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A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder

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World Journal of Pediatrics 2022年第12期18卷 825-834页

作者： Mahasweta Chatterjee Sharmistha saha Swagata Sinha Kanchan Mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector JEM BypassKolkataWest Bengal700107India

Background The serotonin transporter(SERT),encoded by the solute carrier family 6 number 4(SLC6A4)gene,controls serotonin(5-HT)availability and is essential for the regulation of behavioral *** SLC6A4 genetic variants,5-HTTLPR and STin2,were widely investigated in patients with various neurobehavioral disorders,including attention deficit hyperactivity disorder(ADHD).Methods We analyzed the association of the 5-HTTLPR(L/S)and STin2(10/12)variants,plasma 5-HT,and 5-hydroxyindole acetic acid(5-HIAA),as well as SERT messenger RNA(mRNA)with ADHD in the eastern Indian *** families with ADHD probands(n=274)and ethnically matched controls(n=367)were recruited following the Diagnostic and Statistical Manual of Mental *** traits,executive function,and intelligence quotient(IQ)of the probands were assessed using the Conner's Parent Rating Scale–Revised,Parental Account of Children’s Symptoms(PACS),Barkley Deficit in Executive Functioning—Child and Adolescent Scale,and Wechsler Intelligence Scale for Children-III,*** obtaining informed written consent,peripheral blood was collected to analyze genetic variants,plasma 5-HT,5-HIAA,and SERT mRNA *** ADHD probands showed a higher frequency of the 5-HTTLPR“L”allele and“L/L”genotype(P<0.05),lower 5-HIAA level,and higher SERT mRNA *** for behavioral problems and hyperactivity were higher in the presence of the“S”allele and“S/S”genotype,while executive deficit was higher in the presence of the“L”*** score was lower in the presence of the STin2“12”allele and L-12 *** Data obtained indicate a significant association of the serotoninergic system with ADHD,warranting further in-depth investigation.

关键词： Attention deficit hyperactivity disorder 5-Hydroxyindole acetic acid 5-Serotonin 5-HTT-linked polymorphic region SERT mRNA

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On the Geometry of the Anti-canonical Bundle of the Bott–Samelson–Demazure–Hansen Varieties

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1920-1940页

作者： Indranil BISWAS S.Senthamarai KANNAN Pinakinath saha School of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–Samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** S={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−S.

关键词： Bott-Samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

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Nano storage-boxes constructed by the vertical growth of MoS_(2 )on graphene for high-performance Li-S batteries

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Journal of Energy Chemistry 2022年第3期31卷 91-99,I0004页

作者： Bowen Cui Xiaomin Cai Wenqiang Wang Petr saha Gengchao Wang Shanghai Key Laboratory of Advanced Polymeric Materials Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Centre of Polymer Systems University InstituteTomas Bata UniversityTř.T.Bati 5678Zlin 76001ZlínCzech Republic

In order to accelerate the reaction kinetics of lithium-sulfur batteries, the introduction of electro catalysis and proper structural control of the sulfur cathode is urgently needed. MoS_(2) nano sheets was selectively grown vertically (V-MoS_(2)) on the microwave-reduced graphene (rGO) sheets through chemical coupling to construct a self-supporting sulfur cathode with a nano storage-box structure (V-MoS_(2) as the wall and rGO as the bottom). RGO, which has a high conductivity of 37 S cm^(−1), greatly accelerates the transfer of electrons from the active sites on the edge of the layer to the solution. The introduction of carbon tubes can connect the abundant pores in the foam and act as a long-range conductive path. The 2D-orthogonal-2D structure maximally exposes the edge active sites of MoS_(2), and together with graphene form a nano reactor of sulfur, intermediate lithium polysulfides and discharge product Li_(2)S(2). The effective combination of the microstructure confinement of the nano storage-boxes and the efficient synchronous catalytic mechanism of V-MoS_(2) greatly improves the electrochemical performance of the lithium-sulfur batteries. As a result, the assembled lithium-sulfur battery displays a high initial discharge capacity of 1379 mAh g^(−1), good cycle stability (86% capacity retention after 500 cycles at 0.1C) and superior rate performance.

关键词： Edge-rich MoS_(2) Nano boxes Catalytic conversion Lithium-sulfur batteries

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Analysis of a predator-prey model with herd behavior and disease in prey incorporating prey refuge

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International Journal of Biomathematics 2019年第1期12卷 133-171页

作者： Sangeeta saha G.P.Samanta Department of Mathematics Indian Institute of Engineering Science and Technology Shibpur Howrah-711103India

In this work,we have introduced an eco-epidemiological model of an infected predator prey *** of prey refuge gives that a fraction of the infected prey is available to the predator for ***,to make the model more realistic to the environment,we have introduced strong Allee effect in the susceptible *** and positivity of the solution have been *** stability conditions of the equilibrium points have been found with the help of Routh-Hurwitz criterion and it has been observed that if a prey population is infected with a lethal disease,then both the prey(susceptible and infected)and predator cannot survive simultaneously in the system for any parametric *** disease transmission rate and the attack rate on the susceptible have an important role to control the system *** different values of these two key parameters,we have got only healthy or disease-free or predation-free or a fluctuating disease-free or even a fluctuating predator-free system with some certain parametric conditions.

关键词： Allee effect herd behavior infected prey refuge extinction bifurcations

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Highly surface electron-deficient Co_(9)S_(8) nanoarrays for enhanced oxygen evolution

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Green Energy & Environment 2020年第4期5卷 492-498页

作者： Haoxuan Zhang Jingyu Wang Qilin Cheng Petr saha Hao Jiang Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida T.Bati 5678Zlin76001Czech Republic

Tailoring valence electron delocalization of transition metal center is of importance to achieve highly-active electrocatalysts for oxygen evolution reaction(OER).Herein,we demonstrate a“poor sulfur”route to synthesize surface electron-deficient Co_(9)S_(8) nanoarrays,where the binding energy(BE)of Co metal center is considerably higher than all reported Co_(9)S_(8)-based *** resulting Co_(9)S_(8) electrocatalysts only require the overpotentials(h)of 265 and 326 mV at 10 and 100 mA cm^(-2) with a low Tafel slope of 56 mV dec^-(1) and a 60 hlasting stability in alkaline *** OER kinetics are greatly expedited with a low reaction activation energy of 27.9 kJ mol^-(1) as well as abundant OOH*key intermediates(24%),thus exhibiting excellent catalytic *** surface electron-deficient engineering gives an available strategy to improve the catalytic activity of other advanced non-noble electrocatalysts.

关键词： Electron deficiency Co_(9)S_(8) Nanoarray Electrocatalyst Oxygen evolution reaction

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Liver injury induced by COVID 19 treatment–what do we know?

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World Journal of Gastroenterology 2022年第45期28卷 6314-6327页

作者： Lekha saha Soumya Vij Kajal Rawat Department of Pharmacology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

The severity of coronavirus disease 2019(COVID-19)may be correlated with the risk of liver injury *** increasing number of studies indicate that degrees of hepatotoxicity have been associated with using some medications in the management of COVID-19 ***,limited studies have systematically investigated the evidence of drug-induced liver injury(DILI)in COVID-19 *** increasing number of studies indicate that degrees of hepatotoxicity have been associated with using some of these medications in the management of COVID-19 ***,it was relieved after the cessation of these ***,to our knowledge,no studies have systematically investigated the evidence of DILI in COVID-19 *** this review,we discussed the association between hepatotoxicity in COVID-19 patients and the drugs used in these patients and possible mechanisms of *** currently available evidence on the association of different therapeutic agents with hepatotoxicity in COVID-19 patient was systematically reviewed.

关键词： Liver injury COVID-19 Anti-COVID drugs Mechanisms Clinical evidences

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Painlevéintegrability,auto-Bäcklund transformations,new abundant analytic solutions including multi-soliton solutions for time-dependent extended KdV8 equation in nonlinear physics

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Journal of Ocean Engineering and Science 2024年第5期9卷 489-507页

作者： Shailendra Singh S.saha Ray National Institute of Technology Department of MathematicsRourkela 769008India

In this paper,a new eighth-order(1+1)-dimensional time-dependent extended KdV equation has been *** considered equation is being found completely integrable by using the Painlevéanalysis ***,three auto-Bäcklund transformations have been generated by truncating the Painlevéseries at a constant *** auto-Bäcklund transformations have been used to derive various analytic solution families for the newly developed *** solutions include the kink-antikink soliton,kink-soliton,antikink-soliton,periodic-soliton,complex kink-soliton and complex periodic-soliton ***-soliton solutions including N-soliton solution,have been obtained by using the simplified Hirota’s method for the considered *** the results are being expressed graphically to signify the physical importance of the considered equation.

关键词： Higher-order KdV equation Painlevéanalysis Auto-Bäcklund transformation Simplified Hirota method

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Community-based cross-sectional seroprevalence study of hepatitis A in Bangladesh

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World Journal of Gastroenterology 2009年第39期15卷 4932-4937页

作者： Samir K saha Setarunnahar saha Salim Shakur Mohammed Hanif Md Ahsan Habib Sanjoy K Datta Hans L Bock Bangladesh Institute of Child Health Dhaka Shishu Hospital Institute of Public Health Glaxo-SmithKline Biologicals 89 Rue de l'Institut

AIM： TO elucidate the age-distribution of anti-hepatitis A virus （HAY） seroprevalence across different socioeconomic status （SES） categories in Bangladesh which, despite scarce data, is generally deemed to have high endemicity. METHODS： Blood samples of 818 subjects from a stratified samp#e of schools and hospitals, comprising different age categories and SES were collected. They were assayed for total anti-HAV antibodies. Social and medical history data were obtained using a questionnaire. RESULTS： Overall anti-HAV seroprevalence was 69.6%, increasing with age from 1-5 years （40.4%） to 〉 30 years （98.4%）. Seroprevalence was lowest （49.8%） in the high SES group and highest （96.5%） in the rural lower-middle SES group. Among subjects aged 6-20 years, anti-HAV seroprevalence was lowest in urban private school children （43.0%）, followed by urban government school children （76.2%） and rural school children （96.5%）（P 〈 0.01）. Within the high SESgroup, anti-HAV seroprevalence was 32.3% in subjects 〈 10 years and 51.7% in those aged 11-20 years. Until now Bangladesh has been deemed to have high endemicity for HAV. CONCLUSION： The transition from high to intermediate HAV endemicity may be underway; high SES adolescents and adults remain particularly at risk of symptomatic illness. Preventive measures need consideration.

关键词： Age groups Hepatitis A virus Hepatitis A virus seroprevalence Anti-hepatitis A virus antibodies Socioeconomic groups

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Therapies to modulate gut microbiota:Past,present and future

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World Journal of Gastroenterology 2020年第8期26卷 777-788页

作者： Akshita Gupta Srishti saha Sahil Khanna Department of Medicine All India Institute of Medical SciencesNew Delhi 110029India Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States

The human gut microbiota comprises of a complex and diverse array of microorganisms,and over the years the interaction between human diseases and the gut microbiota has become a subject of growing *** microbial milieu in the gastrointestinal tract is central to the pathogenesis of several diseases including antibiotic-associated diarrhea and Clostridioides difficile infection(CDI).Manipulation of this microbial milieu to restore balance by microbial replacement therapies has proven to be a safe and effective treatment for recurrent *** is considerable heterogeneity in various aspects of stool processing and administration for fecal microbiota transplantation(FMT)across different centers globally,and standardized microbioal replacement therapies offer an attractive *** adverse effects associated with FMT are usually ***,there is paucity of data on long term safety of FMT and there is a need for further studies in this *** our increasing understanding of the host-microbiome interaction,there is immense potential for microbial replacement therapies to emerge as a treatment option for several *** role of microbioal replacement therapies in diseases other than CDI is being extensively studied in ongoing clinical trials and it may be a potential treatment option for inflammatory bowel disease,irritable bowel syndrome,obesity,multidrug resistant infections,and neuropsychiatric *** microbiota transplantation for non-CDI disease states should currently be limited only to research settings.

关键词： Fecal microbiota transplantation Microbial replacement therapies Clostridioides difficile infection Microbiome Microbiota Inflammatory bowel disease

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Review of System Strength and Inertia Requirements for the National Electricity Market of Australia

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CSEE Journal of Power and Energy Systems 2019年第3期5卷 295-305页

作者： Huajie Gu Ruifeng Yan Tapan saha Power and Energy Systems Research Group School of Information Technology and Electrical EngineeringThe University of QueenslandBrisbane St LuciaQLD 4072Australia

Synchronous generators(SGs)are still making major contributions to the re-stabilization of a power system following voltage/frequency disturbances,attributed to their inherent capability of providing system strength and ***,SGs powered by fossil fuels are operating to a lesser extent and scheduled for decommissioning in the National Electricity Market(NEM)of Australia due to the accelerating increase of low bidding priced asynchronous generation of wind and solar,which leads to the reduction and even in some cases,a shortage of system strength and *** paper comprehensively reviews the requirements of system strength and inertia in the NEM from an operational security *** is the first country that established the regulation rules of system strength and inertia to accommodate issues of an emerging high penetration level of non-synchronous renewable generation.

关键词： Inertia power system renewable energy system strength

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