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Recent advances in alginate based gastroretentive technologies for drug delivery applications

Medicine in Novel Technology and Devices 2023年第2期18卷 43-54页

作者： Olivia Sen Sreejan Manna Gouranga Nandi Subrata jana sougata jana Department of Pharmaceutical Technology Brainware UniversityBarasatKolkataWest Bengal700125India Division of Pharmaceutics Department of Pharmaceutical TechnologyUniversity of North BengalRaja RammohunpurDist.–DarjeelingWest BengalPin–734013India Department of Chemistry Indira Gandhi National Tribal UniversityAmarkantakMadhya Pradesh484887India Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol713301West BengalIndia Department of Health and Family Welfare Directorate of Health ServicesKolkataIndia

The efficacy of orally delivered medicines can be maximized through enhancing the gastric residence period and modifying the drug release pattern according to therapeutic *** technologies were investigated through recent years for increasing gastric retention of *** are one of the widely studied materials for increasing the retention of drug delivery systems in the stomach *** biodegradability,biocompatibility and non-toxic behavior in combination with the easy fabrication technologies has made biopolymers an interesting option to pharmaceutical scientists for developing gastroretentive drug delivery systems(GRDDS).Several gastroretentive approaches are reported to be efficacious to localize the drug delivery system in the gastric *** are commonly employed polysaccharide for developing various GRDDS including low density systems,mucoadhesive systems,swellable systems,hydrogel forming systems,in situ gelling systems,raft forming systems,magnetic *** abundant availability from marine and bacterial sources in combination with its attractive physicochemical nature has encouraged pharmaceutical researchers to investigate its suitability in developing various drug delivery *** mucoadhesive,hydrogel forming and raft forming behavior of alginates makes alginate suitable for *** attractive properties of alginate makes it a useful biopolymer in the biomedical *** review focuses on the source and chemistry of alginates and describes the applications of alginates in developing novel gastroretentive drug delivery systems.

关键词： Gastroretentive drug delivery system Alginate Low density systems Mucoadhesive systems Hydrogel forming system Drug delivery applications

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Fabrication and evaluation of carboxymethyl guar gum-chitosan interpenetrating polymer network (IPN) nanoparticles for controlled drug delivery

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Medicine in Novel Technology and Devices 2024年第2期22卷 73-79页

作者： Chandrani Roy Arijit Gandhi Sreejan Manna sougata jana Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol713301West BengalIndia Department of Pharmaceutical Technology Brainware UniversityBarasatKolkataWest Bengal700125India Department of Health and Family Welfare Directorate of Health ServicesKolkataIndia

Guar gum(GG)has drawn more interest from researchers in the last several decades for the controlled delivery of *** aim of the research is to fabricate and evaluate an interpenetrating polymer network(IPN)based nanocarriers system employing chemically modified GG to achieve controlled release of *** present study,we have reported the synthesis of carboxymethyl GG-chitosan IPN nanoparticles for controlled release of metformin *** guar gum(CMGG)was synthesized and employed for developing IPN nanoparticles in combination with chitosan in varying polymeric ratios.A cross-linking agent,sodium tripolyphosphate(Na-TPP)was used for the synthesis of IPN colloidal suspension of nanoparticles which was lyophilized to obtain *** carboxymethylation of GG was confirmed through Fourier transform infra-red spec*** mean particle size was 440.6 nm indicating a polydispersity index of *** drug entrapment efficiency was found to vary between 67.461.64%to 88.232.02%.The differential scanning calorimetry study revealed the presence of amorphous metformin hydrochloride as a homogenous dispersion in nanoparticles(NPs)*** vitro drug release study indicated controlled release ability of developed IPN matrix.A2 formulation(chitosan:CMGG-1:1)exhibited 78.110.27%release after 8 *** evaluation performed in alloxan-treated diabetic rat model exhibited a prolonged hypoglycemic efficacy over 6 h,for A2 formulation treated group,compared to the group receiving only metformin HCl,which demonstrated a reduction in blood glucose levels for up to 4 *** study findings demonstrated the efficacy of the CMGG-chitosan based IPN nanoparticulate system for sustained delivery of therapeutic agents.

关键词： Carboxymethyl guar gum Chitosan Interpenetrating polymer network Nanoparticles Controlled release Metformin hydrochloride

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