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中华生物医学工程杂志 2008年第1期14卷 -页

作者： soumitra Roy 王鸣 James Mwilson 宾州大学病理与实验医学系基因治疗研究组美国费城19104 广州疾病预防与控制中心宾州大学病理与实验医学系基因治疗研究组美国费城19104

流感病毒属于正黏病毒科,是一种带衣壳的负链单股RNA病毒.甲乙两型流感病毒为该病毒分科之下的两个属,是人类流感的相关致病原.当前应用的流感疫苗所含成分就是处于流行期间的甲乙型流感病毒的灭活株或减毒株.

关键词：禽流感流感病毒流感疫苗致病原流行期减毒株应用乙型灭活负链单股

A Novel Approach for the Synthesis of (R) and (S)-Nicotine

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International Journal of Organic Chemistry 2022年第4期12卷 189-199页

作者： Rohith Kumar Agarthimoole Sahir Gagan Sudesna Parida Tarur Konikkaledom Dinesh Maheswaran S. Karatholuvhu Namasivayam Palani soumitra Mukherjee ITC Limited ITC Life Sciences and Technology Centre Peenya Industrial Area Phase I Bangalore India Presently at Department of Atmospheric Sciences Texas A&M University College Station Texas USA

Nicotine is an alkaloid mainly found in leaves of tobacco and is used therapeutically for patients seeking relief from tobacco dependence in the form of products such as gums, patches, lozenges etc. In these products, majorly nicotine derived from tobacco is used which is inherently contaminated with undesirable nicotine related substances as impurities at low levels and is difficult to remove. Hence, use of synthetic nicotine is considered as an option which will be devoid of such impurities. In this work, a short and efficient synthesis of (R) and (S) nicotine was achieved by leveraging a key esterification between racemic homoallylic alcohol intermediate (2) and (S)-Ibuprofen (3) to produce diastereomers (5a) and (5b) which were easily separable under standard column chromatography conditions. Use of (S)-Ibuprofen (3) as a chiral resolving agent constitutes a novel approach which was not reported earlier. A subsequent hydrolysis of the diastereomers furnished the homoallylic alcohol intermediates (S)-6a and (R)-6a with high enantiopurity, which was effectively translated to the corresponding (R)-nicotine and (S)-nicotine respectively.

关键词： Nicotine Ibuprofen Diastereomers Column Chromatography Chiral Purity

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禽流感基因疫苗的研制

中华生物医学工程杂志 2007年第3期13卷 190-192页

作者： soumitra Roy Ming Wang James M Wilson 19104 美国费城宾夕法尼亚大学基因治疗研究组广州疾病预防与控制中心中山大学疫苗研究所

流感病毒属于正粘病毒科，是一种带衣壳的负链单股RNA病毒。甲乙两型流感病毒为该病毒分科之下的两个属，是人类流感的相关致病原。当前应用的流感疫苗所含成分就是处于流行期间的甲乙型流感病毒的灭活株或减毒株。

关键词：禽流感基因疫苗流感病毒结构

多西紫杉醇节律化疗联合地塞米松抗小鼠肺癌血管生成的实验研究

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中原医刊 2007年第8期34卷 5-7页

作者：蔡政胡秀峰周芳韩颖 soumitra sudip bhuyan 李醒亚郑州大学第一附属医院肿瘤科郑州450052 河南省肿瘤医院

目的探讨多西紫杉醇节律化疗及地塞米松对C57BL／6小鼠Lewis肺癌（LLC）肿瘤生长和血管生成的影响。方法C57BL／6小鼠皮下接种LLC细胞，随机分组后分别给予相应治疗。隔天测量小鼠体重及肿瘤体积。小鼠处死后称瘤重，应用免疫组化检测... 详细信息

目的探讨多西紫杉醇节律化疗及地塞米松对C57BL／6小鼠Lewis肺癌（LLC）肿瘤生长和血管生成的影响。方法C57BL／6小鼠皮下接种LLC细胞，随机分组后分别给予相应治疗。隔天测量小鼠体重及肿瘤体积。小鼠处死后称瘤重，应用免疫组化检测小鼠肿瘤组织中CD34和HIF-1α蛋白表达。结果对照组皮下瘤重明显大于节律组、地塞米松组和联合组。对照组微血管密度（MVD）明显高于三个实验组（P〈0．05），三个实验组HIF-1α蛋白表达较对照组显著下降（P〈0．05）。结论多西紫杉醇节律化疗和地塞米松可明显抑制LLC的生长及血管生成，其可能的机制之一是通过下调小鼠肿瘤组织中HIF—1α的表达而间接实现抗肿瘤血管生成作用。

关键词：节律化疗地塞米松血管生成缺氧诱导因子-1α

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心理性眼睑痉挛:诊断的困境（英文）

上海精神医学 2016年第6期28卷 346-348页

作者： Das S Sreedharan RP Remadevi PS Saji CV Department of Psychiatry Goverment T.D.Medical College Department of Neurology Goverment General Hospital Department of Neurology Goverment T.D.Medical College

概述:眼睑痉挛是眼轮匝肌不受控制的痉挛性收缩导致眼睛异常抽动或抽搐。它通常持续几秒钟到几分钟,但在严重的情况下,眼睛可能会紧闭数小时。它可能是良性的,无论是原发的还是继发于基底节、锥体束的病变,眼部的创伤或局部病理情况引起... 详细信息

概述:眼睑痉挛是眼轮匝肌不受控制的痉挛性收缩导致眼睛异常抽动或抽搐。它通常持续几秒钟到几分钟,但在严重的情况下,眼睛可能会紧闭数小时。它可能是良性的,无论是原发的还是继发于基底节、锥体束的病变,眼部的创伤或局部病理情况引起的,或是药物所致的。在这里,我们报告一例心理性眼睑痉挛的病例。患者,女性,65岁,发作性无法睁眼6个月。她反复出现突然闭眼,往往要持续1 h。这使其无法人际交往,社会功能受损。详细的体检、包括神经影像学在内的检查排除了神经系统或其他系统性病因。口服药物治疗效果不佳,只在右侧眼睑肌射7个单位的肉毒素,几秒钟内,其双眼症状均得以缓解。之后一次治疗时,只用针刺一下一只眼睛,无需任何药物或暗示,患者就睁开紧闭的双眼。本病例中,患者曾报告过最近家务繁重感到有压力。这一病例表明,真正的运动障碍与功能性障碍鉴别往往有一定难度。因此,在进行任何有创治疗之前,评估患者的内外应激,并对此处理,将获益匪浅。

关键词：眼睑痉挛心理性的运动障碍功能性障碍印度

Principally-Injective Leavitt Path Algebras over Arbitrary Graphs

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Journal of Mathematics and System Science 2019年第3期9卷 86-89页

作者： soumitra Das Ardeline M.Buhphang Department of Mathematics North-Eastern Hill UniversityPermanent CampusShillong 793022MeghalayaIndia

ring R is called right principally-injective if every R-homomorphism f:aR→R,a∈R,extends to R,or equivalently,if every system of equations xa=b(a,b∈R)is solvable in *** this paper we show that for any arbitrary graph E and for a field K,principally-injective conditions for the Leavitt path algebra LK(E)are equivalent to that graph E being *** also show that the principally-injective Leavitt path algebras are precisely the von Neumann regular Leavitt path algebras.

关键词： Leavitt path algebras von Neumann regular rings principally-injective rings arbitrary graph

CapV单氨基酸突变影响大肠杆菌多种生物表型

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CapV单氨基酸突变影响大肠杆菌多种生物表型

Fungal diversity notes 1277-1386:taxonomic and phylogenetic contributions to fungal taxa

中国微生物学会兽医微生物学专业委员会暨中国畜牧兽医学会生物制品学分会2021年学术论坛

作者：李丰阳 Heike B?hre soumitra Mohanty Annelie Brauner Manfred Rohde Ute R?mling

在不同的压力如营养匮乏和抗生素刺激等条件下,细菌分裂抑制可导致细菌的异常生长如丝状。本研究鉴定了一个可能的磷脂酶蛋白,CapV,能够调控大肠杆菌多种生物表型。CapV对大肠杆菌对数期生长影响不明显,但在平台期诱导大量细菌死亡;Cap... 详细信息

在不同的压力如营养匮乏和抗生素刺激等条件下,细菌分裂抑制可导致细菌的异常生长如丝状。本研究鉴定了一个可能的磷脂酶蛋白,CapV,能够调控大肠杆菌多种生物表型。CapV对大肠杆菌对数期生长影响不明显,但在平台期诱导大量细菌死亡;CapV诱导大肠杆菌呈长丝状,菌体表面无明显分隔,可导致DNA异常聚集。生物信息学分析发现CapV含有典型的磷脂酶蛋白结构域PNPLA;点突变PNPLA结构域中GGG[K/R]G和DG[A/G]可使细菌恢复正常形态,而点突变GxSxG却没有作用。此外,CapV抑制了大肠杆菌rdar生物膜形成、CsgD表达和环二鸟苷酸水平。本研究表明,CapV通过干扰DNA分离,致使细菌分裂异常,导致细菌丝状生长并最终引起死亡,提示单氨基酸突变在蛋白质功能进化上的至关重要的作用。

关键词：磷脂酶 CapV 丝状生长生物膜

来源： cnki会议评论

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Fungal Diversity 2020年第5期104卷 1-266页

作者： Hai-Sheng Yuan Xu Lu Yu-Cheng Dai Kevin D.Hyde Yu-He Kan Ivana Kušan Shuang-Hui He Ning-Guo Liu V.Venkateswara Sarma Chang-Lin Zhao Bao-Kai Cui Nousheen Yousaf Guangyu Sun Shu-Yan Liu Fang Wu Chuan-Gen Lin Monika C.Dayarathne Tatiana Baptista Gibertoni Lucas B.Conceição Roberto Garibay-Orijel Margarita Villegas-Ríos Rodolfo Salas-Lizana Tie-Zheng Wei Jun-Zhi Qiu Ze-Fen Yu Rungtiwa Phookamsak Ming Zeng soumitra.paloi Dan-Feng Bao Pranami DAbeywickrama De-Ping Wei Jing Yang Ishara S.Manawasinghe Dulanjalee Harishchandra Rashika S.Brahmanage Nimali Ide Silva Danushka S.Tennakoon Anuruddha Karunarathna Yusufjon Gafforov Dhandevi Pem Sheng-Nan Zhang AndréL.C.Mde Azevedo Santiago Jadson Diogo Pereira Bezerra Bálint Dima Krishnendu Acharya Julieta Alvarez-Manjarrez Ali H.Bahkali Vinod K.Bhatt Tor Erik Brandrud Timur S.Bulgakov E.Camporesi Ting Cao Yu-Xi Chen Yuan-Yuan Chen Bandarupalli Devadatha Abdallah M.Elgorban Long-Fei Fan Xing Du Liu Gao Camila Melo Gonçalves Luis F.P.Gusmão Naruemon Huanraluek Margita Jadan Ruvishika S.Jayawardena Abdul Nasir Khalid Ewald Langer Diogo X.Lima Nelson Correia de Lima-Júnior Carla Rejane Sousa de Lira Jian-Kui(Jack)Liu Shun Liu Saisamorn Lumyong Zong-Long Luo Neven Matočec M.Niranjan JoséRibamar Costa Oliveira-Filho Viktor Papp Eduardo Pérez-Pazos Alan J.L.Phillips Peng-Lei Qiu Yihua Ren Rafael F.Castañeda Ruiz Kamal C.Semwal Karl Soop Carlos A.Fde Souza Cristina Maria Souza-Motta Li-Hua Sun Meng-Le Xie Yi-Jian Yao Qi Zhao Li-Wei Zhou CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China School of Ecology and Nature Conservation Beijing Advanced Innovation Center for Tree Breeding By Molecular DesignBeijing Forestry UniversityBeijing 100083People’s Republic of China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Ruđer BoškovićInstitute Bijenička cesta 5410000 ZagrebCroatia Faculty of Agriculture Natural Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Department of Biotechnology School of Life SciencesPondicherry UniversityR.V.NagarKalapetPondicherry 605014India College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China Department of Botany Govt.College UniversityKatchery RoadLahorePakistan State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection Northwest A&F UniversityYanglingShaanxiPeople’s Republic of China Laboratory of Plant Pathology College of Plant ProtectionJilin Agricultural UniversityChangchun 130118Jilin ProvincePeople’s Republic of China Centro de Biociências Departamento de MicologiaUniversidade Federal de PernambucoCidade UniversitáriaAvenida da Engenharia s/nRecifePernambuco 50740-600Brazil Departamento de Ciências Biológicas Universidade Estadual de Feira de SantanaAv.Transnordestina s/nNovo HorizonteFeira de SantanaBA 44036-900Brazil L

This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and strain culture,combined with DNA sequence analyses.110 taxa are described and illustrated,including five new genera,92 new species,eight new combinations and other taxonomic contributions(one new sequenced species,one new host and three new records)which are accommodated in 40 families and 1 incertae sedis in *** new genera are Amyloceraceomyces,Catenuliconidia,Hansenopezia,Ionopezia and *** new species are Amyloceraceomyces angustisporus,Amylocorticium ellipsosporum,Arthrinium sorghi,Catenuliconidia uniseptata,Clavulina sphaeropedunculata,Colletotrichum parthenocissicola,Coniothyrium triseptatum,Cortinarius indorusseus,***,***,***,***,Diaporthe pimpinel-lae,Dictyosporella guizhouensis,Diplodia torilicola,Fuscoporia marquesiana,***,Hansenopezia decora,Helicoarcta-tus thailandicus,Hirsutella hongheensis,Humidicutis brunneovinacea,Lentaria gossypina,***,Lycoperdon lahorense,***,Magnopulchromyces scorpiophorus,Moelleriella gracilispora,Neodevriesia manglicola,Neodidymelliopsis salvia,***,Neoroussoella magnoliae,Neottiella gigaspora,Ophiosphaerella chiangraiensis,Phaeotremella yunnanensis,Podosphaera yulii,Rigidoporus juniperinus,Rhodofomitopsis pseudofeei,Russula benghalensis,Scleroramularia vermispora,Scytinopogon minisporus,Sporormurispora paulsenii,Thaxteriellopsis obliqus,Tomentella asiae-orientalis,***,***,***,***,***,***,***,***,***-nocystidiata,***,***,***,***,***,***,***,***,***,***,***,***,***,***,***,

关键词： 110 taxa Agaricomycetes Ascomycota Basidiomycota Mucoromycota New combinations New genera New species Phylogeny Taxonomy

Fungal diversity notes 929-1035:taxonomic and phylogenetic contributions on genera and species of fungi

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Fungal Diversity 2019年第2期95卷 1-273页

作者： Rungtiwa Phookamsak Kevin D.Hyde Rajesh Jeewon D.Jayarama Bhat E.B.Gareth Jones Sajeewa S.N.Maharachchikumbura Olivier Raspe Samantha C.Karunarathna Dhanushka N.Wanasinghe Sinang Hongsanan Mingkwan Doilom Danushka S.Tennakoon Alexandre R.Machado Andre L.Firmino Aniket Ghosh Anuruddha Karunarathna Armin Mesic Arun Kumar Dutta Benjarong Thongbai Bandarupalli Devadatha Chada Norphanphoun Chanokned Senwanna Deping Wei Dhandevi Pem Frank Kwekucher Ackah Gen-Nuo Wang Hong-Bo Jiang Hugo Madrid Hyang Burm Lee Ishani D.Goonasekara Ishara S.Manawasinghe Ivana Kusan Josep Cano Josepa Gene Junfu Li Kanad Das Krishnendu Acharya K.N.Anil Raj K.P.Deepna Latha K.W.Thilini Chethana Mao-Qiang He Margarita Duenas Margita Jadan Maria P.Martin Milan C.Samarakoon Monika C.Dayarathne Mubashar Raza Myung Soo Park M.Teresa Telleria Napalai Chaiwan Neven Matocec Nimali Ide Silva Olinto L.Pereira Paras Nath Singh Patinjareveettil Manimohan Priyanka Uniyal Qiu-Ju Shang Rajendra P.Bhatt Rekhani H.Perera Renato Lucio Mendes Alvarenga Sandra Nogal-Prata Sanjay K.Singh Santhiti Vadthanarat Seung-Yoon Oh Shi-Ke Huang Shiwali Rana Sirinapa Konta soumitra.paloi Subashini C.Jayasiri Sun Jeong Jeon Tahir Mehmood Tatiana Baptista Gibertoni Thuong T.T.Nguyen Upendra Singh Vinodhini Thiyagaraja V.Venkateswara Sarma Wei Dong Xian-Dong Yu Yong-Zhong Lu Young Woon Lim Yun Chen Zdenko Tkalcec Zhi-Feng Zhang Zong-Long Luo Dinushani A.Daranagama Kasun M.Thambugala Saowaluck Tibpromma Erio Camporesi Timur S.Bulgakov Asha J.Dissanayake Indunil C.Senanayake Dong Qin Dai Li-Zhou Tang Sehroon Khan Huang Zhang Itthayakorn Promputtha Lei Cai Putarak Chomnunti Rui-Lin Zhao Saisamorn Lumyong Saranyaphat Boonmee Ting-Chi Wen Peter E.Mortimer Jianchu Xu Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Institute of Animal Science State Key Laboratory of AnimalNutritionChinese Academy of Agricultural SciencesBeijing 100193People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Rai 50150Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius No.128/1-J Co-Op Azad Housing SocietyCurcaGoa VelhaIndia Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Botanic Garden Meise Nieuwelaan 381860 MeiseBelgium Federation Wallonie-Bruxelles Service general de l’Enseignement universitaire et de la Recherche scientifiqueRue A.Lavallee 11080 BrusselsBelgium Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518060People’s Republic of China Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004Taiwan Departamento de Micologia Universidade Federal de PernambucoRecifePernambucoBrazil Instituto de Ciencias Agrarias Universidade Federal de UberlandiaMonte CarmeloMinas GeraisBrazil Department of Botany&Microbiology H.N.B.Garhwal UniversitySrinagarGarhwal 246174UttarakhandIndia Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Ruder Boskovic Institute Bijenicka cesta 5410000 ZagrebCroatia Molecular and Applied Mycology and Plant Pathology Laboratory Department of BotanyUniversity of CalcuttaKolkataWest Bengal

This article is the ninth in the series of Fungal Diversity Notes,where 107 taxa distributed in three phyla,nine classes,31 orders and 57 families are described and *** described in the present study include 12 new genera,74 new species,three new combinations,two reference specimens,a re-circumscription of the epitype,and 15 records of sexualasexual morph connections,new hosts and new geographical *** new genera comprise Brunneofusispora,Brunneomurispora,Liua,Lonicericola,Neoeutypella,Paratrimmatostroma,Parazalerion,Proliferophorum,Pseudoastrosphaeriellopsis,Septomelanconiella,Velebitea and ***-four new species are Agaricus memnonius,***,Aleurodiscus patagonicus,Amanita flavoalba,***,Amphisphaeria mangrovei,Baorangia major,Bartalinia kunmingensis,Brunneofusispora sinensis,Brunneomurispora lonicerae,Capronia camelliaeyunnanensis,Clavulina thindii,Coniochaeta simbalensis,Conlarium thailandense,Coprinus trigonosporus,Liua muriformis,Cyphellophora filicis,Cytospora ulmicola,Dacrymyces invisibilis,Dictyocheirospora metroxylonis,Distoseptispora thysanolaenae,Emericellopsis koreana,Galiicola baoshanensis,Hygrocybe lucida,Hypoxylon teeravasati,Hyweljonesia indica,Keissleriella caraganae,Lactarius olivaceopallidus,Lactifluus midnapurensis,Lembosia brigadeirensis,Leptosphaeria urticae,Lonicericola hyaloseptispora,Lophiotrema mucilaginosis,Marasmiellus bicoloripes,Marasmius indojasminodorus,Micropeltis phetchaburiensis,Mucor orantomantidis,Murilentithecium lonicerae,Neobambusicola brunnea,Neoeutypella baoshanensis,Neoroussoella heveae,Neosetophoma lonicerae,Ophiobolus malleolus,Parabambusicola thysanolaenae,Paratrimmatostroma kunmingensis,Parazalerion indica,Penicillium dokdoense,Peroneutypa mangrovei,Phaeosphaeria cycadis,Phanerochaete australosanguinea,Plectosphaerella kunmingensis,Plenodomus artemisiae,***,Proliferophorum thailandicum,Pseudoastrosphaeriellopsis kaveriana,Pseudohelicomyces menglunicu

关键词： 86 new taxa Agaricomycetes Ascomycota Basidiomycota Dacrymycetes Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Mucoromycetes Mucoromycota Pezizomycetes Sordariomycetes Taxonomy