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Hashimoto’s encephalopathy presented with mutism:a case report

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General Psychiatry 2021年第3期34卷 179-181页

作者： soumitra Das Balaswamy Reddy Psychiatry Melbourne HealthParkvilleVictoriaAustralia G.K.Reddy neuropsychiatric hospital KadapaAndhra PradeshIndia

INTRODUCTION Hashimoto’s encephalopathy presents with high serum antithyroid antibody concentra-tions in association with an excellent response to immunosuppressant therapies such as corticosteroids.1 Females were four to five times more likely to be affected by this condi-tion,with a mean age of onset between 41 and 48 years2,though rare occasional paediatric presentations were also reported.

关键词： encephalopathy ed. likely

‘Brain on Fire’:an extraordinary cinematic depiction of the phenomenon of diagnostic overshadowing

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General Psychiatry 2021年第4期34卷 78-79页

作者： soumitra Das Karishma Kulkarni Dept of Adult Psychiatry Melbourne HealthParkvilleVictoriaAustralia

Diagnostic overshadowing refers to a phenomenon commonly characterised by a person with pre-existing or recently diagnosed mental illness receiving inadequate attention for symptoms of physical illness,which are then misattributed as manifestations of the mental *** are potentially several underlying reasons for this,including diagnostic challenges in establishing a medical cause for the presenting symptoms,likely lack of expertise in medicine,stigma directed towards mental illness,a protean or polymorphic presentation not immediately relating to an established nosology,lack of a reliable evidence base in the area leading to an inability to correlate with established medical diagnoses as well as biases towards treating surface-level symp-toms instead of identifying the underlying causes.

关键词： likely establishing illness

Systems Biology of Plant-Microbiome Interactions

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Molecular Plant 2019年第6期12卷 804-821页

作者： Patricia A.Rodriguez Michael Rothballer soumitra Paul Chowdhury Thomas Nussbaumer Caroline Gutjahr Pascal Falter-Braun Institute of Network Biology (INET) Helmholtz Zentrum Munchen German Research Center for Environmental Health Munich Germany Institute of Environmental Medicine (IEM) UNIKA-T Technical University of Munich Augsburg Germany Plant Genetics TUM School of Life Science Weihenstephan Technical University of Munich (TUM) Freising Germany Microbe-Host Interactions Faculty of Biology Ludwig-Maximilians-Universitat (LMU) Mijnchen Munich Germany

In natural environments,plants are exposed to diverse microbiota that they interact with in complex *** plant-pathogen interactions have been intensely studied to understand defense mechanisms in plants,many microbes and microbial communities can have substantial beneficial effects on their plant *** beneficial effects include improved acquisition of nutrients,accelerated growth,resilience against pathogens,and improved resistance against abiotic stress conditions such as heat,drought,and ***,the beneficial effects of bacterial strains or consortia on their host are often cultivar and species specific,posing an obstacle to their general ***,many of the signals that trigger plant immune responses are molecularly highly similar and often identical in pathogenic and beneficial ***,it is unclear what determines the outcome of a particular microbe-host interaction and which factors enable plants to distinguish beneficials from *** unravel the complex network of genetic,microbial,and metabolic interactions,including the signaling events mediating microbe-host interactions,comprehensive quantitative systems biology approaches will be needed.

关键词： plant systems biology plant microbiome microbial communities SynComs microbe-host interactions

Autoimmune thyroiditis presenting as psychosis

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上海精神医学 2017年第3期29卷 174-176页

作者： soumitra DAS Nimisha DOVAL Vikas MOUN Department of Psychiatry Govt. T D Medical College Department of Psychiatry UCMS & GTB Hospital Department of Psychiatry PGI ROHTAK

桥本氏甲状腺炎系一种罕见的自身免疫性疾病,血液中含有大量的自体抗体,主要表现为神经系统症状。有文献报道桥本氏甲状腺炎会出现一些行为症状,而没有明显的神经症状。我们报告的病例较少见,与其他的桥本氏甲状腺炎的常见临床表现不同。

关键词：甲状腺自身免疫性精神病神经症状紊乱行为

A case of clozapine-induced skin picking behaviour

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General Psychiatry 2018年第5期31卷 109-110页

作者： Balaswamy Reddy soumitra Das Srinivas Guruprasad Department of Psychiatry National Institute of Mental Health and Neurosciences(NIMHANS)BengaluruKarnatakaIndia G.K.Reddy Hospital KadapaAndhra PradeshIndia

There is some evidence consistently linking the occurrence of de novo obsessive-compulsive disorder(OCD) with clozapine. This skin-picking disorder is also known as impulsive-compulsive disorder-unspecified which with an increasing convergence with OCD has been placed in the current Diagnostic and statistical manual of mental disorders-fifth edition by American Psychiatric Association(DSM-5), in the category of the obsessive-compulsive and related disorders. To the best of our knowledge, there is no literature relating antipsychotics like clozapine with the occurrence of skin-picking behaviour. In this article, we present a case in whom skin-picking behaviour emerged during the upward dose titration of clozapine and was successfully treated with escitalopram.

关键词： impulsive-compulsive disorder-unspecified skin-picking behaviour

Overview of mental health issues of COVID-19:need of the hour

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General Psychiatry 2020年第3期33卷 189-190页

作者： Barikar Chandrappa Malathesh Seshadri Sekhar Chatterjee soumitra Das Department of Psychiatry National Institute of Mental Health and Neuro SciencesBangaloreIndia Department of Psychiatry West Bengal University of Health SciencesKolkataIndia NorthWestern Mental Health ParkvilleVictoriaAustralia

To the Editor,First detected in Wuhan,China,severe acute respiratory syndrome coronavirus 2(SARS CoV 2)virus is creating havoc worldwide and having an unprecedented impact on public health and society,so much so that it was declared a'Public Health Emergency of International Concern’in January 2020 and further as a‘pandemic’in March *** far,it has affected more than 1.7 million people all over the world,causing 110 thousand deaths across 195 countries.

关键词： acute respiratory Wuhan

A Novel Approach for the Synthesis of (R) and (S)-Nicotine

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International Journal of Organic Chemistry 2022年第4期12卷 189-199页

作者： Rohith Kumar Agarthimoole Sahir Gagan Sudesna Parida Tarur Konikkaledom Dinesh Maheswaran S. Karatholuvhu Namasivayam Palani soumitra Mukherjee ITC Limited ITC Life Sciences and Technology Centre Peenya Industrial Area Phase I Bangalore India Presently at Department of Atmospheric Sciences Texas A&M University College Station Texas USA

Nicotine is an alkaloid mainly found in leaves of tobacco and is used therapeutically for patients seeking relief from tobacco dependence in the form of products such as gums, patches, lozenges etc. In these products, majorly nicotine derived from tobacco is used which is inherently contaminated with undesirable nicotine related substances as impurities at low levels and is difficult to remove. Hence, use of synthetic nicotine is considered as an option which will be devoid of such impurities. In this work, a short and efficient synthesis of (R) and (S) nicotine was achieved by leveraging a key esterification between racemic homoallylic alcohol intermediate (2) and (S)-Ibuprofen (3) to produce diastereomers (5a) and (5b) which were easily separable under standard column chromatography conditions. Use of (S)-Ibuprofen (3) as a chiral resolving agent constitutes a novel approach which was not reported earlier. A subsequent hydrolysis of the diastereomers furnished the homoallylic alcohol intermediates (S)-6a and (R)-6a with high enantiopurity, which was effectively translated to the corresponding (R)-nicotine and (S)-nicotine respectively.

关键词： Nicotine Ibuprofen Diastereomers Column Chromatography Chiral Purity

Subscription to Digital Libraries and Corresponding Journal Impact: A Value-Based Approach to Demand for Digital Research Data—Confucian Integration of Curricula and “Market String” Digital Education Systems

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Journal of Applied Mathematics and Physics 2018年第10期6卷 1988-1996页

作者： soumitra K.Mallick IISWBM&Calcutta University Management HouseCollege Square WestKolkataWest BengalIndia

This paper develops a functional relation between Digital Libraries and Confucion Integrated Curriculum Learning systems. We show that under certain properties of Learning Systems which can implement laissez-faire mar... 详细信息

关键词： Confucian Dao and Li String Classification and Integration of Curricula Digital Libraries

Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women

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World Journal of Cardiology 2021年第5期13卷 130-143页

作者： soumitra Ghosh Divya Kapoor Rajesh Vijayvergiya Sonal Sangwan Sujata Wangkheimayum Sakshi Mehta Veena Dhawan Department ofCardiology PGIMERChandigarh 160012India Department of Experimental Medicine and Biotechnology PGIMERChandigarh 160012India Department of Biochemistry PGIMERChandigarh 160012India

BACKGROUND The established cardiovascular risk factors cannot explain the overall risk of coronary artery disease(CAD),especially in ***,there is a growing need for the assessment of novel biomarkers to identify women at *** receptor for advanced glycation end products(RAGE)and its interaction with the advanced glycation end product(AGE)ligand have been associated with *** soluble fraction of RAGE(sRAGE)antagonizes RAGE signaling and exerts an antiatherogenic *** The study aim was to explore the association between plasma levels of sRAGE and CAD in nondiabetic postmenopausal *** This case-control study included 110 nondiabetic postmenopausal women who were enrolled in two *** I included 55 angiographically proven CAD subjects with>50%stenosis in at least one of the major coronary arteries and Group II included 55 healthy control women who did not have CAD or had<50%stenosis of the coronary *** was confirmed by invasive *** sRAGE was determined by an enzyme-linked immunosorbent *** We observed significantly lower plasma sRAGE concentrations in subjects with CAD vs healthy controls(P<0.05).Univariate and multivariate logistic regression analysis also revealed a significant correlation between plasma sRAGE levels and CAD(P=0.01).Multivariate odds ratios for CAD revealed that subjects with sRAGE concentrations below 225 pg/mL(lowest quartile)had a 6-fold increase in CAD prevalence independent of other risk *** Our findings indicated that low sRAGE levels were independently associated with CAD in nondiabetic postmenopausal *** assessment of CAD in postmenopausal women can be improved by including sRAGE along with other risk factors.

关键词： Coronary artery disease Soluble receptor for advanced glycation end products Postmenopausal status Nondiabetic females Correlation Regression