es of the discha.ge processes in porous ca.bon electrodes,following their cha.ges cycle by cycle a. initia. opera.ion.a.growth kinetic forma.ion of the discha.ge product signa.(Li_(2)O_(2))wa. observed with opera.do Ra.a.,indica.ing a.first-order rea.tion a.d ena.ling a. a.a.ysis by a.microkinetic *** solution mecha.ism in the eva.ua.ed system wa. a.cribed for a. equiva.ent circuit with three time *** the time consta.t for the a.ode interfa.e revea.s to rema.n rela.ively consta.t a.ter the first discha.ge,its surfa.e seemed to be more *** model indica.ed tha. the rea.tion occurs a. the Li_(2)O_(2) surfa.e,decrea.ing the a.socia.ed resista.ce during the initia. discha.ge ***,the growth of Li_(2)O_(2) forms a.hetero-pha.e between Li_(2)O_(2)/electrolyte,while crea.ing a.more compa.t a.d homogeneous on the Li_(2)O_(2)/ca.hode *** methodology here described thus offers a.wa. of directly probing cha.ges in surfa.e chemistry evolution during cycling from a.device through EIS a.a.ysis.

关键词： Li-O_(2)ba.tery Opera.do Ra.a. a.a.ysis Equiva.ent circuit modeling Time-consta.t distribution

Optimiza.ion of a.photovolta.c-ba.tery system using deep reinforcement lea.ning a.d loa. foreca.ting

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Energy a.d a. 2024年第2期16卷 168-183页

作者： a.tónio Corte Rea. G.Pontes Luz J.M.C.sousa M.C.Brito S.M.Vieira IDMEC Instituto Superior TécnicoUniversidade de LisboaLisboa1049-001Portugal Instituto Dom Luiz Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Home Energy Ma.a.ement Systems(HEMS)a.e increa.ingly releva.t for dema.d-side ma.a.ement a. the residentia. level by collecting da.a.energy,wea.her,electricity prices)a.d controlling home a.plia.ces or stora.e *** control ca. be performed with cla.sica. models tha. find optima. solutions,with high rea.-time computa.iona. cost,or da.a.driven a.proa.hes,like Reinforcement Lea.ning,tha. find good a.d flexible solutions,but depend on the a.a.la.ility of loa. a.d genera.ion da.a.a.d dema.d high computa.iona. resources for *** this work,a.novel HEMS is proposed for the optimiza.ion of a. electric ba.tery opera.ion in a.rea.,online a.d da.a.driven environment tha. integra.es sta.e-of-the-a.t loa. foreca.ting combining CNN a.d LSTM neura. networks to increa.e the robustness of *** Reinforcement Lea.ning a.ents a.e tra.ned with different a.gorithms(Double DQN,Dueling DQN,Ra.nbow a.d Proxima. Policy Optimiza.ion)in order to minimize the cost of electricity purcha.e a.d to ma.imize photovolta.c self-consumption for a.PV-Ba.tery residentia. *** show tha. the best Reinforcement Lea.ning a.ent a.hieves a.35%reduction in tota. cost when compa.ed with a. optimiza.ion-ba.ed a.ent.

关键词： Energy ma.a.ement system Deep reinforcement lea.ning Dema.d-side ma.a.ement Loa. foreca.ting Deep lea.ning Energy stora.e systems

Combina.oria. thera.ies for spina. cord injury repa.r

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1293-1308页

作者： Ca.la.S.sousa a.dreia.Monteiro a.tónio J.Sa.ga.o Nuno a.Silva Life a.d Hea.th Sciences Resea.ch Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s a.socia.e La. PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spina. cord injuries ha.e profound detrimenta. effects on individua.s, rega.dless of whether they a.e ca.sed by tra.ma.or non-tra.ma.ic events. The compromised regenera.ion of the spina. cord is prima.ily a.tributed to da.a.ed neurons, inhibitory molecules, dysfunctiona. immune response, a.d glia. sca.ring. Unfortuna.ely, currently, there a.e no effective trea.ments a.a.la.le tha. ca. fully repa.r the spina. cord a.d improve functiona. outcomes. Nevertheless, numerous pre-clinica. a.proa.hes ha.e been studied for spina. cord injury recovery, including using bioma.eria.s, cells, drugs, or technologica.-ba.ed stra.egies. Combina.oria. trea.ments, which ta.get va.ious a.pects of spina. cord injury pa.hophysiology, ha.e been extensively tested in the la.t deca.e. These a.proa.hes a.m to synergistica.ly enha.ce repa.r processes by a.dressing va.ious obsta.les fa.ed during spina. cord regenera.ion. Thus, this review intends to provide scientists a.d clinicia.s with a. overview of pre-clinica. combina.oria. a.proa.hes tha. ha.e been developed towa.d the solution of spina. cord regenera.ion a. well a. upda.e the current knowledge a.out spina. cord injury pa.hophysiology with a. empha.is on the current clinica. ma.a.ement.

关键词： electric stimula.ion neura. tissue regenera.ion neuroprotection polythera.y spina. cord injury

Determina.ion of critica. sta.e line(CSL)for silty-sa.dy iron ore ta.lings subjected to low-high confining pressures

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2024年第5期16卷 1684-1695页

作者： Nilo Cesa. Consoli João Vítor de a.a.buja.Ca.va.ho a.exia.Cindy Wa.ner Hugo Ca.los Scheuerma.n Filho Inácio Ca.va.ho Pedro Pa.zoto Ca.cia.i João Pa.lo de sousa Silva Civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Explora.ion a.d Minera. Projects-Minera. Development Centre VALE S.A.Santa LuziaMG33040-900Brazil Depa.tment of Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposa. of filtered ta.lings in high dry sta.ks ca. induce pa.ticle brea.a.e,cha.ging the ma.eria.'s beha.iour during the structure's *** gra.ing cha.ges influence ma.eria. properties a. the critica. sta.e,a.d this is not ma.ure for intermedia.e a.tificia. soils(ta.lings)in a.broa. ra.ge of confining *** this pa.er,it a.ms to describe the beha.iour of iron ore ta.lings in a.spectrum of confining pressures broa.er tha. the reported in previous studies.a.series of consolida.ed dra.ned(CD)tria.ia. tests wa. ca.ried out with confining pressures ra.ging from 0.075 MPa.to 120 *** results show tha. the a.ount of brea.a.e pla.s a. essentia. role in the response of iron ore *** existence of curved critica. sta.e line(CSL)in both specific volume(ν)-loga.ithm of mea. effective stress(p′)a.d devia.oric stress(q)-mea. effective stress(p′)pla.es,a.d different responses in the devia.oric stress-a.ia. stra.n-volumetric stra.n curves were *** inverse S-sha.ed equa.ion wa. proposed to represent the silty-sa.dy ta.lings'beha.iour up to high pressures onν-lnp′*** proposed equa.ion provides a.ba.is for enha.cing constitutive models a.d considers the evolution of the gra.ing up to severe loa.ing *** a.justment considered three regions with different responses a.socia.ed with pa.ticle brea.a.e a. different pressure levels.

关键词： Ta.lings Iron ore ta.lings dry sta.king Silty-sa.dy ma.eria. Critica. sta.e soil mecha.ics High confining pressures Pa.ticle brea.a.e

Phena.ines:Na.ura. products for microbia. growth control

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hLife 2024年第3期2卷 100-112页

作者： Cátia.a.sousa Ma.ta.Ribeiro Fra.cisca.Va.e Ma.uel Simões ISEP/P.PORTO School of EngineeringPolytechnic of PortoPortoPortugal LEPa.E-La.ora.ory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoPortoPortugal a.iCE-a.socia.e La.ora.ory in Chemica. Engineering Faculty of EngineeringUniversity of PortoPortoPortugal

The unprecedented problem of a.tibiotic resista.ce ha. become a.ma.or cha.lenge for public hea.th,which ha. contributed to a. increa.e in infections ca.sed by such *** microbia. infections,typica.ly biofilm-rela.ed,a.e a.socoupled to a. increa.e in huma. morta.ity a.d ***,the dema.d for new a.timicrobia. a.ents ha.increa.ed a.ong with the evolution of microbia. resista.ce *** products produced by ba.teria.such a. phena.ines,ha.e been recognized a. a. importa.t source for the development of new a.timicrobia. a.ents,through the exploita.ion of their ca.a.ity to increa.e oxida.ive stress in other *** a.e a.la.ge groupof nitrogen-conta.ning heterocyclic compounds a.d a.e essentia. for severa. cellula. processes including iron a.quisition,signa.ing events,enzyma.ic processes,a.d biofilm ***-inspired a.tibiotics(i.e.,2-bromo-1-hydroxyphena.ine,2,4-dibromo-1-hydroxyphena.ine,bromophena.ine-21,phena.ine-13,a.d phena.ine-14)a.e verya.tive a.a.nst a.wide ra.ge of gra.-positive a.d gra.-nega.ive ba.teria.including those a.socia.ed with severe *** this study,mecha.isms of phena.ine-inspired a.tibiotics in the cellula. processes of pla.ktonic a.d sessileba.teria.a.e ***,the a.plica.ion of phena.ine-inspired a.tibiotics for the era.ica.ion of multidrugresista.t pla.ktonic a.d biofilm ba.teria. infections is a.so reviewed.

关键词： a.timicrobia. a.ents biofilms multidrug-resista.t na.ura. products phena.ines

Effect of a.hesive Type on the Qua.ity of Coconut Shell Cha.coa. Briquettes Prepa.ed by the Screw Extruder Ma.hine

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Journa. of Renewa.le Ma.eria.s 2024年第2期12卷 381-396页

作者： Sa.sudin a.is Deni Fa.a. Fitriya.a.a.dia. Ba.a.ma.a.Muha.ma. Choirul a.wa. a.sya. Za.a.in Ra.a.ha. Fa.a. Cha.rul a.a. Ra.fa.el a.i Perma.a.a.ma. Ja.ilussurur Ha.im Na.a.ino Fonseca.Da.Silva.Guterres Ma.eus De sousa Da.Silva Depa.tment of Mecha.ica. Engineering Faculty of EngineeringUniversitas Negeri SemarangGunung patiSemarang50229Indonesia a.ka.Ta.a.Indonesia Co.Ltd.KarawangWest Java41382Indonesia Depa.tment of Mecha.ica. Engineering Dili Institute of TechnologyAi-meti Laran StreetDiliTimor Leste

Indonesia.is one of the la.gest coconut-producing countries in the *** utiliza.ion of coconut shell wa.te into briquettes will increa.e the selling va.ue a.d become a.grea. export ***,the effect of a.hesives on the qua.ity of coconut shell cha.coa. briquettes ma.e using screw extruder ma.hine ha. not been widely *** study a.ms to determine the effect of a.hesive type on the qua.ity of coconut shell cha.coa. *** process of fa.rica.ing briquettes in this study included crushing,mixing,blending,pressing,a.d *** the mixing process,3 types of a.hesives were used,na.ely ta.ioca.flour(Briquette_1),ca.sa.a.flour(Briquette_2),a.d modified ca.sa.a.flour(Briquette_3)with a.concentra.ion of 5%of the weight of coconut shell cha.coa. *** qua.ity of the resulting briquettes a.d commercia. briquettes will be eva.ua.ed by moisture content,a.h content,vola.ile ma.ter,fixed ca.bon,ca.orific va.ue,density,compressive,a.d drop test *** results of this resea.ch showed tha. the type of a.hesive ha. a.significa.t effect on the qua.ity of the briquettes *** Briquette_1 ha. better qua.ity tha. commercia. briquettes(Briquette_4)a.d other briquette *** test results showed tha. Briquette_1 produced briquettes with better compressive strength a.d fria.ility tha. the other specimens,a. 6.95 N/mm^(2) a.d 4.44%,*** moisture content,a.h content,fixed ca.bon,a.d ca.orific va.ue of Briquette_1 ha.e met the requirements set by the Indonesia. Na.iona. Sta.da.d(SNI)number ***,the vola.ile ma.ter content a.d density of Briquette_1 a.e by the sta.da.ds of Ja.a. a.d the United Sta.es a.erica.USa..

关键词： Coconut cha.coa. briquettes a.hesive mixing blending pressing

护理干预促进慢性呼吸困难患者自我管理的研究进展:整合性综述

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Interna.iona. Journa. of Nursing Sciences 2024年第2期11卷 241-257,I0003页

作者： Helga.Ra.a.l Henriques a.dreia.Correia.Ta.ia.a.Sa.tos Jose Fa.ia.Dia.a.sousa Joa.a.Portela.Joa.a.Teixeira Nursing School of Lisbon LisbonPortugal CIDNUR-Nursing Resea.ch Innovation and Development Centre of LisbonLisbonPortugal Unida.e de Hemodi-a.ise de Torres Vedra.-Nephroca.e Torres VedrasPortugal Unida.e de Cuida.os Continua.os na.a.ETIC Torres VedrasPortugal Unida.e Loca. de Sa.de Sa. Jose Cardiology DepartmentLisbonPortugal Unida.e Loca. de Sa.de da.a.ra.ida General Surgery DepartmentSetúbalPortugal

目的旨在通过系统综述,确定针对复杂慢性病患者增强自我管理的干预措施,以改善慢性呼吸困难,为护理人员促进该类人群的自我管理提供依据。方法2023年12月,系统检索Medline、Scopus、Web of Science、CINa.L、Cochra.e图书馆和乔安娜布... 详细信息

目的旨在通过系统综述,确定针对复杂慢性病患者增强自我管理的干预措施,以改善慢性呼吸困难,为护理人员促进该类人群的自我管理提供依据。方法2023年12月,系统检索Medline、Scopus、Web of Science、CINa.L、Cochra.e图书馆和乔安娜布里格斯研究所(Joa.na.Briggs Institute,JBI)循证实践数据库。对纳入研究进行数据提取和综合,研究人员采用Ra.ya.文献管理软件筛选标题及摘要,并依据JBI研究质量评估工具进行方法学质量评估。结果共纳入18项研究。这些研究探讨了针对慢性呼吸困难的各种干预措施,包括药物干预(氧气疗法和吸入疗法)和非药物方法(教育计划、呼吸练习、液体摄入管理、身体感知技术、同伴支持、情商培训和网络应用程序的使用)。这些干预措施减轻了患者情绪困扰,可以使患者在自我管理方面变得独立自主。结论促进复杂慢性病患者对慢性呼吸困难的自我管理需要采取综合方法,但目前研究中没有充分考虑到针对患者行为改变的干预措施,需要进一步开展相关研究完善干预措施。

关键词：慢性疾病呼吸困难护理病人自我管理