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Potential effect of Silybum marianum L. and Cistus ladaniferus *** on urine volume, creatinine clearance and renal function

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Asian Pacific Journal of Tropical Medicine 2018年第6期11卷 393-398页

作者： Nawal El Menyiy Noori Al-Waili Redouan El-Haskoury Meryem Bakour soumia zizi Thia Al-Waili Badiaa Lyoussi Physiology-Pharmacology and Environmental Health Laboratory Faculty of Sciences Dhar MahrazUniversity Sidi Mohamed Ben AbdallahFez 30000Morocco New York Medical Care for Nephrology Richmond HillNew York 11418USA

Objective:To investigate the diuretic and renal effects of Silybum marianum *** Cistus ladaniferus *** normal ***:Four groups of rats were used in each *** first group received water,the second group received Cistus ladaniferus ***(100 mg/kg ***),the third group received Silybum marianum ***(100 mg/kg ***),and the fourth group received furosemide(10 mg/kg ***).Variables including urine volume,plasma and urine sodium,potassium and creatinine,and creatinine clearance were *** experiments were conducted.A single dose of each intervention was used and the variables were measured during 24 h,and the interventions were given daily for a total of 8 d and the variables were measured during various ***:The single dose of each plant extract increased urine volume at all-time intervals and increased urine sodium and potassium excretion without affecting plasma sodium and potassium(P<0.05).On the day 8 after daily administration,the plant extracts induced a significant diuresis and natriuresis without affecting serum electrolytes(P<0.05),while furosemide caused *** plant extracts significantly increased creatinine clearance(P<0.05).Conclusions:Silybum marianum *** Cistus ladaniferus L Increase creatinine clearance and have a significant diuretic effect without affecting serum *** marianum *** more potent than furosemide or Cistus ladaniferus L.

关键词： Silybum marianum L. Cistus ladaniferus L. Diuresis Urine volume Sodium Potassium Creatinine clearance

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Antioxidant and diuretic activity of co-administration of Capparis spinosa honey and propolis in comparison to furosemide

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 974-980页

作者： Soukaina El-Guendouz Noori Al-Waili Smail Aazza Youssef Elamine soumia zizi Thia Al-Waili Ali Al-Waili Badiaa Lyoussi Laboratory Physiology-Pharmacology&Environmental Health Faculty of Sciences Dhar-MahrazUniversity Sidi Mohamed Ben AbdallahFezMorocco New York Medical Care for Nephrology Richmond HillNew York 11418USA

Objective: To study the antioxidant properties of Capparis spinosa(***) honey and propolis and the effect of combined honey and propolis administration on urine volume and electrolytes in ***: *** honey [1 000 mg/kg body weight(***)], propolis(100 mg/kg ***), honey/propolis mixture(*** honey 1 000 mg/kg ***/propolis extract 100 mg/kg ***), distilled water(1 mL/kg ***) and furosemide(10 mg/kg ***) were orally administered to fi ve groups of rats for 21 *** volume, blood and urine sodium,potassium and chloride were *** antioxidant activity of propolis and honey was assessed and their total phenols and flavonoids were ***: Propolis and *** honey contain polyphenols including flavonoids and propolis demonstrated higher antioxidant activities than *** significantly increased urine volume and urine electrolyte *** had no significant effect on urine volume, but co-administration of propolis and honey caused significant *** major changes were observed in plasma electrolytes with the use of honey, propolis or their ***: Honey and propolis have antioxidant activity and contain polyphenols including flavonoids that are more pronounced in *** has a significant diuretic activity alone or in combination with *** is the first study comparing the diuretic effect of co-administration of propolis and *** honey with furosemide.

关键词：蜂蜜 Propolis 抗氧化剂多尿钠钾

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