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High-resolution impedance mapping using electrically activated quantitative phase imaging

Light(Science & Applications) 2021年第2期10卷 186-196页

作者： Cristina Polonschii Mihaela Gheorghiu sorin david Szilveszter Gáspár sorin Melinte Hassaan Majeed Mikhail E.Kandel Gabriel Popescu Eugen Gheorghiu International Centre of Biodynamics 060101 BucharestRomania Institute of Information and Communication Technologies Electronics and Applied MathematicsUniversite Catholique de Louvain1348 Louvain-la-NeuveBelgium Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Retrieving electrical impedance maps at the nanoscale rapidly via nondestructive inspection with a high signal-to-noise ratio is an unmet need,likely to impact various applications from biomedicine to energy *** this study,we develop a multimodal functional imaging instrument that is characterized by the dual capability of impedance mapping and phase quantitation,high spatial resolution,and low temporal *** achieve this,we advance a quantitative phase imaging system,referred to as epi-magnified image spatial spectrum microscopy combined with electrical actuation,to provide complementary maps of the optical path and electrical *** demonstrate our system with high-resolution maps of optical path differences and electrical impedance variations that can distinguish nanosized,semi-transparent,structured coatings involving two materials with relatively similar electrical *** map heterogeneous interfaces corresponding to an indium tin oxide layer exposed by holes with diameters as small as~550 nm in a titanium(dioxide)over-layer deposited on a glass *** show that electrical modulation during the phase imaging of a macro-electrode is decisive for retrieving electrical impedance distributions with submicron spatial resolution-and beyond the limitations of electrode-based technologies(surface or scanning technologies).The findings,which are substantiated by a theoretical model that fits the experimental data very well enable achieving electro-optical maps with high spatial and temporal *** virtues and limitations of the novel optoelectrochemical method that provides grounds for a wider range of electrically modulated optical methods for measuring the electric field locally are critically discussed.

关键词： impedance resolution phase

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Treatment of pulmonary coccidioidomycosis after successful hepatitis C therapy in a patient with fluconazole induced hepatotoxicity

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Open Journal of Gastroenterology 2012年第1期2卷 22-27页

作者： Zohreh Movahedi david Wisinger sorin Petre Jyotsna Ravi Thomas Ardiles Renee Prevette Ali Al-Yaqoobi Abdul Nadir Department of Medicine Maricopa Medical Center Phoenix USA.

A patient with hepatitis C infection and cavitary pul- monary coccidioidomycosis is reported. Treatment of hepatitis C was associated with resolution of flucona- zole-induced hepatotoxicity. Successful treatment of he- patitis C enabled the patient to tolerate increaseing doses of fluconazole. This case highlights that hepatic toxicity of fluconazole can improve after successful treatment of hepatitis C.

关键词： Coccidioidomycosis Fluconazole Hepatotoxicity

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