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Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model

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World Journal of Gastroenterology 2009年第16期15卷 1977-1984页

作者： carmen Frontela Maria Laura Scarino Simonetta Ferruzza Gaspar Ros carmen Martínez Department of Food Science and Nutrition Faculty of Veterinary Science and Food Science and TechnologyMurcia University INRAN National Research Institute for Food and Nutrition

AIM： To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells. METHODS： Both dephytinized （by adding an exogenous phytase） and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 too. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESULTS： Dephytinization of infant cereals significantly increased （P 〈 0.05） the cell uptake efficiency （from 0.66%-6.05% to 3.93%-13%）, retention （from 6.04%-16.68% to 14.75%-20.14%） and transport efficiency （from 0.14%-2.21% to 1.47%-6.02%）, of iron, and the uptake efficiency （from 5.0%-35.4% to 7.3%-41.6%） and retention （from 4.05%-20.53% to 14.45%-61.3%） of zinc, whereas calcium only cell uptake showed a significant increase （P 〈 0.05） after removing phytate from most of the samples analyzed. A positive relationship （P 〈 0.05） between mineral solubility and the cell uptake and transport efficiencies was observed. CONCLUSION： Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food.

关键词： Infant cereals Phytate Iron Calcium Zinc Caco-2 cells BioavaUability

Numerical and safety considerations about the Daguangbao landslide induced by the 2008 Wenchuan earthquake

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 1019-1035页

作者： Manchao He L.Ribeiro e sousa AndréMüller Eurípedes Vargas Jr. R.L.sousa C.sousa Oliveira Weili Gong State Key Laboratory of Geomechanics and Deep Underground Engineering(SKLGDUE) China University of Mining and TechnologyBeijingChina Tongji University ShanghaiChina Pontifical Catholic University of Rio de Janeiro Rio de JaneiroBrazil Khalifa University of Science and Technology Abu DhabiUnited Arab Emirates Technical Institute University of LisbonLisbonPortugal

The 2008 Wenchuan earthquake resulted in a large number of fatalities and caused significant economic *** of landslides,many of which are very large,were triggered by the earthquake.A majority of catastrophic landslides were distributed along the central Longmenshan fault system,at the eastern margin of the Tibetan *** of the landslides resulted in sudden damming of rivers causing flooding,which in turn induced secondary sliding *** the most significant landslides,the Daguangbao landslide was the largest in volume with the maximum *** this,a numerical model of the Daguangbao landslide,using the material point method(MPM),was developed to simulate the interaction of the seismic loads imposed on the *** numerical results then are compared with the post-earthquake *** a consequence of the landslide,a nearly vertical head scarp with a maximum height of about 700 m was *** is considered as a high risk situation that requires constant monitoring and ***,we propose a methodology based on Bayesian networks(BNs)to manage the risk associated with the stability of the rockwall at the Daguangbao landslide site.

关键词： Wenchuan earthquake Longmenshan fault Daguangbao landslide Material point method(MPM) Rockwall

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

GRID-INDEPENDENT CONSTRUCTION OF MULTISTEP METHODS

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Journal of Computational Mathematics 2017年第5期35卷 672-692页

作者： carmen Arevalo Gustaf Soderlind Numerical Analysis Centre for Mathematical Sciences Box 118 SE-22100 Lund Sweden.

A new polynomial formulation of variable step size linear multistep methods is pre- sented, where each k-step method is characterized by a fixed set of k - 1 or k parameters. This construction includes all methods of maximal order （p = k for stiff, and p = k ＋ 1 for nonstiff problems）. Supporting time step adaptivity by construction, the new formulation is not based on extending classical fixed step size methods; instead classical methods are obtained as fixed step size restrictions within a unified framework. The methods are imple- mented in MATLAB, with local error estimation and a wide range of step size controllers. This provides a platform for investigating and comparing different multistep method in realistic operational conditions. Computational experiments show that the new multi- step method construction and implementation compares favorably to existing software, although variable order has not yet been included.

关键词： Linear multistep methods Variable step size Adaptive step size Step sizecontrol Explicit methods Implicit methods Nonstiff methods Stiff methods Initial valueproblems Ordinary differential equations Differential-algebraic equations Implementa-tion.

Axonal growth inhibitors and their receptors in spinal cord injury:from biology to clinical translation

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Neural Regeneration Research 2023年第12期18卷 2573-2581页

作者： Sílvia sousa Chambel Célia Duarte Cruz Experimental Biology Unit Department of BiomedicineFaculty of Medicine of PortoUniversity of PortoPortoPortugal Translational NeuroUrology Instituto de Investigação e Inovação em Saúde-i3S and IBMCUniversidade do PortoPortoPortugal

Axonal growth inhibitors are released during traumatic injuries to the adult mammalian central nervous system, including after spinal cord injury. These molecules accumulate at the injury site and form a highly inhibitory environment for axonal regeneration. Among these inhibitory molecules, myelinassociated inhibitors, including neurite outgrowth inhibitor A, oligodendrocyte myelin glycoprotein, myelin-associated glycoprotein, chondroitin sulfate proteoglycans and repulsive guidance molecule A are of particular importance. Due to their inhibitory nature, they represent exciting molecular targets to study axonal inhibition and regeneration after central injuries. These molecules are mainly produced by neurons, oligodendrocytes, and astrocytes within the scar and in its immediate vicinity. They exert their effects by binding to specific receptors, localized in the membranes of neurons. Receptors for these inhibitory cues include Nogo receptor 1, leucine-rich repeat, and Ig domain containing 1 and p75 neurotrophin receptor/tumor necrosis factor receptor superfamily member 19(that form a receptor complex that binds all myelin-associated inhibitors), and also paired immunoglobulin-like receptor B. Chondroitin sulfate proteoglycans and repulsive guidance molecule A bind to Nogo receptor 1, Nogo receptor 3, receptor protein tyrosine phosphatase σ and leucocyte common antigen related phosphatase, and neogenin, respectively. Once activated, these receptors initiate downstream signaling pathways, the most common amongst them being the Rho A/ROCK signaling pathway. These signaling cascades result in actin depolymerization, neurite outgrowth inhibition, and failure to regenerate after spinal cord injury. Currently, there are no approved pharmacological treatments to overcome spinal cord injuries other than physical rehabilitation and management of the array of symptoms brought on by spinal cord injuries. However, several novel therapies aiming to modulate these inhibitory prot

关键词： chondroitin sulphate proteoglycans collapsin response mediator protein 2 inhibitory molecules leucine-rich repeat and Ig domain containing 1 leucocyte common antigen related myelin-associated glycoprotein neurite outgrowth inhibitor A Nogo receptor 1 Nogo receptor 3 oligodendrocyte myelin glycoprotein p75 neurotrophin receptor Plexin A2 Ras homolog family member A/Rho-associated protein kinase receptor protein tyrosine phosphataseσ repulsive guidance molecule A spinal cord injury tumour necrosis factor receptor superfamily member 19

Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic:Short and middle term outcomes

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World Journal of Methodology 2024年第2期14卷 107-126页

作者： Jacobo Trébol Ana Carabias-Orgaz María carmen Esteban-Velasco Asunción García-Plaza Juan Ignacio González-Munoz Ana Belén Sánchez-Casado Felipe Carlos Parreno-Manchado Marta Eguía-Larrea José Antonio Alcázar-Montero Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Cirugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND The first wave of coronavirus disease 2019(COVID-19)pandemic in Spain lasted from middle March to the end of June *** population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable *** our centre,we managed patients previously and newly diagnosed with *** established a strategy based on limiting perioperative social contacts,preoperative screening(symptoms and reverse transcriptionpolymerase chain reaction)and creating separated in-hospital COVID-19-free pathways for non-infected *** also adopted some practice modifications(surgery in different facilities,changes in staff and guidelines,using continuously changing personal protective equipment…),that supposed new *** To analyse cancer patients with a decision for surgery managed during the first wave,focalizing on outcomes and pandemic-related *** We prospectively included adults with a confirmed diagnosis of colorectal,oesophago-gastric,liver-pancreatic or breast cancer with a decision for surgery,regardless of whether they ultimately underwent *** analysed short-term outcomes[30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection]and outcomes after 3 years(adjuvant therapies,oncological events,death,SARS-CoV-2 infection and vaccination).We also investigated modifications to usual *** From 96 included patients,seven didn’t receive treatment that period and four never(3 due to COVID-19).Operated patients:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortality 3.57%/0%,major complications 7.04%/25.00%,anastomotic leaks 0%/5.00%,3-years disease-free survival(DFS)82.14%/52.4%and overall survival(OS)78.57%/76.2%.Six liver metastases and six pancreatic cancers:no mortality,one major complication,three grade A/B liver failures,one bile leak;3-year DFS 0%/33.3%and OS 50.0%/33.3%(liver metastases/pancreatic carcinoma).5 g

关键词： COVID-19 SARS-CoV-2 Colon cancer Rectal cancer Breast cancer Liver cancer Pancreatic cancer Gastric cancer Oesophageal cancer Surgery

Microwave ablation of solitary T1N0M0 papillary thyroid carcinoma:A case report

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World Journal of Clinical Cases 2023年第20期11卷 4883-4889页

作者： Teresa Dionísio Leando Lajut Filipa sousa Liliana Violante Pedro sousa Department of Radiology Centro Hospitalar de Vila Nova de Gaia e EspinhoVila Nova de Gaia 4430-000Portugal Department of Sugery Centro Hospitalar de Tras-os-Montes e Alto DouroVila Real 5000-508Portugal Department of Radiology CHVNGEVila Nova de Gaia 4430-000Portugal Department of Nuclear Medicine Instituto Portugues de Oncologia do Porto Francisco GentilPorto 4200-072Portugal

BACKGROUND The gold standard treatment for papillary thyroid carcinoma is total thyroidectomy and indications for microwave thermal ablation for primary thyroid cancers have not yet been clearly established However,some patients refuse surgery and others have no indication for it,for example patients under palliative care as in this case,or cannot undergo surgery,based on their *** indications are described in the most recent Korean,North American and European *** ablation,radiofrequency ablation,and microwave ablation are similarly safe and effective,so the choice should be based on the specific competences and resources of the pertaining *** indications are Percutaneous minimally-invasive techniques;they can be useful to stop disease progression and as an alternative to surgery in patients with contraindication or who refuse *** present a case of a thyroid papillary carcinoma with 17 mm effectively treated with microwave thermal ablation and without recurrence after one year of follow *** SUMMARY The authors present a case of a 71-years-old patient with a left lobe papillary thyroid carcinoma with 13 mm×17 mm×13 mm,with no indication for thyroid surgery given the context of another cancer in palliative *** thermoablation was performed on December *** months later he repeated computed tomography(CT)scan,which showed that the tumor had *** months after ablation he underwent a positron emission tomography/CT-fluorodeoxyglucose scan,which didn’t show any evidence of hypermetabolic tumor *** This case shows microwave thermoablation can be a safe and effective alternative to surgery in patients with no conditions to undergo surgery or when they refuse *** treating the tumor,with this minimally invasive technique,we are stopping its growth and avoiding disease progression.

关键词： Thyroid carcinoma Microwave ablation Thyroid nodules Papillary thyroid cancer Thyroid

Using fluorescence-based microplate assay to assess DOM-metal binding in reactive materials for treatment of acid mine drainage

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Journal of Environmental Sciences 2011年第6期23卷 891-896页

作者： carmen Mihaela Neculita Yves Dudal Gerald J Zagury Department of Civil and Environmental Engineering KAIST335 GwahangnoYuseong-guDaejeon 305-701Korea Institut National de la Recherche Agronomique UMR Eco&Sols-Ecologie Fonctionnelle et Biogéochimie des SolsMontpellier SupAgro-INRA-IRD2Place Pierre VialaBatiment 1234060 Montpellier Cedex 2France Department of Civil Geologicaland Mining EngineeringE'cole Polytechnique de Montre'alC.P.6079 Station Centre-villeMontrealQCH3C 3A7Canada

One potential drawback of compost-based passive bioreactors,which is a promising biotechnology for acid mine drainage（AMD） treatment,is the transport of dissolved organic matter（DOM）-metal complexes in surface *** address this problem,the objective of this study was to assess the maximum capacity of organic substrates to release soluble DOM-metal complexes in treated water. The reactivities of DOM in maple wood chips and sawdust,composted poultry manure,and leaf compost were quantified toward Cd2＋,Ni2＋,Fe2＋,and Cu2＋ using fluorescence *** DOM showed the highest reactivity toward Fe,but a limited number of available sites for sorption,whereas DOM-Cd complexes exhibited the lowest fluorescence ***,the DOM from a mixture of wastes formed higher concentrations of DOM-metal complexes relative to sole *** DOM-metal complexes, the concentrations of DOM-Ni complexes were the *** reaching steady-state,low concentrations of DOM-metal complexes were released in treated water,which is in agreement with theoretical predictions based on geochemical ***,in addition to physicochemical characterization,fluorescence quenching technique is recommended for the substrate selection of bioreactors.

关键词： passive bioreactors acid mine drainage DOM reactivity fluorescence quenching metal complexation

Major regulatory mechanisms involved in sperm motility

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Asian Journal of Andrology 2017年第1期19卷 5-14页

作者： Rute Pereira Rosalia Sa Alberto Barros Mario sousa Department of Microscopy Laboratory of Cell Biology Institute of Biomedical Sciences Abel Salazar University of Porto (ICBAS-UP) Rua Jorge Viterbo Ferreira 2284050-313 Porto Portugal and Multidisciplinary Unit for Biomedical Research-UMIB ICBAS-UP Centre for Reproductive Genetics Alberto Barros Av. do Bessa 2401° Dto. Frente 4100-012 Porto Portugal Department of Genetics Faculty of Medicine University of Porto. Alameda Prof. Hernani Monteiro 4200-319 Porto Portugal and Institute of Health Research an Innovation (13S) University of Porto Portugal.

The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies.

关键词： antioxidants calcium membrane channels protein kinases sperm genetic abnormalities sperm motility