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Antioxidant and anti-inflammatory activities of Arbutus unedo aqueous extract

Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 937-944页

作者： Idir Moualek Ghenima Iratni Aiche Nadjet Mestar Guechaoui souad lahcene Karim Houali Laboratory Analytical Biochemistry & Biotechnology Research (LABAB) Faculty of Biological Sciences and Agricultural Sciences Mouloud Mammeri University of Tizi-Ouzou

Objective: To evaluate the antioxidant and anti-inflammatory activities of aqueous extract of Arbutus unedo(A. unedo) ***: In this context, the in vitro antioxidant activity was demonstrated by 2,2-diphenyl-1-picrylhydrazyl, hydroxyl radical and H_2O_2 radical scavenging, ferrous ion chelating, ferric reducing power, total antioxidant capacity and by the protection against peroxidation of b-carotene-linoleic acid in emulsion. The anti-inflammatory activity was evaluated first by studying the membrane of human red blood cells against different hypotonic concentrations of Na Cl and against heat, inhibiting the denaturation of ***: Total phenolic and flavonoid content were found respectively [(207.84 ± 15.03)mg gallic acid equivalent/g, and(13.070 ± 0.096) mg quercetin equivalent/g]. The extract displayed significant scavenging activity of some radicals such as 2,2-diphenyl-1-picrylhydrazyl [IC_(50)at(7.956 ± 0.278) mg/m L],OH [IC_(50)=(1 015.74 ± 46.35 mg/m L)], H_2O_2[IC_(50)=(114.77 ± 16.86) mg/m L] and showed a good antioxidant activity through ferrous ion chelating activity [IC_(50)=(1 014.30 ± 36.21) mg/m L], ferric reducing power [IC_(50)=(156.55 ± 17.40) mg/m L], total antioxidant capacity [IC_(50)=(461.67± 4.16) mg/m L] and b-carotene-linoleic acid protection against peroxidation [I% =(87.04 ± 1.21)% at 1 000 mg/m L].Conclusions: A. unedo showed in vitro anti-inflammatory activity by inhibiting the heat induced albumin denaturation and red blood cells membrane stabilization. Our results show that aqueous leaf extract of A. unedo has good antioxidant activity and interesting anti-inflammatory properties. A. unedo aqueous extract can be used to prevent oxidative and inflammatory processes.

关键词： Arbutus unedo Antioxidant Anti-inflammatory Anti-hemolytic activity

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A Multi-server Queue in a Multi-phase Random Environment with Waiting Servers and Customers'Impatience Under Synchronous Working Vacation Policy

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Journal of the Operations Research Society of China 2023年第3期11卷 459-487页

作者： Meriem Houalef Amina Angelika Bouchentouf lahcene Yahiaoui Mathematics Laboratory University of Sidi Bel AbbesEcole Supérieure En Sciences AppliquéesTlemcen13000Algeria Mathematics Laboratory Djillali Liabes University of Sidi Bel AbbesSidi Bel Abbes22000Algeria Laboratory of Stochastic Models Statistic and ApplicationsUniversity of Saida-Dr.Moulay TaharB.P.138En-NasrSaidaAlgeria

In this paper,we develop an M/M/c queueing system in a Markovian environment with waiting servers,balking and reneging,under both synchronous single and multiple working vacation *** the system is in operative phase j,j=1,K¯,customers are served one by *** the system is empty,the servers have to wait a random period of time before leaving,causing the system to move to vacation phase 0 at which new arrivals can be served at lower *** the method of the probability generating functions,we establish the steady-state analysis of the *** cases of the queueing model are ***,explicit expressions of the useful system characteristics are *** addition,a cost model is constructed to define the optimal values of service rates,simultaneously,to minimize the total expected cost per unit time via a quadratic fit search *** examples are provided to display the impact of different system characteristics.

关键词： Queueing models Random environment Working vacation policy Impatient customers Probability generating function Optimization

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