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3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives:Synthesis, Characterization, and Evaluation on Tumor Cell Lines

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New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

International Journal of Organic Chemistry（有机化学国际期刊） 2021年第1期

作者： Ali Bouattour Mehdi Fakhfakh souhir abid el-gharbi Majdi abid Ludovic Paquin Rémy Le Guevel Thierry Charlier Houcine Ammar Jean-Pierre Bazureau

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International Journal of Organic Chemistry 2024年第3期14卷 107-122页

作者： Marwa Dhiabi Sirine Karoui Mehdi Fakhfakh souhir abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar Laboratoire de Chimie Applique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des Sciences Chimiques de Rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France Department of Chemistry (Science and Arts): Al Qurayat Al-Jouf University Al Jawf Saudi Arabia S2Wave Platform ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPACcell Platform Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de Recherche en Sant Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

关键词： 2-Amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine Microwave Irradiation Tumoral Cell Line in Silico ADMET

ESSENTIAL APPROXIMATE POINT SPECTRA FOR UPPER TRIANGULAR MATRIX OF LINEAR RelATIONS

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Acta Mathematica Scientia 2013年第4期33卷 1187-1201页

作者： souhir elLEUCH Maher MNIF Département de Mathématiques Université de Sfax Faculté des Sciences de SfaxLaboratoire de Physiques Mathématiques

When A E ∈LR（H） and B E ∈LR（K） are given, for C E∈LR（K, H） we denoteby Mc the linear relation acting on the infinite dimensional separable Hilbert space H Kof the formIn this paper, we give the necessary and sufficient conditionson A and B for wh{ch Mc is upper semi-Fredholm with negative index or Weyl for some C C ∈LR（K, H）.

关键词： linear relation Fredholm and semi-Fredholm relation essential approximatepoint spectra for linear relation

Nonlinear Coordinated Passivation Control of Single Machine Infinite Bus Power System with Static Var Compensator

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1557-1565页

作者： Salma Keskes souhir Salleem Larbi Chrifi-Alaoui Mohamed Ben Ali Kammoun electric Machines and Power Networks Control Laboratory from the electrical Engineering Department National Engineering School of Sfax Innovative Technologies Laboratory University of Picardy Jules Verne

We propose a nonlinear coordinated control of the generator excitation and the static var compensator(SVC) in order to enhance the transient stability and voltage regulation of power system by the passivation approach. SVC is installed in the middle of the transmission line of power system and consists of a single machine infinite bus(SMIB) system. The design of the proposed controller consists of two parts. On one hand,the generator excitation controller is designed based on a backstepping controller. On the other hand, the conception of SVC control input is based on the coordinated passivation approach,which can guarantee the asymptotic stability of the closed-loop system. The simulation results show the effectiveness of the proposed controller compared with other methods, which ensures better performance than the uncoordinated control when the system is subjected to a disturbance.

关键词： Coordinated control passivation approach transient stability control design

Control of the electric Vehicles Power Chain with electromagnetic Switches Reducing the Energy Consumption

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Journal of electromagnetic Analysis and Applications 2011年第12期3卷 537-545页

作者： souhir Tounsi 不详

Among the factors slowing down the production of the electric vehicles in big series, we mention the problem of weak autonomy directly bound to the weak storage capacity of the batteries. In this context, this paper describes a strategy of power chain vector control reducing the consumption and integrating a system of energy recuperation. Besides, this power chain is conceived by an analytic approach optimizing the autonomy and reducing the production cost of electric vehicle. The choice of the static converter to electromagnetic switches is a determining factor for the reliability of the global system and the reduction of the consumption. This choice poses a problem of adaptation of this low-frequency converter type to the global system that will be treated in this paper.

关键词： electric Vehicle Motor Converter Control Energy Recuperation electromagnetic Switch

Synthesis of New 2-Phenylamino-4<i>H</i>-chromene-3-carbonitrile Derivatives and Their Effects on Tumor Cell Lines and against Protein Kinases

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International Journal of Organic Chemistry 2020年第2期10卷 88-103页

作者： Ali Bouattour Mehdi Fakhfakh souhir abid Ludovic Paquin Rémy Le Guével Thierry Charlier Sandrine Ruchaud Stéphane Bach Jean-Pierre Bazureau Houcine Ammar Laboratoire de Chimie Appliquée: Hétérocycles Corps Gras et Polymères Faculté des Sciences de Sfax Université de Sfax Sfax Tunisie Département de Chimie Collège des Sciences et des Arts Université de Jouf Al Qurayyat KSA Institut des Sciences Chimiques de Rennes (ISCR) UMR CNRS 6226 Université de Rennes 1 Campus de Beaulieu Rennes France S2 Wave Platform ScanMAT UMS 2001CNRS Université de Rennes 1 Campus de Beaulieu Rennes France Université de Rennes 1 ImPACcell Platform Campus Villejean Rennes France Sorbonne Universités UPMC Université Paris 06 CNRS USR3151 Protein Phosphorylation and Human Disease Unit KISSf Platform Station Biologique Place Georges Teissier Roscoff France

The synthesis of 2-phenylimino-4H-chromene-3-carbonitriles 6(a-d) in good overall yields using an efficient and practical methodology in 3 steps has been implemented in this present work. The first step was a heterocyclization between 2-hydroxybenzaldehyde 1 and propanedinitrile 2 which produced 2-iminocoumarin 3 which was submitted to nitrogen/nitrogen displacement in the presence of aromatic primary amine 4. In the third step, reduction of 5 led to the desired 2-phenylimino-4H-chromene-3-carbonitriles 6. Compounds 5(a-d) and 6(a-d) were evaluated for their potential in vitro cytotoxicity against six selected tumor cell lines (Huh7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and tested for their protein kinase inhibition on eight selected protein kinases. Among them, compounds 5c and 6b exhibited inhibition on HsCK1e (5c: 44% and 6b: 42% at 1 μM) and 5c for cytotoxicity on PC3 cell lines (63% at 25 μM).

关键词： Iminocoumarin 2H-benzopyran 2-Imino-2H-benzopyran 4H-chromene 2-Amino-4H-chromene Nitrogen/Nitrogen Displacement Protein Kinase Inhibition Cytotoxicity

Design of Axial-Flux Motor for Traction Application

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Journal of electromagnetic Analysis and Applications 2009年第2期1卷 73-84页

作者： Nadia Chaker Ibrahim Ben Salah souhir Tounsi Rafik Neji 不详

This paper deals with the design of high power – low dimensions axial-flux permanent-magnet motor intended for trac-tion application. First, two motor configurations are analytically designed and compared using finite element calcula-tion. Then, the configuration yielding the best performances is integrated and modelled with the whole traction chain under MATLAB/SIMULINK environment in order to demonstrate the motor operation on a large speed band.

关键词： Axial-Flux Permanent-Magnet Motor Design Criteria Finite elements Traction Chain Circulation Mission

Transient Stability Analysis during an Improved Coupling Procedure for an Induction Generator Based Wind Generation System to the Grid

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International Journal of Modern Nonlinear Theory and Application 2014年第3期3卷 77-87页

作者： Soulaymen Kammoun Amal Marrekchi souhir Sallem Mohamed Ben Ali Kammoun Commande des Machines electriques et Réseauxde Puissance (CMERP) University of Sfax Sfax Tunisia

For fixed speed wind turbines, the connection of its squirrel cage induction generator (SCIG) to the grid leads to inrush current which can reach an average of 2 p.u. up to 2.5 p.u. in higher wind speed even by using a soft starter. We propose in this paper a new soft starting of squirrel cage induction generator based wind turbine connected to the grid. Our strategy overcomes such transient instability problems and pinpoints rapidly synchronous speed regardless the wind speed acting on pitch angle. The proposed strategy ensures at least 50% reduction of inrush current and 18% gain of WTG starting time. A state model of the system is given including the wind turbine model and the SCIG model in the synchronous reference frame. Simulation results are analysed and compared to the classic coupling procedure.

关键词： Wind Energy Pitch Control Squirrel Cage Induction Generator Transient Stability Soft Starting

Impact of the professional exposure on the spermatic parameters and the results of ICSI at Tunisian unfertile couples

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Advances in Reproductive Sciences 2014年第1期2卷 24-31页

作者： Habib Ben Ali Monia Zaouali Fatma Atig Iheb Bougmiza souhir Mehri Houda Ben Frej Faten Tabka Ali Saad Mounir Ajina Laboratoire de Cytogénétique Génétique Moléculaire et Biologie de la Reproduction Humaines CHU Farhat Hached de Sousse Sousse Tunisie Laboratoire de Physiologie et des Explorations Fonctionnelles Faculté de Médecine de Sousse Sousse Tunisie Service de Médecine Communautaire Faculté de Médecine de Sousse Sousse Tunisie Service de Médecine de Travail CHU Farhat Hached de Sousse Sousse Tunisie Unité de Médecine de la Reproduction CHU Farhat Hached de Sousse Sousse Tunisie

Introduction: The association of the professional exposure to the decline of the male reproductive function had been the subject of several studies but without arriving to one envisagement undeniable of its existence. The ICSI, technique of reference in severe male infertilities, is visavis unexplained failures whose environmental and professional exposure could be about its cause partly. In this work, we tried to highlight an association between certain factors of professional exposure and the deterioration of the spermatic parameters, then to evaluate the effect of such factors on the result of the ICSI. Materials and Methods: It is about a study of the exposed type—no exposed, realized through collaboration between the Unit of Medicine of the Reproduction and the Service of Medicine of Work of the CHU Farhat Hached of Sousse. This study was based on a questionnaire of which part of the items was collected medical files of the patients raising the general characteristics, the profile of exposure as well as the spermatic parameters and the biological assessment of ICSI. Results: Significant associations between the deterioration of sperm and the professional risk factors such as the exposure to the formaldehydes (p = 0.01) and heat (p = 0.001) were noted. The exposure to formaldehydes was associated at the higher risk of oli gozoospermy, of asthenozoospermy with a significant reduction in mobility (p = 0.05), whereas the talks with cement had a risk higher of teratozoospermy. In addition an exposure to heat was associated at the high risk of oligoteratozoospermy. The total rate of pregnancies after ICSI among 220 patients of our series was of 14.47%. The ICSI balance showed a reduction in total fertility rate (76.6% exposed vs 75.3% no exposed). Conclusion: In spite of the limited number of the patients, this study had shown a correlation between certain professional exposures of origin and the deterioration of sperm. They are preliminary results which encourage co

关键词： Male Sterility Professional Exposure Spermogramm ICSI