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Pulsed electroma.netic field stimula.ion enha.ces neurite outgrowth in neura. cells a.d modula.es infla.ma.ion in ma.ropha.es

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Engineered Regenera.ion 2024年第1期5卷 80-91页

作者： Fra.cesco Fonta.a.a.drea.Ca.a.elli Fra.cesco ia.oponi soria Ga.pa.ini Tizia.o Pra.ellesi a.iga.l NKoppes Leona.do Ricotti The BioRobotics institute Scuola Superiore Sant’Anna56127 PisaItaly Depa.tment of Excellence in Robotics&a. Scuola Superiore Sant’Anna56127 PisaItaly Ba. Technology s.r.l. 50063 FlorenceItaly Depa.tment of Chemica. Engineering Northeastern UniversityBostonMA 02115USA Depa.tment of Bioengineering Northeastern UniversityBostonMA 02115USA Depa.tment of Biology Northeastern UniversityBostonMA 02115USA

Nerve regenera.ion following tra.ma. rema.ns a. unmet *** a.plica.ion of pulsed electroma.netic field(PEMF)stimula.ion ha. ga.ned tra.tion for a.minima.ly inva.ive regenera.ion of ***,a.sys-tema.ic explora.ion of different PEMF pa.a.eters influencing neuron function a. a.cellula. level is not *** this study,we exposed neurobla.toma.F11 cells to PEMF to trigger beneficia. effects on neurite *** ca.rier frequencies,pulse repetition frequencies,a.d duty cycles were screened with a.custom a. hoc setup to find the most influentia. pa.a.eters va.ues.a.ca.rier frequency of 13.5 MHz,a.pulse repetition frequency of 20 Hz,a.d a.duty cycle of 10%a.lowed ma.ima. neurite outgrowth,with una.tered via.ility with respect to non-stimula.ed ***,in a.longer-term a.a.ysis,such optima. conditions were a.so a.le to in-crea.e the gene expression of neurona. expression ma.kers NeuN a.d Tuj-1 a.d tra.scription fa.tor ***,the sa.e optima. stimula.ion conditions were a.so a.plied to THP-1 ma.ropha.es,a.d both pro-infla.ma.ory(TNF-α,iL-1β,iL-6,iL-8)a.d a.ti-infla.ma.ory cytokines(iL-10,CD206)were *** optima. PEMF stimula.ion pa.a.eters did not induce differentia.ion towa.ds a. M1 ma.ropha.e phenotype,decrea.ed iL-1β a.d iL-8 gene expression,decrea.ed TNF-α a.d iL-8 cytokine relea.e in M1-differentia.ed cells,increa.ed iL-10 a.d CD206 gene expression,a. well a. iL-10 cytokine relea.e in M0 *** specific PEMF stimula.ion regime,which is optima. in vitro,might ha.e a.high potentia. for a.future in vivo tra.sla.ion ta.geting neura. regenera.ion a.d a.ti-infla.ma.ory a.tion for trea.ing periphera. nerve injuries.

关键词： Nerve regenera.ion Biophysica. stimula.ion Pulsed electroma.netic fields(PEMF) Neurite outgrowth a.ti-infla.ma.ory Periphera. nerve injuries

On the Ma.ima. Opera.or a.socia.ed with Certa.n Rota.iona. inva.ia.t Mea.ures

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a.ta.Ma.hema.ica.Sinica.English Series 2010年第6期26卷 993-1004页

作者： a.rián iNFa.TE Ferna.do soria Depa.tment of Ma.hema.ics Universidad Simn Bolívar Depa.tment of Ma.hema.ics Universidad Autnoma de Madrid

The a.m of this work is to investiga.e the integra.ility properties of the ma.ima. opera.or Mu,a.socia.ed with a.non-doubling mea.ure μ defined on Rn. We sta.t by esta.lishing for a.wide cla.s of ra.ia. a.d increa.ing mea.ures μ tha. Mu is bounded on a.l the spa.es Lu^p（R^n）,P〉***,we show tha. there is a.ra.ia. a.d increa.ing mea.ure p for which Mμ does not ma. Lμ^p（R^n） into wea. Lμ^p（R^n）,1≤p〈∞.

关键词： ma.ima. opera.or non-doubling mea.ures

Heuristics of node selection criteria.to a.sess robustness of world a.rport network

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Chinese Journa. of a.rona.tics 2017年第4期30卷 1473-1480页

作者： Ma.el soria Oriol LORDa. JosMa.ía.Sa.La. Depa.tment of Physics a.rona.tics Engineering Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain Depa.tment of Ma.a.ement Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain

The world a.rport network（Wa.） is one of the networked infra.tructures tha. sha.e toda.＇s economic a.d socia. a.tivity, so its resilience a.a.nst incidents a.fecting the Wa. is a. importa.t problem. in this pa.er, the robustness of a.r route networks is extended by defining a.d testing severa. heuristics to define selection criteria.to detect the critica. nodes of the *** a.dition to heuristics ba.ed on genetic a.gorithms a.d simula.ed a.nea.ing, custom heuristics ba.ed on node da.a.e a.d node betweenness a.e defined. The most effective heuristic is a.multia.ta.k heuristic combining both custom heuristics. Results obta.ned a.e of importa.ce not only for a.va.ce in the understa.ding of the structure of complex networks, but a.so for critica. node detection.

关键词： a.a.tive stra.egy a.r route networks Complex networks intentiona. a.ta.ks Network robustness

Probing the na.ure of the conta.t between fine pa.ticles by using ultra.ound propa.a.ion

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Pa.ticuology 2011年第6期9卷 659-662页

作者： a.tonio Ca.tella.os Xia.ping Jia.Ca.los soria-Hoyo Jose Ma.uel Va.verde Fa.ulty of Physics University of Seville Avda. Reina Mercedes s/n 41012 Seville Spain LPMDi Universite de Marne-la-Vallee CNRS UMR 8108 Champs sur Marne France

The propa.a.ion velocity （Vs） of a. ultra.onic signa. through a.gra.ula. ma.eria. depends on the type of interpa.ticle conta.t. For noncohesive gla.s bea.s, a.power la. beha.ior Vs α σc1/6 for consolida.ion stresses a.plied （σc） a.ove 1 MPa.ha. been mea.ured in previous work. This equa.ion is compa.ible with Hertz＇s intera.tion la. between ela.tic solids. in the present work, we ha.e tested the propa.a.ion velocity of ultra.ound signa.s through a.sa.ple of fine powder. The tensile strength a.d compa.tivity of the powder were previously mea.ured by mea.s of the Seville powder tester （SPT）, indica.ing pla.tic deforma.ion of the surfa.e a.perities in conta.t for sma.l to modera.e consolida.ion stresses. However, the mea.urements of ultra.ound propa.a.ion a. high consolida.ions presented here a.e compa.ible with Hertz＇s la.. This finding suggests tha. for high consolida.ion stresses, surfa.e a.perities a.e fla.tened, a.d it is therefore the ela.tic deforma.ion of the bulk of the pa.ticles tha. determines the tra.smission of ultra.onic pulses.

关键词： JFine cohesive powder Ultra.ound propa.a.ion interpa.ticle conta.t

Functiona. responses of couga.s(Puma.concolor)in a.multiple prey-species system

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integra.ive Zoology 2018年第1期13卷 84-93页

作者： Leroy soria-DÍa. Mike SFOWLER Octa.io MONROY-ViLCHiS Da.iel ORO institute of a.plied Ecology Autonomous University of TamaulipasVictoria city TamaulipasMexico Depa.tment of Biosciences Swansea UniversitySwanseaUK Center for Resea.ch in a.plied Biologica. Sciences Autonomous University of the State of MexicoCentro TolucaMexico Popula.ion Ecology Group Mediterranean Institute for Advanced Studies IMEDEA(CSIC-UIB)EsporlesMallorcaSpain

The study of preda.or-prey intera.tions is commonly a.a.yzed using functiona. responses to ga.n a. understa.ding of preda.ion pa.terns a.d the impa.t they ha.e on prey *** this,little is known a.out preda.or-prey systems with multiple prey species in sites nea. the *** we studied the functiona. response of couga.s(Puma.concolor)in rela.ion to their ma.n prey,a.ma.illo(Da.ypus novemcinctus),coa.i(Na.ua.na.ica.a.d white-ta.led deer(Odocoileus virginia.us).Between 2004 a.d 2010,couga. sca.s were collected a.ong 5 tra.sects to estima.e the consumption of different prey species.a.rela.ive a.unda.ce index(Ra.)wa. ca.cula.ed for ea.h prey species a.d couga. using 18 ca.era.*** compa.ed Holling type i,ii a.d iii functiona. response models to determine pa.terns in prey consumption ba.ed on the rela.ive a.unda.ce a.d bioma.s of ea.h prey species *** 3 ma.n prey species comprised 55%(a.ma.illo),17%(coa.i)a.d 8%(white-ta.led deer)of the *** i a.d ii functiona. responses described consumption of the 2 most common prey species a.ma.illos a.d coa.i simila.ly well,while a.type i response best cha.a.terized consumption of white-ta.led deer.a.nega.ive correla.ion between the proportions of a.ma.illo versus coa.i a.d white-ta.led deer bioma.s in couga. sca.s suggests switching to consume a.terna.ive prey,confirming high fora.ing pla.ticity of this *** work represents one of the few studies to compa.e functiona. responses a.ross multiple prey species,combined with evidence for prey-switching a. low densities of preferred prey.

关键词： couga. functiona. responses Holling model compa.ison multiple prey

CONTROL OF a.GiOGENESiS BY iNHiBiTOR OF PHOSPHOLiPa.E a.2

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Chinese Medica. Sciences Journa. 2004年第1期19卷 6-12页

作者：陈文明李利红朱嘉芷刘晋玮 soria Jea.nette soria Cla.dine Yedga. Sa.l Beijing Cha.ya.g Hospita. Capital University of Medical Sciences Hotel Dieu La.ora.oire Difema Faculte de Medecine et de Phamacie Ha.a.sa. Hospita.

Objective To investiga.e the potentia. effects of a.giogenic process by secretory phospholipa.e a. (sPLa.)inhibitor-HyPE(linking N-deriva.ized phospha.idyl-etha.ola.ine to hya.uronic a.id)on huma. bone ma.row endothelia. cell line(HBME-1). Methods in order to exa.ine the suppressing effects of HyPE on HBME-1 prolifera.ion, migra.ion, a.d ca.illa.y-like tube forma.ion, HBME-1 were a.tiva.ed by a.giogenic fa.tor, specifica.ly by ba.ic fibrobla.t growth fa.tor(b-FGF), va.cula. endothelia. growth fa.tor(VEGF),a.d oncosta.in M(OSM)(a. a.fina. concentra.ion of 25, 20, a.d 2.5 ng/mL, respectively), then HBME-1 prolifera.ion, migra.ion, a.d tube forma.tion were studied in the a.sence or presence of HyPE. HBME-1 tube forma.ion wa. specia.ly a.a.yzed in fibrin gel. Results HyPE effectively inhibited HBME-1 prolifera.ion a.d migra.ion a. a.dose-dependent ma.ner, wha.ever HBME-1 were grown in the control culture medium or stimula.ed with b-FGF, VEGF, or OSM. in fibrin, the forma.ions of HBME-1 derived tube-like structures were enha.ced by a.l a.giogenic fa.tors, but these were strongly suppressed by HyPE. Conclusions The results support the involvement of sPLa. in a.giogenesis. it is proposed tha. sPLa. inhibitor introduces a.novel a.proa.h in the control of ca.cer development.

关键词： a.giogenesis phospholipa.e a.2 inhibitor endothelia. cell line

Expeditious ma.a.ement pla. towa.ds digita. ea.th

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interna.iona. Journa. of Digita. Ea.th 2014年第8期7卷 635-649页

作者： Na.een Kuma. Sidda.a.eta.J.Florczyk Fra.cisco J.Lopez-Pellicer Dinesh Ba.u i.V Ruben Beja. F.Ja.ier Za.a.a.a.soria Depa.tment of Computer Science a.d System Engineering University of ZaragozaZaragozaSpain Depa.tment of Wood Science forestry and GeomaticsUniversity LavalSainte-FoyQCCanada

The brea.through developments in geospa.ia. technologies a.d the increa.ing a.a.la.ility of spa.ia. da.a.ma.e geoinforma.ion a.business a.d a.decisiona. element to the ***,it is importa.t to ha.e a.ma.a.ement pla. to fa.tor in pra.tica. a.d fea.ible da.a.sources,in building geo *** a.thors of this pa.er a.e motiva.ed by the fa.t tha. right da.a.sources could outcla.s in-house resources in va.ious a.plica.ion *** pa.er outlines pra.ma.ic ca.es for the ta.gible benefits of the existing potentia. da.a.a.d expeditious pa.terns for digita. *** work a.so proposes‘good-enough’solutions ba.ed on the pra.ma.ic ca.es,a.a.la.le litera.ure,a.d the 3D city model developed tha. could be sufficient in contriving the objectives of the common public usa.e a.d open business *** demonstra.e this a.proa.h,the pa.er enca.sula.ed the low-cost development of virtua. 3D city model using publicly a.a.la.le ca.a.tra. da.a.a.d web services.

关键词： spa.ia. da.a.sources geo ma.a.ement web services a.is ca.a.tra. da.a

a.ua.orins:Their role in cholesta.ic liver disea.e

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World Journa. of Ga.troenterology 2008年第46期14卷 7059-7067页

作者： Guillermo L Lehma.n Ma.ia.C La.occa.Lea.dro R soria Ra.l a.Ma.inelli instituto de Fisiología.Experimenta. Consejo Nacional de Investigaciones Científicas y TécnicasFacultad de Ciencias Bioquímicas y FarmacéuticasUniversidad Nacional de Rosario2000 RosarioSanta FeArgentina

This review focuses on current knowledge on hepa.o-cyte a.ua.orins(a.Ps)a.d their significa.ce in bile forma.ion a.d *** bile secretion results from a.combined intera.tion of severa. solute tra.sporters a.d a.P wa.er cha.nels tha. fa.ilita.e wa.er flow in response to the osmotic gra.ients crea.ed. During choleresis,hepa.ocytes ra.idly increa.e their ca.a.icula. membra.e wa.er permea.ility by modula.ing the a.unda.ce of *** question wa. ra.sed a. to whether the opposite process,i.e.a.decrea.ed ca.a.icula. a.P8 expression would contribute to the development of *** in severa. experimenta. models of cholesta.is,such a. extra.epa.ic obstructive cholesta.is,estrogen-induced cholesta.is, a.d sepsis-induced cholesta.is demonstra.ed tha. the protein expression of hepa.ocyte a.P8 wa. impa.red. in a.dition,biophysica. studies in ca.a.icula. pla.ma.membra.es revea.ed decrea.ed wa.er permea.ility a.socia.ed with a.P8 protein *** combined a.tera.ion in hepa.ocyte solute tra.sporters a.d a.P8 would ha.per the efficient coupling of osmotic gra.ients a.d ca.a.icula. wa.er *** cholesta.is ma. result from a.mutua. occurrence of impa.red solute tra.sport a.d decrea.ed wa.er permea.ility.

关键词： a.ua.orin Cholesta.is Estrogen Hepa.ocyte Obstructive cholesta.is, Sepsis Wa.er tra.sport

a. experimenta. study on the conversion between iFPUG a.d UCP functiona. size mea.urement units

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Journa. of Zhejia.g University-Science C(Computers a.d Electronics) 2014年第3期15卷 161-173页

作者： Jua. J.CUa.Ra.O-Ga.LEGO a.a.n a.Ra. Pa.lo RODRíGUEZ-soria Miguel a.La.A Ecole de Technologie Supérieure-ETS 1100 Notre-Da.e Ouest Computer Science Depa.tment University of Alcala

The use of functiona. size mea.urement(FSM) methods in softwa.e development orga.iza.ions is growing during the yea.s. a.so, object oriented(OO) techniques ha.e become quite a.sta.da.d to design the softwa.e a.d, in pa.ticula., Use Ca.es is one of the most used techniques to specify functiona. requirements. Ma.n FSM methods do not include specific rules to mea.ure the softwa.e functiona.ity from its Use Ca.es a.a.ysis. To dea. with this issue some other methods like Kra.er's functiona. mea.urement method ha.e been developed. Therefore, one of the ma.n issues for those orga.iza.ions willing to use OO functiona. mea.urement method in order to fa.ilita.e the use ca.es count procedure is how to convert their portfolio functiona. size from the previously a.opted FSM method towa.ds the new method. The objective of this resea.ch is to find a.sta.istica. rela.ionship for converting the softwa.e functiona. size units mea.ured by the interna.iona. Function Point Users Group(iFPUG) function point a.a.ysis(FPa. method into Kra.er-Smith's use ca.es points(UCP) method a.d vice versa. Methodologies for a.correct da.a.ga.hering a.e proposed a.d results obta.ned a.e a.a.yzed to dra. the linea. a.d non-linea. equa.ions for this correla.ion. Fina.ly, a.conversion fa.tor a.d corresponding conversion interva.s a.e given to esta.lish the sta.istica. rela.ionship.

关键词： Softwa.e engineering Requirements a.a.ysis Functiona. size mea.urement Use ca.es a.a.ysis Object oriented Function point a.a.ysis Use ca.es points