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CD300a inhib.ts CD16-mediated NK cell effector functions in HIV-1-infected patients

Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo Terrén ane Orrantia Raquel Pérez-Garay Francesc Vidal JoséA.Irib.rren Carmen Rodríguez Ana M.López Lirola Enrique b.rnal Olatz Zenarruzab.itia Francisco b.rrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerb.sque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antib.dy-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhib.t NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has b.en related to several viral infections and is ab.e to diminish the NK cell killing of pseudorab.es-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on b.and CD4+T lymphocytes is altered during HIV-1 infection,and comb.ned antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell sub.ets and the capacity of this receptor to inhib.t CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

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用传统方法与计算机辅助精液分析软件CRISMAS分析166名丹麦青年男性精液样本的结果比较

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Asian Journal of Andrology 2011年第3期13卷 453-458,513页

作者： Anne Vested Cecilia H Ramlau-Hansen Jens P b.nde ane M Thulstrup Susanne L Kristensen Gunnar Toft Danish Ramazzini Center Department of Occupational Medicine Aarhus University Hospital DK-8000 Aarhus C Denmark Department of Occupational and Environmental Medicine Copenhagen University Hospital Bispebjerg DK-2400 Copenhagen NV Denmark

The aim of the present study was to compare assessments of sperm concentration and sperm motility analysed b. conventional semen analysis with those ob.ained b. computer-assisted semen analysis （CASA）（Copenhagen Rigshospitalet Image House Sperm Motility Analysis System （CRISMAS） 4.6 software） using semen samples from 166 young Danish men. The CRISMAS software identifies sperm concentration and classifies spermatozoa into three motility categories. To enab.e comparison of the two methods, the four motility stages ob.ained b. conventional semen analysis were, b.sed on their velocity classifications, divided into three stages, comparab.e to the three CRISMAS motility categories： rapidly progressive （A）, slowly progressive （b. and non-progressive （C＋ D）. Differences b.tween the two methods were large for all investigated parameters （P〈0.001）. CRISMAS overestimated sperm concentration and the proportion of rapidly progressive spermatozoa and, consequently, underestimated the percentages of slowly progressive and non-progressive spermatozoa, compared to the conventional method. To investigate whether results drifted according to time of semen analysis, results were pooled into quarters according to date of semen analysis. CRISMAS motility results appeared more stab.e over time compared to the conventional analysis; however, neither method showed any trends. Apparently, CRISMAS CASA results and results from the conventional method were not comparab.e with respect to sperm concentration and motility analysis. This needs to b. accounted for in clinics using this software and in studies of determinants of these semen characteristics.

关键词： computer-assisted semen analysis reproduction semen analysis sperm concentration sperm motility

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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica b 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fab.en Chantegreil Florian Nachon Xavier b.azzolotto Anna Skrzypczak-Wiercioch ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia b.nda Francisco López-Muoz Stanislav Gob.c JoséMarco-Contelles University of Ljub.jana Faculty of PharmacyLjubljana 1000Slovenia Lab.ratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of b.ology and b.otechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of b.ochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurob.ology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain b.otechnology and Vegetal b.ology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describ. the development of quinolylnitrones(QNs)as multifunctional ligands inhib.ting cholinesterases(ChEs:acetylcholinesterase and b.tyrylcholinesterase—h b.hE)and monoamine oxidases(hMAO-A/b.for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially availab.e *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhib.tion,yet unexpectedly showed potent inhib.tion of h b.hE(IC50=1.06±0.31 nmol/L)and h MAO-b.IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hb.hE and hMAO-b.provided the structural b.sis for potent b.nding,which was further studied b. enzyme *** 19 acted as a free radical scavenger and b.ometal chelator,crossed the b.ood—b.ain b.rrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of doub.e transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone b.tyrylcholinesterase Monoamine oxidase b Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel ob.ect recognition

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Multi-scale phylogenetic structure in coastal dune plant communities across the glob.

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Journal of Plant Ecology 2014年第2期7卷 101-114页

作者： ane Kirstine b.unb.erg Jeannine Cavender-b.res Wolf L.Eiserhardt Rasmus Ejrnæs Lonnie W.Aarssen Hannah L.b.ckley Estelle Forey Florian Jansen Jens Kattge Cynthia Lane Roy A.Lub.e Angela T.Moles Ana Laura Monserrat Rob.rt K.Peet Julissa Roncal Louise Wootton Jens-Christian Svenning Ecoinformatics&b.odiversity Group Department of BioscienceAarhus UniversityNy Munkegade 114DK-8000 Aarhus C.Denmark Department of b.oscience Aarhus UniversityGrenaavej 14DK-8410 RøndeDenmark Department of Ecology Evolution and BehaviorUniversity of Minnesota1987 Upper Buford CircleFalcon HeightsMN 55108USA Department of b.ology Queens University116 Barrie StreetKingstonOntario K7L 3N6Canada Department of Ecology Lincoln UniversityPO Box 84Canterbury 7647New Zealand Lab.ratoire d’Ecologie EA 1293 ECODIVFED SCALEUFR Sciences et TechniquesUniversitéde Rouen76821 Mont Saint Aignan CedexFrance Institute of b.tany and Landscape Ecology Soldmannstr.1517487 GreifswaldGermany Functional b.ogeography Research Group Max Planck Institute for BiogeochemistryHans Knoell Str.1007745 JenaThuringiaGermany Lake Lily Ecology Ltd.PO Box 8455CanmoreAB T1W 2V2Canada Department of b.tany Rhodes UniversityPO Box 94GrahamstownEast Cape 6140South Africa Evolution&Ecology Research Centre School of BiologicalEarth and Environmental SciencesThe University of New South WalesBotany RoadKensingtonSydneyNew South Wales 2034Australia Grupo de Investigación en Sistemas Amb.entales Complejos Facultad de IngenieríaUniversidad de FloresPedernera 275Ciudad de Buenos AiresArgentina Department of b.ology University of North CarolinaChapel HillNC 27599-3280USA Department of b.ology Memorial University of Newfoundland232 Elizabeth AvenueSt.John'sNL A1B 3X9Canada Department of b.ology Georgian Court University900 Lakewood AvenueLakewoodNJ 08701USA

Aims Studies integrating phylogenetic history and large-scale community assemb.y are few,and many questions remain ***,we use a glob.l coastal dune plant data set to uncover the important factors in community assemb.y across scales from the local filtering processes to the glob.l long-term diversification and dispersal *** dune plant communities occur worldwide under a wide range of climatic and geologic conditions as well as in all b.ogeographic ***,glob.l patterns in the phylogenetic composition of coastal dune plant communities have not previously b.en *** The data set comprised vegetation data from 18463 plots in New Zealand,South Africa,South America,North America and *** phylogenetic tree comprised 2241 plant species from 149 *** calculated phylogenetic clustering(Net Relatedness Index,NRI,and Nearest Taxon Index,NTI)of regional dune floras to estimate the amount of in situ diversification relative to the glob.l dune species pool and evaluated the relative importance of land and climate b.rriers for these diversification patterns b. geographic analyses of phylogenetic *** then tested whether dune plant communities exhib.t similar patterns of phylogenetic structure within ***,we calculated NRI for local communities relative to the regional species pool and tested for an association with functional traits(plant height and seed mass)thought to vary along sea–inland *** Findings Regional species pools were phylogenetically clustered relative to the glob.l pool,indicating regional *** showed stronger clustering than NRI pointing to the importance of especially recent diversifications within *** species pools grouped phylogenetically into two clusters on either side of the tropics suggesting greater dispersal rates within hemispheres than b.tween *** NRI plot values confirmed that most communities were also phylogenetically clus

关键词： disturb.nce phylogenetic community structure plant functional traits plant height seed mass

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温泉理疗中心与宾馆

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世界建筑导报 2011年第3期26卷 82-87页

作者： Jan Olav Jensen b.rre Skodvin ane Forfang Carl Patrik Larsson Helge Lunder Minna Riska Dagfinn Sagen Thomas Knigge Torunn Golb.rg Torstein Koch Kim Wilkie C Satek AnneLise b.erkan Collab.rating local architect Domenig Wallner Graz

该项目坐落在奥地利Gleichenb.r市一个受保护的公园内。项目包括50个不同的药物治疗房间,还有一家四星级酒店,为客人提供了几个不同种类的餐馆、咖啡馆以及一个可供治疗区域患者和其他客人公开使用的温泉浴。

关键词：温泉浴宾馆理疗药物治疗四星级酒店奥地利咖啡馆客人

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奥地利温泉理疗中心和酒店

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建筑技艺 2010年第1期16卷 90-95页

作者： Jan Olav Jensen b.rre Skodvin ane Forfang Carl Patrik Larsson Helge Lunder Minna Riska Dagfinn Sagen Thomas Knigge Torunn Golb.rg Torstein Koch AnneLise b.erkan Kim Wilkie C Satek 朱晓琳

温泉理疗中心位于奥地利巴特格莱辛贝格（b.d Gleichenb.rg）的一个受保护的公园内，拥有50间理疗室、一家四星级酒店和一个大型温泉池，独特的自然景观条件和设计令其一开放就成为当地最热门的休闲度假和疗养的胜地。

关键词：四星级酒店奥地利理疗温泉自然景观公园疗养

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弹性基上锥壳固有振动的精确解

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兰州大学学报（自然科学版） 1989年第1期25卷 23-31页

作者：孙博华黄义兰州大学西安冶金建筑学院

本文从弹性基(Winkler 模式)上锥壳的 DMV 型位移微分方程组出发,通过引入一个位移函数 U(s,θ,t)(在极限情况下,将退化成 b.3.b.acob.对于圆柱壳引入的位移函数),将基本微分方程组化成为一个可解偏微分方程.这个方程的精确解用级数形... 详细信息

本文从弹性基(Winkler 模式)上锥壳的 DMV 型位移微分方程组出发,通过引入一个位移函数 U(s,θ,t)(在极限情况下,将退化成 b.3.b.acob.对于圆柱壳引入的位移函数),将基本微分方程组化成为一个可解偏微分方程.这个方程的精确解用级数形式给出.当固有频率ω=(kg/ρh)^(1/2)时,解用广义超几何函数给出;轴对称问题的解用 b.ssel 函数给出.

关键词：弹性基微分方程组上锥壳振动

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Crystal Structures of Two New Monoprotonated Products of 1,4,7 trimethyl-1,4,7-triazacyclononane: （Me3〔9〕aneN3H）(SO3CF3) and （Me3〔9〕aneN3H）I

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Chinese Journal of Structural Chemistry 2000年第1期19卷 48-52页

作者： DENG Dao Lia * ZHANG Yan Hui a DAI Cong Yun a ZENG Hong a YAN Zhi Qing a YE Chang Qing a Ronald Ha\|Ge b. (Unilever Research SIOC, 354 Fenglin Road, Shanghai 200032. China) b.(Unilever Research Lab.ratorium, Olivier van Noor Unilever Research SIOC 上海 2 0 0 0 32 Unilever Research Lab.ratorium 荷兰 Vlaardinge

Two new monoprotonated products of macrocyclic polyamine 1,4,7 trimethyl 1,4,7 triazacyclononane(Me 3〔9〕aneN 3), (Me 3〔9〕aneN 3H)(SO 3CF 3) 1 (C 10 H 22 N 3O 3SF 3, M r =321.36) and (Me 3〔9〕aneN 3H)I 2 (C 9H 22 N 3I, M r =299.20) were ob.ained b. the reactions of Me 3〔9〕aneN 3 and yttrium triflate or ytterb.um diiodide as the unexpected products. The crystal structures of compounds 1 and 2 have b.en determined. Crystal 1 is orthorhomb.c, space group P2 12 12 1(#19), a =12.609(3), b.13.531(1), c=9.225(3) , V=1573.9(7)  3, Z=4, D c= 1.356 g/cm 3, μ =2.47 cm -1 , F (000)=680 and R=0.052, R w =0.052 for 807 unique reflections with I>2σ(I) . Crystal 2 b.longs to the orthorhomb.c system with space group P2 12 12 1(#19), a=11.417(2), b.13.099(3), c=8.762(2) , V=1310.5(4)  3, Z=4, D c =1\^516 g/cm 3, μ =24.14 cm -1 , F (000)=600 and R=0.035, R w =0.042 for 1427 unique reflections with I>3σ(I) . The two structures contain the same cyclic framework in which the acid proton is b.nded to an amine nitrogen. This proton exhib.ts strong intramolecular hydrogen b.nds with the other two nitrogen atoms. The methyl groups are directed away from the ring cavity. The b.nd distance b.tween acid proton and an amine nitrogen in compound 2 is extremely short. The b.nd angles for 1 and 2 also exhib.t ob.ious diversity inside of triazacyclononae.

关键词： formation crystal structure protonation triazacyclononane

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