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Conventional treatments and non-PEGylated liposome encapsulated doxorubicin for visceral leishmaniasis:A scoping review

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Asian Pacific Journal of Tropical Medicine 2022年第7期15卷 293-307页

作者： soumya ranjan Satapathy Rudra Narayan Sahoo School of Pharmaceutical Sciences Siksha‘O’Anusandhan(Deemed to be University)BhubaneswarIndia School of Pharmacy and Life Sciences Centurion University of Technology and ManagementOdishaIndia

Visceral leishmaniasis(VL),also known as Kala-azar,is caused by Leishmania(L.)donovani complex,which includes *** and *** and is associated with a high death rate as compared to the cutaneous and subcutaneous *** of VL includes chemotherapeutic agents which are associated with some major hurdles like toxicities,parenteral administration,high cost,parasite resistance and ***,there is an urgent requirement to develop novel chemotherapeutic agents or repurposing of existing drugs against *** formulation of new chemical entity for the treatment of VL is laborious,time consuming and associated with huge financial ***,screening of existing chemotherapeutic agents is a good alternative to avail cost-effective treatment option for ***-PEGylated liposome encapsulated doxorubicin(Myocet®)is proposed as an alternative treatment option for VL in this review ***,we covered the fundamental aspects of VL,loophole associated with available current treatment strategies and non-PEGylated liposome encapsulated doxorubicin as a novel alternative formulation for treating VL,as this liposomal delivery system of doxorubicin might passively target the intra-cellular regions of macrophage.

关键词： Visceral leishmaniasis Doxorubicin Passive targeting Repositioning Non-PEGylated liposome encapsulated doxorubicin Resistance

Life cycle greenhouse gas emissions from five contrasting rice production systems in the tropics

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Pedosphere 2023年第6期33卷 960-971页

作者： Pradeep K.DASH Pratap BHATTACHARYYA soumya R.PADHY Amaresh K.nayak Annie POONAM Sangita MOHANTY Crop Production Division Indian Council of Agriculture Research(ICAR)-National Rice Research Institute(NRRI)GuttackOdisha 753006India

Carbon footprint (CF) quantification of major rice production systems (RPSs) is a prerequisite for developing strategies for climate change mitigation in agriculture. Total life cycle greenhouse gas emissions (LC-GHGs) from rice production to consumption might provide precise CFs for RPSs. Therefore, we assessed three segments (pre-farm, on-farm, and post-farm) of LC-GHGs under five major contrasting RPSs, i.e., aerobic rice (AR), shallow lowland rice(SLR), system of rice intensification (SRI), deep water rice (DWR), and zero-tilled direct-seeded rice (ZTR), in India to determine the corresponding *** footprint was the lowest for ZTR, while LC-GHGs were the lowest for AR. Therefore, AR is an adequate option for short-term reduction of GHG emissions. However, ZTR might be promoted by incentives as a long-term strategy. Among segmental LC-GHGs, on-farm GHG emissions contributed less than the other two segmental GHG emissions. The post-farm (i.e., farm gate to consumption) segment contributed the largest proportion (54%–69%) of total LC-GHGs, followed by pre-farm (i.e., cradle to farm) segment (21%–27%) and on-farm operation (11%–23%). These findings suggest that post-farm components that contribute to maximum GHG emissions must be scientifically tackled with proactive policy initiatives. However, the data of this segment are limited and scattered. Therefore, real-time assessment of GHG emissions during post-farm operation and input transportation from cradle to farm requires more precise quantification. Although CF in SRI was higher, this system had the potential to achieve higher yields and better soil carbon storage. Therefore,SRI may be encouraged from the perspectives of food security and long-term sustainability by reducing GHG emissions by three to four times.

关键词： carbon-equivalent emission carbon footprint climate change mitigation global warming management practice soil carbon stock:

Fatal intracranial bleedings in a viper bite:A case report

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Chinese Journal of Traumatology 2023年第2期26卷 121-124页

作者： Alagarasan Naveen Manas ranjan Sahu Manoj Kumar Mohanty Kimi soumya Padhi Ashis Patnaik Department of Forensic Medicine&Toxicology All India Institute of Medical Sciences(AMS)BhubaneswarOdishaIndia Department of Neurosurgery Al India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia

Viper bite envenomation represents a significant occupational hazard among agricultural workers in *** viper bite envenomation is usually suspected when a patient presents with predominant local symptoms at the bitten site,including pain,swelling,and ***,systemic findings such as diffuse intravascular coagulation,hypotension,and shock may alert physicians of viper bite envenomation rather than a neurotoxic snake ***,cerebral complications are rare in viper bites but may potentially *** nervous system involvement in a viper bite is either due to neurotoxins or hemorrhagins present in the venom,which may induce cerebral thrombosis,ischemia,infarction,and *** we present a case of a previously healthy adult male who succumbed to extensive subarachnoid,intracerebral,and intraventricular hemorrhages involving bilateral cerebral hemispheres following viper snake bite *** report highlights the importance of anticipating cerebral complications in viper bite envenomation,a rare *** also emphasizes the need for early antisnake venom administration to prevent and control systemic envenomation and its complications.

关键词： Snake bite Viper Intracerebral hemorrhage Subarachnoid hemorrhage Anti-snake venom

Design of a Robust Optimal Decentralized PI Controller Based on Nonlinear Constraint Optimization For Level Regulation: An Experimental Study

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 187-199页

作者： soumya ranjan Mahapatro Bidyadhar Subudhi Sandip Ghosh Department of Electrical Engineering National Institute of Technology RourkelaRourkela 769008India School of Electrical Sciences Indian Institute of TechnologyFarmagudiGoa 403401India Department of Electrical Engineering Indian Institute of TechnologyVaranasi 221005India

This paper presents the development of a new robust optimal decentralized PI controller based on nonlinear optimization for liquid level control in a coupled tank system. The proposed controller maximizes the closed-loop bandwidth for specified gain and phase margins, with constraints on the overshoot ratio to achieve both closed-loop performance and robustness. In the proposed work, a frequency response fitting model reduction technique is initially employed to obtain a first order plus dead time(FOPDT) model of each higher order subsystem. Furthermore, based on the reduced order model, a proposed controller is designed. The stability and performance of the proposed controller are verified by considering multiplicative input and output uncertainties. The performance of the proposed optimal robust decentralized control scheme has been compared with that of a decentralized PI controller. The proposed controller is implemented in real-time on a coupled tank system. From the obtained results,it is shown that the proposed optimal decentralized PI controller exhibits superior control performance to maintain the desired level, for both the nominal as well as the perturbed case as compared to a decentralized PI controller.

关键词： Index Terms—Decentralized control multivariable system process control parameter uncertainty robustness

A Novel Multi-agent Formation Control Law With Collision Avoidance

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 558-568页

作者： Arindam Mondal Laxmidhar Behera soumya ranjan Sahoo Anupam Shukla Department of Electrical Engineering Indian Institute of Technology IEEE ABV-Indian Institute of Information Technology & Management

In this paper a stable formation control law that simultaneously ensures collision avoidance has been *** is assumed that the communication graph is undirected and *** proposed formation control law is a combination of the consensus term and the collision avoidance term(CAT).The first order consensus term is derived for the proposed model,while ensuring the Lyapunov *** consensus term creates and maintains the desired formation shape,while the CAT avoids the *** the collision avoidance,the potential function based CAT makes the agents repel from each *** unrestricted repelling magnitude cannot ensure the graph connectivity at the time of collision *** we have proposed a formation control law,which ensures this connectivity even during the collision *** is achieved by the proposed novel adaptive potential *** potential function adapts itself,with the online tuning of the critical variable associated with *** tuning has been done based on the lower bound of the critical variable,which is derived from the proposed connectivity *** efficacy of the proposed scheme has been validated using simulations done based on formations of six and thirty-two agents respectively.

关键词： Consensus collision avoidance formation control graph theory stability

Blue-green crystals:A telltale sign of poorer outcome?

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Journal of Acute Disease 2022年第6期11卷 254-255页

作者： Rajeev ranjan soumya Jagannath Mahapatra Tushar Sehgal Department of Laboratory Medicine All India Institute of Medical SciencesNew Delhi110029India Department of Gastroenterology All India Institute of Medical SciencesNew Delhi110029India

Dear editors,Here we present the case of a 27-year-old male who came to the emergency with a high spiking fever,worsening upper abdominal pain,and shortness of breath for the last 3 *** consent had been taken from the *** patient had complaints of multiple episodes of vomiting and *** examination,the patient was febrile(101ºF)with a pulse rate of 130 per minute(normal:60-100 per minute)and blood pressure of 108/68 mmHg(normal:120/80 mmHg).

关键词： vomiting febrile fever

Least-Square Support Vector Machine and Wavelet Selection for Hearing Loss Identification

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 299-313页

作者： Chaosheng Tang Deepak ranjan nayak Shuihua Wang School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo454000China Department of Computer Science and Engineering Malaviya National Institute of TechnologyJaipur302017India School of Mathematics and Actuarial Science University of LeicesterLeicesterLE17RHUK Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia

Hearing loss(HL)is a kind of common illness,which can significantly reduce the quality of *** example,HL often results in mishearing,misunderstanding,and communication ***,it is necessary to provide early diagnosis and timely treatment for *** study investigated the advantages and disadvantages of three classical machine learning methods:multilayer perceptron(MLP),support vector machine(SVM),and least-square support vector machine(LS-SVM)approach andmade a further optimization of the LS-SVM model via wavelet *** investigation illustrated that themultilayer perceptron is a shallowneural network,while the least square support vector machine uses hinge loss function and least-square ***,a wavelet selection method was proposed,and we found db4 can achieve the best *** experiments showed that the LS-SVM method can identify the hearing loss disease with an overall accuracy of three classes as 84.89±1.77,which is superior to SVM *** results show that the least-square support vector machine is effective in hearing loss identification.

关键词： Hearing loss wavelet entropy multilayer perceptron least square support vector machine

Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy:a report and review of literature

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Journal of Otology 2020年第3期15卷 112-116页

作者： K Devaraja Dipak ranjan nayak Department of Otorhinolaryngology and Head and Neck Surgery Kasturba Medical CollegeManipal Academy of Higher EducationUdupiKarnataka576104India

Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves *** can it also effect one or more of cranial nerves IX,X,XI,and *** present a case of malignant otitis externa which presented with symptomatic palsy of IX and XII nerves sparing the VII cranial *** patient though later on had internal jugular vein thrombosis,which we presume is due to the involvement of the parapharyngeal space that prompted us to reconsider the diagnosis,and later on,to aggravate the *** proper blood sugar control and appropriate long term antibiotics,not only that the patient is disease free at one year follow up,but the cranial nerve deficits also *** from sharing the clinical and management details of this patient,we have reviewed the relevant literature in the discussion,which has shed some light onto some of the interesting facts about this condition and its prognosis.

关键词： Skull base osteomyelitis Malignant otitis externa Hypoglossal palsy Diabetes mellitus Internal jugular vein

Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease

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World Journal of Hepatology 2022年第7期14卷 1421-1437页

作者： Sagnik Biswas Manas Vaishnav Piyush Pathak Deepak Gunjan soumya Jagannath Mahapatra Saurabh Kedia Gyanranjan Rout Bhaskar Thakur Baibaswata nayak Ramesh Kumar Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Division of Biostatistics UT Southwestern Medical CenterDallasTexas 75390United States Department of Gastroenterology All India Institute of Medical SciencesPatna 800014BiharIndia

BACKGROUND Platelet transfusion in acute variceal bleeding(AVB)is recommended by few guidelines and is common in routine clinical practice,even though the effect of thrombocytopenia and platelet transfusion on the outcomes of AVB is *** To determine how platelet counts,platelets transfusions,and fresh frozen plasma transfusions affect the outcomes of AVB in cirrhosis patients in terms of bleeding control,rebleeding,and *** Prospectively maintained database was used to analyze the outcomes of cirrhosis patients who presented with *** outcomes were assessed as the risk of rebleeding at days 5 and 42,and risk of death at day 42,considering the platelet counts and platelet *** score matching(PSM)was used to compare the outcomes in those who received platelet *** comparisons were done using Kaplan-Meier curves with log-rank tests and Coxproportional hazard model for rebleeding and for 42-d *** The study included 913 patients,with 83.5%men,median age 45 years,and Model for End-stage Liver Disease score *** count50×10^(9)/L were found in 23(2.5%),168(18.4%),and 722(79.1%)patients,*** rates were similar between the three platelet groups on days 5 and 42(13%,6.5%,and 4.7%,respectively,on days 5,P=0.150;and 21.7%,17.3%,and 14.4%,respectively,on days 42,P=0.433).At day 42,the mortality rates for the three platelet groups were also similar(13.0%,23.2%,and 17.2%,respectively,P=0.153).On PSM analysis patients receiving platelets transfusions(n=89)had significantly higher rebleeding rates on day 5(14.6%vs 4.5%;P=0.039)and day 42(32.6%vs 15.7%;P=0.014),compared to those who didn'*** mortality rates were also higher among patients receiving platelets(25.8%vs 23.6%;P=0.862),although the difference was not *** multivariate analysis,platelet transfusion and not platelet count,was independently associated with 42-d *** e

关键词： Gastrointestinal Hemorrhage Platelet transfusion Thrombocytopenia Fresh frozen plasma Portal hypertension Mortality